公开(公告)号：US20110237647A1

公开(公告)日：2011-09-29

申请号：US13062673

申请日：2008-09-08

申请人： Senji Shirasawa ,  Takahiro Fujimoto ,  Toshiyuki Tsunoda ,  Keiko Doi ,  Midori Koyanagi

发明人： Senji Shirasawa ,  Takahiro Fujimoto ,  Toshiyuki Tsunoda ,  Keiko Doi ,  Midori Koyanagi

IPC分类号： A61K31/713 ,  C12N15/63 ,  C12N5/071 ,  C07H21/02 ,  A61P35/00 ,  A61P37/06

CPC分类号： A61K31/713 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/531

摘要： The inhibitory RNA for inhibiting the expression of ZFAT gene according to this invention is a siRNA comprising a sense RNA having a base sequence of contiguous 20 to 20 bases, preferably 23 to 27 bases, of ZFAT mRNA and an anti-sense RNA having a base sequence complementary to the base sequence of the sense RNA or a shRNA comprising a double-stranded RNA (dsRNA) with the sense RNA connected to the anti-sense RNA via a loop sequence.The inhibitory RNA for inhibiting the expression of ZFAT gene according to this invention decreases a rate of cell proliferation of cancer cells, etc., induces apoptosis of cells including cancer cells, or inhibits an immunoresponse by inhibiting the expression of the ZFAT gene. Therefore, the inhibitory RNA of this invention is useful for development of molecular target agents particularly for cancer cells or immunosuppressive agents.

摘要翻译： 用于抑制本发明的ZFAT基因表达的抑制性RNA是包含具有ZFAT mRNA连续20至20个碱基，优选23至27个碱基的碱基序列的正义RNA和具有碱基的反义RNA的siRNA 与有义RNA的碱基序列互补的序列或包含通过环序列连接到反义RNA的有义RNA的双链RNA（dsRNA）的shRNA。 根据本发明抑制ZFAT基因表达的抑制性RNA降低了癌细胞等的细胞增殖速度，诱导包括癌细胞在内的细胞的凋亡，或通过抑制ZFAT基因的表达来抑制免疫应答。 因此，本发明的抑制性RNA可用于开发特别用于癌细胞或免疫抑制剂的分子靶因子。

公开(公告)号：US08580562B2

公开(公告)日：2013-11-12

申请号：US13062673

申请日：2008-09-08

申请人： Senji Shirasawa ,  Takahiro Fujimoto ,  Toshiyuki Tsunoda ,  Keiko Doi ,  Midori Koyanagi

发明人： Senji Shirasawa ,  Takahiro Fujimoto ,  Toshiyuki Tsunoda ,  Keiko Doi ,  Midori Koyanagi

IPC分类号： C12N15/85 ,  C12N15/63 ,  C07H21/02 ,  C07H21/04

CPC分类号： A61K31/713 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/531

摘要： The inhibitory RNA for inhibiting the expression of ZFAT gene according to this invention is a siRNA comprising a sense RNA having a base sequence of contiguous 20 to 20 bases, preferably 23 to 27 bases, of ZFAT mRNA and an anti-sense RNA having a base sequence complementary to the base sequence of the sense RNA or a shRNA comprising a double-stranded RNA (dsRNA) with the sense RNA connected to the anti-sense RNA via a loop sequence.The inhibitory RNA for inhibiting the expression of ZFAT gene according to this invention decreases a rate of cell proliferation of cancer cells, etc., induces apoptosis of cells including cancer cells, or inhibits an immunoresponse by inhibiting the expression of the ZFAT gene. Therefore, the inhibitory RNA of this invention is useful for development of molecular target agents particularly for cancer cells or immunosuppressive agents.

摘要翻译： 用于抑制本发明的ZFAT基因表达的抑制性RNA是包含具有ZFAT mRNA连续20至20个碱基，优选23至27个碱基的碱基序列的正义RNA和具有碱基的反义RNA的siRNA 与有义RNA的碱基序列互补的序列或包含通过环序列连接到反义RNA的有义RNA的双链RNA（dsRNA）的shRNA。 根据本发明抑制ZFAT基因表达的抑制性RNA降低了癌细胞等的细胞增殖速度，诱导包括癌细胞在内的细胞的凋亡，或通过抑制ZFAT基因的表达来抑制免疫应答。 因此，本发明的抑制性RNA可用于开发特别用于癌细胞或免疫抑制剂的分子靶因子。

公开(公告)号：US20120180150A1

公开(公告)日：2012-07-12

申请号：US13496314

申请日：2010-09-28

申请人： Takahiro Fujimoto ,  Senji Shirasawa

发明人： Takahiro Fujimoto ,  Senji Shirasawa

IPC分类号： A01K67/027 ,  G01N33/566 ,  C12N15/63 ,  C07K19/00

CPC分类号： C07K14/705 ,  A01K67/0275 ,  A01K2217/20 ,  A01K2227/105 ,  C07K14/47

摘要： The instant invention provides an inositol 1,4,5-triphaosphate receptor (IP3R)-binding protein and its transgenic non-human mammalian animal.The inositol 1,4,5-triphaosphate receptor-binding protein comprises an inositol 1,4,5-triphaosphate receptor-binding protein with a protein including KRAP protein (SQ ID NOS. 1-4) bound to inositol 1,4,5-triphosphate (IP3R) protein (SQ ID NOS. 5-8). The IP3R activity inhibitor contains the IP3R-binding protein as a major ingredient. The transgenic non-human mammal of the instant invention carries the IP3R-binding protein. The site of binding of the KRAP protein to the IP3R protein is located in an amino acid region composed of 19 amino acids ranging from amino acid 200 to amino acid 218 of the mouse KRAP protein and an 19-amino acid region corresponding to that of the mouse KRAP protein for any animal species other than mouse.

摘要翻译： 本发明提供肌醇1,4,5-三磷酸酯受体（IP3R）结合蛋白及其转基因非人哺乳动物。 肌醇1,4,5-三磷酸酯受体结合蛋白包含肌醇1,4,5-三磷酸酯受体结合蛋白，其与包含与肌醇1,4,5结合的KRAP蛋白（SQ ID NO.1-4）的蛋白质 - 三磷酸（IP3R）蛋白（SQ ID NO.5- 8）。 IP3R活性抑制剂含有IP3R结合蛋白作为主要成分。 本发明的转基因非人哺乳动物携带IP3R结合蛋白。 KRAP蛋白与IP3R蛋白的结合位点位于由小鼠KRAP蛋白的氨基酸200至氨基酸218的19个氨基酸组成的氨基酸区域中，该氨基酸区域与 小鼠KRAP蛋白用于小鼠以外的任何动物物种。

公开(公告)号：US08045860B2

公开(公告)日：2011-10-25

申请号：US12318526

申请日：2008-12-30

申请人： Kensuke Matsui ,  Takahiro Fujimoto

发明人： Kensuke Matsui ,  Takahiro Fujimoto

IPC分类号： H04B10/00

CPC分类号： H04B10/40

摘要： An optical transceiver stores an output A/D value which is A/D-converted from reference voltage in an EEPROM as correction data in preparing the optical transceiver. The optical transceiver, receiving a request for outputting a monitored value from an external device connected therewith, calculates a variation based on difference between the output A/D value which is A/D-converted from the reference voltage at the timing when the request for outputting the monitored value is received and the correction data stored in the EEPROM. Then, the optical transceiver uses the calculated variation to convert current of light-input power which is input thereinto into voltage, amplify the voltage, and A/D-convert the voltage to thereby correct the output A/D value. The optical transceiver outputs the corrected A/D value to the connected external device as the monitored value.

摘要翻译： 光收发器将在EEPROM中的参考电压进行A / D转换的输出A / D值存储在准备光收发器中作为校正数据。 从收发与外部连接的外部装置输出监视值的请求的光收发信机，根据在请求的时刻的基准电压的A / D转换后的输出A / D值之差， 输出监视值并将修正数据存储在EEPROM中。 然后，光收发器使用计算的变化将输入的光输入功率的电流转换为电压，放大电压，并对电压进行A / D转换，从而校正输出A / D值。 光收发器将校正的A / D值作为监视值输出到连接的外部设备。

公开(公告)号：US09394953B2

公开(公告)日：2016-07-19

申请号：US14123260

申请日：2012-05-31

申请人： Takanori Kato ,  Takahiro Fujimoto ,  Kazutaka Asabe ,  Atsushi Sakaguchi ,  Yasushi Karino ,  Shin-ichi Saga ,  Takashi Maejima ,  Satoru Nakano ,  Takeshi Nakano

发明人： Takanori Kato ,  Takahiro Fujimoto ,  Kazutaka Asabe ,  Atsushi Sakaguchi ,  Yasushi Karino ,  Shin-ichi Saga ,  Takashi Maejima ,  Satoru Nakano ,  Takeshi Nakano

IPC分类号： F16D65/092 ,  F16D55/22 ,  B61H5/00

CPC分类号： F16D55/22 ,  B61H5/00 ,  F16D65/092

摘要： A disc brake for railway vehicles includes a brake disc fixed to a wheel or an axle of a railway vehicle and a brake lining configured to be pressed against a frictional surface of the brake disc by a brake caliper. The brake lining includes a plurality of friction members arranged to be spaced from each other, each of the friction members having a surface that faces the frictional surface of the brake disc, a metallic backing secured to back surfaces of the friction members, and a base plate supporting the friction members on the back surface side via spring members. The base plate is mounted to a brake caliper; wherein the friction members are provided in pairs with each pair being formed by two adjacent ones of the friction members, and the metallic backing is a one-piece member provided for each pair of the friction members.

摘要翻译： 轨道车辆的盘式制动器包括固定到铁路车辆的车轮或车轴的制动盘和构造成通过制动钳压在制动盘的摩擦表面上的制动衬片。 制动衬片包括多个彼此分开设置的摩擦构件，每个摩擦构件具有面向制动盘的摩擦表面的表面，固定到摩擦构件的后表面的金属背衬和基座 板经由弹簧构件支撑背面侧的摩擦构件。 基板安装在制动钳上; 其中摩擦构件成对设置，每对摩擦构件由两个相邻的摩擦构件形成，并且金属背衬是为每对摩擦构件设置的单件构件。

公开(公告)号：US08794398B2

公开(公告)日：2014-08-05

申请号：US13110325

申请日：2011-05-18

申请人： Takahiro Fujimoto ,  Kazutaka Asabe ,  Takanori Kato ,  Hiroshi Nogami ,  Hirotoshi Kawabe

发明人： Takahiro Fujimoto ,  Kazutaka Asabe ,  Takanori Kato ,  Hiroshi Nogami ,  Hirotoshi Kawabe

IPC分类号： F16D65/12 ,  F16D55/02 ,  F16D55/40

CPC分类号： F16D65/12 ,  B61H5/00 ,  F16D65/0006 ,  F16D65/124 ,  F16D65/128 ,  F16D65/847 ,  F16D2065/1332 ,  F16D2065/138 ,  F16D2065/1392

摘要： A brake disc for a railway vehicle, including a ring-shaped plate portion with a front side serving as a frictional surface and a plurality of fins being projected and disposed radially on the back side of the plate portion, the plate portion being fixed to a wheel, wherein a rib is provided between fins adjacent to each other, and a slit developing in the direction from a wheel-side face of the rib toward the back side of the plate portion is disposed in a circumferentially intermediate portion of the rib, thereby making it possible to suppress the deformation caused by frictional heat.

摘要翻译： 一种用于铁路车辆的制动盘，包括具有作为摩擦表面的前侧的环形板部分和沿板部的后侧径向突出并设置的多个翅片，所述板部固定到 轮，其中在彼此相邻的翅片之间设置有肋，并且在肋的周向中间部分上设置从肋的轮侧面朝向板部的后侧的方向形成的狭缝，由此 使得可以抑制由摩擦热引起的变形。

公开(公告)号：US20090059066A1

公开(公告)日：2009-03-05

申请号：US12230117

申请日：2008-08-22

申请人： Yasuhiro Yamauchi ,  Takahiro Fujimoto

发明人： Yasuhiro Yamauchi ,  Takahiro Fujimoto

IPC分类号： H04N7/01

CPC分类号： H04N7/012 ,  G06F3/14 ,  G09G5/39 ,  G09G2310/0224 ,  G09G2310/0227 ,  G09G2310/0229

摘要： A double rate processing part generates, at a double rate, a non-interlaced image signal every frame to twice generate a double-rate non-interlaced signal which has identical information duplicately. An interlace part, after a predetermined process is carried out on the double-rate non-interlaced signal twice generated by the double rate processing part, extracts an odd scan lines from one of the twice generated double-rate non-interlaced signal to generate an odd scan line image signal, extracts an even scan lines from the other of the twice generated double-rate non-interlaced signal to generate an even scan line image signal, so as to obtain an interlaced image signal for one frame.

摘要翻译： 双速率处理部分以双倍速率产生每帧的非隔行扫描图像信号，以两次重复产生具有相同信息的双速率非隔行扫描信号。 在由双速率处理部分两次产生的双速率非隔行信号执行预定处理之后，从两次产生的双倍速率非隔行信号之一提取奇数扫描线，以产生一个隔行扫描部分 奇数扫描线图像信号，从两倍生成的双倍速率非隔行信号中的另一个提取偶数扫描线，以产生偶数扫描线图像信号，以获得一帧的隔行扫描图像信号。

公开(公告)号：US20120273454A1

公开(公告)日：2012-11-01

申请号：US13453308

申请日：2012-04-23

申请人： Takashi IHARA ,  Takahiro Fujimoto

发明人： Takashi IHARA ,  Takahiro Fujimoto

IPC分类号： C09K13/00 ,  H01B13/00 ,  C09K13/04

CPC分类号： H05K3/067 ,  H01L21/32134 ,  H01L51/0017 ,  H01L51/0023 ,  H01L51/0037 ,  H05K1/09 ,  H05K3/064 ,  H05K2201/0329

摘要： An etching liquid for a conductive polymer is disclosed which comprises greater than 0.5 wt % but no greater than 30 wt % of (NH4)4Ce(S04)4.

摘要翻译： 公开了一种用于导电聚合物的蚀刻液，其包含大于0.5重量％但不大于30重量％的（NH 4）4 Cl（SO 4）4。

公开(公告)号：US20100089872A1

公开(公告)日：2010-04-15

申请号：US12442867

申请日：2007-09-13

申请人： Takashi Ihara ,  Takahiro Fujimoto

发明人： Takashi Ihara ,  Takahiro Fujimoto

IPC分类号： B44C1/22 ,  C09K13/04

CPC分类号： H05K3/067 ,  H01L21/32134 ,  H01L51/0017 ,  H01L51/0023 ,  H01L51/0037 ,  H05K1/09 ,  H05K3/064 ,  H05K2201/0329

摘要： The object is to provide an etching liquid for a conductive polymer having excellent etching capability toward a conductive polymer, and a method for patterning a conductive polymer employing the etching liquid for a conductive polymer. The conductive etching liquid of the present invention is selected from the group consisting of (1) an etching liquid comprising greater than 0.5 wt % but no greater than 70 wt % of (NH4)2Ce(NO3)8 or at least 0.5 wt % but no greater than 30 wt % of Ce(SO4)2, (2) an etching liquid comprising greater than 0.5 wt % but no greater than 30 wt % of (NH4)4Ce(SO4)4, (3) an etching liquid comprising a hypochlorous acid salt aqueous solution having an effective chlorine concentration of at least 0.06 wt % and a pH of greater than 3 but less than 8, (4) an etching liquid comprising nitrosyl chloride which comprises at least 5 wt % of hydrochloric acid and at least 20 wt % of nitric acid, a (hydrochloric acid concentration+0.51×nitric acid concentration) value being no greater than 35 wt %, and a (hydrochloric acid concentration+0.5×nitric acid concentration) value being at least 30 wt %, (5) an etching liquid comprising at least 3 wt % but no greater than 40 wt % of a bromic acid compound and at least 4 wt % of an inorganic acid, (6) an etching liquid comprising at least 6 wt % but no greater than 40 wt % of a chloric acid compound and at least 7 wt % of a hydrogen halide, (7) an etching liquid comprising at least 0.001 wt % but no greater than 20 wt % of a permanganic acid compound, and (8) an etching liquid comprising at least 3 wt % but no greater than 30 wt % of a hexavalent chromium compound.

摘要翻译： 本发明的目的是提供一种用于导电聚合物的蚀刻液，该导电聚合物对导电聚合物具有优异的蚀刻能力，以及使用该导电聚合物蚀刻液对导电聚合物进行构图的方法。 本发明的导电蚀刻液体选自（1）包含大于0.5重量％但不大于70重量％的（NH 4）2 Cl（NO 3）8或至少0.5重量％的蚀刻液体，但是 不大于30重量％的Ce（SO 4）2，（2）包含大于0.5重量％但不大于30重量％的（NH 4）4 Cl（SO 4）4的蚀刻液，（3） 具有至少0.06重量％的有效氯浓度和大于3但小于8的pH的次氯酸盐水溶液，（4）包含亚硝酰氯的蚀刻液，其包含至少5重量％的盐酸和至少 20重量％的硝酸，（盐酸浓度+ 0.51×硝酸浓度）值不大于35重量％，（盐酸浓度+ 0.5倍硝酸浓度）值为30重量％以上（ 5）包含至少3重量％但不大于40重量％的溴酸化合物的蚀刻液， 至少4重量％的无机酸，（6）包含至少6重量％但不大于40重量％的氯酸化合物和至少7重量％的卤化氢的蚀刻液，（7）蚀刻 包含至少0.001重量％但不大于20重量％的高锰酸化合物的液体，和（8）包含至少3重量％但不大于30重量％的六价铬化合物的蚀刻液。

公开(公告)号：US20070160374A1

公开(公告)日：2007-07-12

申请号：US11403610

申请日：2006-04-13

申请人： Kensuke Matsui ,  Tetsuya Kiyonaga ,  Takahiro Fujimoto ,  Hiroshi Yamada

发明人： Kensuke Matsui ,  Tetsuya Kiyonaga ,  Takahiro Fujimoto ,  Hiroshi Yamada

IPC分类号： H04B10/04

CPC分类号： H04B10/504

摘要： An optical transmitter includes a laser diode drive circuit for driving a laser diode in accordance with a laser diode current that superimposes a pilot signal on a “0” logic level and a “1” logic level of a transmission signal, the pilot signal having a low-frequency compared with the transmission signal, so as to become an opposite phase each other, a monitor circuit for monitoring an optical output of the laser diode, a filter circuit for extracting a low-frequency component of the pilot signal from an output of the monitor circuit, a phase compare circuit for comparing a phase of the low-frequency component of the pilot signal extracted by the filter circuit with a phase of the pilot signal, and a deterioration judgment circuit for judging whether or not the laser diode deteriorates in accordance with a comparison result of the phase compare circuit.

摘要翻译： 光发射机包括：激光二极管驱动电路，用于根据激光二极管电流驱动激光二极管，激光二极管电流将导频信号叠加在“0”逻辑电平和“1”逻辑电平的传输信号上，该导频信号具有 低频与传输信号相比，以便成为相反的相位，用于监视激光二极管的光输出的监视电路，用于从导频信号的输出中提取导频信号的低频分量的滤波电路 监视电路，用于将由滤波电路提取的导频信号的低频分量的相位与导频信号的相位进行比较的相位比较电路，以及用于判断激光二极管是否劣化的劣化判断电路 根据相位比较电路的比较结果。