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公开(公告)号：US08841104B2
公开(公告)日：2014-09-23
申请号：US13091510
申请日：2011-04-21
申请人： Sergey A. Dryga , Victor C. Esch , Lisa-Jo Ann Clarizia , Eddie W. Adams , Thearith H. Ung , Ravil A. Sitdikov
发明人： Sergey A. Dryga , Victor C. Esch , Lisa-Jo Ann Clarizia , Eddie W. Adams , Thearith H. Ung , Ravil A. Sitdikov
IPC分类号： C12Q1/24 , G01N33/563 , G01N33/543 , C12Q1/68 , C07K16/12 , C12N13/00 , C07K1/22
CPC分类号： G01N33/5434 , B01L3/502738 , B01L2300/0636 , C07K1/22 , C07K16/1267 , C12N13/00 , C12Q1/68 , C12Q1/6806 , G01N21/64 , G01N33/53 , G01N33/54333 , G01N2446/90 , Y10T436/25 , Y10T436/25375 , C12Q2565/629 , C12Q2563/143
摘要： The invention generally relates to methods of using compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen, and magnets to isolate a pathogen from a body fluid sample.
摘要翻译： 本发明一般涉及使用组合物的方法，所述组合物包括一组磁性颗粒，每组的成员与特异于病原体的抗体缀合，以及磁体，用于将病原体与体液样品分离。
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2.发明申请公开(公告)号：US20110263833A1
公开(公告)日：2011-10-27
申请号：US13091506
申请日：2011-04-21
申请人： Sergey A. Dryga , Victor C. Esch , Lisa-Jo Ann Clarizia , Eddie W. Adams , Thearith H. Ung , Ravil A. Sitdikov
发明人： Sergey A. Dryga , Victor C. Esch , Lisa-Jo Ann Clarizia , Eddie W. Adams , Thearith H. Ung , Ravil A. Sitdikov
IPC分类号： C07K16/12
CPC分类号： G01N33/54333 , C07K1/22 , C07K16/1267 , C12N13/00 , C12Q1/6806 , G01N33/56911 , C12Q2565/629 , C12Q2563/143
摘要： The invention generally relates to compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen.
摘要翻译： 本发明一般涉及包括一组磁性颗粒的组合物，每组的成员与特异于病原体的抗体缀合。
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公开(公告)号：US20110262925A1
公开(公告)日：2011-10-27
申请号：US13091510
申请日：2011-04-21
申请人： Sergey A. Dryga , Victor C. Esch , Lisa-Jo Ann Clarizia , Eddie W. Adams , Thearith H. Ung , Ravil A. Sitdikov
发明人： Sergey A. Dryga , Victor C. Esch , Lisa-Jo Ann Clarizia , Eddie W. Adams , Thearith H. Ung , Ravil A. Sitdikov
IPC分类号： C12Q1/68 , G01N33/577 , G01N33/569
CPC分类号： G01N33/5434 , B01L3/502738 , B01L2300/0636 , C07K1/22 , C07K16/1267 , C12N13/00 , C12Q1/68 , C12Q1/6806 , G01N21/64 , G01N33/53 , G01N33/54333 , G01N2446/90 , Y10T436/25 , Y10T436/25375 , C12Q2565/629 , C12Q2563/143
摘要： The invention generally relates to methods of using compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen, and magnets to isolate a pathogen from a body fluid sample.
摘要翻译： 本发明一般涉及使用组合物的方法，所述组合物包括一组磁性颗粒，每组的成员与特异于病原体的抗体缀合，以及磁体，用于将病原体与体液样品分离。
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4.发明授权公开(公告)号：US09428547B2
公开(公告)日：2016-08-30
申请号：US13091506
申请日：2011-04-21
申请人： Sergey A. Dryga , Victor C. Esch , Lisa-Jo Ann Clarizia , Eddie W. Adams , Thearith H. Ung , Ravil A. Sitdikov
发明人： Sergey A. Dryga , Victor C. Esch , Lisa-Jo Ann Clarizia , Eddie W. Adams , Thearith H. Ung , Ravil A. Sitdikov
IPC分类号： C12Q1/70 , C12M3/00 , G01N33/53 , G01N33/567 , C07K1/22 , C07K16/12 , C12N13/00 , C12Q1/68 , G01N33/543
CPC分类号： G01N33/54333 , C07K1/22 , C07K16/1267 , C12N13/00 , C12Q1/6806 , G01N33/56911 , C12Q2565/629 , C12Q2563/143
摘要： The invention generally relates to compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen.
摘要翻译： 本发明一般涉及包括一组磁性颗粒的组合物，每组的成员与特异于病原体的抗体缀合。
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公开(公告)号：US09671395B2
公开(公告)日：2017-06-06
申请号：US13091548
申请日：2011-04-21
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/53 , G01N33/554 , G01N33/543 , G01N33/569 , C07K1/22 , C07K16/12 , C12N13/00 , G01N24/08 , G01R33/465 , A61B5/055
CPC分类号： G01N33/54326 , A61B5/055 , B01L3/502761 , B01L2200/0647 , B01L2400/043 , C07K1/22 , C07K16/1267 , C12N13/00 , C12N15/1013 , C12Q1/6806 , C12Q1/689 , C12Q2565/633 , G01N24/08 , G01N33/54333 , G01N33/56911 , G01N2333/195 , G01N2446/20 , G01R33/465 , Y10T428/2982 , C12Q2565/629 , C12Q2563/143
摘要： The invention generally relates to conducting an assay on a sample that isolates a pathogen from the sample and allows for analysis of the pathogen with minimal (i.e., at most 24 hrs of culturing) or no culturing of the pathogen. In certain embodiments, the invention provides methods for identifying a pathogen from a sample that involve obtaining a sample including a pathogen, conducting an assay that isolates the pathogen from the sample, culturing the isolated pathogen for at most about 24 hrs, and analyzing the pathogen.
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公开(公告)号：US20110262932A1
公开(公告)日：2011-10-27
申请号：US13091518
申请日：2011-04-21
IPC分类号： G01N33/569 , C01G49/10 , C01G49/08 , C12N1/20 , C07K16/12
CPC分类号： G01N33/54326 , A61B5/055 , B01L3/502761 , B01L2200/0647 , B01L2400/043 , C07K1/22 , C07K16/1267 , C12N13/00 , C12N15/1013 , C12Q1/6806 , C12Q1/689 , C12Q2565/633 , G01N24/08 , G01N33/54333 , G01N33/56911 , G01N2333/195 , G01N2446/20 , G01R33/465 , Y10T428/2982 , C12Q2565/629 , C12Q2563/143
摘要： The invention generally relates to compositions that include magnetic particles bound to pathogens in a body fluid.
摘要翻译： 本发明一般涉及包含与体液中的病原体结合的磁性颗粒的组合物。
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公开(公告)号：US20110262927A1
公开(公告)日：2011-10-27
申请号：US13091548
申请日：2011-04-21
CPC分类号： G01N33/54326 , A61B5/055 , B01L3/502761 , B01L2200/0647 , B01L2400/043 , C07K1/22 , C07K16/1267 , C12N13/00 , C12N15/1013 , C12Q1/6806 , C12Q1/689 , C12Q2565/633 , G01N24/08 , G01N33/54333 , G01N33/56911 , G01N2333/195 , G01N2446/20 , G01R33/465 , Y10T428/2982 , C12Q2565/629 , C12Q2563/143
摘要： The invention generally relates to conducting an assay on a sample that isolates a pathogen from the sample and allows for analysis of the pathogen with minimal (i.e., at most 24 hrs of culturing) or no culturing of the pathogen. In certain embodiments, the invention provides methods for identifying a pathogen from a sample that involve obtaining a sample including a pathogen, conducting an assay that isolates the pathogen from the sample, culturing the isolated pathogen for at most about 24 hrs, and analyzing the pathogen.
摘要翻译： 本发明一般涉及对从样品中分离病原体的样品进行测定，并允许以最小（即培养最多24小时）或不培养病原体来分析病原体。 在某些实施方案中，本发明提供了从样品中鉴定病原体的方法，所述病原体涉及获得包含病原体的样品，进行将病原体与样品分离的培养物，培养分离的病原体至多约24小时，并分析病原体 。
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公开(公告)号：US09562896B2
公开(公告)日：2017-02-07
申请号：US13091534
申请日：2011-04-21
IPC分类号： G01N33/00 , G01N33/543 , G01N33/569 , C07K1/22 , C07K16/12 , C12N13/00 , C12Q1/68 , G01N24/08 , G01R33/465 , A61B5/055
CPC分类号： G01N33/54326 , A61B5/055 , B01L3/502761 , B01L2200/0647 , B01L2400/043 , C07K1/22 , C07K16/1267 , C12N13/00 , C12N15/1013 , C12Q1/6806 , C12Q1/689 , C12Q2565/633 , G01N24/08 , G01N33/54333 , G01N33/56911 , G01N2333/195 , G01N2446/20 , G01R33/465 , Y10T428/2982 , C12Q2565/629 , C12Q2563/143
摘要： The invention generally relates to conducting an assay on a sample that isolates a bacterium from the sample, in which the assay isolates as low as about 1 CFU/ml of bacteria in the sample.
摘要翻译： 本发明一般涉及对从样品中分离出细菌的样品进行测定，其中测定分离出样品中低至约1CFU / ml的细菌。
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公开(公告)号：US20110262926A1
公开(公告)日：2011-10-27
申请号：US13091534
申请日：2011-04-21
IPC分类号： C12Q1/02 , G01N33/569 , G01N27/00 , C12Q1/04 , C12Q1/68
CPC分类号： G01N33/54326 , A61B5/055 , B01L3/502761 , B01L2200/0647 , B01L2400/043 , C07K1/22 , C07K16/1267 , C12N13/00 , C12N15/1013 , C12Q1/6806 , C12Q1/689 , C12Q2565/633 , G01N24/08 , G01N33/54333 , G01N33/56911 , G01N2333/195 , G01N2446/20 , G01R33/465 , Y10T428/2982 , C12Q2565/629 , C12Q2563/143
摘要： The invention generally relates to conducting an assay on a sample that isolates a bacterium from the sample, in which the assay isolates as low as about 1 CFU/ml of bacteria in the sample.
摘要翻译： 本发明一般涉及对从样品中分离出细菌的样品进行测定，其中测定分离出样品中低至约1CFU / ml的细菌。
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公开(公告)号：US20130109590A1
公开(公告)日：2013-05-02
申请号：US13720771
申请日：2012-12-19
IPC分类号： G01N33/569
CPC分类号： G01N33/56911 , C07K1/22 , C07K16/1267 , C07K2317/33 , C12N13/00 , C12Q1/6806 , G01N33/54333 , G01N33/56905 , G01N2333/4724 , G01N2400/00 , G01N2446/80 , C12Q2563/131 , C12Q2563/143 , C12Q2565/629
摘要： The invention generally relates to using magnetic particles and magnets to isolate a target analyte from a sample. In certain embodiments, methods of the invention involve introducing to a sample at least one set of magnetic particles having at least one type of lectin in order to create a mixture, incubating the mixture such that the lectin binds to a carbohydrate on a surface of a target in the sample to thereby form target/particle complexes, in which the incubating is performed in the presence of a buffer that influences binding, and applying a magnetic field to separate target/particle complexes from remaining components of the sample, thereby isolating target/magnetic particle complexes.
摘要翻译： 本发明一般涉及使用磁性颗粒和磁体从样品中分离出目标分析物。 在某些实施方案中，本发明的方法包括向样品中引入至少一组具有至少一种类型的凝集素的磁性颗粒，以产生混合物，将混合物孵育，使得凝集素结合到表面上的碳水化合物 以形成目标/颗粒复合物，其中在存在影响结合的缓冲液的情况下进行孵育，并施加磁场以将样品的剩余组分与目标/颗粒复合物分离，由此分离靶/ 磁性颗粒复合物。
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