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19 条记录 (耗时 0.029 秒)

    Recombinant KAT enzyme and process for its preparation
    2.
    发明授权
    Recombinant KAT enzyme and process for its preparation 失效
    重组KAT酶及其制备方法

    公开(公告)号：US6136572A

    公开(公告)日：2000-10-24

    申请号：US765889

    申请日：1997-04-01

    申请人： Luca Benatti ,  Jerome Breton ,  Carmela Speciale ,  Etsuo Okuno ,  Robert Schwarcz ,  Monica Mosca

    发明人： Luca Benatti ,  Jerome Breton ,  Carmela Speciale ,  Etsuo Okuno ,  Robert Schwarcz ,  Monica Mosca

    IPC分类号： C12N15/09 ,  A61K31/47 ,  A61K35/76 ,  A61K38/45 ,  A61K48/00 ,  A61P25/28 ,  C07D215/48 ,  C12N5/10 ,  C12N9/10 ,  C12N15/54 ,  C12Q1/68 ,  C12R1/91 ,  C12P17/00 ,  C07H21/04

    CPC分类号： C12N9/1096 ,  A61K48/00

    摘要： Disclosed are isolated DNAs encoding a kynurenine aminotransferase selected from the group consisting of:(a) isolated DNA sequences which encode rat KAT;(b) an isolated DNA sequence which hybridizes to isolated DNA sequences of (a) above and which encodes a mammalian KAT enzyme; and(c) an isolated DNA sequence differing from the isolated DNA sequences of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes a KAT enzyme.Vectors and host cells containing the same, oligonucleotide probes for identifying kynurenine aminotransferase, and isolated and purified kynurenine aminotransferase are also disclosed.

    摘要翻译： PCT No.PCT / US95 / 07855 Sec。 371日期1997年04月1日 102（e）日期1997年4月1日PCT提交1995年6月23日PCT公布。 公开号WO96 / 01893 日期1996年1月25日公开是编码选自以下的犬尿氨酸氨基转移酶的分离的DNA：（a）编码大鼠KAT的分离的DNA序列; （b）分离的DNA序列，其与上述（a）的分离的DNA序列杂交并编码哺乳动物KAT酶; 和（c）由于遗传密码的简并性而编码KAT酶，密码子序列中与（a）和（b）分离的DNA序列不同的分离的DNA序列。 还公开了含有相同载体和宿主细胞，用于鉴定犬尿氨酸氨基转移酶的寡核苷酸探针和分离纯化的犬尿氨酸转氨酶。

    Recombinant kat enzyme from rat
    3.
    发明授权
    Recombinant kat enzyme from rat 失效
    来自大鼠的重组kat酶

    公开(公告)号：US5817496A

    公开(公告)日：1998-10-06

    申请号：US271667

    申请日：1994-07-07

    申请人： Luca Benatti ,  Jerome Breton ,  Carmela Speciale ,  Etsuo Okuno ,  Robert Schwarcz ,  Monica Mosca

    发明人： Luca Benatti ,  Jerome Breton ,  Carmela Speciale ,  Etsuo Okuno ,  Robert Schwarcz ,  Monica Mosca

    IPC分类号： C12N15/09 ,  A61K31/47 ,  A61K35/76 ,  A61K38/45 ,  A61K48/00 ,  A61P25/28 ,  C07D215/48 ,  C12N5/10 ,  C12N9/10 ,  C12N15/54 ,  C12Q1/68 ,  C12R1/91

    CPC分类号： C12N9/1096 ,  A61K48/00

    摘要： Disclosed are isolated DNAs encoding a kynurenine aminotransferase selected from the group consisting of: (a) an isolated DNA sequence which encodes rat KAT; (b) an isolated DNA sequence which hybridizes to the isolated DNA sequence of (a) above and which encodes a KAT enzyme; and (c) an isolated DNA sequence differing from the isolated DNA sequences of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes a KAT enzyme. Also disclosed are vectors and host cells containing the same; oligonucleotide probes for identifying kynurenine aminotransferase; and isolated and purified kynurenine aminotransferase.

    摘要翻译： 公开了编码选自以下的犬尿氨酸转氨酶的分离的DNA：（a）编码大鼠KAT的分离的DNA序列; （b）分离的DNA序列，其与上述（a）的分离的DNA序列杂交并编码KAT酶; 和（c）由于遗传密码的简并性而编码KAT酶，密码子序列中与（a）和（b）分离的DNA序列不同的分离的DNA序列。 还公开了载体和含有其的宿主细胞; 用于鉴定犬尿氨酸转氨酶的寡核苷酸探针; 和纯化的犬尿氨酸氨基转移酶。

    Alpha-aminoamide derivatives useful in the treatment of cognitive disorders
    6.
    发明授权
    Alpha-aminoamide derivatives useful in the treatment of cognitive disorders 有权
    可用于治疗认知障碍的α-氨基酰胺衍生物

    公开(公告)号：US08741957B2

    公开(公告)日：2014-06-03

    申请号：US12304455

    申请日：2007-06-13

    申请人： Patricia Salvati ,  Stefano Rossetti ,  Luca Benatti

    发明人： Patricia Salvati ,  Stefano Rossetti ,  Luca Benatti

    IPC分类号： A61K31/165 ,  A61K31/404 ,  A61K31/085 ,  A61K31/135 ,  A61K31/341 ,  A61K31/402

    CPC分类号： A61K31/404 ,  A61K31/085 ,  A61K31/135 ,  A61K31/165 ,  A61K31/341 ,  A61K31/402

    摘要： The present invention is in the field of pharmacotherapy of cognitive deficits in learning and memory by administering an α-aminoamide, particularly safinamide. Examples of disturbances in cognition that can be treated with compounds of the invention are the ones associated with disorders such as autism, dyslexia, attention deficit hyperactivity disorder, schizophrenia, obsessive compulsive disorders, psychosis, bipolar disorders, depression, Tourette's syndrome, Mild Cognitive Impairment (MCI) and disorders of learning in children, adolescents and adults, Age Associated Memory Impairment, Age Associated Cognitive Decline, Alzheimer's Disease, Parkinson's Disease, Down's Syndrome, traumatic brain injury Huntington's Disease, Progressive Supranuclear Palsy (PSP), HIV, stroke, vascular diseases, Pick's or Creutzfeldt-Jacob diseases, multiple sclerosis (MS), other white matter disorders and drug-induced cognitive worsening.

    摘要翻译： 本发明通过给予α-氨基酰胺，特别是safinamide，在学习和记忆中的认知缺陷的药物治疗领域。 可以用本发明化合物治疗的认知障碍的例子是与自闭症，阅读困难，注意缺陷多动障碍，精神分裂症，强迫症，精神病，双相情感障碍，抑郁症，Tourette综合征，轻度认知障碍 （MCI）和儿童，青少年和成年人学习障碍，年龄相关记忆障碍，年龄相关认知衰退，阿尔茨海默病，帕金森病，唐氏综合征，创伤性脑损伤亨廷顿病，进行性核核麻痹（PSP），艾滋病毒，中风， 血管疾病，Pick's或Creutzfeldt-Jacob疾病，多发性硬化症（MS），其他白质病症和药物诱导的认知恶化。

    Halothenoyl-cyclopropane-1-carboxylic acid derivatives
    7.
    发明申请
    Halothenoyl-cyclopropane-1-carboxylic acid derivatives 审中-公开
    卤代苯甲酰基 - 环丙烷-1-羧酸衍生物

    公开(公告)号：US20060116329A1

    公开(公告)日：2006-06-01

    申请号：US10536307

    申请日：2003-11-25

    申请人： Luca Benatti ,  Ruggero Fariello ,  Patricia Salvati ,  Roberto Pellicciari ,  Carla Caccia

    发明人： Luca Benatti ,  Ruggero Fariello ,  Patricia Salvati ,  Roberto Pellicciari ,  Carla Caccia

    IPC分类号： A61K31/7052 ,  A61K31/381 ,  C07D333/38

    CPC分类号： C07D333/28

    摘要： Compounds of formula (I) wherein R is hydroxy, linear or branched C1-C6 alkoxy, phenoxy, benzyloxy, a group —N(R1R2) wherein R1 is hydrogen, linear or branched C1-C4 alkyl, benzyl, phenyl and R2 is hydrogen or linear or branched C1-C4 alkyl, or R is a glycoside residue or a primary alkoxy residue from ascorbic acid, optionally having one or more hydroxy groups alkylated or acylated by linear or branched C1-C4 alkyl or acyl groups; X is a halogen atom and n 1 or 2 are long lasting inhibitors of kynurenine 3-monooxygenase (KMO) and potent glutamate (GLU) release inhibitors.

    摘要翻译： 式（I）的化合物，其中R是羟基，直链或支链C 1 -C 6烷氧基，苯氧基，苄氧基，-N（R 1， 其中R 1是氢，直链或支链C 1 -C 4烷基，C 1 -C 4烷基， 苄基，苯基和R 2是氢或直链或支链C 1 -C 4烷基，或R是糖苷残基或伯烷氧基 任选具有一个或多个由直链或支链C 1 -C 4烷基或酰基烷基化或酰化的羟基的抗坏血酸残基; X是卤素原子，n 1或2是犬尿苷3-单加氧酶（KMO）和强力谷氨酸（GLU）释放抑制剂的长效抑制剂。