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34 条记录 (耗时 0.023 秒)

    Process for producing carboxylic acid ester
    1.
    发明授权
    Process for producing carboxylic acid ester 失效
    羧酸酯的制备方法

    公开(公告)号：US5302746A

    公开(公告)日：1994-04-12

    申请号：US44708

    申请日：1993-04-12

    申请人： Seiji Koono ,  Osamu Moriya ,  Toshio Noguchi ,  Haruki Okamura

    发明人： Seiji Koono ,  Osamu Moriya ,  Toshio Noguchi ,  Haruki Okamura

    IPC分类号： C07C67/08 ,  C07C67/58 ,  C07C69/54 ,  C07C69/52

    CPC分类号： C07C67/08

    摘要： A process for producing a carboxylic acid ester which comprises reacting a carboxylic acid with an alcohol in the presence of an acid catalyst to produce a reaction solution and neutralizing the reaction solution, characterized by using a countercurrently contacting column for neutralization, into which the esterified reaction solution is introduced at the lower portion of the column, an aqueous strong alkaline solution at a middle portion and an aqueous weak alkaline solution at an upper portion, removing a neutralized oil phase containing the carboxylic acid ester from the top of the column and removing an aqueous phase from the bottom, thereby continuously neutralizing the reaction solution.

    摘要翻译： 一种制备羧酸酯的方法，其包括在酸催化剂存在下使羧酸与醇反应以产生反应溶液并中和反应溶液，其特征在于使用逆流接触的中和柱，其中酯化反应 溶液引入塔的下部，中间部分的强碱性水溶液和上部的弱碱性水溶液，从塔的顶部除去含有羧酸酯的中和油相，并除去 水相，从而连续中和反应溶液。

    Vγ9Vδ2 T cell proliferation agent, method for producing activated Vγ9Vδ2 T cells, and uses thereof
    2.
    发明授权
    Vγ9Vδ2 T cell proliferation agent, method for producing activated Vγ9Vδ2 T cells, and uses thereof 有权
    Vγ9Vδ2T细胞增殖剂，活化的Vγ9Vδ2T细胞的制造方法及其用途

    公开(公告)号：US07749760B2

    公开(公告)日：2010-07-06

    申请号：US12316973

    申请日：2008-12-17

    申请人： Haruki Okamura ,  Shuji Kubo ,  Wen Li

    发明人： Haruki Okamura ,  Shuji Kubo ,  Wen Li

    IPC分类号： C12N5/078 ,  C12N5/0783 ,  C07K14/54 ,  C07F9/40

    CPC分类号： A61K31/663 ,  A61K38/20 ,  A61K38/2013 ,  C12N5/0638 ,  C12N2501/2302 ,  C12N2501/2318 ,  C12N2501/999 ,  Y02A50/411 ,  A61K2300/00

    摘要： A Vγ9Vδ2 T cell proliferation agent includes at least a bisphosphonate, interleukin 2, and interleukin 18. Since IL-18 has properties that improve cell viability by inhibiting cell death, IL-18 is presumably capable of acting as a cofactor for the bisphosphonate so as to significantly increase the effect of Vγ9Vδ2 T cell proliferation by the bisphosphonate and the IL-2. This allows providing a Vγ9Vδ2 T cell proliferation agent capable of growing Vγ9Vδ2 T cells with a proliferated efficiency significantly high compared to conventional methods so that the proliferated Vγ9Vδ2 T cells have a high antitumor activity and high cytokine productivity.

    摘要翻译： Vγ9Vδ2T细胞增殖剂包括至少二膦酸盐，白细胞介素2和白细胞介素18.由于IL-18具有通过抑制细胞死亡来改善细胞活力的性质，因此推测IL-18能够作为双膦酸盐的辅因子，以便 显着增加了双膦酸盐和IL-2对Vγ9Vδ2T细胞增殖的影响。 这允许提供与常规方法相比，能够以增殖效率显着增加Vγ9Vδ2T细胞的Vγ9Vδ2T细胞增殖剂，使得增殖的Vγ9Vδ2T细胞具有高抗肿瘤活性和高细胞因子生产力。

    Purification of hydroxyphenylpropionic acid ester
    3.
    发明授权
    Purification of hydroxyphenylpropionic acid ester 失效
    羟基苯丙酸酯的纯化

    公开(公告)号：US4739080A

    公开(公告)日：1988-04-19

    申请号：US868742

    申请日：1986-05-30

    申请人： Manji Sasaki ,  Chinehito Ebina ,  Haruki Okamura ,  Shinichi Yachigo ,  Tamaki Ishii

    发明人： Manji Sasaki ,  Chinehito Ebina ,  Haruki Okamura ,  Shinichi Yachigo ,  Tamaki Ishii

    IPC分类号： C07D493/10 ,  C08K5/1575 ,  C07D319/04

    CPC分类号： C07D493/10

    摘要： Method for the purification of 3,9-bis{2-[3-(3-tert-butyl-4-hydroxy-5-methylphenyl)propionyloxy]-1,1-dimethylethyl} -2,4,8,10-tetraoxaspiro[5.5]undecane, to form crystals having a crystalline structure which, when subjected to Cu-K.sub..alpha. X-ray diffraction, show sharp X-ray diffraction peaks at angles of diffraction, to 2.theta.=2.8.degree., 2.theta.=8.7.degree. and 2.theta.=11.7.degree., by recrystallizing the ester at a temperature lower than 40.degree. C. using as a recrystallization solvent, A C.sub.5 -C.sub.10 alicyclic hydrocarbon, which may contain a limited amount of certain other solvents, or using a mixed solvent of a C.sub.5 -C.sub.10 aliphatic hydrocarbon and at least one other certain solvent in a certain weight ratio.

    摘要翻译： 纯化3,9-双{2- [3-（3-叔丁基-4-羟基-5-甲基苯基）丙酰氧基] -1,1-二甲基乙基} -2,4,8,10-四氧杂螺环 [5.5]十一烷，以形成具有晶体结构的晶体，当经受Cu-Kαα射线衍射时，衍射角呈现尖锐的X射线衍射峰，为2θ= 2.8°，2θ= 8.7° 和2θ= 11.7°，通过在低于40℃的温度下使酯重结晶，使用可能含有有限量的某些其它溶剂的A C5-C10脂环族烃，或使用混合溶剂 一种C 5 -C 10脂族烃和至少一种其它特定溶剂。