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    Functional surface coating
    5.
    发明授权
    Functional surface coating 有权
    功能性表面涂层

    公开(公告)号：US08178602B2

    公开(公告)日：2012-05-15

    申请号：US12632609

    申请日：2009-12-07

    申请人： Guoqiang Mao ,  Steven W. Metzger ,  Michael J. Lochhead

    发明人： Guoqiang Mao ,  Steven W. Metzger ,  Michael J. Lochhead

    IPC分类号： C08K5/15 ,  C08K5/1535 ,  A61K8/73 ,  C08L83/00

    CPC分类号： G01N33/54393 ,  G01N33/5306 ,  G01N2035/00158 ,  Y10T428/31504 ,  Y10T428/31612 ,  Y10T428/31663 ,  Y10T428/31678

    摘要： Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer. Surface coatings are also described having both non-specific protein binding properties combined with functional groups for specific binding activity thereby providing surface coating that specifically recognize target proteins but limit binding to non-specific protein.

    摘要翻译： 描述了制备具有低非特异性结合的功能性薄膜或表面涂层的组合物和方法。 薄膜含有特定的官能团和非特异性结合驱避剂组分。 薄膜共价结合或被动地吸附到各种固体基质上。 指定的官能团为薄膜改性的固体表面和非特异性结合驱除剂组分提供了特定的活性，显着降低了与薄膜改性固体表面的非特异性结合。 非特异性结合驱避剂组分不影响薄膜中指定的官能团活性。 在这些方法中，指定的官能团通过间隔基团固定在固体基质上。 还描述了表面涂层具有与特异性结合活性的官能团结合的非特异性蛋白质结合特性，从而提供特异性识别靶蛋白但限制与非特异性蛋白结合的表面涂层。

    Multi-layer coated porous materials and methods of making the same
    6.
    发明授权
    Multi-layer coated porous materials and methods of making the same 有权
    多层涂层多孔材料及其制作方法

    公开(公告)号：US07507469B2

    公开(公告)日：2009-03-24

    申请号：US11506353

    申请日：2006-08-18

    申请人： Guoqiang Mao ,  George Greene, IV ,  Li Yao

    发明人： Guoqiang Mao ,  George Greene, IV ,  Li Yao

    IPC分类号： B32B27/08

    CPC分类号： G01N33/558 ,  G01N33/521 ,  G01N33/54353 ,  G01N33/54366 ,  G01N33/54393 ,  Y10T428/249953 ,  Y10T428/249991 ,  Y10T428/249992 ,  Y10T428/249993

    摘要： Multi-layer coated materials and methods of making them are disclosed. In a specific embodiment, a porous polymeric substrate is pre-activated and immersed in a polyelectrolyte solution to form a first layer having an electric charge and at least one functional group. The coated material is next immersed in a second solution of a material having an electric charge opposite of that of the first layer to provide a bi-layer coating. This process can be repeated to form multi-layer coatings on porous substrates.

    摘要翻译： 公开了多层涂覆材料及其制备方法。 在具体实施方案中，将多孔聚合物基材预活化并浸入聚电解质溶液中以形成具有电荷和至少一个官能团的第一层。 接着将涂覆的材料浸入具有与第一层相反的电荷的材料的第二溶液中以提供双层涂层。 可以重复该过程以在多孔基材上形成多层涂层。

    Hydroxyl functional surface coating
    7.
    发明授权
    Hydroxyl functional surface coating 失效
    羟基官能表面涂层

    公开(公告)号：US07501157B2

    公开(公告)日：2009-03-10

    申请号：US11035849

    申请日：2005-01-13

    申请人： Guoqiang Mao ,  Steven W. Metzger ,  Michael J. Lochhead ,  David A. Goldberg ,  Charles H. Greef ,  David W. Grainger

    发明人： Guoqiang Mao ,  Steven W. Metzger ,  Michael J. Lochhead ,  David A. Goldberg ,  Charles H. Greef ,  David W. Grainger

    IPC分类号： B05D3/02

    CPC分类号： G01N33/54393 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  G01N33/5306 ,  G01N2035/00158

    摘要： Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer. Surface coatings are also described having both non-specific protein binding properties combined with functional groups for specific binding activity thereby providing surface coating that specifically recognize target proteins but limit binding to non-specific protein.

    摘要翻译： 描述了制备具有低非特异性结合的功能性薄膜或表面涂层的组合物和方法。 薄膜含有特定的官能团和非特异性结合驱避剂组分。 薄膜共价结合或被动地吸附到各种固体基质上。 指定的官能团为薄膜改性的固体表面和非特异性结合驱除剂组分提供了特定的活性，显着降低了与薄膜改性固体表面的非特异性结合。 非特异性结合驱避剂组分不影响薄膜中指定的官能团活性。 在这些方法中，指定的官能团通过间隔基团固定在固体基质上。 还描述了表面涂层具有与特异性结合活性的官能团结合的非特异性蛋白质结合特性，从而提供特异性识别靶蛋白但限制与非特异性蛋白结合的表面涂层。

    Hydroxyl functional surface coating
    10.
    发明申请
    Hydroxyl functional surface coating 失效
    羟基官能表面涂层

    公开(公告)号：US20050147758A1

    公开(公告)日：2005-07-07

    申请号：US11035849

    申请日：2005-01-13

    申请人： Guoqiang Mao ,  Steven Metzger ,  Michael Lochhead ,  David Goldberg ,  Charles Greef ,  David Grainger

    发明人： Guoqiang Mao ,  Steven Metzger ,  Michael Lochhead ,  David Goldberg ,  Charles Greef ,  David Grainger

    IPC分类号： G01N33/53 ,  G01N33/543 ,  G01N35/00 ,  B05D3/02

    CPC分类号： G01N33/54393 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  G01N33/5306 ,  G01N2035/00158

    摘要： Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer. Surface coatings are also described having both non-specific protein binding properties combined with functional groups for specific binding activity thereby providing surface coating that specifically recognize target proteins but limit binding to non-specific protein.

    摘要翻译： 描述了制备具有低非特异性结合的功能性薄膜或表面涂层的组合物和方法。 薄膜含有特定的官能团和非特异性结合驱避剂组分。 薄膜共价结合或被动地吸附到各种固体基质上。 指定的官能团为薄膜改性的固体表面和非特异性结合驱除剂组分提供了特定的活性，显着降低了与薄膜改性固体表面的非特异性结合。 非特异性结合驱避剂组分不影响薄膜中指定的官能团活性。 在这些方法中，指定的官能团通过间隔基团固定在固体基质上。 还描述了表面涂层具有与特异性结合活性的官能团结合的非特异性蛋白质结合特性，从而提供特异性识别靶蛋白但限制与非特异性蛋白结合的表面涂层。