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    Heterocyclic ppar modulators
    3.
    发明申请
    Heterocyclic ppar modulators 审中-公开
    杂环ppar调节剂

    公开(公告)号：US20060241157A1

    公开(公告)日：2006-10-26

    申请号：US10540341

    申请日：2003-12-31

    申请人： Scott Conner ,  Tianwei Ma ,  Nathan Mantlo ,  Daniel Mayhugh ,  Jeffrey Schkeryantz ,  Alan Warshawsky ,  Guoxin Zhu

    发明人： Scott Conner ,  Tianwei Ma ,  Nathan Mantlo ,  Daniel Mayhugh ,  Jeffrey Schkeryantz ,  Alan Warshawsky ,  Guoxin Zhu

    IPC分类号： A61K31/425 ,  A61K31/42 ,  A61K31/415 ,  C07D261/02 ,  C07D231/12

    CPC分类号： C07D231/12 ,  C07D233/20 ,  C07D233/22 ,  C07D233/64 ,  C07D249/06 ,  C07D253/04 ,  C07D261/08

    摘要： The present invention is directed to compounds represented by the following structural formula, Formula I: wherein: (a) X is selected from the group consisting of a single bond, O, S, S(O)2 and N; (b) U is an aliphatic linker; (c) Y is selected from the group consisting of O, C, S, NH and a single bond; (d) E is C(R3)(R4)A or A and wherein (i) A is selected from the group consisting of carboxyl, tetrazole, C1-C6 alkylnitrile, carboxamide, sulfonamide and acylsulfonamide; (e) Z1 and Z2 are each independently selected from the group consisting of N, O, and C with the proviso that at least one of Z1 and Z2 is N; (f) Z3 is selected from the group consisting of N, O, and C. (g) R8 is selected from the group consisting of hydrogen, C1-C6 alkyl, C1-C4 alkylenyl and halo; (h) R9 is selected from the group consisting of hydrogen, C1-C4 alkyl, C1-C4 alkylenyl, halo, aryl-C0-C4 alkyl, heteroaryl, C1-C6 allyl, and OR29.

    摘要翻译： 本发明涉及由以下结构式（I）表示的化合物：其中：（a）X选自单键，O，S，S（O）2和N; （b）U是脂族连接体; （c）Y选自O，C，S，NH和单键; （d）E是C（R3）（R4）A或A，其中（i）A选自羧基，四唑，C 1 -C 6烷基腈，甲酰胺，磺酰胺和酰基磺酰胺; （e）Z1和Z2各自独立地选自N，O和C，条件是Z1和Z2中的至少一个是N; （f）Z 3选自N，O和C.（g）R 8选自氢，C 1 -C 6烷基，C 1 -C 4亚烷基和卤素; （h）R 9选自氢，C 1 -C 4烷基，C 1 -C 4亚烷基，卤素，芳基-C 0 -C 4烷基，杂芳基，C 1 -C 6烯丙基和OR 29。

    Fused heterocyclic derivatives as ppar modulators
    6.
    发明申请
    Fused heterocyclic derivatives as ppar modulators 失效
    熔融杂环衍生物作为ppar调节剂

    公开(公告)号：US20060205744A1

    公开(公告)日：2006-09-14

    申请号：US10539477

    申请日：2003-12-31

    申请人： Scott Conner ,  Nathan Mantlo ,  Guoxin Zhu

    发明人： Scott Conner ,  Nathan Mantlo ,  Guoxin Zhu

    IPC分类号： A61K31/519 ,  A61K31/4745 ,  A61K31/428 ,  A61K31/423 ,  C07D498/02 ,  C07D491/02

    CPC分类号： C07D209/10 ,  C07D235/18 ,  C07D263/57 ,  C07D277/60 ,  C07D277/66 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D513/04

    摘要： The present invention is directed to compounds represented by the following structural formula, Formula I: wherein (a) X is selected from the group consisting of a single bond, O, S, S(O)2 and N; (b) U is an aliphatic linker, (c) Y is selected from the group consisting of C, O, S, NH and a single bond; (d) E is C(R3) (R4) A or A and wherein (i) A is selected from the group consisting of carboxyl, tetrazole, C1-C6 alkylnitrile, carboxamidek, sulfonamide and acylsulfonamide; (e) B is selected from the group consisting of S, O, C, and N; (f) Z is selected from the group consisting of N and C; with the proviso that when B is C then Z is N.

    摘要翻译： 本发明涉及由以下结构式（I）表示的化合物：其中（a）X选自单键，O，S，S（O）2和 N; （b）U是脂族连接体，（c）Y选自C，O，S，NH和单键; （d）E是C（R3）（R4）A或A，其中（i）A选自羧基，四唑，C 1 -C 6 烷基腈，羧酰胺，磺酰胺和酰基磺酰胺; （e）B选自S，O，C和N; （f）Z选自N和C; 条件是当B为C时，则Z为N.

    Bicyclic derivatives as ppar modulators
    8.
    发明申请
    Bicyclic derivatives as ppar modulators 失效
    双环衍生物作为ppar调节剂

    公开(公告)号：US20070106081A1

    公开(公告)日：2007-05-10

    申请号：US10596322

    申请日：2004-12-16

    申请人： Scott Conner ,  Nathan Mantlo ,  Guoxin Zhu ,  Robert Herr

    发明人： Scott Conner ,  Nathan Mantlo ,  Guoxin Zhu ,  Robert Herr

    IPC分类号： C07D231/56

    CPC分类号： C07D409/12 ,  C07D231/56

    摘要： The present invention is directed to compounds represented by the following structural formula, Formula (I), and stereoisomers, pharmaceutically acceptable salts, solvates and hydrates thereof, wherein: (a) R2 is selected from the group consisting of C0-C8 alkyl and C1-4-heteroalkyl; (b) X is selected from the group consisting of a single bond, O, S, S(O)2 and N; (c) U is an aliphatic linker wherein one carbon atom of the aliphatic linker is optionally replaced with O, NH or S, and wherein such aliphatic linker is optionally substituted with from one to four substituents each independently selected from R30; (d) Y is selected from the group consisting of C, O, S, NH and a single bond; and (e) E is C(R3)(R4)A or A.

    摘要翻译： 本发明涉及由下列结构式（I）表示的化合物及其立体异构体，药学上可接受的盐，溶剂合物和水合物，其中：（a）R2选自C 0〜 C 1 -C 8烷基和C 1-4 - 杂烷基; （b）X选自单键O，S，S（O）2 N和N; （c）U是脂族连接体，其中脂族连接体的一个碳原子任选被O，NH或S取代，并且其中这种脂族连接体任选地被1至4个独立地选自R 30的取代基取代; （d）Y选自C，O，S，NH和单键; 和（e）E是C（R3）（R4）A或A。

    Peroxisome proliferator activated receptor modulators
    9.
    发明申请
    Peroxisome proliferator activated receptor modulators 失效
    过氧化物酶体增殖物激活受体调节剂

    公开(公告)号：US20060084663A1

    公开(公告)日：2006-04-20

    申请号：US10505103

    申请日：2003-02-13

    申请人： Scott Conner ,  Nathan Mantlo ,  Guoxin Zhu

    发明人： Scott Conner ,  Nathan Mantlo ,  Guoxin Zhu

    IPC分类号： A61K31/506 ,  A61K31/501 ,  A61K31/497 ,  A61K31/4439 ,  C07D417/02

    CPC分类号： C07D413/04 ,  C07D263/32 ,  C07D277/24 ,  C07D277/26 ,  C07D413/10 ,  C07D417/04 ,  C07D417/10

    摘要： The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts thereof, Formula I: wherein: (a) R5 is selected from the group consisting of (C1-C6) alkyl, (C1-C6) alkenyl, substituted aryl(C0-C4)alkyl, substituted aryloxy(C0-C4)alkyl, substituted arylthio(C0-C4)alkyl, unsubstituted aryl(C0-C4)alkyl, unsubstituted aryloxy(C0-C4)alkyl, and unsubstituted arylthio(C0-C4)alkyl; (b) T1 is C or N; (c) Q is selected from the group consisting of O, a single bond, O(CH2)q and C; (d) q is 1 or 2; (e) W is selected from the group consisting of O, S, (CH2)rN(R20)(CH2)k, NHSO2, C(O)N(R20)(CH2)r, (CH2)rN(R20)C(O), and SO2; (f) X is CmH2m; (g) m is 0, 1 or 2; (h) A is an functional group selected from the group consisting of carboxyl, C1-C3 alkylnitrile, carboxamide, and (CH2)nCOOR19; and (i) R19 is selected from the group consisting of hydrogen, optionally substituted C1-C4alkyl and optionally substituted arylmethyl.

    摘要翻译： 本发明涉及由以下结构式表示的化合物及其药学上可接受的盐，式I：其中：（a）R 5选自（C 1 -C 3） （C 1 -C 6）烷基，（C 1 -C 6 -C 6）链烯基，取代的芳基（C 0 -C 6 - 取代的芳氧基（C 0 -C 4 -C 4烷基）烷基，取代的芳硫基（C 0 -C 4 - 烷基，未取代的芳基（C 0 -C 4 -C 4）烷基，未取代的芳氧基（C 0 -C 4 - 烷基和未取代的芳硫基（C 0 -C 4 -C 4）烷基; （b）T1为C或N; （c）Q选自O，单键，O（CH 2 CH 2）q C和C; （d）q为1或2; （e）W选自O，S，（CH 2）n N（R 20）（CH 2 CH 2） C（O）N（R 20）（CH 2）n），（CH