公开(公告)号：US07449519B2

公开(公告)日：2008-11-11

申请号：US10546017

申请日：2004-02-16

申请人： Shinichi Sato ,  Yukihiro Nomura ,  Jun Inui

发明人： Shinichi Sato ,  Yukihiro Nomura ,  Jun Inui

IPC分类号： C08F8/00

CPC分类号： C08F8/42 ,  C08G65/336

摘要： An object of the present invention is to provide a curable resin having a silyl group at the terminal that is also moisture-hardening resin which has lower in viscosity when it is used and provides superior adhesiveness when it is utilized for adhesive, sealant, and paint. The object of the invention could be achieved by a curable resin that has silicon atom-containing groups having a silicon atom bound to one or more hydrolysable groups such as alkoxy groups, acetoxy groups and oxim groups at the ends of the molecule, thioether and hydroxyl groups in the molecule, and a polymer having a polyoxyalkylene, (meth)acrylic ester, or hydrocarbon polymer as the main chain skeleton.

摘要翻译： 本发明的目的是提供一种在末端具有甲硅烷基的固化性树脂，其也是使用时粘度较低的水分硬化性树脂，并且当用于粘合剂，密封剂和涂料时具有优异的粘合性 。 本发明的目的可以通过一种可固化树脂来实现，该可固化树脂具有硅原子与分子末端的一个或多个可水解基团如烷氧基，乙酰氧基和肟基结合的硅原子，硫醚和羟基 和具有聚氧化烯，（甲基）丙烯酸酯或烃聚合物作为主链骨架的聚合物。

公开(公告)号：US20060079605A1

公开(公告)日：2006-04-13

申请号：US10546017

申请日：2004-02-16

申请人： Shinichi Sato ,  Yukihiro Nomura ,  Jun Inui

发明人： Shinichi Sato ,  Yukihiro Nomura ,  Jun Inui

IPC分类号： C09J4/00

CPC分类号： C08F8/42 ,  C08G65/336

摘要： An object of the present invention is to provide a curable resin having a silyl group at the terminal that is also moisture-hardening resin which has lower in viscosity when it is used and provides superior adhesiveness when it is utilized for adhesive, sealant, and paint. The object of the invention could be achieved by a curable resin that has silicon atom-containing groups having a silicon atom bound to one or more hydrolysable groups such as alkoxy groups, acetoxy groups and oxim groups at the ends of the molecule, thioether and hydroxyl groups in the molecule, and a polymer having a polyoxyalkylene, (meth)acrylic ester, or hydrocarbon polymer as the main chain skeleton.

摘要翻译： 本发明的目的是提供一种在末端具有甲硅烷基的固化性树脂，其也是使用时粘度较低的水分硬化性树脂，并且当用于粘合剂，密封剂和涂料时具有优异的粘合性 。 本发明的目的可以通过一种可固化树脂来实现，该可固化树脂具有硅原子与分子末端的一个或多个可水解基团如烷氧基，乙酰氧基和肟基结合的硅原子，硫醚和羟基 和具有聚氧化烯，（甲基）丙烯酸酯或烃聚合物作为主链骨架的聚合物。

公开(公告)号：US20110200746A1

公开(公告)日：2011-08-18

申请号：US13073415

申请日：2011-03-28

申请人： Takashi Kida ,  Jun Inui ,  Manabu Hashimoto ,  Hiroyuki Fujimoto ,  Shinichi Sato

发明人： Takashi Kida ,  Jun Inui ,  Manabu Hashimoto ,  Hiroyuki Fujimoto ,  Shinichi Sato

IPC分类号： B05D5/10

CPC分类号： C08G18/755 ,  C08G18/10 ,  C08G18/4825 ,  C08K3/16 ,  C08K3/38 ,  C08L61/00 ,  C08L101/10 ,  C08L2666/16 ,  C09J7/38 ,  C09J175/08 ,  C09J2205/102 ,  C09J2475/00 ,  C08G18/3893

摘要： It is provided a method for producing a pressure-sensitive adhesive tape or sheet which is superior in a heat-resistance. A mixture is prepared by uniformly mixing a specific polymer having hydrolyzable silyl end groups and urethane linkages and/or urea linkages in the main chains or side chains with tackifying resins. A fluorine-containing compound selected from the group consisting of boron trifluoride, complex of boron trifluoride, fluorinating agent and alkali metal salt of fluorine-containing inorganic acid is uniformly mixed into the mixture to obtain a precursor of a pressure-sensitive adhesive agent. The adhesive precursor is applied on the surface of a tape substrate or sheet substrate. It is obtained a pressure-sensitive adhesive layer having three-dimensional reticulation structures by curing the specific polymer having hydrolyzable silyl end groups. Thereby, it is obtained the pressure-sensitive adhesive tape or sheet.

摘要翻译： 提供了一种制造耐热性优异的压敏粘合带或片材的方法。 通过在主链或侧链中与增粘树脂均匀混合具有可水解甲硅烷基端基的特定聚合物和氨基甲酸酯键和/或脲键来制备混合物。 将由三氟化硼，氟化三氟化硼，氟化剂和含氟无机酸的碱金属盐组成的组中的含氟化合物均匀混合，得到压敏粘合剂的前体。 将粘合剂前体施加在带基材或片基材的表面上。 通过固化具有可水解甲硅烷基端基的特定聚合物获得具有三维网状结构的压敏粘合剂层。 由此，获得了压敏粘合带或片材。

公开(公告)号：US08197896B2

公开(公告)日：2012-06-12

申请号：US13073415

申请日：2011-03-28

申请人： Takashi Kida ,  Jun Inui ,  Manabu Hashimoto ,  Hiroyuki Fujimoto ,  Shinichi Sato

发明人： Takashi Kida ,  Jun Inui ,  Manabu Hashimoto ,  Hiroyuki Fujimoto ,  Shinichi Sato

IPC分类号： B05D5/00

CPC分类号： C08G18/755 ,  C08G18/10 ,  C08G18/4825 ,  C08K3/16 ,  C08K3/38 ,  C08L61/00 ,  C08L101/10 ,  C08L2666/16 ,  C09J7/38 ,  C09J175/08 ,  C09J2205/102 ,  C09J2475/00 ,  C08G18/3893

摘要： It is provided a method for producing a pressure-sensitive adhesive tape or sheet which is superior in a heat-resistance. A mixture is prepared by uniformly mixing a specific polymer having hydrolyzable silyl end groups and urethane linkages and/or urea linkages in the main chains or side chains with tackifying resins. A fluorine-containing compound selected from the group consisting of boron trifluoride, complex of boron trifluoride, fluorinating agent and alkali metal salt of fluorine-containing inorganic acid is uniformly mixed into the mixture to obtain a precursor of a pressure-sensitive adhesive agent. The adhesive precursor is applied on the surface of a tape substrate or sheet substrate. It is obtained a pressure-sensitive adhesive layer having three-dimensional reticulation structures by curing the specific polymer having hydrolyzable silyl end groups. Thereby, it is obtained the pressure-sensitive adhesive tape or sheet.

摘要翻译： 提供了一种制造耐热性优异的压敏粘合带或片材的方法。 通过在主链或侧链中与增粘树脂均匀混合具有可水解甲硅烷基端基的特定聚合物和氨基甲酸酯键和/或脲键来制备混合物。 将由三氟化硼，氟化三氟化硼，氟化剂和含氟无机酸的碱金属盐组成的组中的含氟化合物均匀混合，得到压敏粘合剂的前体。 将粘合剂前体施加在带基材或片基材的表面上。 通过固化具有可水解甲硅烷基端基的特定聚合物获得具有三维网状结构的压敏粘合剂层。 由此，获得了压敏粘合带或片材。

公开(公告)号：US4678785A

公开(公告)日：1987-07-07

申请号：US792402

申请日：1985-10-29

申请人： Hideki Ao ,  Minoru Obata ,  Jun Inui

发明人： Hideki Ao ,  Minoru Obata ,  Jun Inui

IPC分类号： C07D413/04 ,  A61K31/535 ,  A61K31/54 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  C07D417/04

CPC分类号： C07D417/04

摘要： A thiadiazine compound of the formula: ##STR1## a method for preparing said compound and a pharmaceutical composition containing said compound, wherein X is methylene which may be optionally substituted by an alkyl of up to 3 carbon atoms; R is hydrogen atom or methyl group; and n is an integer of 1 or 2.Since the compounds exhibit potent cardiotonic and coronary vasodilator activities and further inhibitory activity on platelet aggregation, they are useful as cardiotonic and antithrombotic drugs.

摘要翻译： 下式的噻二嗪化合物：＆lt; IMAGE＆gt;用于制备所述化合物的方法和含有所述化合物的药物组合物，其中X为任选被至多3个碳原子的烷基取代的亚甲基; R为氢原子或甲基; 并且n为1或2的整数。由于该化合物显示出有力的强心剂和冠状血管扩张剂活性和对血小板聚集的进一步抑制活性，因此它们可用作强心剂和抗血栓形成药物。

公开(公告)号：US4997834A

公开(公告)日：1991-03-05

申请号：US440374

申请日：1989-11-22

申请人： Tomio Muro ,  Toshio Seki ,  Masao Abe ,  Jun Inui ,  Hiroyuki Sato

发明人： Tomio Muro ,  Toshio Seki ,  Masao Abe ,  Jun Inui ,  Hiroyuki Sato

IPC分类号： C07D213/75 ,  C07D213/82 ,  C07D213/89 ,  C07D401/12

CPC分类号： C07D213/75 ,  C07D213/82 ,  C07D213/89 ,  C07D401/12

摘要： A trans-4-amino(alkyl)-1-pyridylcarbamoylcyclohexane compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are the same or different, and respectively represent hydrogen, C.sub.1-10 alkyl, C.sub.2-5 alkanoyl, formyl, C.sub.1-4 alkoxy-carbonyl, amidino, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkylcarbonyl, phenyl, phenylalkyl, benzoyl, naphthoyl, phenylalkoxycarbonyl, benzylidene, pyridylcarbonyl, piperidyl, pyrrolidylidene or piperidylidene which may be optionally substituted on the ring or R.sup.1 and R.sup.2 together with the adjacent nitrogen atom form 5 to 6-membered cycle which may have oxygen atom, sulfur atom or optionally substituted nitrogen atom in the cycle, or together with the adjacent nitrogen atom form phthalimido, R.sup.3 represents hydrogen or C.sub.1-4 alkyl, R.sup.4 represents hydrogen or C.sub.1-4 alkyl, R.sup.5 represents hydrogen, hydroxy, C.sub.1-4 alkyl or phenylalkoxy. R.sup.6 represents hydrogen or C.sub.1-4 alkyl, A represents single bond, C.sub.1-5 straight chain alkylene, or alkylene which is substituted by C.sub.1-4 alkyl, n represents 0 to 1, an optical isomer thereof and a pharmaceutically acceptable acid addition salt thereof.These compounds possess antihypertensive activity, and coronary, cerebral and kidney circulation-improving activities and are useful as antihypertensive agents and agents for prevention and treatment of circulatory diseases.

公开(公告)号：US4918074A

公开(公告)日：1990-04-17

申请号：US154398

申请日：1988-02-10

申请人： Yoshinao Tsuda ,  Tadashi Mishina ,  Minoru Obata ,  Kazuhiko Araki ,  Jun Inui ,  Tadao Nakamura

发明人： Yoshinao Tsuda ,  Tadashi Mishina ,  Minoru Obata ,  Kazuhiko Araki ,  Jun Inui ,  Tadao Nakamura

IPC分类号： C07D487/04

CPC分类号： C07D487/04

摘要： A polyazaheterocycle compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, wherein each symbol is as defined in the specification.Said compounds exhibit calcium antagonistic and/or calcium agonistic activities.

摘要翻译： 下式的多元杂环化合物：其中每个符号如说明书中所定义。 所述化合物表现出钙拮抗和/或钙激动活性。

公开(公告)号：US4618607A

公开(公告)日：1986-10-21

申请号：US448576

申请日：1982-12-10

申请人： Kazuhiko Araki ,  Hideki Ao ,  Jun Inui ,  Kenichi Aihara

发明人： Kazuhiko Araki ,  Hideki Ao ,  Jun Inui ,  Kenichi Aihara

IPC分类号： C07D211/90 ,  C07D213/89 ,  C07D401/04 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D407/12 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D491/10 ,  A61K31/445 ,  A61K31/55 ,  C07D401/14

CPC分类号： C07D213/89 ,  C07D211/90 ,  C07D401/04 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D491/10

摘要： 1,4-Dihydropyridine-3,5-dicarboxylic acid ester derivatives of the general formula: ##STR1## or acid addition salts thereof, wherein W is --CH.dbd. or --N.dbd.; Y is --CH.dbd.CH--, --O--, --S--, --CH.dbd.N(O)p-- (p is zero or 1) or --N(R)-- (R is hydrogen or lower alkyl); X.sup.1, X.sup.2 and X.sup.3 are the same or different, and are each hydrogen, halogen, nitro, trifluoromethyl, cyano or lower alkylthio; Z is aryl or 5- or 6-membered aromatic heterocyclic ring (which may have a substituent or two or three substituents which may be the same or different, and the substituent may be halogen, lower alkyl, lower alkoxy, lower alkanoylamino, cyano, nitro, lower alkylthio, trifluoromethyl, sulfamoyl, di-lower alkylsulfamoyl, amino or di-lower alkylamino); ##STR2## is 5- to 7-membered heterocyclic ring which may have nitrogen atom, oxygen atom, sulfur atom or unsaturated bond on the ring, and may be substituted by lower alkyl, lower alkoxycarbonyl, lower alkanoylamino, ethylenedioxy or --(CH.sub.2).sub.m --OR.sup.4 (R.sup.4 is hydrogen, lower alkyl or lower alkanoyl and m is 0, 1 or 2); R.sup.1 and R.sup.2 are the same or different, and are each lower alkyl; R.sup.3 is lower alkyl, aralkyl, heteroaralkyl; and n is an integer 1 to 5. Such compounds are useful as antihypertensive agents and as therapeutic agents for cardiac and cerebral circulation disorders.

摘要翻译： 1,4-二氢吡啶-3,5-二羧酸酯衍生物或其酸加成盐，其中W是-CH =或-N =; Y是-CH = CH-，-O-，-S-，-CH = N（O）p - （p是0或1）或-N（R） - （R是氢或低级烷基） X1，X2和X3相同或不同，各自为氢，卤素，硝基，三氟甲基，氰基或低级烷硫基; Z是芳基或5-或6-元芳族杂环（其可以具有取代基或两个或三个可以相同或不同的取代基，并且取代基可以是卤素，低级烷基，低级烷氧基，低级烷酰基氨基，氰基， 硝基，低级烷硫基，三氟甲基，氨磺酰基，二低级烷基氨磺酰基，氨基或二低级烷基氨基）。 可以在环上具有氮原子，氧原子，硫原子或不饱和键的5-至7-元杂环，并且可被低级烷基，低级烷氧基羰基，低级烷酰基氨基，亚乙二氧基或 - （CH 2） m-OR4（R4是氢，低级烷基或低级烷酰基，m是0,1或2）。 R 1和R 2相同或不同，并且各自为低级烷基; R3是低级烷基，芳烷基，杂芳烷基; 并且n为1至5的整数。这些化合物可用作抗高血压剂和作为心脏和脑循环障碍的治疗剂。