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公开(公告)号：US20090130717A1
公开(公告)日：2009-05-21
申请号：US12084878
申请日：2006-05-16
申请人： Satoshi Omura , Hiroshi Tomoda , Yong-pil Kim , Hideaki Hanaki , Atsuko Matsumoto , Yoko Takahashi
发明人： Satoshi Omura , Hiroshi Tomoda , Yong-pil Kim , Hideaki Hanaki , Atsuko Matsumoto , Yoko Takahashi
摘要： A microorganism represented by a strain K04-0144 belonging to Streptomyces sp. having ability to produce K04-0144 substance is cultured in the medium, and the isolated K04-0144A substance, K04-0144B substance and K04-0144C substance therefrom have strong antibacterial activities against Gram-positive bacteria including methicillin-resistant Streptococcus aureus (MRSA), consequently these are useful as the therapeutic agents for infectious disease caused by MRSA as well as infectious diseases caused by multidrug including β-lactam antibiotics resistant bacteria. Further, similarly, since the novel K04-0144D substance isolated from the cultured liquid has the action for enhancing the effect of β-lactam antibiotics, which are utilized as the antibacterial agents, in combination with them, it is useful as the therapeutic agent for infectious diseases caused by methicillin-resistant Staphylococcus aureus (MRSA) and multidrug including β-lactam antibiotics resistant bacteria.
摘要翻译： 属于Streptomyces sp。的菌株K04-0144所代表的微生物 在培养基中培养生产K04-0144物质的能力，分离的K04-0144A物质，K04-0144B物质和K04-0144C物质对革兰氏阳性菌（包括耐甲氧西林金黄色葡萄球菌（MRSA））具有很强的抗菌活性， 因此，这些可用作由MRSA引起的感染性疾病的治疗剂以及由多种药物（包括β-内酰胺抗生素抗性细菌）引起的感染性疾病。 此外，类似地，由于从培养液体中分离的新型K04-0144D物质具有增强作为抗菌剂的β-内酰胺抗生素与其组合的作用，因此可用作治疗剂 由耐甲氧西林金黄色葡萄球菌（MRSA）引起的感染性疾病和包括β-内酰胺抗生素抗性细菌在内的多种药物。
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公开(公告)号：US07973147B2
公开(公告)日：2011-07-05
申请号：US12084878
申请日：2006-05-16
申请人： Satoshi Omura , Hiroshi Tomoda , Yong-pil Kim , Hideaki Hanaki , Atsuko Matsumoto , Yoko Takahashi
发明人： Satoshi Omura , Hiroshi Tomoda , Yong-pil Kim , Hideaki Hanaki , Atsuko Matsumoto , Yoko Takahashi
摘要： A microorganism represented by a strain K04-0144 belonging to Streptomyces sp. having ability to produce K04-0144 substance is cultured in the medium, and the isolated K04-0144A substance, K04-0144B substance and K04-0144C substance therefrom have strong antibacterial activities against Gram-positive bacteria including methicillin-resistant Streptococcus aureus (MRSA), consequently these are useful as the therapeutic agents for infectious disease caused by MRSA as well as infectious diseases caused by multidrug including β-lactam antibiotics resistant bacteria. Further, similarly, since the novel K04-0144D substance isolated from the cultured liquid has the action for enhancing the effect of β-lactam antibiotics, which are utilized as the antibacterial agents, in combination with them, it is useful as the therapeutic agent for infectious diseases caused by methicillin-resistant Staphylococcus aureus (MRSA) and multidrug including β-lactam antibiotics resistant bacteria.
摘要翻译： 属于Streptomyces sp。的菌株K04-0144所代表的微生物 在培养基中培养生产K04-0144物质的能力，分离的K04-0144A物质，K04-0144B物质和K04-0144C物质对革兰氏阳性菌（包括耐甲氧西林金黄色葡萄球菌（MRSA））具有很强的抗菌活性， 因此，这些可用作由MRSA引起的感染性疾病的治疗剂以及由多种药物（包括β-内酰胺抗生素抗性细菌）引起的感染性疾病。 此外，类似地，由于从培养液中分离的新型K04-0144D物质具有增强作为抗菌剂的β-内酰胺抗生素与其组合的作用，因此可用作治疗剂 用于由耐甲氧西林金黄色葡萄球菌（MRSA）引起的感染性疾病和包含β-内酰胺抗生素抗性细菌的多药物。
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公开(公告)号：US20060089298A1
公开(公告)日：2006-04-27
申请号：US10508413
申请日：2003-01-17
申请人： Satoshi Omura , Hiroshi Tomoda , Masato Iwatsuki , Yoko Takahashi
发明人： Satoshi Omura , Hiroshi Tomoda , Masato Iwatsuki , Yoko Takahashi
摘要： The present invention is comprised of culturing a microorganism having ability to produce K01-B0171-B substance and/or K01-B0171-C substance in a medium, accumulating K01-B0171-B substance and/or K01-B0171-C substance in a culture fluid and isolating K01-B0171-B substance and/or, K01-B0171-C substance from the culture fluid. The obtained K01-B0171-B substance, K01-B0171-C substance or a composition of these substances is expected to be useful as a medicament of antituberculous agent.
摘要翻译： 本发明包括在培养基中培养具有生产K01-B0171-B物质和/或K01-B0171-C物质的微生物的微生物，将K01-B0171-B物质和/或K01-B0171-C物质累积在 培养液并从培养液中分离K01-B0171-B物质和/或K01-B0171-C物质。 获得的K01-B0171-B物质，K01-B0171-C物质或这些物质的组合物预期可用作抗结核药物的药物。
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公开(公告)号：US07439225B2
公开(公告)日：2008-10-21
申请号：US10508413
申请日：2003-01-17
申请人： Satoshi Omura , Hiroshi Tomoda , Masato Iwatsuki , Yoko Takahashi
发明人： Satoshi Omura , Hiroshi Tomoda , Masato Iwatsuki , Yoko Takahashi
IPC分类号： A61K38/12
摘要： The present invention is comprised of culturing a microorganism having ability to produce K01-B0171-B substance and/or K01-B0171-C substance in a medium, accumulating K01-B0171-B substance and/or K01-B0171-C substance in a culture fluid and isolating K01-B0171-B substance and/or, K01-B0171-C substance from the culture fluid. The obtained K01-B0171-B substance, K01-B0171-C substance or a composition of these substances is expected to be useful as a medicament of antituberculous agent.
摘要翻译： 本发明包括在培养基中培养具有生产K01-B0171-B物质和/或K01-B0171-C物质的微生物的微生物，将K01-B0171-B物质和/或K01-B0171-C物质累积在 培养液并从培养液中分离K01-B0171-B物质和/或K01-B0171-C物质。 获得的K01-B0171-B物质，K01-B0171-C物质或这些物质的组合物预期可用作抗结核药物的药物。
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公开(公告)号：US20060287252A1
公开(公告)日：2006-12-21
申请号：US10571263
申请日：2004-02-09
申请人： Satoshi Omura , Akio Abe , Masato Iwatuki , Yoko Takahashi , Hiroshi Tomoda
发明人： Satoshi Omura , Akio Abe , Masato Iwatuki , Yoko Takahashi , Hiroshi Tomoda
IPC分类号： A61K38/04 , C12P21/04 , C12P17/00 , C07D403/02 , C07K5/04
CPC分类号： C12R1/465 , C07K5/1024 , C12P17/165
摘要： A microorganism belonging to the genus Streptomyces and being capable of producing substance K01-0509-A1 and/or substance K01-0509-A2 is cultured in a medium. Then, the substance K01-0509-A1 and/or the substance K01-0509-A2 having been thus accumulated in the liquid culture medium are collected from the medium. It is expected that the obtained substances are efficacious as drugs which are selectively effective on pathogenic gram-negative bacteria having the type III secretion system.
摘要翻译： 在培养基中培养属于链霉菌属的能够产生物质K01-0509-A1和/或物质K01-0509-A2的微生物。 然后，从介质中收集已经积累在液体培养基中的物质K01-0509-A1和/或物质K01-0509-A2。 预期所获得的物质作为对具有III型分泌系统的病原性革兰氏阴性细菌有选择性的药物是有效的。
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公开(公告)号：US20060014825A1
公开(公告)日：2006-01-19
申请号：US10492654
申请日：2002-10-11
申请人： Satoshi Omura , Hiroshi Tomoda , Yoko Takahashi
发明人： Satoshi Omura , Hiroshi Tomoda , Yoko Takahashi
IPC分类号： A61K31/365 , C12P17/02 , C07D313/00
CPC分类号： C07D313/00 , C07D315/00 , C12P17/08 , C12R1/465
摘要： The present invention relates to effective drugs for mycosis caused by so called fungi such as fungi and yeast. The present invention is comprised of culturing a microorganism belonging to genus Streptomyces and having ability to produce K99-5278A substance, K99-5278B substance and K99-5278C substance in a medium, accumulating K99-5278A substance, K99-5278B substance and K99-5278C substance in the cultured medium and isolating K99-5278A substance, K99-5278B substance and K99-5278C substance from the cultured mass. The thus obtained substances can be expected as a novel antifungal agent.
摘要翻译： 本发明涉及由所谓的真菌如真菌和酵母引起的用于真菌病的有效药物。 本发明包括培养属于链霉菌属的微生物，并且能够在培养基中生产K99-5278A物质，K99-5278B物质和K99-5278C物质，积累K99-5278A物质，K99-5278B物质和K99-5278C 培养基中的物质，并从培养物质中分离K99-5278A物质，K99-5278B物质和K99-5278C物质。 可以预期由此获得的物质作为新颖的抗真菌剂。
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公开(公告)号：US06747056B2
公开(公告)日：2004-06-08
申请号：US10359145
申请日：2003-02-06
IPC分类号： A61K3140
CPC分类号： C07D207/32
摘要： The present invention comprising culturing a microorganism which belongs to genus Streptomyces and has ability to produce K99-5041-C1x substance and/or K99-5041-C2x substance in a medium, accumulating K99-5041-C1x substance and/or K99-5041-C2x substance in the culture fluid, and isolating K99-5041-C1x substance and/or K99-5041-C2x substance form the cultured mass. Since the obtained K99-5041-C1x substance and/or K99-5041-C2x substance exhibit inhibitory activity against lanosterol synthase, these substances are expected to apply clinically for preventive and therapeutic agents caused by accumulation of cholesterol in humans and antifungal agents.
摘要翻译： 本发明包括培养属于链霉菌属的微生物，并且能够在培养基中产生K99-5041-C1x物质和/或K99-5041-C2x物质，积累K99-5041-C1x物质和/或K99-5041- 培养液中的C2x物质，并从培养物质中分离K99-5041-C1x物质和/或K99-5041-C2x物质。 由于所获得的K99-5041-C1x物质和/或K99-5041-C2x物质对羊毛甾醇合酶表现出抑制活性，所以预期这些物质将临床应用于人类和抗真菌剂中胆固醇积聚引起的预防和治疗剂。
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8.发明授权公开(公告)号：US06512008B1
公开(公告)日：2003-01-28
申请号：US09857268
申请日：2001-08-22
申请人： Satoshi Omura , Hiroshi Tomoda , Yoko Takahashi
发明人： Satoshi Omura , Hiroshi Tomoda , Yoko Takahashi
IPC分类号： C12P1718
CPC分类号： C12P13/008 , C07F15/025 , C12P9/00 , C12R1/465
摘要： The present invention relates to novel substance having inhibitory action on cholesteryl ester transfer protein, WK-5344A substance and WK-5344B substance, and process for production thereof. A microorganism belonging to genus Streptomyces having ability to produce WK-5344A substance and WK-5344B substance is cultured in a medium, and the WK-5344A substance and the WK-5344B substance are accumulated in the medium, then the WK-5344A substance and the WK-5344B substance are isolated from the said medium. Since the present substance shows significant inhibitory action on cholesteryl ester transfer protein, the substance is effective for prevention and treatment of diseases caused by accumulation of cholesterol in human.
摘要翻译： 本发明涉及对胆固醇酯转移蛋白，WK-5344A物质和WK-5344B物质具有抑制作用的新物质及其生产方法。 在培养基中培养属于具有产生WK-5344A物质和WK-5344B物质的链霉菌属的微生物，将WK-5344A物质和WK-5344B物质累积在培养基中，然后将WK-5344A物质和 WK-5344B物质与所述介质分离。 由于本物质对胆固醇酯转移蛋白质具有显着的抑制作用，所以该物质对于预防和治疗由人胆固醇积累引起的疾病是有效的。
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公开(公告)号：US08367707B2
公开(公告)日：2013-02-05
申请号：US12903624
申请日：2010-10-13
申请人： Kimihiko Goto , Ryo Horikoshi , Mariko Tsuchida , Kazuhiko Oyama , Satoshi Omura , Hiroshi Tomoda , Toshiaki Sunazuka
发明人： Kimihiko Goto , Ryo Horikoshi , Mariko Tsuchida , Kazuhiko Oyama , Satoshi Omura , Hiroshi Tomoda , Toshiaki Sunazuka
IPC分类号： A01N43/40 , A61K31/44 , C07D211/34
CPC分类号： A01N43/90
摘要： Disclosed is a composition for use as a pest control agent, comprising a compound represented by formula (I) or an agriculturally and horticulturally acceptable salt thereof as active ingredient and an agriculturally and horticulturally acceptable carrier:
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公开(公告)号：US20110105769A1
公开(公告)日：2011-05-05
申请号：US12867435
申请日：2009-02-12
申请人： Hiroshi Tomoda , Ryuji Uchida , Rokuro Masuma , Satoshi Omura
发明人： Hiroshi Tomoda , Ryuji Uchida , Rokuro Masuma , Satoshi Omura
IPC分类号： C07D407/10 , C12P17/06 , C12N1/14
CPC分类号： A61K36/06 , C07D311/92 , C12P17/162 , C12R1/80
摘要： This invention relates to substance FKI-3864 represented by the following formula [I] having an inhibitory activity on the synthesis of triacylglycerols and a method for preparing the same. The substance FKI-3864 can be prepared by a method comprising culturing a microorganism which belongs to the genus Penicillium and is capable of producing the substance FKI-3864, and particularly Penicillium pinophilum FKI-3864 (FERM BP-11093) so as to accumulate the substance FKI-3864 in the culture and collecting the substance FKI-3864 from the culture. The substance has an inhibitory activity on the synthesis of intracellular triacylglycerols and is useful for prevention or treatment of obesity.
摘要翻译： 本发明涉及具有对三酰基甘油合成抑制活性的下式[I]表示的物质FKI-3864及其制备方法。 物质FKI-3864可以通过包括培养属于青霉属的微生物并能够产生物质FKI-3864，特别是嗜热青霉FKI-3864（FERM BP-11093）的方法来制备，以便积累 培养物质FKI-3864，从培养物中收集物质FKI-3864。 该物质对细胞内三酰基甘油的合成具有抑制活性，可用于预防或治疗肥胖症。
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