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公开(公告)号:US20050158780A1
公开(公告)日:2005-07-21
申请号:US11029949
申请日:2005-01-04
申请人: Shawn Lupold , Yun Lin , Brian Hicke , Donald Coffey
发明人: Shawn Lupold , Yun Lin , Brian Hicke , Donald Coffey
IPC分类号: C12N15/09 , A61K47/48 , A61K51/00 , A61P35/00 , C07K14/705 , C07K17/02 , C12N15/115 , C12Q1/68 , C07F5/00 , C07H21/02
CPC分类号: C12Q1/6886 , C07K14/705 , C12N15/115 , C12N2310/322
摘要: Methods are provided for generating nucleic acid ligands of Prostate Specific Membrane Antigen (PSMA). The methods of the invention use the SELEX method for the isolation of nucleic acid ligands. The invention also includes nucleic acid ligands to PSMA, and methods and compositions for the treatment and diagnosis of disease using the nucleic acid ligands.
摘要翻译: 提供了用于产生前列腺特异性膜抗原(PSMA)的核酸配体的方法。 本发明的方法使用SELEX方法分离核酸配体。 本发明还包括PSMA的核酸配体,以及使用核酸配体治疗和诊断疾病的方法和组合物。
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公开(公告)号:US20060172352A1
公开(公告)日:2006-08-03
申请号:US11400698
申请日:2006-04-06
申请人: Donald Coffey , Alan Partin , Robert Getzenberg
发明人: Donald Coffey , Alan Partin , Robert Getzenberg
IPC分类号: G01N33/574
CPC分类号: G01N33/57434 , C07K14/47 , Y10S436/813
摘要: Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy of a cell and treating cell proliferative disorders associated with the NMP. Also provided are substantially purified polypeptides and nucleotide sequences encoding the NMPs of the invention.
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公开(公告)号:US20060090494A1
公开(公告)日:2006-05-04
申请号:US11263109
申请日:2005-10-31
申请人: Dan Manole , Donald Coffey , Michael Moore
发明人: Dan Manole , Donald Coffey , Michael Moore
IPC分类号: F25D23/12
CPC分类号: F25B5/02 , F25B5/04 , F25B2600/111 , G06F1/20 , G06F1/206 , G06F1/26 , H05K7/20936 , Y02B30/743
摘要: A refrigeration system for use in cooling electronic equipment includes a closed vapor compression circuit having operably disposed therein a compressor, a condenser, a first expansion device, a second expansion device, and a two-part evaporator. A first part of the evaporator receives working fluid from the first expansion device at a first pressure, and a second part of the evaporator receives working fluid from the second expansion device at a second pressure that is different than the first pressure.
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公开(公告)号:US06385828B1
公开(公告)日:2002-05-14
申请号:US09939633
申请日:2001-08-28
IPC分类号: D02J118
CPC分类号: D02J1/18
摘要: An apparatus for splitting a fiber tow, the apparatus having a spreading bar comprising a crown and a circular or oval-shaped splitter bar comprising grooves around the circumference of the splitter bar, wherein each of the grooves does not circumscribe the complete circumference of the splitter bar, and a method therefor are disclosed.
摘要翻译: 一种用于分割纤维束的装置,该装置具有包括冠的扩展杆和包围围绕分流杆的圆周的凹槽的圆形或椭圆形分离杆,其中每个凹槽不包围分离器的整个圆周 酒吧及其方法被公开。
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公开(公告)号:US20060090493A1
公开(公告)日:2006-05-04
申请号:US11262187
申请日:2005-10-28
申请人: Dan Manole , Donald Coffey
发明人: Dan Manole , Donald Coffey
CPC分类号: F28D1/04 , F25B39/02 , F25B2500/18 , F25D19/02 , F25D2317/0651 , F25D2317/0654 , F25D2317/0661 , F25D2317/0664 , Y10S62/903 , Y10T29/4935 , Y10T29/49359 , Y10T29/49385 , Y10T29/49396 , Y10T29/49771
摘要: A complete refrigeration system (CRS) including at least one heat exchanger which is designed to occupy an irregular volume to reduce the overall profile of the CRS. The heat exchanger may be a condenser or an evaporator, and includes a substantially solid body made of a thermally conductive metal, plastic, or other material. A plurality of fluid and refrigerant passageways are defined substantially within the solid body for conducing fluid and refrigerant, respectively, through the solid body and facilitating the transfer of heat between the fluid and refrigerant. Also disclosed is a method wherein the spatial orientation of each passageway is optimized with respect to all of the other passageways and the walls of the solid body by determining the relative distance of each passageway from all of the other passageways and the walls of the solid body at a plurality of points along each passageway, followed by adjusting the spatial orientation of the passageway accordingly.
摘要翻译: 完整的制冷系统(CRS)包括至少一个热交换器,其被设计成占据不规则的体积以减小CRS的整体轮廓。 热交换器可以是冷凝器或蒸发器,并且包括由导热金属,塑料或其它材料制成的基本上固体。 多个流体和制冷剂通道基本上限定在固体内部,用于分别通过固体导管流体和制冷剂,并且有助于流体和制冷剂之间的热传递。 还公开了一种方法,其中通过确定每个通道与所有其它通道和固体的壁的相对距离,相对于所述固体的所有其它通道和壁来优化每个通道的空间取向 在沿着每个通道的多个点处,随后相应地调整通道的空间取向。
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公开(公告)号:US20050123418A1
公开(公告)日:2005-06-09
申请号:US10988399
申请日:2004-11-12
申请人: Dan Manole , Donald Coffey , Alicia Frostick
发明人: Dan Manole , Donald Coffey , Alicia Frostick
IPC分类号: F04C18/344 , F04C23/00 , F04C29/00 , F25B1/00 , F25B1/04 , F25B31/00 , G06F1/20 , F04B17/00 , F04B35/04
CPC分类号: F04C18/3442 , F04C23/00 , F04C2210/26 , F25B1/00 , F25B2500/01 , G06F1/20
摘要: Compact compressors and refrigeration systems that can be used to cool computers, servers, and other electronic equipment. Each compact compressor or refrigeration system includes a compact, substantially enclosed hermitic housing having a simple geometry profile, such as a rectilinear profile, which enables the compact compressor or refrigeration system to be easily inserted within a slot, for example, of an electronic component such as a computer server. In one embodiment, a compact compressor is provided, which includes a motor-compressor unit within the housing, including a stator, a rotor disposed interiorly of the stator, and a compressor mechanism disposed interiorly of the rotor to provide a compact profile. In another embodiment, the housing includes the foregoing compact motor-compressor unit, and further includes a condenser formed within one of the walls of the housing and an evaporator formed within another wall of the housing such that the housing defines a completely contained, compact refrigeration system. Alternatively, in another embodiment, the housing may include only one of the condenser and evaporator, with the other of the condenser and evaporator configured as a modular component which is attached to the housing.
摘要翻译: 可用于冷却计算机,服务器和其他电子设备的紧凑型压缩机和制冷系统。 每个紧凑型压缩机或制冷系统都包括紧凑的基本上封闭的密封壳体,其具有简单的几何形状,例如直线轮廓,这使得紧凑型压缩机或制冷系统能够容易地插入例如电子部件 作为计算机服务器。 在一个实施例中,提供一种紧凑型压缩机,其包括在壳体内的电动机 - 压缩机单元,包括定子,设置在定子内部的转子和设置在转子内部以提供紧凑型材的压缩机构。 在另一个实施例中,壳体包括前述的紧凑型电动机 - 压缩机单元,并且还包括形成在壳体的一个壁内的冷凝器和形成在壳体的另一壁内的蒸发器,使得壳体限定完全容纳的紧凑制冷 系统。 或者,在另一个实施例中,壳体可以仅包括冷凝器和蒸发器中的一个,冷凝器和蒸发器中的另一个被配置为附接到壳体的模块化部件。
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