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公开(公告)号：US08609640B2
公开(公告)日：2013-12-17
申请号：US12180408
申请日：2008-07-25
申请人： Sergei Agoulnik , Bruce Decosta , Hong Du , Yimin Jiang , Xiang-Yi Li , Kenichi Nomoto , John (Yuan) Wang , Huiming Zhang , Jiayi Wu
发明人： Sergei Agoulnik , Bruce Decosta , Hong Du , Yimin Jiang , Xiang-Yi Li , Kenichi Nomoto , John (Yuan) Wang , Huiming Zhang , Jiayi Wu
IPC分类号： A01N57/00 , A61K31/665 , A01N43/02 , A61K31/335 , A01N43/76 , A61K31/42 , A61K31/415 , A61K31/497 , A61K31/535
CPC分类号： A61K31/365 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4523 , A61K31/496 , A61K31/5377 , A61K31/665 , A61K45/06
摘要： The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.
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公开(公告)号：US20130303489A1
公开(公告)日：2013-11-14
申请号：US13794635
申请日：2013-03-11
申请人： Sergei Agoulnik , Bruce Decosta , Hong Du , Yimin Jiang , Xiang-Yi Li , Kenichi Nomoto , John (Yuan) Wang , Huiming Zhang
发明人： Sergei Agoulnik , Bruce Decosta , Hong Du , Yimin Jiang , Xiang-Yi Li , Kenichi Nomoto , John (Yuan) Wang , Huiming Zhang
IPC分类号： A61K31/365 , A61K45/06 , A61K31/4178 , A61K31/496 , A61K31/422 , A61K31/5377 , A61K31/4025 , A61K31/4523 , A61K31/665
CPC分类号： A61K31/365 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4523 , A61K31/496 , A61K31/5377 , A61K31/665 , A61K45/06
摘要： The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.
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公开(公告)号：US20090082313A1
公开(公告)日：2009-03-26
申请号：US12180408
申请日：2008-07-25
申请人： Sergei Agoulnik , Bruce Decosta , Hong Du , Yimin Jiang , Xiang-Yi Li , Kenichi Nomoto , John (Yuan) Wang , Huiming Zhang
发明人： Sergei Agoulnik , Bruce Decosta , Hong Du , Yimin Jiang , Xiang-Yi Li , Kenichi Nomoto , John (Yuan) Wang , Huiming Zhang
IPC分类号： A61K31/665 , A61K31/335 , A61K31/422 , A61K31/4178 , A61P35/00 , A61P35/02 , A61P35/04 , A61K31/496 , A61K31/5377
CPC分类号： A61K31/365 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4523 , A61K31/496 , A61K31/5377 , A61K31/665 , A61K45/06
摘要： The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.
摘要翻译： 本发明提供了用于治疗特定癌症的化合物，药物组合物和方法。 这样的组合物通常可以包含式（I）的化合物：其中R 1 -R 3如本文所定义，或其药学上可接受的盐或酯; 和药学上可接受的载体。
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公开(公告)号：US20090291998A1
公开(公告)日：2009-11-26
申请号：US12396849
申请日：2009-03-03
申请人： Sergei Agoulnik , Kozo Akasaka , Francis Fang , Jean-Christophe Harmange , Lynn Hawkins , Yimin Jiang , Charles Johannes , Xiang-Yi Li , Pamela McGuinness , Erin A. Murphy , Shawn Schiller , Mary Vermeulen , Jiayi Wu
发明人： Sergei Agoulnik , Kozo Akasaka , Francis Fang , Jean-Christophe Harmange , Lynn Hawkins , Yimin Jiang , Charles Johannes , Xiang-Yi Li , Pamela McGuinness , Erin A. Murphy , Shawn Schiller , Mary Vermeulen , Jiayi Wu
IPC分类号： A61K31/4035 , C07D303/36 , C07D317/06 , C07D307/78 , C07D209/04 , C07D311/04 , A61K31/336 , A61K31/357 , A61K31/343 , A61K31/352 , A61P35/00
CPC分类号： C07D209/48 , A61K38/00 , C07D303/36 , C07D405/12 , C07D407/12 , C07F5/025 , C07F9/65502 , C07K5/06139
摘要： The present invention provides compounds having formula (1): wherein R1-R6, A, J, D, A, G, Q, w, x, y, and z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of cancer and/or inflammatory disorders, and more generally as proteasome inhibitors.
摘要翻译： 本发明提供具有式（1）的化合物：其中R 1 -R 6，A，J，D，A，G，Q，w，x，y和z如本文中所述的类别和亚类所述， 其药物组合物及其用于治疗癌症和/或炎症性疾病的方法，更一般地，作为蛋白酶体抑制剂。
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公开(公告)号：US07524883B2
公开(公告)日：2009-04-28
申请号：US10501120
申请日：2003-01-08
申请人： Sergei Agoulnik , Kozo Akasaka , Frank Fang , Jean-Christophe Harmange , Lynn Hawkins , Yimin Jiang , Charles Johannes , Xiang-Yi Li , Pamela McGuiness , Erin A. Murphy , Shawn Schiller , Mary Vermeulen , Jiayi Wu
发明人： Sergei Agoulnik , Kozo Akasaka , Frank Fang , Jean-Christophe Harmange , Lynn Hawkins , Yimin Jiang , Charles Johannes , Xiang-Yi Li , Pamela McGuiness , Erin A. Murphy , Shawn Schiller , Mary Vermeulen , Jiayi Wu
IPC分类号： C07D303/46 , A61K31/336
CPC分类号： C07D209/48 , A61K38/00 , C07D303/36 , C07D405/12 , C07D407/12 , C07F5/025 , C07F9/65502 , C07K5/06139
摘要： The present invention provides compounds having formula (1): wherein R1-R6, A, J, D, E, G, Q, w, x, y, and z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of cancer and/or inflammatory disorders, and more generally as proteasome inhibitors.
摘要翻译： 本发明提供了具有式（1）的化合物：其中R 1 -R 6，A，J，D，E，G，Q，w，x，y和z如本文中所述的类别和亚类所述， 其药物组合物及其用于治疗癌症和/或炎症性疾病的方法，更一般地，作为蛋白酶体抑制剂。
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公开(公告)号：US20050101781A1
公开(公告)日：2005-05-12
申请号：US10501120
申请日：2003-01-08
申请人： Sergei Agoulnik , Kozo Akasaka , Francis Fang , Jean-Christophe Harmange , Lynn Hawkins , Yimin Jiang , Charles Johannes , Xiang-Yi Li , Pamela McGuinness , Erin Murphy , Shawn Schiller , Mary Vermeulen , Jiayi Wu
发明人： Sergei Agoulnik , Kozo Akasaka , Francis Fang , Jean-Christophe Harmange , Lynn Hawkins , Yimin Jiang , Charles Johannes , Xiang-Yi Li , Pamela McGuinness , Erin Murphy , Shawn Schiller , Mary Vermeulen , Jiayi Wu
IPC分类号： C07D303/14 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/336 , A61K31/343 , A61K31/353 , A61K31/36 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/4045 , A61K31/4427 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/498 , A61K31/662 , A61K31/69 , A61K38/00 , A61P29/00 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/00 , A61P43/00 , C07C233/76 , C07C235/82 , C07C237/06 , C07C237/08 , C07C271/22 , C07D209/48 , C07D303/36 , C07D405/12 , C07D407/12 , C07F5/02 , C07F9/655 , C07K5/078 , A61K31/382 , C07D43/02 , C07D49/02
CPC分类号： C07D209/48 , A61K38/00 , C07D303/36 , C07D405/12 , C07D407/12 , C07F5/025 , C07F9/65502 , C07K5/06139
摘要： The present invention provides compounds haviang formula (1): wherein R1-R6, A, J, D, E, G, Q, w, x, y, and z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of cancer and/or inflammatory disorders, and more generally as proteasome inhibitors.
摘要翻译： 本发明提供了式（1）化合物：其中R 1 -R 6，A，J，D，E，G，Q，w，x，y， 和z如本文中所述的一般和类别和亚类所述，并且另外提供其药物组合物，以及其用于治疗癌症和/或炎症性疾病的方法，更一般地，作为蛋白酶体抑制剂。
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公开(公告)号：US07799827B2
公开(公告)日：2010-09-21
申请号：US10507067
申请日：2003-03-07
申请人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
发明人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
IPC分类号： A61K31/335 , C07D313/00
CPC分类号： C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要： The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, X, Y, Z, and n are as defined herein.
摘要翻译： 本发明提供了具有式（I）的化合物：另外提供了其合成方法及其用于治疗各种疾病（包括炎性或自身免疫性疾病以及涉及恶性肿瘤或增加血管发生的疾病）的方法，其中R1-R11， X，Y，Z和n如本文所定义。
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公开(公告)号：US08329742B2
公开(公告)日：2012-12-11
申请号：US12839873
申请日：2010-07-20
申请人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
发明人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
IPC分类号： A61K31/355 , C07D313/00
CPC分类号： C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要： The present invention provides methods for the use of compounds having formula (I) in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, t, X, Y, Z, and n are as defined herein.
摘要翻译： 本发明提供了使用具有式（I）的化合物在治疗各种疾病（包括炎性或自身免疫性疾病）以及涉及恶性肿瘤或增加血管发生的疾病的方法，其中R1-R11，t，X，Y，Z和n 如本文所定义。
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公开(公告)号：US20110144101A1
公开(公告)日：2011-06-16
申请号：US12839873
申请日：2010-07-20
申请人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
发明人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
IPC分类号： A61K31/5377 , A61K31/335 , A61K31/4184 , A61P29/00 , A61P37/00 , A61P17/06 , A61P11/06 , A61P35/00 , A61P1/00
CPC分类号： C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要： The present invention provides methods for the use of compounds having formula (I) in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, t, X, Y, Z, and n are as defined herein.
摘要翻译： 本发明提供了使用具有式（I）的化合物在治疗各种疾病（包括炎性或自身免疫性疾病）以及涉及恶性肿瘤或增加血管发生的疾病的方法，其中R1-R11，t，X，Y，Z和n 如本文所定义。
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公开(公告)号：US20130196987A1
公开(公告)日：2013-08-01
申请号：US13663857
申请日：2012-10-30
申请人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-Andre Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
发明人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-Andre Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
IPC分类号： C07D405/12 , C07D491/044 , C07D313/00
CPC分类号： C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要： The present invention provides compounds, methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis.
摘要翻译： 本发明提供了化合物，其合成方法及其用于治疗各种疾病（包括炎性或自身免疫性疾病）以及涉及恶性肿瘤或增加血管生成的疾病的方法。
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