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1.发明授权Methods for synthesizing sugar chains using β1,3-N-acetylglucosaminyltransferase 有权使用1,3-N-乙酰葡糖胺基转移酶合成糖链的方法公开(公告)号：US08722366B2
公开(公告)日：2014-05-13
申请号：US13164814
申请日：2011-06-21
申请人： Katsutoshi Sasaki , Norihiko Shiraishi , Ayumi Natsume , Yoji Yamada , Satoshi Nakagawa , Susumu Sekine
发明人： Katsutoshi Sasaki , Norihiko Shiraishi , Ayumi Natsume , Yoji Yamada , Satoshi Nakagawa , Susumu Sekine
CPC分类号： C12N9/1051 , A61K38/00 , C07K2319/02 , C12N9/1085
摘要： The present invention provides a novel polypeptide having a β1,3-N-acetylglucosaminyltransferase activity; a method for producing the polypeptide; a DNA which encodes the polypeptide; a recombinant vector into which the DNA is inserted; a transformant comprising the recombinant vector; a method for producing a sugar chain or complex carbohydrate, using the polypeptide; a method for producing a sugar chain or complex carbohydrate, using the transformant; an antibody which recognizes the polypeptide; a method for screening a substance which changes the expression of the gene which encodes the polypeptide; and a method for screening a substance which changes the activity of the polypeptide.
摘要翻译： 本发明提供了具有“1,3-N-乙酰葡糖胺基转移酶”活性的新型多肽; 一种生产该多肽的方法; 编码多肽的DNA; 插入DNA的重组载体; 包含重组载体的转化体; 使用该多肽制备糖链或复合碳水化合物的方法; 使用该转化体生产糖链或复合碳水化合物的方法; 识别多肽的抗体; 用于筛选改变编码多肽的基因表达的物质的方法; 以及筛选改变多肽活性的物质的方法。
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公开(公告)号：US20120156732A1
公开(公告)日：2012-06-21
申请号：US13164814
申请日：2011-06-21
申请人： Katsutoshi Sasaki , Norihiko Shiraishi , Ayumi Natsume , Yoji Yamada , Satoshi Nakagawa , Susumu Sekine
发明人： Katsutoshi Sasaki , Norihiko Shiraishi , Ayumi Natsume , Yoji Yamada , Satoshi Nakagawa , Susumu Sekine
IPC分类号： C12P19/18
CPC分类号： C12N9/1051 , A61K38/00 , C07K2319/02 , C12N9/1085
摘要： The present invention provides a novel polypeptide having a β1,3-N-acetylglucosaminyltransferase activity; a method for producing the polypeptide; a DNA which encodes the polypeptide; a recombinant vector into which the DNA is inserted; a transformant comprising the recombinant vector; a method for producing a sugar chain or complex carbohydrate, using the polypeptide; a method for producing a sugar chain or complex carbohydrate, using the transformant; an antibody which recognizes the polypeptide; a method for screening a substance which changes the expression of the gene which encodes the polypeptide; and a method for screening a substance which changes the activity of the polypeptide.
摘要翻译： 本发明提供了具有“1,3-N-乙酰葡糖胺基转移酶”活性的新型多肽; 一种生产该多肽的方法; 编码多肽的DNA; 插入DNA的重组载体; 包含重组载体的转化体; 使用该多肽制备糖链或复合碳水化合物的方法; 使用该转化体生产糖链或复合碳水化合物的方法; 识别多肽的抗体; 用于筛选改变编码多肽的基因表达的物质的方法; 以及筛选改变多肽活性的物质的方法。
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公开(公告)号：US20100196392A1
公开(公告)日：2010-08-05
申请号：US12505133
申请日：2009-07-17
申请人： Norihiko SHIRAISHI , Akiko Furuya , Hiroe Toki , Hiroshi Ando , Masayo Suzuki , Tsuguo Kubota
发明人： Norihiko SHIRAISHI , Akiko Furuya , Hiroe Toki , Hiroshi Ando , Masayo Suzuki , Tsuguo Kubota
IPC分类号： A61K39/395 , C07K16/00 , C12N5/00 , C12N15/13 , C12N15/63 , C12N5/07 , C12P21/00 , G01N33/53 , A61P35/00
CPC分类号： C07K16/28 , A61K39/39533 , A61K2039/505 , C07H21/04 , C07K16/30 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C12N5/12 , C12N15/09 , C12N15/63 , C12N2800/10 , G01N33/574 , G01N33/6872 , G01N33/6893
摘要： An object of the present invention is to provide a monoclonal antibody which is useful for treating or diagnosing a disease relating to system ASC amino acid transporter 2 (hereinafter, referred to as “ASCT2”) or a method using the antibody. The present invention provides a monoclonal antibody which specifically recognizes a native three-dimensional structure of an extracellular region of ASCT2 and binds to the extracellular region, or an antibody fragment thereof; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which contains the DNA; a transformant obtainable by introducing the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a therapeutic agent using the antibody or the antibody fragment thereof, and a diagnostic agent using the antibody or the antibody fragment thereof.
摘要翻译： 本发明的目的是提供一种单克隆抗体，其可用于治疗或诊断与ASC系统ASC氨基酸转运蛋白2有关的疾病（以下称为“ASCT2”）或使用该抗体的方法。 本发明提供特异性识别ASCT2细胞外区域的天然三维结构并结合细胞外区域或其抗体片段的单克隆抗体; 产生抗体的杂交瘤; 编码抗体的DNA; 含有DNA的载体; 通过引入载体可获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及使用该抗体或其抗体片段的治疗剂，以及使用该抗体或其抗体片段的诊断剂。
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公开(公告)号：US08093361B2
公开(公告)日：2012-01-10
申请号：US11628745
申请日：2005-06-07
申请人： Atsushi Ochiai , Norihiko Shiraishi , Yoko Kato , Toshio Ota , Susume Sekine , Kenya Shitara , Akiko Furuya , So Ohta , Emi Hosaka , Yuka Sasaki
发明人： Atsushi Ochiai , Norihiko Shiraishi , Yoko Kato , Toshio Ota , Susume Sekine , Kenya Shitara , Akiko Furuya , So Ohta , Emi Hosaka , Yuka Sasaki
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00 , C12P21/04 , G01N33/53 , G01N33/574
CPC分类号： G01N33/57492 , C07K16/28 , C07K2317/732 , C07K2317/734
摘要： The present invention provides an antibody which specifically recognizes three-dimensional structure of an extracellular region of a polypeptide encoded by PERP (p53 apoptosis effector related to PMP-22) gene and binds to the extracellular region. The antibody of the present invention is useful for treatment of various diseases which highly expresses a polypeptide encoded by the PERP gene. Also, a polypeptide encoded by the PERP gene or a cell expressing the polypeptide can be specifically detected by an immunological method using the antibody, so that the antibody is useful for diagnosis of various diseases related to PERP.
摘要翻译： 本发明提供一种特异性识别由PERP编码的多肽的细胞外区域的三维结构的抗体（与PMP-22相关的p53凋亡效应）并结合到细胞外区域。 本发明的抗体可用于治疗高表达由PERP基因编码的多肽的各种疾病。 此外，可以通过使用抗体的免疫学方法来特异性检测由PERP基因编码的多肽或表达多肽的细胞，使得该抗体可用于诊断与PERP相关的各种疾病。
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公开(公告)号：US20130202607A1
公开(公告)日：2013-08-08
申请号：US13584478
申请日：2012-08-13
申请人： Norihiko SHIRAISHI , Akiko FURUYA , Hiroe TOKI , Hiroshi ANDO , Masayo SUZUKI , Tsuguo KUBOTA
发明人： Norihiko SHIRAISHI , Akiko FURUYA , Hiroe TOKI , Hiroshi ANDO , Masayo SUZUKI , Tsuguo KUBOTA
CPC分类号： C07K16/28 , A61K39/39533 , A61K2039/505 , C07H21/04 , C07K16/30 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C12N5/12 , C12N15/09 , C12N15/63 , C12N2800/10 , G01N33/574 , G01N33/6872 , G01N33/6893
摘要： An object of the present invention is to provide a monoclonal antibody which is useful for treating or diagnosing a disease relating to system ASC amino acid transporter 2 (hereinafter, referred to as “ASCT2”) or a method using the antibody. The present invention provides a monoclonal antibody which specifically recognizes a native three-dimensional structure of an extracellular region of ASCT2 and binds to the extracellular region, or an antibody fragment thereof; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which contains the DNA; a transformant obtainable by introducing the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a therapeutic agent using the antibody or the antibody fragment thereof, and a diagnostic agent using the antibody or the antibody fragment thereof.
摘要翻译： 本发明的目的是提供一种单克隆抗体，其可用于治疗或诊断与ASC系统ASC氨基酸转运蛋白2有关的疾病（以下称为“ASCT2”）或使用该抗体的方法。 本发明提供特异性识别ASCT2细胞外区域的天然三维结构并结合细胞外区域或其抗体片段的单克隆抗体; 产生抗体的杂交瘤; 编码抗体的DNA; 含有DNA的载体; 通过引入载体可获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及使用该抗体或其抗体片段的治疗剂，以及使用该抗体或其抗体片段的诊断剂。
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公开(公告)号：US07972815B2
公开(公告)日：2011-07-05
申请号：US12019793
申请日：2008-01-25
申请人： Katsutoshi Sasaki , Norihiko Shiraishi , Ayumi Natsume , Yoji Yamada , Satoshi Nakagawa , Susume Sekine
发明人： Katsutoshi Sasaki , Norihiko Shiraishi , Ayumi Natsume , Yoji Yamada , Satoshi Nakagawa , Susume Sekine
CPC分类号： C12N9/1051 , A61K38/00 , C07K2319/02 , C12N9/1085
摘要： The present invention provides a novel polypeptide having a β1,3-N-acetylglucosaminyl transferase activity; a method for producing the polypeptide; a DNA which encodes the polypeptide; a recombinant vector into which the DNA is inserted; a transformant comprising the recombinant vector; a method for producing a sugar chain or complex carbohydrate, using the polypeptide; a method for producing a sugar chain or complex carbohydrate, using the transformant; an antibody which recognizes the polypeptide; a method for screening a substance which changes the expression of the gene which encodes the polypeptide; and a method for screening a substance which changes the activity of the polypeptide.
摘要翻译： 本发明提供了具有“1,3-N-乙酰氨基葡糖基转移酶活性”的新型多肽; 一种生产该多肽的方法; 编码多肽的DNA; 插入DNA的重组载体; 包含重组载体的转化体; 使用该多肽制备糖链或复合碳水化合物的方法; 使用该转化体生产糖链或复合碳水化合物的方法; 识别多肽的抗体; 用于筛选改变编码多肽的基因表达的物质的方法; 以及筛选改变多肽活性的物质的方法。
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公开(公告)号：US20090258007A1
公开(公告)日：2009-10-15
申请号：US11628745
申请日：2005-06-07
申请人： Atsushi Ochiai , Norihiko Shiraishi , Yoko Kato , Toshio Ota , Susumu Sekine , Kenya Shitara , Akiko Furuya , So Ohta , Emi Hosaka , Yuka Sasaki
发明人： Atsushi Ochiai , Norihiko Shiraishi , Yoko Kato , Toshio Ota , Susumu Sekine , Kenya Shitara , Akiko Furuya , So Ohta , Emi Hosaka , Yuka Sasaki
IPC分类号： A61K39/395 , C07K16/00 , C12N5/12 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/00 , G01N33/53 , C12Q1/68 , A61P35/00
CPC分类号： G01N33/57492 , C07K16/28 , C07K2317/732 , C07K2317/734
摘要： The present invention provides an antibody which specifically recognizes three-dimensional structure of an extracellular region of a polypeptide encoded by PERP (p53 apoptosis effector related to PMP-22) gene and binds to the extracellular region. The antibody of the present invention is useful for treatment of various diseases which highly expresses a polypeptide encoded by the PERP gene. Also, a polypeptide encoded by the PERP gene or a cell expressing the polypeptide can be specifically detected by an immunological method using the antibody, so that the antibody is useful for diagnosis of various diseases related to PERP.
摘要翻译： 本发明提供一种特异性识别由PERP编码的多肽的细胞外区域的三维结构的抗体（与PMP-22相关的p53凋亡效应）并结合到细胞外区域。 本发明的抗体可用于治疗高表达由PERP基因编码的多肽的各种疾病。 此外，可以通过使用抗体的免疫学方法特异性检测由PERP基因编码的多肽或表达多肽的细胞，使得该抗体可用于诊断与PERP相关的各种疾病。
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8.发明授权DNA encoding an anti-system ASC amino acid transporter 2 (ASCT2) antibody 有权编码抗系统ASC氨基酸转运蛋白2（ASCT2）抗体的DNA公开(公告)号：US08945870B2
公开(公告)日：2015-02-03
申请号：US13584478
申请日：2012-08-13
申请人： Norihiko Shiraishi , Akiko Furuya , Hiroe Toki , Hiroshi Ando , Masayo Suzuki , Tsuguo Kubota
发明人： Norihiko Shiraishi , Akiko Furuya , Hiroe Toki , Hiroshi Ando , Masayo Suzuki , Tsuguo Kubota
IPC分类号： C07H21/04 , C12N15/09 , C12N15/12 , C12N15/13 , C12N15/63 , C12N5/07 , C12N5/10 , C12N5/12 , C07K16/28 , G01N33/68 , C07K16/30 , G01N33/574 , A61K39/395 , A61K39/00
CPC分类号： C07K16/28 , A61K39/39533 , A61K2039/505 , C07H21/04 , C07K16/30 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C12N5/12 , C12N15/09 , C12N15/63 , C12N2800/10 , G01N33/574 , G01N33/6872 , G01N33/6893
摘要： An object of the present invention is to provide a monoclonal antibody which is useful for treating or diagnosing a disease relating to system ASC amino acid transporter 2 (hereinafter, referred to as “ASCT2”) or a method using the antibody. The present invention provides a monoclonal antibody which specifically recognizes a native three-dimensional structure of an extracellular region of ASCT2 and binds to the extracellular region, or an antibody fragment thereof; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which contains the DNA; a transformant obtainable by introducing the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a therapeutic agent using the antibody or the antibody fragment thereof, and a diagnostic agent using the antibody or the antibody fragment thereof.
摘要翻译： 本发明的目的是提供一种单克隆抗体，其可用于治疗或诊断与ASC系统ASC氨基酸转运蛋白2有关的疾病（以下称为“ASCT2”）或使用该抗体的方法。 本发明提供特异性识别ASCT2细胞外区域的天然三维结构并结合细胞外区域或其抗体片段的单克隆抗体; 产生抗体的杂交瘤; 编码抗体的DNA; 含有DNA的载体; 通过引入载体可获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及使用该抗体或其抗体片段的治疗剂，以及使用该抗体或其抗体片段的诊断剂。
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公开(公告)号：US08268592B2
公开(公告)日：2012-09-18
申请号：US12505133
申请日：2009-07-17
申请人： Norihiko Shiraishi , Akiko Furuya , Hiroe Toki , Hiroshi Ando , Masayo Suzuki , Tsuguo Kubota
发明人： Norihiko Shiraishi , Akiko Furuya , Hiroe Toki , Hiroshi Ando , Masayo Suzuki , Tsuguo Kubota
CPC分类号： C07K16/28 , A61K39/39533 , A61K2039/505 , C07H21/04 , C07K16/30 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C12N5/12 , C12N15/09 , C12N15/63 , C12N2800/10 , G01N33/574 , G01N33/6872 , G01N33/6893
摘要： An object of the present invention is to provide a monoclonal antibody which is useful for treating or diagnosing a disease relating to system ASC amino acid transporter 2 (hereinafter, referred to as “ASCT2”) or a method using the antibody. The present invention provides a monoclonal antibody which specifically recognizes a native three-dimensional structure of an extracellular region of ASCT2 and binds to the extracellular region, or an antibody fragment thereof; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which contains the DNA; a transformant obtainable by introducing the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a therapeutic agent using the antibody or the antibody fragment thereof, and a diagnostic agent using the antibody or the antibody fragment thereof.
摘要翻译： 本发明的目的是提供一种单克隆抗体，其可用于治疗或诊断与ASC系统ASC氨基酸转运蛋白2有关的疾病（以下称为“ASCT2”）或使用该抗体的方法。 本发明提供特异性识别ASCT2细胞外区域的天然三维结构并结合细胞外区域或其抗体片段的单克隆抗体; 产生抗体的杂交瘤; 编码抗体的DNA; 含有DNA的载体; 通过引入载体可获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及使用该抗体或其抗体片段的治疗剂，以及使用该抗体或其抗体片段的诊断剂。
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10.发明授权Process for producing carbohydrates using β 1,3-N-acetyl-glucosaminyltransferase 有权使用β1,3-N-乙酰基 - 氨基葡萄糖转移酶生产碳水化合物的方法公开(公告)号：US07005279B1
公开(公告)日：2006-02-28
申请号：US10019735
申请日：2000-06-29
申请人： Katsutoshi Sasaki , Norihiko Shiraishi , Ayumi Natsume , Yoji Yamada , Satoshi Nakagawa , Susumu Sekine
发明人： Katsutoshi Sasaki , Norihiko Shiraishi , Ayumi Natsume , Yoji Yamada , Satoshi Nakagawa , Susumu Sekine
CPC分类号： C12N9/1051 , A61K38/00 , C07K2319/02 , C12N9/1085
摘要： The present invention provides a novel polypeptide having a β1,3-N-acetylglucosaminyltransferase activity; a method for producing the polypeptide; a DNA which encodes the polypeptide; a recombinant vector into which the DNA is inserted; a transformant comprising the recombinant vector; a method for producing a sugar chain or complex carbohydrate, using the polypeptide; a method for producing a sugar chain or complex carbohydrate, using the transformant; an antibody which recognizes the polypeptide; a method for screening a substance which changes the expression of the gene which encodes the polypeptide; and a method for screening a substance which changes the activity of the polypeptide.
摘要翻译： 本发明提供了具有β1,3-N-乙酰葡糖胺基转移酶活性的新型多肽; 一种生产该多肽的方法; 编码多肽的DNA; 插入DNA的重组载体; 包含重组载体的转化体; 使用该多肽制备糖链或复合碳水化合物的方法; 使用该转化体生产糖链或复合碳水化合物的方法; 识别多肽的抗体; 用于筛选改变编码多肽的基因表达的物质的方法; 以及筛选改变多肽活性的物质的方法。
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