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1.发明授权Cyanoacrylate tissue adhesive formulations with multipurpose rheology modifiers 有权具有多用途流变改性剂的氰基丙烯酸酯组织粘合剂配方公开(公告)号：US08815975B2
公开(公告)日：2014-08-26
申请号：US12386401
申请日：2009-04-18
IPC分类号： A61L24/00 , A61K8/72 , C08G18/42 , C08L67/00 , C08G63/08 , C08G63/44 , A61L24/06 , A61L24/04
CPC分类号： A61L24/06 , A61L24/04 , A61K6/0017 , C08L33/14 , A61K6/0023
摘要： Absorbable and non-absorbable cyanoacrylate tissue adhesive/sealant formulations include at least one multipurpose carboxylic, acid-bearing C-succinylated polymeric rheology modifier capable of increasing the viscosity of the liquid formulation, while controlling the anionic polymerization of the cyanoacrylate monomers and increasing the compliance of the cured solid adhesive.
摘要翻译： 可吸收和不可吸收的氰基丙烯酸酯组合粘合剂/密封剂制剂包括至少一种多功能羧酸，含酸的C琥珀酰化聚合物流变改性剂，其能够增加液体制剂的粘度，同时控制氰基丙烯酸酯单体的阴离子聚合并增加顺应性 的固化固体粘合剂。
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2.发明申请Cyanoacrylate tissue adhesive formulations with multipurpose rheology modifiers 有权具有多用途流变改性剂的氰基丙烯酸酯组织粘合剂配方公开(公告)号：US20090264555A1
公开(公告)日：2009-10-22
申请号：US12386401
申请日：2009-04-18
IPC分类号： A61L24/04
CPC分类号： A61L24/06 , A61L24/04 , A61K6/0017 , C08L33/14 , A61K6/0023
摘要： Absorbable and non-absorbable cyanoacrylate tissue adhesive/sealant formulations include at least one multipurpose carboxylic, acid-bearing C-succinylated polymeric rheology modifier capable of increasing the viscosity of the liquid formulation, while controlling the anionic polymerization of the cyanoacrylate monomers and increasing the compliance of the cured solid adhesive.
摘要翻译： 可吸收和不可吸收的氰基丙烯酸酯组合粘合剂/密封剂制剂包括至少一种多功能羧酸，含酸的C琥珀酰化聚合物流变改性剂，其能够增加液体制剂的粘度，同时控制氰基丙烯酸酯单体的阴离子聚合并增加顺应性 的固化固体粘合剂。
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公开(公告)号：US20080220045A1
公开(公告)日：2008-09-11
申请号：US12080649
申请日：2008-04-04
IPC分类号： A61F2/28
CPC分类号： A61L24/0084 , A61L24/0042 , A61L24/0089 , A61L27/446 , A61L27/46 , A61L27/58 , A61L2430/02 , C08L35/04
摘要： Self-setting, absorbable bioactive polycyanoacrylate-based composites include at least one inorganic phosphate salt or a combination of at least one inorganic phosphate salt and calcium silicate in a cyanoacrylate matrix. The composites can be reinforced with single- or multicomponent absorbable, warp-knitted mesh, thus producing a broad range of absorbable, bioactive biomaterials suitable for use not only as preferred absorbable alternatives to the commercial non-absorbable polymethyl methacrylate bone cements, but also for repairing or replacing cranial and maxillofacial bone defects and other complex defects through guided bone regeneration.
摘要翻译： 自制的可吸收的生物活性聚氰基丙烯酸酯复合材料包括氰基丙烯酸酯基体中的至少一种无机磷酸盐或至少一种无机磷酸盐和硅酸钙的组合。 复合材料可以用单组分或多组分可吸收的经编织物加强，从而产生广泛范围的可吸收的生物活性生物材料，不仅适用于商业上不可吸收的聚甲基丙烯酸甲酯骨水泥的优选可吸收替代物，而且适用于 通过引导骨再生修复或替代颅面和颌面骨缺损及其他复杂缺陷。
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4.发明申请公开(公告)号：US20170313808A1
公开(公告)日：2017-11-02
申请号：US15652135
申请日：2017-07-17
IPC分类号： C08G18/73 , C08G18/42 , A61L27/18 , C08G64/02 , C08G18/48 , A61L27/52 , A61L24/00 , C08G18/34 , C08G18/32 , C08G18/12 , C08L75/04 , C08G18/44
CPC分类号： C08G18/73 , A61L24/0021 , A61L27/18 , A61L27/52 , A61L27/54 , A61L2300/404 , A61L2300/416 , A61L2300/426 , A61L2400/06 , A61L2430/06 , C08G18/12 , C08G18/244 , C08G18/3206 , C08G18/341 , C08G18/4244 , C08G18/428 , C08G18/4283 , C08G18/44 , C08G18/4808 , C08G18/4837 , C08G18/4854 , C08G18/4887 , C08G18/758 , C08G18/771 , C08G64/0241 , C08G2230/00 , C08L75/04 , C09J133/18 , C08G18/3228 , C08L75/06 , C08L71/02
摘要： Bioactive liquid formulations are formed of combinations of absorbable, segmented aliphatic polyurethane compositions and liquid polyether for use as vehicles for the controlled release of at least one active agent for the conventional and unconventional treatment of different forms of cancer and the management of at least one type of bacterial, fungal, and viral infection.
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5.发明申请公开(公告)号：US20090233887A1
公开(公告)日：2009-09-17
申请号：US12380391
申请日：2009-02-26
CPC分类号： C08G18/73 , A61L24/0021 , A61L27/18 , A61L27/52 , A61L2430/06 , C08G18/12 , C08G18/3206 , C08G18/341 , C08G18/4244 , C08G18/428 , C08G18/4283 , C08G18/44 , C08G18/4887 , C08G64/0241 , C08G2230/00 , C08L75/04
摘要： Hydroswellable, absorbable and non-absorbable, aliphatic, segmented polyurethanes and polyurethane-urea capable of swelling in the biological environment with associated increase in volume of at least 3 percent have more than one type of segments, including those derived from polyethylene glycol and the molecular chains are structurally tailored to allow the use of corresponding formulations and medical devices as carriers for bioactive agents, rheological modifiers of cyanoacrylate-based tissue adhesives, as protective devices for repairing defective or diseased components of articulating joints and their cartilage, and scaffolds for cartilage tissue engineering.
摘要翻译： 能够在生物环境中膨胀的可渗透，可吸收和不可吸收的脂肪族，分段聚氨酯和聚氨酯 - 尿素，其体积增加至少3％具有多于一种类型的链段，包括衍生自聚乙二醇和分子 链条在结构上被定制以允许使用相应的制剂和医疗装置作为生物活性剂的载体，基于氰基丙烯酸酯的组织粘合剂的流变改性剂，作为用于修复关节关节及其软骨的缺陷或患病组分的保护装置，以及用于软骨组织的支架 工程。
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6.发明申请公开(公告)号：US20140046019A1
公开(公告)日：2014-02-13
申请号：US14058640
申请日：2013-10-21
IPC分类号： C08G64/02
CPC分类号： C08G18/73 , A61L24/0021 , A61L27/18 , A61L27/52 , A61L2430/06 , C08G18/12 , C08G18/3206 , C08G18/341 , C08G18/4244 , C08G18/428 , C08G18/4283 , C08G18/44 , C08G18/4887 , C08G64/0241 , C08G2230/00 , C08L75/04
摘要： Hydroswellable, absorbable and non-absorbable, aliphatic, segmented polyurethanes and polyurethane-urea capable of swelling in the biological environment with associated increase in volume of at least 3 percent have more than one type of segments, including those derived from polyethylene glycol and the molecular chains are structurally tailored to allow the use of corresponding formulations and medical devices as carriers for bioactive agents, rheological modifiers of cyanoacrylate-based tissue adhesives, as protective devices for repairing defective or diseased components of articulating joints and their cartilage, and scaffolds for cartilage tissue engineering.
摘要翻译： 能够在生物环境中膨胀的可渗透，可吸收和不可吸收的脂肪族，分段聚氨酯和聚氨酯 - 尿素，其体积增加至少3％具有多于一种类型的链段，包括衍生自聚乙二醇和分子 链条在结构上被定制以允许使用相应的制剂和医疗装置作为生物活性剂的载体，基于氰基丙烯酸酯的组织粘合剂的流变改性剂，作为用于修复关节关节及其软骨的缺陷或患病组分的保护装置，以及用于软骨组织的支架 工程。
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公开(公告)号：US08865205B2
公开(公告)日：2014-10-21
申请号：US12229142
申请日：2008-08-20
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
CPC分类号： A61B17/06166 , A61B2017/00889 , A61L17/145 , A61L27/34 , A61L29/085
摘要： Swellable, coated sutures have a swellable polymeric coating and a fibrous component, wherein the coating is formed of an absorbable or non-absorbable polymer, while the fibrous component is formed of a synthetic absorbable or non-absorbable monofilament yarn, synthetic absorbable or non-absorbable braided multifilament yarn, braided silk multifilament yarn or combinations thereof. In certain instances, the coating is used as a carrier for the controlled delivery of different types of bioactive agents, including those having antimicrobial, anti-inflammatory, anesthetic, tissue growth-promoting, and antineoplastic activities.
摘要翻译： 可膨胀的涂层缝合线具有可溶胀的聚合物涂层和纤维组分，其中涂层由可吸收或不可吸收的聚合物形成，而纤维组分由合成的可吸收或不可吸收的单丝纱线，合成的可吸收或不可吸收的聚合物形成， 可吸收编织复丝纱，编织丝复丝纱或其组合。 在某些情况下，涂层用作用于受控递送不同类型的生物活性剂的载体，包括具有抗微生物，抗炎，麻醉，组织生长促进和抗肿瘤活性的生物活性剂。
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公开(公告)号：US07842749B2
公开(公告)日：2010-11-30
申请号：US11175636
申请日：2005-07-05
IPC分类号： C08L31/00
CPC分类号： A61L26/0014 , A61L26/0076 , C08F293/005 , C08L53/00 , C08L2666/02
摘要： This invention deals with a tissue protecting, spray-on film composition comprising an amphiphilic film-forming, segmented/block copolymer derived form at least one water-soluble monomer and at least another water-insoluble monomer, wherein the film can be formed from a water soluble organic solvent such as 2-propanol, acetone, and ethyl acetate. The film can contain a bioactive agent including those to have antimicrobial, anesthetic, anti-inflammatory, and wound-healing activities.
摘要翻译： 本发明涉及包含形成至少一种水溶性单体和至少另一种水不溶性单体的两亲成膜，分段/嵌段共聚物的组织保护喷涂膜组合物，其中该膜可由 水溶性有机溶剂如2-丙醇，丙酮和乙酸乙酯。 该膜可以含有包括具有抗微生物剂，麻醉剂，抗炎和伤口愈合活性的生物活性剂。
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9.发明申请Radiation and radiochemically sterilized fiber-reinforced, composite urinogenital stents 有权辐射和放射化学灭菌的纤维增强，复合尿殖器支架公开(公告)号：US20090177286A1
公开(公告)日：2009-07-09
申请号：US12378221
申请日：2009-02-12
IPC分类号： A61F2/04
CPC分类号： A61F2/86 , A61F2/04 , A61F2/94 , A61F2210/0004 , A61F2210/0076 , A61L31/048 , A61L31/129 , A61L31/148 , A61L31/16 , A61L31/18 , A61L2300/404 , A61L2300/416 , A61M25/0108 , A61M27/008
摘要： A radiation and radiochemically sterilized, multi-component, fiber-reinforced composite, absorbable/disintegratable urinogenital stent, such as an endoureteral stent, with radiomodulated residence time in the biological site of 1 to 10 weeks depending on the high energy radiation dose used for sterilization.
摘要翻译： 辐射和放射化学消毒的多组分纤维增强复合材料，可吸收/分解的尿道内支架，如输尿管内支架，根据用于灭菌的高能量辐射剂量，在生物部位的放射性调节停留时间为1至10周 。
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公开(公告)号：US07416559B2
公开(公告)日：2008-08-26
申请号：US11390403
申请日：2006-03-27
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： C08F265/04
CPC分类号： A61L17/12 , A61F2/82 , A61F2250/0067 , A61L31/06 , A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/00 , C08G63/08 , C08G63/64 , C08L67/04
摘要： Pharmacologically active, easy-to-deploy, biomechanically compatible, inflatable endovascular, drug-eluting stent are formed of a primary expandable polymeric or metallic construct, intimately mantled with a biomechanically compatible, polymeric microporous, microfibrous, compliant, stretchable fabric formed by direct electrospinning onto the outside surface of the primary construct using at least one polymer solution containing at least one active compound, selected from those expected to control key biological events leading to in-stent restenosis.
摘要翻译： 药物活性，易于部署，生物力学兼容，可充气的血管内药物洗脱支架由主要的可扩张聚合物或金属构造体形成，与生物力学相容的聚合物微孔，微纤维，柔顺的可伸缩织物紧密结合，通过直接静电纺丝形成 使用至少一种含有至少一种活性化合物的聚合物溶液在主要构建体的外表面上，所述活性化合物选自预期控制导致支架内再狭窄的关键生物学事件的活性化合物。
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