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1.发明申请公开(公告)号：US20170313808A1
公开(公告)日：2017-11-02
申请号：US15652135
申请日：2017-07-17
IPC分类号： C08G18/73 , C08G18/42 , A61L27/18 , C08G64/02 , C08G18/48 , A61L27/52 , A61L24/00 , C08G18/34 , C08G18/32 , C08G18/12 , C08L75/04 , C08G18/44
CPC分类号： C08G18/73 , A61L24/0021 , A61L27/18 , A61L27/52 , A61L27/54 , A61L2300/404 , A61L2300/416 , A61L2300/426 , A61L2400/06 , A61L2430/06 , C08G18/12 , C08G18/244 , C08G18/3206 , C08G18/341 , C08G18/4244 , C08G18/428 , C08G18/4283 , C08G18/44 , C08G18/4808 , C08G18/4837 , C08G18/4854 , C08G18/4887 , C08G18/758 , C08G18/771 , C08G64/0241 , C08G2230/00 , C08L75/04 , C09J133/18 , C08G18/3228 , C08L75/06 , C08L71/02
摘要： Bioactive liquid formulations are formed of combinations of absorbable, segmented aliphatic polyurethane compositions and liquid polyether for use as vehicles for the controlled release of at least one active agent for the conventional and unconventional treatment of different forms of cancer and the management of at least one type of bacterial, fungal, and viral infection.
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2.发明申请公开(公告)号：US20090233887A1
公开(公告)日：2009-09-17
申请号：US12380391
申请日：2009-02-26
CPC分类号： C08G18/73 , A61L24/0021 , A61L27/18 , A61L27/52 , A61L2430/06 , C08G18/12 , C08G18/3206 , C08G18/341 , C08G18/4244 , C08G18/428 , C08G18/4283 , C08G18/44 , C08G18/4887 , C08G64/0241 , C08G2230/00 , C08L75/04
摘要： Hydroswellable, absorbable and non-absorbable, aliphatic, segmented polyurethanes and polyurethane-urea capable of swelling in the biological environment with associated increase in volume of at least 3 percent have more than one type of segments, including those derived from polyethylene glycol and the molecular chains are structurally tailored to allow the use of corresponding formulations and medical devices as carriers for bioactive agents, rheological modifiers of cyanoacrylate-based tissue adhesives, as protective devices for repairing defective or diseased components of articulating joints and their cartilage, and scaffolds for cartilage tissue engineering.
摘要翻译： 能够在生物环境中膨胀的可渗透，可吸收和不可吸收的脂肪族，分段聚氨酯和聚氨酯 - 尿素，其体积增加至少3％具有多于一种类型的链段，包括衍生自聚乙二醇和分子 链条在结构上被定制以允许使用相应的制剂和医疗装置作为生物活性剂的载体，基于氰基丙烯酸酯的组织粘合剂的流变改性剂，作为用于修复关节关节及其软骨的缺陷或患病组分的保护装置，以及用于软骨组织的支架 工程。
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3.发明申请公开(公告)号：US20140046019A1
公开(公告)日：2014-02-13
申请号：US14058640
申请日：2013-10-21
IPC分类号： C08G64/02
CPC分类号： C08G18/73 , A61L24/0021 , A61L27/18 , A61L27/52 , A61L2430/06 , C08G18/12 , C08G18/3206 , C08G18/341 , C08G18/4244 , C08G18/428 , C08G18/4283 , C08G18/44 , C08G18/4887 , C08G64/0241 , C08G2230/00 , C08L75/04
摘要： Hydroswellable, absorbable and non-absorbable, aliphatic, segmented polyurethanes and polyurethane-urea capable of swelling in the biological environment with associated increase in volume of at least 3 percent have more than one type of segments, including those derived from polyethylene glycol and the molecular chains are structurally tailored to allow the use of corresponding formulations and medical devices as carriers for bioactive agents, rheological modifiers of cyanoacrylate-based tissue adhesives, as protective devices for repairing defective or diseased components of articulating joints and their cartilage, and scaffolds for cartilage tissue engineering.
摘要翻译： 能够在生物环境中膨胀的可渗透，可吸收和不可吸收的脂肪族，分段聚氨酯和聚氨酯 - 尿素，其体积增加至少3％具有多于一种类型的链段，包括衍生自聚乙二醇和分子 链条在结构上被定制以允许使用相应的制剂和医疗装置作为生物活性剂的载体，基于氰基丙烯酸酯的组织粘合剂的流变改性剂，作为用于修复关节关节及其软骨的缺陷或患病组分的保护装置，以及用于软骨组织的支架 工程。
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4.发明申请Cyanoacrylate tissue adhesive formulations with multipurpose rheology modifiers 有权具有多用途流变改性剂的氰基丙烯酸酯组织粘合剂配方公开(公告)号：US20090264555A1
公开(公告)日：2009-10-22
申请号：US12386401
申请日：2009-04-18
IPC分类号： A61L24/04
CPC分类号： A61L24/06 , A61L24/04 , A61K6/0017 , C08L33/14 , A61K6/0023
摘要： Absorbable and non-absorbable cyanoacrylate tissue adhesive/sealant formulations include at least one multipurpose carboxylic, acid-bearing C-succinylated polymeric rheology modifier capable of increasing the viscosity of the liquid formulation, while controlling the anionic polymerization of the cyanoacrylate monomers and increasing the compliance of the cured solid adhesive.
摘要翻译： 可吸收和不可吸收的氰基丙烯酸酯组合粘合剂/密封剂制剂包括至少一种多功能羧酸，含酸的C琥珀酰化聚合物流变改性剂，其能够增加液体制剂的粘度，同时控制氰基丙烯酸酯单体的阴离子聚合并增加顺应性 的固化固体粘合剂。
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公开(公告)号：US20080220045A1
公开(公告)日：2008-09-11
申请号：US12080649
申请日：2008-04-04
IPC分类号： A61F2/28
CPC分类号： A61L24/0084 , A61L24/0042 , A61L24/0089 , A61L27/446 , A61L27/46 , A61L27/58 , A61L2430/02 , C08L35/04
摘要： Self-setting, absorbable bioactive polycyanoacrylate-based composites include at least one inorganic phosphate salt or a combination of at least one inorganic phosphate salt and calcium silicate in a cyanoacrylate matrix. The composites can be reinforced with single- or multicomponent absorbable, warp-knitted mesh, thus producing a broad range of absorbable, bioactive biomaterials suitable for use not only as preferred absorbable alternatives to the commercial non-absorbable polymethyl methacrylate bone cements, but also for repairing or replacing cranial and maxillofacial bone defects and other complex defects through guided bone regeneration.
摘要翻译： 自制的可吸收的生物活性聚氰基丙烯酸酯复合材料包括氰基丙烯酸酯基体中的至少一种无机磷酸盐或至少一种无机磷酸盐和硅酸钙的组合。 复合材料可以用单组分或多组分可吸收的经编织物加强，从而产生广泛范围的可吸收的生物活性生物材料，不仅适用于商业上不可吸收的聚甲基丙烯酸甲酯骨水泥的优选可吸收替代物，而且适用于 通过引导骨再生修复或替代颅面和颌面骨缺损及其他复杂缺陷。
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公开(公告)号：US08034850B2
公开(公告)日：2011-10-11
申请号：US11601994
申请日：2006-11-20
CPC分类号： A61K6/0038 , A61K6/0017 , A61K6/083 , A61L24/0084 , C08L33/00
摘要： Self-setting, bioactive, absorbable composites are derived from inorganic phosphate microparticles and a cyanoacrylate matrix of a methoxypropyl cyanoacrylate at a weight to volume ratio of at least 20/80 of microparticles/matrix. The self-setting composites are capable of the controlled release of bone mineralizing ions, antimicrobials, and bone growth promoters. Such composites are useful as bone cements, fillers, and/or substitutes.
摘要翻译： 自制，生物活性，可吸收的复合材料衍生自无机磷酸盐微粒和氰基丙烯酸甲氧基丙酯的氰基丙烯酸酯基质，体积比至少为20/80微米/基质。 自固化复合材料能够控制骨矿化离子，抗微生物剂和骨生长促进剂的释放。 这样的复合材料可用作骨水泥，填料和/或替代物。
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7.发明授权Cyanoacrylate tissue adhesive formulations with multipurpose rheology modifiers 有权具有多用途流变改性剂的氰基丙烯酸酯组织粘合剂配方公开(公告)号：US08815975B2
公开(公告)日：2014-08-26
申请号：US12386401
申请日：2009-04-18
IPC分类号： A61L24/00 , A61K8/72 , C08G18/42 , C08L67/00 , C08G63/08 , C08G63/44 , A61L24/06 , A61L24/04
CPC分类号： A61L24/06 , A61L24/04 , A61K6/0017 , C08L33/14 , A61K6/0023
摘要： Absorbable and non-absorbable cyanoacrylate tissue adhesive/sealant formulations include at least one multipurpose carboxylic, acid-bearing C-succinylated polymeric rheology modifier capable of increasing the viscosity of the liquid formulation, while controlling the anionic polymerization of the cyanoacrylate monomers and increasing the compliance of the cured solid adhesive.
摘要翻译： 可吸收和不可吸收的氰基丙烯酸酯组合粘合剂/密封剂制剂包括至少一种多功能羧酸，含酸的C琥珀酰化聚合物流变改性剂，其能够增加液体制剂的粘度，同时控制氰基丙烯酸酯单体的阴离子聚合并增加顺应性 的固化固体粘合剂。
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公开(公告)号：US08076388B2
公开(公告)日：2011-12-13
申请号：US12080649
申请日：2008-04-04
CPC分类号： A61L24/0084 , A61L24/0042 , A61L24/0089 , A61L27/446 , A61L27/46 , A61L27/58 , A61L2430/02 , C08L35/04
摘要： Self-setting, absorbable bioactive polycyanoacrylate-based composites include at least one inorganic phosphate salt or a combination of at least one inorganic phosphate salt and calcium silicate in a cyanoacrylate matrix. The composites can be reinforced with single- or multicomponent absorbable, warp-knitted mesh, thus producing a broad range of absorbable, bioactive biomaterials suitable for use not only as preferred absorbable alternatives to the commercial non-absorbable polymethyl methacrylate bone cements, but also for repairing or replacing cranial and maxillofacial bone defects and other complex defects through guided bone regeneration.
摘要翻译： 自制的可吸收的生物活性聚氰基丙烯酸酯复合材料包括氰基丙烯酸酯基体中的至少一种无机磷酸盐或至少一种无机磷酸盐和硅酸钙的组合。 复合材料可以用单组分或多组分可吸收的经编织物加强，从而产生广泛范围的可吸收的生物活性生物材料，不仅适用于商业上不可吸收的聚甲基丙烯酸甲酯骨水泥的优选可吸收替代物，而且适用于 通过引导骨再生修复或替代颅面和颌面骨缺损及其他复杂缺陷。
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