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公开(公告)号：US09982898B2
公开(公告)日：2018-05-29
申请号：US13144220
申请日：2009-10-02
申请人： Shoji Yamada , Kenichi Sakoda , Masao Akiyoshi , Akira Takamori , Nobuaki Uehara , Tomoya Fukui , Seiji Nakashima , Naoki Iwamoto , Satoshi Michihata , Isao Otsuka , Masayuki Tsuji
发明人： Shoji Yamada , Kenichi Sakoda , Masao Akiyoshi , Akira Takamori , Nobuaki Uehara , Tomoya Fukui , Seiji Nakashima , Naoki Iwamoto , Satoshi Michihata , Isao Otsuka , Masayuki Tsuji
CPC分类号： F24F1/0007 , F24F1/0029 , F24F1/0059 , F24F13/24 , F24F13/30 , F24F2013/247 , F28D2020/0013
摘要： An indoor unit includes a casing having a suction port formed in an upper part and a blow-out port formed on a lower side at a front face part, an axial-flow or diagonal-flow fan provided on the downstream side of the suction port in the casing, and a heat exchanger provided on the downstream side of the fan and on the upstream side of the blow-out port in the casing, in which air blown out of the fan and refrigerant are heat-exchanged.
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公开(公告)号：US20120018117A1
公开(公告)日：2012-01-26
申请号：US13144220
申请日：2009-10-02
申请人： Shoji Yamada , Kenichi Sakoda , Masao Akiyoshi , Akira Takamori , Nobuaki Uehara , Tomoya Fukui , Seiji Nakashima , Naoki Iwamoto , Satoshi Michihata , Isao Otsuka , Masayuki Tsuji
发明人： Shoji Yamada , Kenichi Sakoda , Masao Akiyoshi , Akira Takamori , Nobuaki Uehara , Tomoya Fukui , Seiji Nakashima , Naoki Iwamoto , Satoshi Michihata , Isao Otsuka , Masayuki Tsuji
CPC分类号： F24F1/0007 , F24F1/0029 , F24F1/0059 , F24F13/24 , F24F13/30 , F24F2013/247 , F28D2020/0013
摘要： An indoor unit includes a casing having a suction port formed in an upper part and a blow-out port formed on a lower side at a front face part, an axial-flow or diagonal-flow fan provided on the downstream side of the suction port in the casing, and a heat exchanger provided on the downstream side of the fan and on the upstream side of the blow-out port in the casing, in which air blown out of the fan and refrigerant are heat-exchanged.
摘要翻译： 室内机包括：上部形成有吸入口的壳体和形成在前面部的下侧的吹出口，设置在吸入口的下游侧的轴流或斜流风扇 并且设置在风扇的下游侧和壳体内的吹出口的上游侧的热交换器，其中从风扇吹出的空气和制冷剂被热交换。
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公开(公告)号：US20220306573A1
公开(公告)日：2022-09-29
申请号：US17046752
申请日：2019-04-11
申请人： Jason Jingxi ZHANG , Chandra VARGEESE , Naoki IWAMOTO , Chikdu Shakti SHIVALILA , Nayantara KOTHARI , Ann Fiegen DURBIN , Selvi RAMASAMY , Pachamuthu KANDASAMY , Jayakanthan KUMARASAMY , Gopal Reddy BOMMINENI , Subramanian MARAPPAN , Sethumadhavan DIVAKARAMENON , David Charles Donnel BUTLER , Genliang LU , Hailin YANG , Mamoru SHIMIZU , Prashant MONIAN , WAVE LIFE SCIENCES LTD.
发明人： Jason Jingxin Zhang , Chandra Vargeese , Naoki Iwamoto , Chikdu Shakti Shivalila , Nayantara Kothari , Ann Fiegen Durbin , Selvi Ramasamy , Pachamuthu Kandasamy , Jayakanthan Kumarasamy , Gopal Reddy Bommineni , Subramanian Marappan , Sethumadhavan Divakaramenon , David Charles Donnell Butler , Genliang Lu , Hailin Yang , Mamoru Shimizu , Prashant Monian
IPC分类号： C07C317/28 , C07H21/02 , C07H21/04 , C12N15/113
摘要： Among other things, the present disclosure provides designed oligonucleotides, compositions, and methods of use thereof. In some embodiments, the present disclosure provides technologies useful for reducing levels of transcripts. In some embodiments, the present disclosure provides technologies useful for modulating transcript splicing. In some embodiments, provided technologies can alter splicing of a dystrophin (DMD) transcript. In some embodiments, the present disclosure provides methods for treating diseases, such as Duchenne muscular dystrophy, Becker's muscular dystrophy, etc.
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公开(公告)号：US20190249173A1
公开(公告)日：2019-08-15
申请号：US16098658
申请日：2017-05-03
申请人： Chandra VARGEESE , Jason Jingxin ZHANG , Sethumadhavan DIVAKARAMENON , David Charles Donnell BUTLER , Genliang LU , Naoki IWAMOTO , Hailin YANG , Maria David FRANK-KAMENETSKY , Subramanian MARAPPAN , WAVE LIFE SCIENCES LTD.
发明人： Chandra Vargeese , Jason Jingxin Zhang , Sethumadhavan Divakaramenon , David Charles Donnell Butler , Genliang Lu , Naoki Iwamoto , Hailin Yang , Maria David Frank-Kamenetsky , Subramanian Marappan
IPC分类号： C12N15/11 , A61K31/7088 , A61K47/54
CPC分类号： C12N15/111 , A61K31/7088 , A61K47/542 , C12N2310/11 , C12N2310/14 , C12N2310/141 , C12N2310/16 , C12N2310/20 , C12N2310/315 , C12N2310/3515 , C12N2320/32
摘要： In some embodiments, the present disclosure pertains to compositions and methods related to delivery of a biologically active agent, wherein the compositions comprise a biologically active agent and a lipid. In various embodiments, the lipid is selected from: lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, alpha-linolenic acid, gamma-linolenic acid, docosa-hexaenoic acid (cis-DHA), turbinaric acid and dilinoleyl. In some embodiments, a composition and method are useful for delivery of a biologically active agent to a particular cell or tissue, e.g., a muscle cell or tissue.
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公开(公告)号：US09744183B2
公开(公告)日：2017-08-29
申请号：US13381323
申请日：2010-07-06
申请人： Gregory L. Verdine , Meena . , Naoki Iwamoto
发明人： Gregory L. Verdine , Meena . , Naoki Iwamoto
CPC分类号： A61K31/70 , C07F9/65515 , C07H21/00
摘要： Described herein are nucleic acid prodrugs and nucleic acid prodrugs comprising chiral phosphorous moieties. Also described herein are methods of making and using nucleic acid prodrugs and nucleic acid prodrugs comprising chiral phosphorous moieties.
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公开(公告)号：US20120316224A1
公开(公告)日：2012-12-13
申请号：US13381323
申请日：2010-07-06
申请人： Gregory L. Verdine , Meena Meena , Naoki Iwamoto
发明人： Gregory L. Verdine , Meena Meena , Naoki Iwamoto
IPC分类号： A61K31/7084 , A61K31/711 , A61P35/00 , C07H21/04
CPC分类号： A61K31/70 , C07F9/65515 , C07H21/00
摘要： Described herein are nucleic acid prodrugs and nucleic acid prodrugs comprising chiral phosphorous moieties. Also described herein are methods of making and using nucleic acid prodrugs and nucleic acid prodrugs comprising chiral phosphorous moieties.
摘要翻译： 本文描述的是包含手性磷部分的核酸前药和核酸前药。 本文还描述了制备和使用包含手性磷部分的核酸前药和核酸前药的方法。
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公开(公告)号：US5621865A
公开(公告)日：1997-04-15
申请号：US688217
申请日：1996-07-29
申请人： Naoki Iwamoto , Toshio Abe , Hiroyuki Sakai
发明人： Naoki Iwamoto , Toshio Abe , Hiroyuki Sakai
CPC分类号： G06T19/20 , G06T2219/2016
摘要： The present invention relates to a graphics processing apparatus for plotting three-dimensional graphics by using a grid, and to a method of use of the apparatus. An arbitrary plane grid is displayed on a display screen, the displayed grid is variously changed and the three-dimensional graphic is plotted using the changed grid. The possible changes of the grid include a grid translation, a grid spacing change, a grid rotation, the selection of a grid display/non-display mode, coincidence/non-coincidence of the reference points of the graphic with the grid, and the like. Also, the apparatus executes a corner processing, including arc processing and straight line processing. In the arc processing, the corner processing is executed by selecting two straight lines and inputting a radius to define a corner joining the two lines; and in the straight line processing, the corner processing is executed by selecting two straight lines and inputting the length and angle of a line segment to join them.
摘要翻译： 本发明涉及一种用于通过使用网格绘制三维图形的图形处理装置以及该装置的使用方法。 任意平面网格显示在显示屏幕上，显示的网格被不同地改变，并且使用改变的网格来绘制三维图形。 网格的可能变化包括网格平移，网格间距变化，网格旋转，网格显示/非显示模式的选择，图形与网格的参考点的重合/非重合，以及 喜欢。 此外，该装置执行包括电弧处理和直线处理的拐角处理。 在电弧处理中，通过选择两条直线并输入半径来定义连接两条线的拐角来执行拐角处理; 并且在直线处理中，通过选择两条直线并输入线段的长度和角度来连接它们来执行拐角处理。
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公开(公告)号：US20230203087A1
公开(公告)日：2023-06-29
申请号：US17926987
申请日：2021-05-24
申请人： Pachamuthu Kandasamy , Jayakanthan Kumarasamy , Chandra Vargeese , Subramanian Marappan , Gopal Bommineni , Mamoru Shimizu , Naoki Iwamoto , Stephany Standley , Yuanjing Liu , Amy Jada Andreucci , Genliang LU , Onanong Chivatakarn , Akbar Husain Khan , WAVE LIFE SCIENCES LTD.
发明人： Pachamuthu Kandasamy , Jayakanthan Kumarasamy , Chandra Vargeese , Subramanian Marappan , Gopal Reddy Bommineni , Mamoru Shimizu , Naoki Iwamoto , Stephany Michelle Standley , Yuanjing Liu , Amy Jada Andreucci , Genliang Lu , Onanong Chivatakarn , Akbar Husain Khan
IPC分类号： C07H21/04 , C07F9/165 , C07D295/02
CPC分类号： C07H21/04 , C07F9/165 , C07D295/02
摘要： The present disclosure provides modified oligonucleotides and compositions and methods thereof. In some embodiments, provided technologies comprise modified sugars and/or modified internucleotidic linkages. In some embodiments, the present disclosure provides technologies for preparing modified oligonucleotides. In some embodiments, the present disclosure provides chirally controlled oligonucleotide compositions and methods for their preparation and uses.
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公开(公告)号：US20140194610A1
公开(公告)日：2014-07-10
申请号：US14233579
申请日：2012-07-13
IPC分类号： C07H21/04 , C07H13/04 , C07C309/66 , C07D295/108
CPC分类号： C07H21/04 , A61K31/66 , A61K31/70 , C07C309/66 , C07D295/108 , C07H13/04
摘要： Described herein are methods for the synthesis of derivatives of thiosulfonate reagents. Said reagents have utility for the synthesis of phosphorothiotriesters from H-phosphonates in a stereospecific fashion.
摘要翻译： 本文描述了合成硫代磺酸盐试剂衍生物的方法。 所述试剂可用于以立体特异性方式从H-膦酸盐合成磷酰化产物。
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公开(公告)号：US20120011710A1
公开(公告)日：2012-01-19
申请号：US13155639
申请日：2011-06-08
申请人： Naoki Iwamoto , Hidenori Inoue
发明人： Naoki Iwamoto , Hidenori Inoue
IPC分类号： B23P19/00
CPC分类号： B21D43/003 , B21D22/04 , Y10T29/53178 , Y10T29/53261
摘要： A positioning apparatus for a thin plate material having a positioning hole, correctly and speedily positions the thin plate material in an in-plane direction without deforming the positioning hole. The apparatus has a pilot holder having a hold face, a positioning pin having a tapered tip and supported by the pilot holder so that the tapered tip protrudes from the hold face of the pilot holder, a pad having a pad face that opposes the hold face of the pilot holder, and a movable member having a stop face that opposes the positioning pin and a relief hole for avoiding the tapered tip of the positioning pin from hitting the stop face, the movable member resiliently supported on the pad so that the movable member is vertically movable. The pilot holder and the pad in which the thin plate material is set between the hold face and the pad face relatively move to insert the tapered tip of the positioning pin into the positioning hole of the thin plate material to be engaged with the tapered tip at the position of the relief hole, thereby positioning the thin plate material in an in-plane direction. The stop face of the movable member is flush with or protruding from the pad face of the pad.
摘要翻译： 一种用于具有定位孔的薄板材料的定位装置，正确且快速地将薄板材料定位在面内方向上而不使定位孔变形。 该装置具有具有保持面的导向架，定位销具有锥形末端，并由导向架保持器支撑，使得锥形尖端从导向架的保持面突出，具有与保持面相对的垫面的垫 以及具有与所述定位销相对的止动面的可动构件和用于避开所述定位销的所述锥形尖端的止动面的释放孔，所述可动构件弹性地支撑在所述垫上，使得所述可动构件 是可垂直移动的。 其中薄板材料设置在保持面和衬垫面之间的导向架和衬垫相对移动以将定位销的锥形尖端插入到薄板材料的定位孔中，以与锥形尖端接合 释放孔的位置，从而将薄板材料定位在面内方向上。 可动件的止动面与垫的垫面齐平或突出。
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