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公开(公告)号：US08580562B2
公开(公告)日：2013-11-12
申请号：US13062673
申请日：2008-09-08
CPC分类号： A61K31/713 , C12N15/113 , C12N2310/14 , C12N2310/531
摘要： The inhibitory RNA for inhibiting the expression of ZFAT gene according to this invention is a siRNA comprising a sense RNA having a base sequence of contiguous 20 to 20 bases, preferably 23 to 27 bases, of ZFAT mRNA and an anti-sense RNA having a base sequence complementary to the base sequence of the sense RNA or a shRNA comprising a double-stranded RNA (dsRNA) with the sense RNA connected to the anti-sense RNA via a loop sequence.The inhibitory RNA for inhibiting the expression of ZFAT gene according to this invention decreases a rate of cell proliferation of cancer cells, etc., induces apoptosis of cells including cancer cells, or inhibits an immunoresponse by inhibiting the expression of the ZFAT gene. Therefore, the inhibitory RNA of this invention is useful for development of molecular target agents particularly for cancer cells or immunosuppressive agents.
摘要翻译： 用于抑制本发明的ZFAT基因表达的抑制性RNA是包含具有ZFAT mRNA连续20至20个碱基，优选23至27个碱基的碱基序列的正义RNA和具有碱基的反义RNA的siRNA 与有义RNA的碱基序列互补的序列或包含通过环序列连接到反义RNA的有义RNA的双链RNA（dsRNA）的shRNA。 根据本发明抑制ZFAT基因表达的抑制性RNA降低了癌细胞等的细胞增殖速度，诱导包括癌细胞在内的细胞的凋亡，或通过抑制ZFAT基因的表达来抑制免疫应答。 因此，本发明的抑制性RNA可用于开发特别用于癌细胞或免疫抑制剂的分子靶因子。
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公开(公告)号：US20110237647A1
公开(公告)日：2011-09-29
申请号：US13062673
申请日：2008-09-08
CPC分类号： A61K31/713 , C12N15/113 , C12N2310/14 , C12N2310/531
摘要： The inhibitory RNA for inhibiting the expression of ZFAT gene according to this invention is a siRNA comprising a sense RNA having a base sequence of contiguous 20 to 20 bases, preferably 23 to 27 bases, of ZFAT mRNA and an anti-sense RNA having a base sequence complementary to the base sequence of the sense RNA or a shRNA comprising a double-stranded RNA (dsRNA) with the sense RNA connected to the anti-sense RNA via a loop sequence.The inhibitory RNA for inhibiting the expression of ZFAT gene according to this invention decreases a rate of cell proliferation of cancer cells, etc., induces apoptosis of cells including cancer cells, or inhibits an immunoresponse by inhibiting the expression of the ZFAT gene. Therefore, the inhibitory RNA of this invention is useful for development of molecular target agents particularly for cancer cells or immunosuppressive agents.
摘要翻译： 用于抑制本发明的ZFAT基因表达的抑制性RNA是包含具有ZFAT mRNA连续20至20个碱基，优选23至27个碱基的碱基序列的正义RNA和具有碱基的反义RNA的siRNA 与有义RNA的碱基序列互补的序列或包含通过环序列连接到反义RNA的有义RNA的双链RNA（dsRNA）的shRNA。 根据本发明抑制ZFAT基因表达的抑制性RNA降低了癌细胞等的细胞增殖速度，诱导包括癌细胞在内的细胞的凋亡，或通过抑制ZFAT基因的表达来抑制免疫应答。 因此，本发明的抑制性RNA可用于开发特别用于癌细胞或免疫抑制剂的分子靶因子。
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公开(公告)号：US5048941A
公开(公告)日：1991-09-17
申请号：US417438
申请日：1989-10-05
申请人： Masami Hamada , Hiroshi Fujiwara , Kosaku Tsuboshima , Masahiko Kinukawa , Toshiyuki Tsunoda , Takashi Nagano , Kazyuki Minami , Shigeo Tokunaga , Masanori Kaneda , Tomonori Ishikawa
发明人： Masami Hamada , Hiroshi Fujiwara , Kosaku Tsuboshima , Masahiko Kinukawa , Toshiyuki Tsunoda , Takashi Nagano , Kazyuki Minami , Shigeo Tokunaga , Masanori Kaneda , Tomonori Ishikawa
CPC分类号： G02B21/0012 , Y10T307/50
摘要： The surgical microscope comprises a stand, an arm movably attached to said stand for sustaining a microscope body, an electric control equipment divided into a plural number of units removably piled up on said stand and a foot switch unit to be used for executing various types of functions. Accommodated in each unit are a function control means having a single specific function or plural specific functions different from those of the other units and an independent power source means connected to said function control means in a relation of 1:1 or in a different combination. The surgical microscope can be designed compact as a whole, has high operability and assures high security during operation. Should a function be lost due to troubles during operation, the surgical microscope prevents the other functions from being influenced by the troubles and allows to speedily restore the lost function.
摘要翻译： 手术显微镜包括支架，可移动地附接到所述支架上用于维持显微镜主体的臂，分割成可移除地堆叠在所述支架上的多个单元的电控设备和用于执行各种类型的脚踏开关单元 功能。 在每个单元中容纳有具有与其它单元不同的单个特定功能或多个特定功能的功能控制装置和以1：1或不同组合连接到所述功能控制装置的独立电源装置。 手术显微镜整体设计紧凑，操作性好，操作安全性高。 如果由于操作中的麻烦而导致功能丧失，则手术显微镜防止其他功能受到麻烦的影响，并且能够快速恢复丢失的功能。
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4.发明授权Motor speed regulating circuit with starter and storage medium drive using the same 失效带起动器和存储介质驱动器的电机调速电路采用相同的
公开(公告)号：US5621288A
公开(公告)日：1997-04-15
申请号：US340372
申请日：1994-11-14
申请人： Kunio Seki , Toshiyuki Tsunoda , Yuichi Ohkubo
发明人： Kunio Seki , Toshiyuki Tsunoda , Yuichi Ohkubo
摘要： A motor speed regulating circuit includes a speed signal generator for generating a speed signal having a frequency proportional to the speed of the motor, synchronously with the rotation of the motor. A time difference detector is used for detecting a time difference between the period of the speed signal and a predetermined standard time. A control voltage generator is used for generating a speed control voltage to be applied to the motor in accordance with a detected time difference and feedback-controlling the speed of the motor in accordance with the standard time. A starter is used for starting the motor after the motor is stopped. The motor can be reliably restarted after it has been stopped.
摘要翻译： 电动机速度调节电路包括速度信号发生器，用于与电动机的旋转同步地产生具有与电动机速度成比例的频率的速度信号。 时差检测器用于检测速度信号的周期与预定的标准时间之间的时间差。 控制电压发生器用于根据检测到的时间差产生要施加到电动机的速度控制电压，并根据标准时间反馈控制电动机的速度。 电机停止后，起动器用于启动电机。 电机停止后可以可靠地重新起动。
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公开(公告)号：US4802749A
公开(公告)日：1989-02-07
申请号：US81333
申请日：1987-08-04
申请人： Takayoshi Togino , Hiroshi Fujiwara , Yutaka Takabayashi , Takashi Nagano , Takashi Fukaya , Kazuyuki Minami , Toshiyuki Tsunoda
发明人： Takayoshi Togino , Hiroshi Fujiwara , Yutaka Takabayashi , Takashi Nagano , Takashi Fukaya , Kazuyuki Minami , Toshiyuki Tsunoda
CPC分类号： G02B21/0012 , G02B21/22
摘要： In order to allow the surgical operator and his assistant to make stereoscopic viewing of the region of surgery with a same magnification and in coaxial relationship, the surgical microscope comprises: a common objective lens; a pair of variable magnification optical systems disposed on the image side of the objective lens; and a pair of light beam splitting members disposed on the image side of the pair of variable magnification optical systems, respectively, wherein arrangement is provided so that paired observational optical paths are to be directed to extend respectively in a plurality of directions each having a predetermined angle relative to a plane containing the optical axes of the pair of variable magnification optical systems, within a plane crossing these optical axes at right angles, respectively. The pair of light beam splitting members are constituted as an optical path splitting unit, and the barrel section and the optical path splitting unit are removably coupled to each other.
摘要翻译： 为了允许外科手术者和他的助手以相同的放大倍率和同轴的关系对外科手术区域进行立体观察，手术显微镜包括：普通物镜; 设置在物镜的像侧的一对可变放大光学系统; 以及分别设置在一对可变倍率光学系统的像侧上的一对光束分离部件，其中设置了配置，使得成对的观察光路分别指向在具有预定的多个方向的多个方向上延伸 相对于包含该对可变放大光学系统的光轴的平面的角度，分别在与这些光轴成直角相交的平面内。 所述一对光束分离构件构成为光路分离单元，并且所述筒部和所述光路分离单元彼此可拆卸地连接。
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公开(公告)号：US06771033B2
公开(公告)日：2004-08-03
申请号：US10341342
申请日：2003-01-14
IPC分类号： H02P600
CPC分类号： H02P6/182 , Y10S388/911
摘要： A drive control system, with PLL control, drives a rotatable multi-phase sensor-less motor by switching a current of a field coil of each phase depending on the rotating phase of the motor. When the motor is driven, a desired phase is selected as a detection phase, and a voltage induced on the coil of the detection phase is detected when power is fed for a predetermined time to the field coils other than the detection phase. A magnetic pole position is detected from the amplitude condition of the detected induced voltage. Based on this detection, the power-feeding phase of the motor drive is determined. Power feeding and pole position detection are performed alternately.
摘要翻译： 具有PLL控制的驱动控制系统通过根据电动机的旋转相位切换每相的励磁线圈的电流来驱动可旋转的多相无传感器电动机。 当电机被驱动时，选择期望的相位作为检测相位，并且当向除了检测相位之外的励磁线圈供电预定时间时检测在检测相位线圈上感应的电压。 从检测到的感应电压的振幅条件检测磁极位置。 基于该检测，确定电动机驱动器的供电相位。 交替执行供电和极位置检测。
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公开(公告)号：US06344721B2
公开(公告)日：2002-02-05
申请号：US09818511
申请日：2001-03-28
IPC分类号： H02P540
CPC分类号： H02P6/22
摘要： A pulse current having such a short duration as the rotor does not react is passed through field coils of respective phases of a brushless motor in first and second, mutually opposite, directions sequentially, voltages induced, by the pulse currents in two directions at each of the field coils of the non-conducting phase are combined, the polarity of a combined voltage is detected, and a field coil pair where a current is to be passed to start the motor is determined based on the result of detection for each of field coil of the non-conducting phase.
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公开(公告)号：US06340873B2
公开(公告)日：2002-01-22
申请号：US09893549
申请日：2001-06-29
IPC分类号： H02P540
CPC分类号： H02P6/22
摘要： A pulse current having such a short duration as the rotor does not react is passed through field coils of respective phases of a brushless motor in first and second, mutually opposite, directions sequentially, voltages induced, by the pulse currents in two directions at each of the field coils of the non-conducting phase are combined, the polarity of a combined voltage is detected, and a field coil pair where a current is to be passed to start the motor is determined based on the result of detection for each of field coil of the non-conducting phase.
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公开(公告)号：US20090212851A1
公开(公告)日：2009-08-27
申请号：US12342710
申请日：2008-12-23
IPC分类号： G05F1/10
CPC分类号： H02M1/32 , H02M3/158 , H02M2001/0009 , H02M2001/0025
摘要： High-accuracy overcurrent detection is performed, while a loss resulting from the current detection is significantly reduced. A switch section outputs the voltage between the both terminals of a current detection resistor using an AND signal between an output signal from a hysteresis comparator and an output signal from a pre-driver. The voltage is filtered by an electrostatic capacitor element and a resistor, and inputted to a comparator. The comparator makes a comparison between the signals inputted to the two input terminals thereof, and outputs the result of the comparison to a digital filter. When an overcurrent begins to flow in a power supply unit, the levels of the voltages inputted to the two input terminals of the comparator are inverted so that the comparator outputs an inversion signal to the digital filter. The digital filter outputs a detection signal to an overcurrent detection circuit when an arbitrary time has elapsed.
摘要翻译： 执行高精度过电流检测，而由电流检测导致的损耗显着降低。 开关部分使用来自迟滞比较器的输出信号和来自预驱动器的输出信号之间的AND信号来输出电流检测电阻器的两端之间的电压。 电压由静电电容器元件和电阻器滤波，并输入到比较器。 比较器对输入到其两个输入端的信号进行比较，并将比较结果输出到数字滤波器。 当过电流在电源单元中流动时，输入到比较器的两个输入端的电压的电平被反相，使得比较器向数字滤波器输出反相信号。 当任意时间过去时，数字滤波器将检测信号输出到过电流检测电路。
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公开(公告)号：US4878746A
公开(公告)日：1989-11-07
申请号：US178967
申请日：1988-04-07
CPC分类号： G02B21/24 , G02B21/0012 , G02B21/082 , G02B21/22
摘要： A surgical microscope apparatus provided with a failure detecting device for conducting an initial examination and an ordinary examination of an illumination device and a failure detecting device for conducting the ordinary examination of an electric magnification and focusing device, in order to make it possible to self-examine what is defective and indicate the result when failure is caused. The failure of the illumination device is immediately indicated by the self examination of the failure detecting device when a power source is turned on for use.
摘要翻译： 一种手术显微镜装置，具有进行初次检查的故障检测装置和普通的照明装置的检查以及进行电放大和聚焦装置的普通检查的故障检测装置， 检查有无故障，并在发生故障时指示结果。 当电源接通使用时，通过故障检测装置的自检立即表示照明装置的故障。
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