CELL CARRIER, METHODS OF MAKING AND USE
    4.
    发明申请
    CELL CARRIER, METHODS OF MAKING AND USE 有权
    细胞载体,制备和使用方法

    公开(公告)号:US20120156773A1

    公开(公告)日:2012-06-21

    申请号:US13287611

    申请日:2011-11-02

    IPC分类号: C12N5/071 C12N5/077

    摘要: A method of culturing adherent cells is provided, wherein the method comprises providing a carrier for growing the cells, comprising one or more surfaces; and one or more relief features/indentations are present on one or more of the surfaces, wherein the carrier has a length at least about 0.2 mm, a width at least about 0.2 mm, and a height in a range from about 0.012 mm to 0.5 mm; and wherein each of the relief features/indentations has a height above the surfaces in a range from about 2 to 200 μm, and width in a range from about 20 to 200 μm; seeding the cells on the carriers; and growing the cells on the carrier.

    摘要翻译: 提供培养贴壁细胞的方法,其中所述方法包括提供用于生长所述细胞的载体,包含一个或多个表面; 并且在一个或多个表面上存在一个或多个消除特征/凹陷,其中载体具有至少约0.2mm,宽度至少约0.2mm的长度,以及在约0.012mm至0.5的范围内的高度 毫米 并且其中每个所述浮雕特征/压痕的表面高度在约2至200μm的范围内,宽度在约20至200μm的范围内; 将细胞接种在载体上; 并在载体上生长细胞。

    Cell carrier, methods of making and use
    5.
    发明授权
    Cell carrier, methods of making and use 有权
    细胞载体,制备和使用方法

    公开(公告)号:US09453196B2

    公开(公告)日:2016-09-27

    申请号:US13287611

    申请日:2011-11-02

    IPC分类号: C12N5/071 C12N5/00

    摘要: A method of culturing adherent cells is provided, wherein the method comprises providing a carrier for growing the cells, comprising one or more surfaces; and one or more relief features/indentations are present on one or more of the surfaces, wherein the carrier has a length at least about 0.2 mm, a width at least about 0.2 mm, and a height in a range from about 0.012 mm to 0.5 mm; and wherein each of the relief features/indentations has a height above the surfaces in a range from about 2 to 200 μm, and width in a range from about 20 to 200 μm; seeding the cells on the carriers; and growing the cells on the carrier.

    摘要翻译: 提供培养贴壁细胞的方法,其中所述方法包括提供用于生长所述细胞的载体,包含一个或多个表面; 并且在一个或多个表面上存在一个或多个消除特征/凹陷,其中载体具有至少约0.2mm,宽度至少约0.2mm的长度,以及在约0.012mm至0.5的范围内的高度 毫米 并且其中每个所述浮雕特征/压痕的表面高度在约2至200μm的范围内,宽度在约20至200μm的范围内; 将细胞接种在载体上; 并在载体上生长细胞。

    Methods of making cell carrier
    6.
    发明授权
    Methods of making cell carrier 有权
    细胞载体的制备方法

    公开(公告)号:US09453197B2

    公开(公告)日:2016-09-27

    申请号:US13287632

    申请日:2011-11-02

    摘要: A method of making a carrier for growing cells, including providing a polymer film; embossing a patterned surface one or more sides of the polymer film with an embossing roller; generating a pattern of structured indentations on the polymer film; and discretizing the patterned polymer film into a plurality of portions. The embossing pattern generates relief features on the carrier surface. An alternative method of making a carrier is also provided, including extruding a polymer film; embossing a patterned surface on the polymer film with a roller; generating a pattern of structured indentations on the polymer film; imparting a surface treatment to the film; and discretizing the treated polymer film into a plurality of portions.

    摘要翻译: 一种制造用于生长细胞的载体的方法,包括提供聚合物膜; 用压花辊将聚合物膜的一个或多个侧面压花图案化表面; 在聚合物膜上产生结构化凹痕的图案; 并将图案化的聚合物膜离散成多个部分。 压花图案在载体表面上产生浮雕特征。 还提供制备载体的替代方法,包括挤出聚合物膜; 用辊子在聚合物膜上压花图案化表面; 在聚合物膜上产生结构化凹痕的图案; 对薄膜进行表面处理; 并将经处理的聚合物膜离散成多个部分。

    METHODS OF MAKING CELL CARRIER
    7.
    发明申请
    METHODS OF MAKING CELL CARRIER 有权
    制作细胞载体的方法

    公开(公告)号:US20130034669A1

    公开(公告)日:2013-02-07

    申请号:US13287632

    申请日:2011-11-02

    IPC分类号: C23C16/513 B29C59/02

    摘要: A method of making a carrier for growing cells, including providing a polymer film; embossing a patterned surface one or more sides of the polymer film with an embossing roller; generating a pattern of structured indentations on the polymer film; and discretizing the patterned polymer film into a plurality of portions. The embossing pattern generates relief features on the carrier surface. An alternative method of making a carrier is also provided, including extruding a polymer film; embossing a patterned surface on the polymer film with a roller; generating a pattern of structured indentations on the polymer film; imparting a surface treatment to the film; and discretizing the treated polymer film into a plurality of portions.

    摘要翻译: 一种制造用于生长细胞的载体的方法,包括提供聚合物膜; 用压花辊将聚合物膜的一个或多个侧面压花图案化表面; 在聚合物膜上产生结构化凹痕的图案; 并将图案化的聚合物膜离散成多个部分。 压花图案在载体表面上产生浮雕特征。 还提供制备载体的替代方法,包括挤出聚合物膜; 用辊子在聚合物膜上压花图案化表面; 在聚合物膜上产生结构化凹痕的图案; 对薄膜进行表面处理; 并将经处理的聚合物膜离散成多个部分。

    SILICONE RUBBER COMPOSITIONS COMPRISING BISMUTH OXIDE AND ARTICLES MADE THEREFROM
    10.
    发明申请
    SILICONE RUBBER COMPOSITIONS COMPRISING BISMUTH OXIDE AND ARTICLES MADE THEREFROM 失效
    含硅氧烷的硅橡胶组合物及其制品

    公开(公告)号:US20110112406A1

    公开(公告)日:2011-05-12

    申请号:US13006677

    申请日:2011-01-14

    IPC分类号: A61B8/00

    CPC分类号: G10K11/30 C08G77/04 C08L83/04

    摘要: The present invention provides novel filled silicone compositions comprising a nano-particulate metal oxide filler selected from nano-particulate monoclinic alpha-phase bismuth oxide, nano-particulate erbium oxide, and mixtures thereof. The new composite compositions exhibit a combination of outstanding performance characteristics in both the cured and uncured states. Thus, the uncured formulations are typically free flowing liquids which are self-leveling, which de-gas readily under vacuum, are readily colorable through the addition of pigments, and which cure at temperatures of about 60° C. The cured compositions possess outstanding acoustic characteristics which make them ideally suited for use in applications such as acoustic lenses for medical imaging and therapy. For example, the acoustic impedance of compositions provided by the present invention is closely matched to the acoustic impedance of human tissue. This may result in an enhancement of ultrasound transmission efficiency between the lens of an ultrasound probe comprising such a composition and the patient.

    摘要翻译: 本发明提供新型填充的硅氧烷组合物,其包含选自纳米颗粒单斜晶α-氧化铋,纳米颗粒铒氧化物及其混合物的纳米颗粒金属氧化物填料。 新的复合组合物在固化状态和未固化状态下显示出突出的性能特征的组合。 因此,未固化的制剂通常是自流平液体,其是自流平的,其在真空下容易地脱气,通过添加颜料容易着色,并且在约60℃的温度下固化。固化的组合物具有优异的声学 使其非常适合用于诸如用于医学成像和治疗的声学透镜的应用中。 例如,由本发明提供的组合物的声阻抗与人体组织的声阻抗紧密匹配。 这可能导致包括这种组合物的超声波探头的透镜与患者之间的超声传输效率的增强。