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公开(公告)号：US08034850B2
公开(公告)日：2011-10-11
申请号：US11601994
申请日：2006-11-20
CPC分类号： A61K6/0038 , A61K6/0017 , A61K6/083 , A61L24/0084 , C08L33/00
摘要： Self-setting, bioactive, absorbable composites are derived from inorganic phosphate microparticles and a cyanoacrylate matrix of a methoxypropyl cyanoacrylate at a weight to volume ratio of at least 20/80 of microparticles/matrix. The self-setting composites are capable of the controlled release of bone mineralizing ions, antimicrobials, and bone growth promoters. Such composites are useful as bone cements, fillers, and/or substitutes.
摘要翻译： 自制，生物活性，可吸收的复合材料衍生自无机磷酸盐微粒和氰基丙烯酸甲氧基丙酯的氰基丙烯酸酯基质，体积比至少为20/80微米/基质。 自固化复合材料能够控制骨矿化离子，抗微生物剂和骨生长促进剂的释放。 这样的复合材料可用作骨水泥，填料和/或替代物。
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公开(公告)号：US08076388B2
公开(公告)日：2011-12-13
申请号：US12080649
申请日：2008-04-04
CPC分类号： A61L24/0084 , A61L24/0042 , A61L24/0089 , A61L27/446 , A61L27/46 , A61L27/58 , A61L2430/02 , C08L35/04
摘要： Self-setting, absorbable bioactive polycyanoacrylate-based composites include at least one inorganic phosphate salt or a combination of at least one inorganic phosphate salt and calcium silicate in a cyanoacrylate matrix. The composites can be reinforced with single- or multicomponent absorbable, warp-knitted mesh, thus producing a broad range of absorbable, bioactive biomaterials suitable for use not only as preferred absorbable alternatives to the commercial non-absorbable polymethyl methacrylate bone cements, but also for repairing or replacing cranial and maxillofacial bone defects and other complex defects through guided bone regeneration.
摘要翻译： 自制的可吸收的生物活性聚氰基丙烯酸酯复合材料包括氰基丙烯酸酯基体中的至少一种无机磷酸盐或至少一种无机磷酸盐和硅酸钙的组合。 复合材料可以用单组分或多组分可吸收的经编织物加强，从而产生广泛范围的可吸收的生物活性生物材料，不仅适用于商业上不可吸收的聚甲基丙烯酸甲酯骨水泥的优选可吸收替代物，而且适用于 通过引导骨再生修复或替代颅面和颌面骨缺损及其他复杂缺陷。
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3.发明授权Absorbable/biodegradable composite yarns and property-modulated surgical implants therefrom 有权可吸收/可生物降解的复合纱线及其调制外科植入物公开(公告)号：US08585772B2
公开(公告)日：2013-11-19
申请号：US11886370
申请日：2006-04-20
IPC分类号： A61F2/02
CPC分类号： A61L17/12 , A61F2210/0004 , A61L17/145 , A61L27/34 , A61L27/58 , A61L31/10 , A61L31/148 , C08L67/04
摘要： Absorbable/biodegradable composite yarns contain at least two types of fibrous components having distinctly different absorption and strength retention profiles and are useful in constructing surgical implants, such as sutures and meshes with integrated physicochemical and biological properties, wherein these properties are modulated through varying the individual yarn content and controlling the geometry of these constructs.
摘要翻译： 可吸收/可生物降解的复合纱线含有至少两种具有明显不同的吸收和强度保持分布的纤维组分，并且可用于构建外科植入物，例如具有整合的物理化学和生物学特性的缝线和网格，其中这些性质通过改变个体 纱线含量并控制这些结构的几何形状。
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4.发明授权公开(公告)号：US08579939B2
公开(公告)日：2013-11-12
申请号：US11978795
申请日：2007-10-30
申请人： Shalaby W Shalaby
发明人： Shalaby W Shalaby
CPC分类号： A61B17/06166 , A61B2017/00004 , A61B2017/00889 , A61B2017/00893 , A61L17/005 , A61L17/10 , A61L17/145 , A61L2300/202 , A61L2300/404 , A61L2300/41 , A61L2300/412 , A61L2300/416 , A61L2300/452 , A61L2300/606
摘要： Silk/absorbable polyester hybrid medical devices for tissue repair and regeneration are formed of degummed, naturally produced, multifilament silk yarn in combination with at least one absorbable polyester in the form of a surface coating, with or without an antimicrobial agent, for producing value-added braided silk sutures and multifilament yarn, as well as silk/absorbable polyester fiber composites, for producing tailored hybrid sutures, meshes, and scaffolds for tissue regeneration.
摘要翻译： 用于组织修复和再生的丝/可吸收聚酯混合医疗装置由脱胶，天然生产的复丝丝与至少一种表面涂层形式的可吸收聚酯组合，具有或不具有抗微生物剂， 添加编织丝缝和复丝纱，以及丝/可吸收聚酯纤维复合材料，用于生产用于组织再生的定制混合缝合线，网孔和支架。
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公开(公告)号：US08057817B2
公开(公告)日：2011-11-15
申请号：US11667933
申请日：2005-12-14
申请人： Shalaby W Shalaby
发明人： Shalaby W Shalaby
IPC分类号： A61F13/02
CPC分类号： A61K9/0036 , A61F6/142
摘要： This invention generally covers a ringed-mesh intravaginal device and applicator therefore wherein the ringed-mesh comprises a composite ring comprising a flexible matrix containing one or more bioactive agent or agents and needed excipients or modulators, and the said matrix is reinforced with a fibrous construct to provided needed initial and in-use biomechanical stability. Of special application of the medicated, ringed-mesh is its use for securing contraception relying on biomechanical, pharmacological, and biochemical means.
摘要翻译： 本发明通常涵盖环形网状阴道内装置和施用器，其中环形网包括复合环，复合环包含含有一种或多种生物活性剂或试剂和所需赋形剂或调节剂的柔性基质，所述基质用纤维结构 以提供所需的初始和使用中的生物力学稳定性。 特殊应用的戒药网是用于依靠生物力学，药理学和生化手段确保避孕方法。
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6.发明授权Inorganic-organic melt-extruded hybrid yarns and fibrous composite medical devices thereof 有权无机 - 有机熔融挤出混合纱线及其纤维复合医疗装置公开(公告)号：US07820289B2
公开(公告)日：2010-10-26
申请号：US12456826
申请日：2009-06-23
CPC分类号： D01F1/10 , A61F2/0063 , A61L17/005 , A61L17/10 , A61L17/145 , A61L31/127 , A61L31/128 , A61L31/148 , A61L31/16 , A61L31/18 , A61L2300/622 , A61L2300/624 , D01F6/62 , D01F6/625 , D01F6/64 , D01F6/86 , D02G3/04 , D02G3/38 , D02G3/448 , Y10T428/249938 , Y10T428/29 , Y10T428/2913 , Y10T428/2915 , Y10T428/2931 , Y10T428/298 , Y10T442/105 , Y10T442/3146 , Y10T442/3154 , Y10T442/3171 , Y10T442/3301 , Y10T442/425 , Y10T442/431 , Y10T442/438 , Y10T442/444
摘要： Composite fibrous constructs are made of combinations of inorganic-organic hybrid monofilament or multifilament yarns containing at least 6 weight percent of inorganic micro-/nanoparticles and organic monofilament or multifilament yarn with typical examples of the hybrid yarn matrix made of absorbable or non-absorbable thermoplastic polymers and final constructs being in the form of knitted or woven meshes and braided ligatures intended to perform under specific mechanically, biologically, and/or radiologically related functions.
摘要翻译： 复合纤维构造物由含有至少6重量％的无机微/纳米颗粒和有机单丝或多丝纱的无机 - 有机杂化单丝或复丝纱的组合制成，具有由可吸收或不可吸收的热塑性塑料制成的混合纱线基质的典型实例 聚合物和最终构造物是针织或梭织网格和编织结扎的形式，旨在在特定的机械，生物学和/或放射学相关功能下进行。
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公开(公告)号：US07371256B2
公开(公告)日：2008-05-13
申请号：US10735063
申请日：2003-12-12
申请人： Shalaby W Shalaby
发明人： Shalaby W Shalaby
CPC分类号： A61F2/06
摘要： This invention deals with a composite vascular construct, which is formed of a first, blood contacting component and a second, tissue contacting component. Preferably, the present vascular constructs are in the form of a vascular patch or vascular graft with surface-activated, non-absorbable fabric with immobilized biomolecules on the blood contacting surface, and an absorbable, compliant film or microporous sheath on the other surface of the non-absorbable component of the composite graft or patch.
摘要翻译： 本发明涉及由第一血液接触组分和第二组织接触组分形成的复合血管构建体。 优选地，本发明的血管构建体是具有在血液接触表面上具有固定的生物分子的具有表面活化的不可吸收的织物的血管斑块或血管移植物的形式，以及在所述血液接触表面的另一表面上的可吸收的柔顺膜或微孔护套 复合移植物或补片的不可吸收组分。
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公开(公告)号：US08507614B2
公开(公告)日：2013-08-13
申请号：US12322841
申请日：2009-02-07
IPC分类号： C08G63/91
CPC分类号： A61B17/72 , A61B17/7258 , A61B17/866 , A61B2017/00004 , A61B2017/00557 , A61L31/06 , A61L31/148 , C08L67/04 , C08L2666/18
摘要： Absorbable, multiphasic, crystalline, solid blend compositions having at least two first order thermal transitions, are formed of a segmented l-lactide copolymer as the principal or major component and at least one additional crystalline thermoplastic absorbable polyester having glycolide-based sequences, a fraction of which participated in ester-ester interchange reactions with lactide-based sequences to produce crystalline materials with modulated properties for use in producing orthopedic and tissue-repair devices.
摘要翻译： 具有至少两个一级热转变的可吸收的，多相的，结晶的，固体共混物组合物由分段的l-丙交酯共聚物作为主要或主要组分形成，以及至少一种另外的结晶热塑性可吸收聚酯，其具有基于乙交酯的序列， 其中参与与基于丙交酯的序列的酯 - 酯交换反应以产生具有用于生产矫形和组织修复装置的调制性质的结晶材料。
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9.发明授权Radiation and radiochemically sterilized fiber-reinforced, composite urinogenital stents 有权辐射和放射化学灭菌的纤维增强，复合尿殖器支架公开(公告)号：US08083806B2
公开(公告)日：2011-12-27
申请号：US12378221
申请日：2009-02-12
CPC分类号： A61F2/86 , A61F2/04 , A61F2/94 , A61F2210/0004 , A61F2210/0076 , A61L31/048 , A61L31/129 , A61L31/148 , A61L31/16 , A61L31/18 , A61L2300/404 , A61L2300/416 , A61M25/0108 , A61M27/008
摘要： A radiation and radiochemically sterilized, multi-component, fiber-reinforced composite, absorbable/disintegratable urinogenital stent, such as an endoureteral stent, with radiomodulated residence time in the biological site of 1 to 10 weeks depending on the high energy radiation dose used for sterilization.
摘要翻译： 辐射和放射化学消毒的多组分纤维增强复合材料，可吸收/分解的尿道内支架，如输尿管内支架，根据用于灭菌的高能量辐射剂量，在生物部位的放射性调节停留时间为1至10周 。
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10.发明授权Antimicrobial, radiopaque, microfiber-reinforced, polymeric methacrylate bone cement 有权抗菌，不透射线，超细纤维增强，聚合甲基丙烯酸酯骨水泥公开(公告)号：US07981945B2
公开(公告)日：2011-07-19
申请号：US12223211
申请日：2007-02-06
IPC分类号： A61F2/00
CPC分类号： A61K9/5026
摘要： An methacrylate bone cement is toughened and rendered radiopaque by reinforcing with electrospun microfibers including a radiopacifier and antimicrobial agents to provide a bone cement for use in repairing bone or other hard tissues.
摘要翻译： 通过用包括放射性增透剂和抗微生物剂在内的电纺丝微纤维进行增强，使甲基丙烯酸酯骨水泥硬化并变得不透射线，以提供用于修复骨或其它硬组织的骨粘固剂。
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