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    Microship and method for cell arrangement
    1.
    发明申请
    Microship and method for cell arrangement 审中-公开
    细胞和细胞排列方法

    公开(公告)号：US20100043882A1

    公开(公告)日：2010-02-25

    申请号：US12308434

    申请日：2007-06-15

    申请人： Setsuya Sato ,  Toshiyuki Yamato ,  Katsuaki Hayashi ,  Yoshitaka Matsumoto ,  Takahiro Ochiya ,  Isamu Oh

    发明人： Setsuya Sato ,  Toshiyuki Yamato ,  Katsuaki Hayashi ,  Yoshitaka Matsumoto ,  Takahiro Ochiya ,  Isamu Oh

    IPC分类号： F16L41/00

    CPC分类号： C12M33/00 ,  B01L3/502761 ,  G01N15/1056 ,  Y10T137/0318 ,  Y10T137/85938

    摘要： [Problems]To provide a microchip for cell arranging which transfers and arranges the cell accurately and quickly, by combining advantages of the method of an optical tweezer and of micro channel.[Means for Solving Problems]A microchip for arranging cells, including a base, the base comprising: at least one cell supply channel including a cell inlet port in liquid communication with a supply mechanism configured to supply the cells into the cell supply channel; at least one cell drain channel including a cell drain port in fluid communication with a drain mechanism, the cell drain channel configured to guide the cells to the cell drain port; at least one reservoir for temporarily storing the cells flowing between the cell supply channel and the cell drain channel; at least one cell arrangement portion for receiving cells introduced from the reservoir, the cell arrangement portion comprising plural compartments partitioned by a wall; and at least one junction channel extending from the cell arrangement portion to the reservoir; wherein the reservoir is wider than the cell supply channel, the cell drain channel and the junction channel.

    摘要翻译： [问题]通过组合光镊方法和微通道的优点，提供一种用于细胞排列的微芯片，其通过精确而快速地传送和排列细胞。 解决问题的手段一种用于布置电池的微芯片，包括基座，所述基座包括：至少一个电池供应通道，包括与供配给将电池供应到电池供应通道的供电机构液体连通的电池入口; 至少一个单元排放通道，包括与漏极机构流体连通的单元排出端口，所述单元排放通道被配置为将单元引导到单元排放端口; 至少一个存储器，用于临时存储在单元供应通道和单元排放通道之间流动的单元; 至少一个用于接收从储存器引入的单元的单元布置部分，单元布置部分包括由壁分隔的多个隔室; 以及从单元布置部分延伸到储存器的至少一个接合通道; 其中所述储存器比所述电池供给通道，所述电池排出通道和所述接合通道宽。

    PHARMACEUTICAL PRODUCT FOR PREVENTING OR TREATING ALZHEIMER'S DISEASE
    2.
    发明申请
    PHARMACEUTICAL PRODUCT FOR PREVENTING OR TREATING ALZHEIMER'S DISEASE 审中-公开
    用于预防或治疗阿尔茨海默病的药物产品

    公开(公告)号：US20140341882A1

    公开(公告)日：2014-11-20

    申请号：US14344420

    申请日：2012-09-07

    申请人： Takahiro Ochiya

    发明人： Takahiro Ochiya

    IPC分类号： A61K38/48

    CPC分类号： A61K38/4886 ,  A61K35/28 ,  C12Y304/24011

    摘要： The present invention provides a therapeutic agent for Alzheimer's disease. The therapeutic agent contains membrane vesicles (exosomes) of adipose tissue-derived mesenchymal stem cells, and the membrane vesicles (exosomes) contain neprilysin. Through the research by the inventors of the present invention, it was revealed that exosomes secreted by human adipose tissue-derived mesenchymal stem cells contain neprilysin, which degrades amyloid-β as a pathogenic protein of Alzheimer's disease. When exosomes secreted by human adipose tissue-derived mesenchymal stem cells were administered to the brains of Alzheimer's disease model mice, the generation of amyloid-β was inhibited.

    摘要翻译： 本发明提供了阿尔茨海默病的治疗剂。 治疗剂含有脂肪组织来源的间充质干细胞的膜囊泡（外来体），膜囊泡（外来体）含有血培养液。 通过本发明的发明人的研究，揭示了由人脂肪组织衍生的间充质干细胞分泌的外来体含有上皮蛋白，其降解淀粉样蛋白 - 作为阿尔茨海默氏病的致病蛋白质。 当将人脂肪组织来源的间充质干细胞分泌的外来体施用于阿尔茨海默病模型小鼠的脑中时，淀粉样蛋白的生成 被抑制。

    THERAPEUTIC AGENT FOR TUMOR
    4.
    发明申请
    THERAPEUTIC AGENT FOR TUMOR 有权
    肿瘤治疗剂

    公开(公告)号：US20120252881A1

    公开(公告)日：2012-10-04

    申请号：US13498771

    申请日：2010-10-01

    申请人： Takahiro Ochiya ,  Ryou-u Takahashi

    发明人： Takahiro Ochiya ,  Ryou-u Takahashi

    IPC分类号： A61K31/7088 ,  A61P35/00 ,  A61K31/713

    CPC分类号： A61K31/7088 ,  A61K31/713 ,  C12N15/113 ,  C12N2310/141 ,  C12N2330/10 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/178

    摘要： The present invention provides a therapeutic agent for a tumor, particularly a therapeutic agent for drug-resistant cancer, an agent for suppression or prophylaxis of tumor metastasis, and an agent for suppression or prophylaxis of cancer recurrence, containing a nucleic acid containing miR27b or a nucleotide having a nucleotide sequence having an identity of 70% or more with the nucleotide sequence shown by SEQ ID NO: 1 and having a function equivalent to miR27b.

    摘要翻译： 本发明提供了一种用于肿瘤的治疗剂，特别是耐药性癌症的治疗剂，抑制或预防肿瘤转移的药剂，以及抑制或预防癌症复发的药物，其含有含有miR27b或 具有与SEQ ID NO：1所示的核苷酸序列同一性为70％以上且具有与miR27b相当的功能的核苷酸序列的核苷酸。

    Nanobio device of imitative anatomy structure
    5.
    发明授权
    Nanobio device of imitative anatomy structure 有权
    模拟解剖结构的Nanobio装置

    公开(公告)号：US07736893B2

    公开(公告)日：2010-06-15

    申请号：US11353603

    申请日：2006-02-14

    申请人： Masanao Munekane ,  Hiroyuki Wada ,  Kouji Iwasaki ,  Toshiaki Fujii ,  Takahiro Ochiya ,  Yusuke Yamamoto ,  Takumi Teratani

    发明人： Masanao Munekane ,  Hiroyuki Wada ,  Kouji Iwasaki ,  Toshiaki Fujii ,  Takahiro Ochiya ,  Yusuke Yamamoto ,  Takumi Teratani

    IPC分类号： C12N5/00

    CPC分类号： G01N33/5088 ,  Y10T436/11

    摘要： Objects to be achieved by the invention are to provide a nanobio device in which cultured cells are organized at a high-level in a state near in vivo, and to provide a method of using the nanobio device of imitative anatomy structure. The nanobio device of imitative anatomy structure of the invention is obtained by manufacturing a substrate with a bio-compatible substance and arranging a plurality of types of cells thereon in a desired array. A method of manufacturing a nanobio device in the invention includes a step of manufacturing a substrate for a nanobio device by a micromachine processing technique and a step of arranging a plurality of cultured cells on the substrate in a desired array with laser optical tweezers.

    摘要翻译： 通过本发明实现的目的是提供一种纳米生物装置，其中培养细胞在体内接近的状态下组织在高水平，并提供使用模拟解剖结构的纳米装置的方法。 本发明的模拟解剖结构的纳米装置通过用生物相容性物质制造衬底并以期望的阵列布置多种类型的细胞而获得。 在本发明中制造纳米装置的方法包括通过微机械加工技术制造纳米装置用基板的步骤，以及使用激光光学镊子以期望的阵列在基板上排列多个培养细胞的步骤。

    Novel Method of Nucleic Acid Transfer
    7.
    发明申请
    Novel Method of Nucleic Acid Transfer 审中-公开
    核酸转移的新方法

    公开(公告)号：US20080318319A1

    公开(公告)日：2008-12-25

    申请号：US10583277

    申请日：2004-12-15

    申请人： Yoshiko Minakuchi ,  Takahiro Ochiya

    发明人： Yoshiko Minakuchi ,  Takahiro Ochiya

    IPC分类号： C12N15/87 ,  C01F11/24

    CPC分类号： C12N15/1136 ,  C12N15/111 ,  C12N2310/14 ,  C12N2320/32

    摘要： The present invention provides a method of nucleic acid transfer comprising the following steps (a) and (b): (a) contacting a nucleic acid with a cell in a medium; and (b) following the step (a), contacting the medium of (a) with a high-concentration solution of a metal salt, a nucleic acid transfer agent comprising solid metal salt or a high-concentration solution of a metal salt as an ingredient, and the like.

    摘要翻译： 本发明提供核酸转移方法，其包括以下步骤（a）和（b）：（a）使核酸与培养基中的细胞接触; 和（b）在步骤（a）之后，使（a）的介质与金属盐的高浓度溶液，包含固体金属盐的核酸转移剂或作为金属盐的高浓度溶液接触 成分等。