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110 条记录 (耗时 0.039 秒)

    Invitroinhibition of the HIV virus with ionic tungstoniobate compounds
    6.
    发明授权
    Invitroinhibition of the HIV virus with ionic tungstoniobate compounds 失效
    用离子桐酯化合物体外抑制HIV病毒

    公开(公告)号：US5512305A

    公开(公告)日：1996-04-30

    申请号：US66007

    申请日：1993-08-26

    申请人： Michael J. Abrams ,  Gerald E. Bossard ,  Craig L. Hill ,  Raymond F. Schinazi ,  Brian R. C. Theobald

    发明人： Michael J. Abrams ,  Gerald E. Bossard ,  Craig L. Hill ,  Raymond F. Schinazi ,  Brian R. C. Theobald

    IPC分类号： A61K33/24 ,  A61K33/42 ,  C01G39/00

    CPC分类号： A61K33/24 ,  A61K33/42

    摘要： Tungstoniobate compounds containing an ion of general formula A.sub.x W.sub.y Nb.sub.a O.sub.b !.sup.p- Iwhere A=P, Si, Ge, x=0 or an integer from 1 to 10, y is an integer from 1 to 10, y is an integer from 1 to 40, a is an integer from 1 to 8, b is an integer from 15 to 150, and p is an integer dependent upon the nature and oxidation state of element A, have been found to be active against viruses including especially HIV and Herpes Simplex. Pharmaceutical compositions and methods of treatment are disclosed.

    摘要翻译： PCT No.PCT / GB91 / 02101 Sec。 371日期：1993年8月26日 102（e）日期1993年8月26日PCT 1991年11月27日PCT公布。 出版物WO92 / 09292 日期：1992年6月11日，含有通式[Ax Wy Nba Ob] pI的离子的噻吩类化合物，其中A = P，Si，Ge，x = 0或1至10的整数，y为1至10的整数 y为1至40的整数，a为1至8的整数，b为15至150的整数，p为取决于元素A的性质和氧化态的整数，已被发现是有活性的 针对特别是HIV和单纯疱疹的病毒。 公开了药物组合物和治疗方法。

    Polyoxometalate compounds as antiviral agents
    8.
    发明授权
    Polyoxometalate compounds as antiviral agents 失效

    公开(公告)号：US06911470B1

    公开(公告)日：2005-06-28

    申请号：US08140885

    申请日：1993-10-25

    申请人： Raymond F. Schinazi ,  Craig L. Hill

    发明人： Raymond F. Schinazi ,  Craig L. Hill

    IPC分类号： C07C229/26 ,  C07C279/14 ,  C07D233/54 ,  A61K31/28

    CPC分类号： C07D233/64 ,  C07C229/26 ,  C07C279/14

    摘要： Polyoxometalate compounds which exhibit anti-retroviral activity are disclosed. Compounds with anti-retroviral activity include those having the following general molecular formulas: M7PW11O39 M8SiW11O39 M9HSiW9O34 M8HPW9O34 M10(TM)4(PW9O34)2 M16(TM)4(P2W15O56)2 M14[NaP5W30O110] M12(TM)3(PW9O34)2 M6P2W18O62 wherein M is an alkali metal, NH4+ or other common monocation or soluble dication, or any combination of the above provided adequate water solubility is exhibited, or histidinium ion, argininium ion, or lysinium ion or any dication of a dipeptide or oligopeptide with 2 protonated basic amino acid residues, or any combination of these monocations or dications with each other or with any common inorganic cation, and TM is a divalent transition metal ion, such as Mn, Fe, Co, Ni, Cu and Zn.

    Use of (R)-Penciclovir Triphosphate for the Manufacture of a Medicament for the Treatment of Viral Diseases
    10.
    发明申请
    Use of (R)-Penciclovir Triphosphate for the Manufacture of a Medicament for the Treatment of Viral Diseases 审中-公开
    （R） - 普罗昔洛韦三磷酸酯用于制造药物治疗病毒性疾病的用途

    公开(公告)号：US20110092458A1

    公开(公告)日：2011-04-21

    申请号：US12976599

    申请日：2010-12-22

    申请人： Richard Anthony Vere Hodge ,  Raymond F. Schinazi

    发明人： Richard Anthony Vere Hodge ,  Raymond F. Schinazi

    IPC分类号： A61K31/675 ,  A61P31/18

    CPC分类号： A61K31/522 ,  A61K31/661

    摘要： A method of treatment of: i) HIV-1 infections in mammals, including humans; or ii) HBV infections in mammals, including humans; which method comprises the administration to the human in need of such treatment, an effective amount of the (R)-enantiomer of the triphosphate of a compound of formula (A) or a pharmaceutically acceptable salt thereof; and compounds for use in the method.

    摘要翻译： 一种治疗方法：i）哺乳动物，包括人类中的HIV-1感染; 或ii）哺乳动物，包括人类中的HBV感染; 该方法包括向需要这种治疗的人施用有效量的式（A）化合物的三磷酸的（R） - 对映异构体或其药学上可接受的盐; 和用于该方法的化合物。