公开(公告)号：US07449519B2

公开(公告)日：2008-11-11

申请号：US10546017

申请日：2004-02-16

申请人： Shinichi Sato ,  Yukihiro Nomura ,  Jun Inui

发明人： Shinichi Sato ,  Yukihiro Nomura ,  Jun Inui

IPC分类号： C08F8/00

CPC分类号： C08F8/42 ,  C08G65/336

摘要： An object of the present invention is to provide a curable resin having a silyl group at the terminal that is also moisture-hardening resin which has lower in viscosity when it is used and provides superior adhesiveness when it is utilized for adhesive, sealant, and paint. The object of the invention could be achieved by a curable resin that has silicon atom-containing groups having a silicon atom bound to one or more hydrolysable groups such as alkoxy groups, acetoxy groups and oxim groups at the ends of the molecule, thioether and hydroxyl groups in the molecule, and a polymer having a polyoxyalkylene, (meth)acrylic ester, or hydrocarbon polymer as the main chain skeleton.

摘要翻译： 本发明的目的是提供一种在末端具有甲硅烷基的固化性树脂，其也是使用时粘度较低的水分硬化性树脂，并且当用于粘合剂，密封剂和涂料时具有优异的粘合性 。 本发明的目的可以通过一种可固化树脂来实现，该可固化树脂具有硅原子与分子末端的一个或多个可水解基团如烷氧基，乙酰氧基和肟基结合的硅原子，硫醚和羟基 和具有聚氧化烯，（甲基）丙烯酸酯或烃聚合物作为主链骨架的聚合物。

公开(公告)号：US20060079605A1

公开(公告)日：2006-04-13

申请号：US10546017

申请日：2004-02-16

申请人： Shinichi Sato ,  Yukihiro Nomura ,  Jun Inui

发明人： Shinichi Sato ,  Yukihiro Nomura ,  Jun Inui

IPC分类号： C09J4/00

CPC分类号： C08F8/42 ,  C08G65/336

摘要： An object of the present invention is to provide a curable resin having a silyl group at the terminal that is also moisture-hardening resin which has lower in viscosity when it is used and provides superior adhesiveness when it is utilized for adhesive, sealant, and paint. The object of the invention could be achieved by a curable resin that has silicon atom-containing groups having a silicon atom bound to one or more hydrolysable groups such as alkoxy groups, acetoxy groups and oxim groups at the ends of the molecule, thioether and hydroxyl groups in the molecule, and a polymer having a polyoxyalkylene, (meth)acrylic ester, or hydrocarbon polymer as the main chain skeleton.

摘要翻译： 本发明的目的是提供一种在末端具有甲硅烷基的固化性树脂，其也是使用时粘度较低的水分硬化性树脂，并且当用于粘合剂，密封剂和涂料时具有优异的粘合性 。 本发明的目的可以通过一种可固化树脂来实现，该可固化树脂具有硅原子与分子末端的一个或多个可水解基团如烷氧基，乙酰氧基和肟基结合的硅原子，硫醚和羟基 和具有聚氧化烯，（甲基）丙烯酸酯或烃聚合物作为主链骨架的聚合物。

公开(公告)号：US20090264602A1

公开(公告)日：2009-10-22

申请号：US12494540

申请日：2009-06-30

申请人： Shigeki Mori ,  Yukihiro Nomura ,  Kazuhiro Iyo ,  Shinichi Sato

发明人： Shigeki Mori ,  Yukihiro Nomura ,  Kazuhiro Iyo ,  Shinichi Sato

IPC分类号： C08L77/00 ,  C08L83/00 ,  C08L75/04 ,  C08L61/00 ,  C08L83/05

CPC分类号： C08L101/10 ,  C08G18/10 ,  C08G18/4825 ,  C08G18/4837 ,  C08G18/755 ,  C09J175/08 ,  C08G18/289

摘要： Disclosed is a moisture-curing type curable resin composition containing: a curable resin intramolecularly having a silicon-containing functional group; and a Lewis acid or a complex of the Lewis acid as a curing catalyst, the Lewis acid being selected from the group consisting of metal halides and boron halides, which is rapidly cured at room temperature. The silicon-containing functional group is represented by general formula: —SiX1X2X3 or —SiR1X1 X2 (wherein, X1, X2 and X3 respectively represent a hydrolytic group and may be the same as or different from each other, and R1 represents a substituted or unsubstituted organic group having 1 to 20 carbons). If the silicon-containing functional group is —SiR1X1 X2, the curable resin further contains intramolecularly a polar component that is one of urethane, thiourethane, urea, thiourea, substituted urea, substituted thiourea, amide, and sulfide bonds, and hydroxyl, secondary amino and tertiary amino groups. Two-part type adhesive is constitutible with separating the curable resin from the curing catalyst.

摘要翻译： 公开了一种湿固化型固化性树脂组合物，其含有：分子内具有含硅官能团的固化性树脂; 路易斯酸或作为固化催化剂的路易斯酸的络合物，所述路易斯酸选自金属卤化物和卤化硼，其在室温下快速固化。 含硅官能团由以下通式表示：-SiX1X2X3或-SiR1X1 X2（其中，X1，X2和X3分别表示水解基团，可以相同或不同，R1表示取代或未取代的 碳原子数为1〜20的有机基团）。 如果含硅官能团为-SiR1X1 X2，则固化性树脂还分子内含有氨基甲酸酯，硫代氨基甲酸酯，脲，硫脲，取代的脲，取代的硫脲，酰胺和硫键之一的极性成分，羟基，仲氨基 和叔氨基。 两部分型粘合剂是可固化树脂与固化催化剂分离的组成成分。

公开(公告)号：US20060189736A1

公开(公告)日：2006-08-24

申请号：US10564843

申请日：2004-07-16

申请人： Shigeki Mori ,  Yukihiro Nomura ,  Kazuhiro Iyo ,  Shinichi Sato

发明人： Shigeki Mori ,  Yukihiro Nomura ,  Kazuhiro Iyo ,  Shinichi Sato

IPC分类号： C08K3/38

CPC分类号： C08L101/10 ,  C08G18/10 ,  C08G18/4825 ,  C08G18/4837 ,  C08G18/755 ,  C09J175/08 ,  C08G18/289

摘要： Disclosed is a moisture-curing type curable resin composition containing: a curable resin intramolecularly having a silicon-containing functional group; and a Lewis acid or a complex of the Lewis acid as a curing catalyst, the Lewis acid being selected from the group consisting of metal halides and boron halides, which is rapidly cured at room temperature. The silicon-containing functional group is represented by general formula: —SiX1X2X3 or —SiR1X1X2 (wherein, X1, X2 and X3 respectively represent a hydrolytic group and may be the same as or different from each other, and R1 represents a substituted or unsubstituted organic group having 1 to 20 carbons). If the silicon-containing functional group is —SiR1X1X2, the curable resin further contains intramolecularly a polar component that is one of urethane, thiourethane, urea, thiourea, substituted urea, substituted thiourea, amide, and sulfide bonds, and hydroxyl, secondary amino and tertiary amino groups. Two-part type adhesive is constitutible with separating the curable resin from the curing catalyst.

摘要翻译： 公开了一种湿固化型固化性树脂组合物，其含有：分子内具有含硅官能团的固化性树脂; 路易斯酸或作为固化催化剂的路易斯酸的络合物，所述路易斯酸选自金属卤化物和卤化硼，其在室温下快速固化。 含硅官能团由以下通式表示：-SiX 1 X 2 X 3或-SiR 1 O / X 1 2 X 2（其中，X 1，X 2，X 3和X 3） >分别表示水解基团，可以相同也可以不同，R 1表示取代或未取代的碳原子数1〜20的有机基团）。 如果含硅官能团是-SiR 1 X 1 X 2 O 2，那么可固化树脂还分子内含有极性组分，其为 氨基甲酸酯，硫代氨基甲酸酯，脲，硫脲，取代的脲，取代的硫脲，酰胺和硫键，以及羟基，仲氨基和叔氨基。 两部分型粘合剂是可固化树脂与固化催化剂分离的组成成分。

公开(公告)号：US07576167B2

公开(公告)日：2009-08-18

申请号：US10564843

申请日：2004-07-16

申请人： Shigeki Mori ,  Yukihiro Nomura ,  Kazuhiro Iyo ,  Shinichi Sato

发明人： Shigeki Mori ,  Yukihiro Nomura ,  Kazuhiro Iyo ,  Shinichi Sato

IPC分类号： C08G77/06

CPC分类号： C08L101/10 ,  C08G18/10 ,  C08G18/4825 ,  C08G18/4837 ,  C08G18/755 ,  C09J175/08 ,  C08G18/289

摘要： Disclosed is a moisture-curing type curable resin composition containing: a curable resin intramolecularly having a silicon-containing functional group; and a Lewis acid or a complex of the Lewis acid as a curing catalyst, the Lewis acid being selected from the group consisting of metal halides and boron halides, which is rapidly cured at room temperature. The silicon-containing functional group is represented by general formula: —SiX1X2X3 or —SiR1X1X2 (wherein, X1, X2 and X3 respectively represent a hydrolytic group and may be the same as or different from each other, and R1 represents a substituted or unsubstituted organic group having 1 to 20 carbons). If the silicon-containing functional group is —SiR1X1X2, the curable resin further contains intramolecularly a polar component that is one of urethane, thiourethane, urea, thiourea, substituted urea, substituted thiourea, amide, and sulfide bonds, and hydroxyl, secondary amino and tertiary amino groups. Two-part type adhesive is constitutible with separating the curable resin from the curing catalyst.

摘要翻译： 公开了一种湿固化型固化性树脂组合物，其含有：分子内具有含硅官能团的固化性树脂; 路易斯酸或作为固化催化剂的路易斯酸的络合物，所述路易斯酸选自金属卤化物和卤化硼，其在室温下快速固化。 含硅官能团由以下通式表示：-SiX1X2X3或-SiR1X1X2（其中，X1，X2和X3分别表示水解基团，可以相同或不同，R1表示取代或未取代的有机物 具有1至20个碳的基团）。 如果含硅官能团为-SiR1X1X2，则固化性树脂还分子内含有作为氨基甲酸酯，硫代氨基甲酸酯，尿素，硫脲，取代的脲，取代的硫脲，酰胺和硫键的氨基的极性成分，羟基，仲氨基和 叔氨基。 两部分型粘合剂是可固化树脂与固化催化剂分离的组成成分。

公开(公告)号：US20050182225A1

公开(公告)日：2005-08-18

申请号：US10516039

申请日：2003-05-29

申请人： Shinichi Sato ,  Ayako Inoue ,  Shigeki Mori ,  Yukihiro Nomura

发明人： Shinichi Sato ,  Ayako Inoue ,  Shigeki Mori ,  Yukihiro Nomura

IPC分类号： C08G18/10 ,  C08G18/12 ,  C08G18/24 ,  C08G18/67 ,  C08G18/80 ,  C08G18/83 ,  C09J175/08 ,  C08G77/08

CPC分类号： C08G18/672 ,  C08G18/10 ,  C08G18/12 ,  C08G18/246 ,  C08G18/677 ,  C08G18/8054 ,  C08G18/837 ,  C08G2190/00 ,  C09J175/08 ,  C08G18/289 ,  C08G18/3893

摘要： There is provided a composition comprising a sililated urethane resin having a polyoxyalkylene polymer as its main chain, having a reactive silicon group at a terminal of the molecule and having a substituted urea bond in the molecule, a diluent (B) having a boiling point of not lower than 250° C. and a curing catalyst (C), wherein the curing catalyst (C) is a reaction product of a poly(dialkylstannoxane) dicarboxylate represented by the following general formula (1) and a silicate compound represented by the general formula R3nSi(OR4)4-n (2).

摘要翻译： 提供一种组合物，其包含具有聚氧化烯聚合物作为其主链的硅烷化聚氨酯树脂，在分子的末端具有反应性硅基并在分子中具有取代的脲键，沸点为 不低于250℃的固化催化剂（C），其中固化催化剂（C）是由以下通式（1）表示的聚（二烷基锡氧烷）二羧酸酯与由通式（1）表示的硅酸盐化合物的反应产物 式（3）其中，R 1，R 2，R 3，R 3，

公开(公告)号：US08110645B2

公开(公告)日：2012-02-07

申请号：US12494540

申请日：2009-06-30

申请人： Shigeki Mori ,  Yukihiro Nomura ,  Kazuhiro Iyo ,  Shinichi Sato

发明人： Shigeki Mori ,  Yukihiro Nomura ,  Kazuhiro Iyo ,  Shinichi Sato

IPC分类号： C08G77/60

CPC分类号： C08L101/10 ,  C08G18/10 ,  C08G18/4825 ,  C08G18/4837 ,  C08G18/755 ,  C09J175/08 ,  C08G18/289

摘要： Disclosed is a moisture-curing type curable resin composition containing: a curable resin intramolecularly having a silicon-containing functional group; and a Lewis acid or a complex of the Lewis acid as a curing catalyst, the Lewis acid being selected from the group consisting of metal halides and boron halides, which is rapidly cured at room temperature. The silicon-containing functional group is represented by general formula: —SiX1X2X3 or —SiR1X1 X2 (wherein, X1, X2 and X3 respectively represent a hydrolytic group and may be the same as or different from each other, and R1 represents a substituted or unsubstituted organic group having 1 to 20 carbons). If the silicon-containing functional group is —SiR1X1 X2, the curable resin further contains intramolecularly a polar component that is one of urethane, thiourethane, urea, thiourea, substituted urea, substituted thiourea, amide, and sulfide bonds, and hydroxyl, secondary amino and tertiary amino groups. Two-part type adhesive is constitutable with separating the curable resin from the curing catalyst.

摘要翻译： 公开了一种湿固化型固化性树脂组合物，其含有：分子内具有含硅官能团的固化性树脂; 路易斯酸或作为固化催化剂的路易斯酸的络合物，所述路易斯酸选自金属卤化物和卤化硼，其在室温下快速固化。 含硅官能团由以下通式表示：-SiX1X2X3或-SiR1X1 X2（其中，X1，X2和X3分别表示水解基团，可以相同或不同，R1表示取代或未取代的 碳原子数为1〜20的有机基团）。 如果含硅官能团为-SiR1X1 X2，则固化性树脂还分子内含有氨基甲酸酯，硫代氨基甲酸酯，脲，硫脲，取代的脲，取代的硫脲，酰胺和硫键之一的极性成分，羟基，仲氨基 和叔氨基。 两部分型粘合剂是可固化树脂与固化催化剂分离的组成部分。

公开(公告)号：US07977331B1

公开(公告)日：2011-07-12

申请号：US11962622

申请日：2007-12-21

申请人： Takahiro Oka ,  Kazutaka Ikegashira ,  Shintaro Hirashima ,  Hiroshi Yamanaka ,  Satoru Noji ,  Yasushi Niwa ,  Yoko Matsumoto ,  Toshihiro Sato ,  Izuru Ando ,  Yukihiro Nomura

发明人： Takahiro Oka ,  Kazutaka Ikegashira ,  Shintaro Hirashima ,  Hiroshi Yamanaka ,  Satoru Noji ,  Yasushi Niwa ,  Yoko Matsumoto ,  Toshihiro Sato ,  Izuru Ando ,  Yukihiro Nomura

IPC分类号： A61K31/53 ,  A61K31/495 ,  A61K31/519 ,  A61K31/44 ,  A61K31/415 ,  A61K31/40 ,  C07D253/00 ,  C07D487/00 ,  C07D239/02 ,  C07D471/02 ,  C07D209/80

CPC分类号： C07D513/04 ,  C07D487/04 ,  C07D487/14 ,  C07D498/04 ,  C07D498/14

摘要： The present invention relates to a tetracyclic fused heterocyclic compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable a salt thereof, and a hepatitis C virus (HCV) polymerase inhibitor and a therapeutic agent for hepatitis C containing this compound. The compound of the present invention shows an anti-HCV activity based on the HCV polymerase inhibitory activity, and useful as an agent for the prophylaxis or treatment of hepatitis C.

摘要翻译： 本发明涉及由下式[I]表示的四环稠合杂环化合物，其中各符号如说明书中所定义，或其药学上可接受的盐，丙型肝炎病毒（HCV）聚合酶抑制剂和治疗剂 含有该化合物的丙型肝炎。 本发明化合物基于HCV聚合酶抑制活性显示抗HCV活性，可用作预防或治疗丙型肝炎的药剂。

公开(公告)号：US20090053308A1

公开(公告)日：2009-02-26

申请号：US11885467

申请日：2006-03-03

申请人： Hajime Ishida ,  Yukihiro Nomura

发明人： Hajime Ishida ,  Yukihiro Nomura

IPC分类号： A61K9/62 ,  A61K9/56 ,  A61K9/58 ,  A61P35/00 ,  A61K9/14 ,  A61K31/4188

CPC分类号： A61K9/5078 ,  A61K9/4816 ,  A61K9/4866 ,  A61K9/5026 ,  A61K9/5042 ,  A61K9/5047 ,  A61K31/4164 ,  A61K31/4188

摘要： The present invention relates to a controlled release capsule preparation for oral administration, which contains (i) a granule containing a physiologically active substance which is a compound represented by the formula: wherein n is an integer of 1 to 3, and Ar is an aromatic ring optionally having substituent(s), or a salt thereof, and a hydrophilic polymer, and coated with an enteric coating agent and the like, and (ii) a fluidizer. According to the present invention, a controlled release composition for oral administration of an imidazole derivative, which has steroid C17,20-lyase inhibiting activity and which has remarkably improved sustainability of the blood concentration, is provided.

摘要翻译： 本发明涉及口服给药的控释胶囊制剂，其包含（i）含有下式表示的化合物的生理活性物质的颗粒：其中n为1〜3的整数，Ar为芳香族 任选具有取代基的环或其盐和亲水性聚合物，并用肠溶衣剂等涂布，和（ii）流化剂。 根据本发明，提供了具有类固醇C17,20-裂解酶抑制活性并显着改善血液浓度可持续性的咪唑衍生物的口服给药组合物。

公开(公告)号：US4765927A

公开(公告)日：1988-08-23

申请号：US893887

申请日：1986-08-06

申请人： Yukihiro Nomura ,  Yoko Okuda

发明人： Yukihiro Nomura ,  Yoko Okuda

IPC分类号： A23D7/06 ,  A23D9/06 ,  C09K15/06 ,  C09K15/08 ,  C09K15/32 ,  C11B5/00

CPC分类号： C11B5/0007 ,  C11B5/0092

摘要： This invention relates to an antioxidizing composition which comprises an antioxidant such as tocopherol, BHT or BHA; condensed phosphate such as pentapolyphosphate; and citric acid. The antioxidizing composition has antioxidant action superior to conventional compositions and has good compatibility with fat, oil and food containing fat or oil. The antioxidizing composition preferably comprises tocopherol, lecithin, pentapolyphosphate and citric acid.

摘要翻译： 本发明涉及抗氧化组合物，其包含抗氧化剂如生育酚，BHT或BHA; 缩聚磷酸盐如五聚磷酸盐; 和柠檬酸。 抗氧化组合物具有优于常规组合物的抗氧化作用，并且与脂肪，油和含有脂肪或油的食品具有良好的相容性。 抗氧化组合物优选包含生育酚，卵磷脂，五聚磷酸盐和柠檬酸。