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公开(公告)号：US09357215B2
公开(公告)日：2016-05-31
申请号：US13764831
申请日：2013-02-12
申请人： Michael Boden , Scott D. Boden
发明人： Michael Boden , Scott D. Boden
CPC分类号： H04N19/90 , H04N21/4307 , H04N21/631 , H04N21/6581 , H04N21/8106
摘要： In some embodiments, a request for an audio stream associated with a video output may be received. Upon receiving the request, the requested audio stream may be encoded for transmission over a network and sent to a user device associated with the request.
摘要翻译： 在一些实施例中，可以接收与视频输出相关联的音频流的请求。 在接收到请求时，所请求的音频流可以被编码用于通过网络传输并发送到与该请求相关联的用户设备。
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2.发明申请NOGGIN INHIBITORY COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO 有权用于操作的NOGGIN抑制组合物及其相关方法公开(公告)号：US20130337082A1
公开(公告)日：2013-12-19
申请号：US13980598
申请日：2012-02-23
CPC分类号： A61L27/00 , A61L27/12 , A61L27/227 , A61L27/54 , A61L2300/414 , A61L2300/432 , A61L2430/02
摘要： This disclosure relates to compounds and compositions for forming bone and methods related thereto. In certain embodiments, the disclosure relates to methods of forming bone comprising implanting a bone graft composition comprising a growth factor such as BMP in a subject at a site of desired bone growth or enhancement in combination with a Noggin blocker.
摘要翻译： 本公开涉及用于形成骨的化合物和组合物及其相关方法。 在某些实施方案中，本公开内容涉及形成骨的方法，包括在Noggin阻断剂组合的期望骨生长或增强的部位，在受试者中植入包含生长因子如BMP的骨移植组合物。
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公开(公告)号：US08469964B2
公开(公告)日：2013-06-25
申请号：US11431693
申请日：2006-05-10
CPC分类号： A61B17/15 , A61B17/06166 , A61B17/68 , A61B17/72 , A61B50/30 , A61B2017/00464 , A61B2017/564 , A61B2050/005 , A61B2050/006 , A61B2090/061 , A61F2/0095 , A61F2/28 , A61F2002/2817 , A61F2002/2825 , A61F2002/30062 , A61F2002/30115 , A61F2002/30116 , A61F2002/30131 , A61F2002/30138 , A61F2002/30159 , A61F2002/30235 , A61F2002/30237 , A61F2002/30238 , A61F2002/30551 , A61F2002/30593 , A61F2002/30616 , A61F2002/30617 , A61F2002/30677 , A61F2002/30714 , A61F2002/30822 , A61F2002/30827 , A61F2002/30828 , A61F2002/30831 , A61F2002/3096 , A61F2002/4658 , A61F2210/0004 , A61F2230/0006 , A61F2230/0013 , A61F2230/0017 , A61F2230/0028 , A61F2230/0069 , A61F2250/0089 , A61F2250/0097 , A61F2310/00179 , A61F2310/00365 , A61L27/54 , A61L2300/222 , A61L2300/252 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/432 , A61L2300/802
摘要： A bone cutting template is disclosed and can include a body. A plurality of grooves can be formed along the body and each groove can correspond to an incremental length of the body. The bone cutting template can include a plurality of length stamps along the body. Each of the plurality of length stamps can be adjacent to a corresponding groove.
摘要翻译： 骨切割模板被公开并且可以包括身体。 可以沿着主体形成多个槽，并且每个槽可对应于主体的增量长度。 骨切割模板可以包括沿着身体的多个长度邮票。 多个长度标记中的每一个可以与相应的凹槽相邻。
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公开(公告)号：US08293232B2
公开(公告)日：2012-10-23
申请号：US13353632
申请日：2012-01-19
CPC分类号： A61K9/0024 , A61K9/0085 , A61K38/177 , A61K38/1774 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/1875 , A61K38/19 , A61K38/30 , A61K47/42 , A61L27/24 , A61L27/54 , A61L27/56 , A61L2300/414
摘要： A carrier matrix may be delivered to a target position within a patient in a minimally invasive manner by first cutting a collagen sponge sheet into a plurality of relatively small pieces. These pieces are sized so that, when wet, they are capable of flowing through a cannula and/or reduced-diameter syringe tip. The pieces are placed into a syringe and wetted, say with a morphogenic solution, and optionally mixed with a bulking material, which is similarly sized to fit through the cannula. The thoroughly mixed and wetted product forms a viscous aggregate which may then be injected into the patient at the target site.
摘要翻译： 通过首先将胶原海绵片切割成多个相对小的片，可以以微创方式将载体基质递送到患者体内的目标位置。 这些件的尺寸使得在潮湿时它们能够流过套管和/或减小直径的针头。 将片放置在注射器中并用形态发生溶液润湿，并且可选地与填充材料混合，膨胀材料的尺寸类似于穿过套管。 充分混合和润湿的产品形成粘性聚集体，然后可以在目标部位将其注入患者体内。
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公开(公告)号：US08268008B2
公开(公告)日：2012-09-18
申请号：US11489262
申请日：2006-07-19
申请人： Randal R. Betz , Scott D. Boden , Christine Clark , Nanette Forsyth , John W. Morris , Kathy Traianedes
发明人： Randal R. Betz , Scott D. Boden , Christine Clark , Nanette Forsyth , John W. Morris , Kathy Traianedes
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2/4455 , A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2002/30059 , A61F2002/30075 , A61F2002/30153 , A61F2002/30329 , A61F2002/30593 , A61F2002/30677 , A61F2002/30805 , A61F2002/30957 , A61F2002/30975 , A61F2002/4649 , A61F2210/0061 , A61F2220/0025 , A61F2230/0019 , A61F2310/00293 , A61F2310/00329 , A61F2310/00365 , A61L27/3608 , A61L27/365 , A61L27/3658 , A61L27/38 , A61L31/005 , A61L2430/02
摘要： An osteoimplant is made up of a coherent aggregate of elongate bone particles.
摘要翻译： 骨植入物由细长骨颗粒的相干骨料组成。
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公开(公告)号：US20110092953A1
公开(公告)日：2011-04-21
申请号：US12977310
申请日：2010-12-23
申请人： Neil Beals , Jeffrey L. Scifert , Scott D. Boden
发明人： Neil Beals , Jeffrey L. Scifert , Scott D. Boden
CPC分类号： A61K9/0024 , A61K9/0085 , A61K38/177 , A61K38/1774 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/1875 , A61K38/19 , A61K38/30 , A61K47/42 , A61L27/24 , A61L27/54 , A61L27/56 , A61L2300/414
摘要： A carrier matrix may be delivered to a target position within a patient in a minimally invasive manner by first cutting a collagen sponge sheet into a plurality of relatively small pieces. These pieces are sized so that, when wet, they are capable of flowing through a cannula and/or reduced-diameter syringe tip. The pieces are placed into a syringe and wetted, say with a morphogenic solution, and optionally mixed with a bulking material, which is similarly sized to fit through the cannula. The thoroughly mixed and wetted product forms a viscous aggregate which may then be injected into the patient at the target site.
摘要翻译： 通过首先将胶原海绵片切割成多个相对小的片，可以以微创方式将载体基质递送到患者体内的目标位置。 这些件的尺寸使得在潮湿时它们能够流过套管和/或减小直径的针头。 将片放置在注射器中并用形态发生溶液润湿，并且可选地与填充材料混合，膨胀材料的尺寸类似于穿过套管。 充分混合和润湿的产品形成粘性聚集体，然后可以在目标部位将其注入患者体内。
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7.发明申请OSTEOGENIC IMPLANTS WITH COMBINED IMPLANT MATERIALS AND METHODS FOR SAME 有权具有组合植入物的OSTEOGENIC植入物及其方法公开(公告)号：US20100266661A1
公开(公告)日：2010-10-21
申请号：US12687518
申请日：2010-01-14
申请人： William F. McKay , Scott D. Boden , Neil B. Beals
发明人： William F. McKay , Scott D. Boden , Neil B. Beals
CPC分类号： A61B17/707 , A61B17/8085 , A61B2017/00004 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2430/02 , C07K14/51 , C07K14/78 , Y10S514/801
摘要： Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.
摘要翻译： 描述的是成骨植入物，其包括至少部分地由承载成骨蛋白质例如骨形态发生蛋白质的第二种植体材料覆盖的第一种植体材料。 第一植入材料可以包括矿物并且提供用于支撑骨向内生长的内部支架部分，并且第二植入材料可以包括覆盖第一植入材料并且具有吸入其中的液体成骨蛋白质制剂的胶原蛋白或其它海绵载体。 相关植入材料及其制备和使用方法构成本发明的另外方面。
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8.发明授权Osteogenic implants with combined implant materials, and materials and methods for same 有权具有组合种植体材料的成骨植入物，以及用于其的材料和方法公开(公告)号：US07722895B1
公开(公告)日：2010-05-25
申请号：US11361026
申请日：2006-02-23
申请人： William F. McKay , Scott D. Boden , Neil Beals
发明人： William F. McKay , Scott D. Boden , Neil Beals
IPC分类号： A61F2/00 , A61F2/02 , A61F2/28 , A61K38/00 , A61K38/16 , A61K38/17 , A61K38/18 , C07K14/78 , C07K14/51
CPC分类号： A61B17/707 , A61B17/8085 , A61B2017/00004 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2430/02 , C07K14/51 , C07K14/78 , Y10S514/801
摘要： Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.
摘要翻译： 描述的是成骨植入物，其包括至少部分地由承载成骨蛋白质例如骨形态发生蛋白质的第二种植体材料覆盖的第一种植体材料。 第一植入材料可以包括矿物并且提供用于支撑骨向内生长的内部支架部分，并且第二植入材料可以包括覆盖第一植入材料并且具有吸入其中的液体成骨蛋白质制剂的胶原蛋白或其它海绵载体。 相关植入材料及其制备和使用方法构成本发明的另外方面。
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公开(公告)号：US07517866B2
公开(公告)日：2009-04-14
申请号：US11433059
申请日：2006-05-12
申请人： Scott D. Boden
发明人： Scott D. Boden
CPC分类号： C07K14/51 , A61K38/00 , A61K48/00 , C07K14/4702 , C07K14/52
摘要： The present invention is directed to isolated nucleic acid molecules that encode LIM mineralization protein, or LMP. The invention further provides vectors comprising splice variants of nucleotide sequences that encode LMP, as well as host cells comprising those vectors. Moreover, the present invention relates to methods of inducing bone formation by transfecting osteogenic precursor cells with an isolated nucleic acid molecule comprising a nucleotide sequence encoding splice variants of LIM mineralization protein. The transfection may occur ex vivo or in vivo by direct injection of virus or naked plasmid DNA. In a particular embodiment, the invention provides a method of fusing a spine by transfecting osteogenic precursor cells with an isolated nucleic acid molecule having a nucleotide sequence encoding LIM mineralization protein, admixing the transfected osteogenic precursor cells with a matrix and contacting the matrix with the spine. Finally, the invention relates to methods for inducing systemic bone formation by stable transfection of host cells with the vectors of the invention.
摘要翻译： 本发明涉及编码LIM矿化蛋白或LMP的分离的核酸分子。 本发明还提供了包含编码LMP的核苷酸序列的剪接变体的载体，以及包含这些载体的宿主细胞。 此外，本发明涉及通过用包含编码LIM矿化蛋白的剪接变体的核苷酸序列的分离的核酸分子转染成骨前体细胞诱导骨形成的方法。 转染可以通过直接注射病毒或裸体质粒DNA离体或体内发生。 在一个具体实施方案中，本发明提供了一种通过用具有编码LIM矿化蛋白的核苷酸序列的分离的核酸分子转染成骨前体细胞来融合脊柱的方法，将转染的成骨前体细胞与基质混合并使基质与脊柱 。 最后，本发明涉及通过用本发明的载体稳定转染宿主细胞诱导全身骨形成的方法。
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公开(公告)号：US07045614B1
公开(公告)日：2006-05-16
申请号：US09959578
申请日：2000-04-28
申请人： Scott D. Boden , Gregory A. Hair
发明人： Scott D. Boden , Gregory A. Hair
IPC分类号： C07H21/04
CPC分类号： C07K14/51 , A61K38/00 , A61K48/00 , C07K14/4702 , C07K14/52
摘要： The present invention is directed to isolated nucleic acid molecules that encode LIM mineralization protein, or LMP. The invention further provides vectors comprising splice variants of nucleotide sequences that encode LMP, as well as host cells comprising those vectors. Moreover, the present invention relates to methods of inducing bone formation by transfecting osteogenic precursor cells with an isolated nucleic acid molecule comprising a nucleotide sequence encoding splice variants of LIM mineralization protein. The transfection may occur ex vivo or in vivo by direct injection of virus or naked plasmid DNA. In a particular embodiment, the invention provides a method of fusing a spine by transfecting osteogenic precursor cells with an isolated nucleic acid molecule having a nucleotide sequence encoding LIM mineralization protein, admixing the transfected osteogenic precursor cells with a matrix and contacting the matrix with the spine. Finally, the invention relates to methods for inducing systemic bone formation by stable transfection of host cells with the vectors of the invention.
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