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公开(公告)号：US20050119168A1
公开(公告)日：2005-06-02
申请号：US10948367
申请日：2004-09-23
申请人： Srikanth Venkatraman , F. Njoroge , Wanli Wu , Viyyoor Girijavallabhan , Brian McKittrick , Jing Su , Francisco Velazquez , Patrick Pinto
发明人： Srikanth Venkatraman , F. Njoroge , Wanli Wu , Viyyoor Girijavallabhan , Brian McKittrick , Jing Su , Francisco Velazquez , Patrick Pinto
IPC分类号： A61K31/33 , A61K38/00 , A61K38/12 , A61K38/21 , C07D245/04 , C07D401/12 , C07D403/12 , C07D409/12 , C07D487/04 , C07D513/04 , C07K5/02 , C07K5/08
CPC分类号： C07D245/04 , A61K31/33 , A61K38/12 , A61K38/21 , A61K38/212 , C04B35/632 , C07D401/12 , C07D403/12 , C07D409/12 , C07D487/04 , C07D513/04 , C07K5/0217 , C07K5/0802 , A61K2300/00
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them to treat disorders associated with the HCV protease. The novel compounds typically include a 15-20 member macrocycle and have the general structure of structural Formula 1: wherein Z′, L′, M′, R1, X and D are defined herein.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新化合物以及包含这些化合物的药物组合物及其用于治疗与HCV蛋白酶相关的病症的方法。 新化合物通常包括15-20个成员大环，并且具有结构式1的一般结构：其中Z'，L'，M'，R 1，X和D在本文中定义。
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公开(公告)号：US20060205672A1
公开(公告)日：2006-09-14
申请号：US11241656
申请日：2005-09-30
申请人： Anil Saksena , Viyyoor Girijavallabhan , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping McCormick , Haiyan Wang , Russell Pike , Stephane Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. Njoroge , Ashok Arasappan , Tejal Parekh , Ashit Ganguly , Kevin Chen , Srikanth Venkatraman , Henry Vaccaro , Patrick Pinto , Bama Santhanam , Scott Kemp , Odile Levy , Marguerita Lim-Wilby , Susan Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
发明人： Anil Saksena , Viyyoor Girijavallabhan , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping McCormick , Haiyan Wang , Russell Pike , Stephane Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. Njoroge , Ashok Arasappan , Tejal Parekh , Ashit Ganguly , Kevin Chen , Srikanth Venkatraman , Henry Vaccaro , Patrick Pinto , Bama Santhanam , Scott Kemp , Odile Levy , Marguerita Lim-Wilby , Susan Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
CPC分类号： C07K5/0202 , A61K38/00 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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3.发明申请公开(公告)号：US20070032433A1
公开(公告)日：2007-02-08
申请号：US10052386
申请日：2002-01-18
申请人： Anil Saksena , Viyyoor Girijavallabhan , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping Mc Cormick , Haiyan Wang , Russell Pike , Stephane Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. Njoroge , Ashok Arasappan , Tejal Parekh , Ashit Ganguly , Kevin Chen , Srikanth Venkatraman , Henry Vaccaro , Patrick Pinto , Bama Santhanam , Scott Kemp , Odile Levy , Marguerita Lim-wilby , Susan Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang , Jesse Wong , Latha Nair
发明人： Anil Saksena , Viyyoor Girijavallabhan , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping Mc Cormick , Haiyan Wang , Russell Pike , Stephane Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. Njoroge , Ashok Arasappan , Tejal Parekh , Ashit Ganguly , Kevin Chen , Srikanth Venkatraman , Henry Vaccaro , Patrick Pinto , Bama Santhanam , Scott Kemp , Odile Levy , Marguerita Lim-wilby , Susan Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang , Jesse Wong , Latha Nair
CPC分类号： C07K5/0804 , A61K38/00 , C07K5/0202 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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公开(公告)号：US07592419B2
公开(公告)日：2009-09-22
申请号：US10948367
申请日：2004-09-23
申请人： Srikanth Venkatraman , F. George Njoroge , Wanli Wu , Viyyoor M. Girijavallabhan , Brian McKittrick , Jing Su , Francisco Velazquez , Patrick A. Pinto
发明人： Srikanth Venkatraman , F. George Njoroge , Wanli Wu , Viyyoor M. Girijavallabhan , Brian McKittrick , Jing Su , Francisco Velazquez , Patrick A. Pinto
CPC分类号： C07D245/04 , A61K31/33 , A61K38/12 , A61K38/21 , A61K38/212 , C04B35/632 , C07D401/12 , C07D403/12 , C07D409/12 , C07D487/04 , C07D513/04 , C07K5/0217 , C07K5/0802 , A61K2300/00
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them to treat disorders associated with the HCV protease. The novel compounds typically include a 15-20 member macrocycle and have the general structure of structural Formula 1: wherein Z′, L′, M′, R1, X and D are defined herein.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新化合物以及包含这些化合物的药物组合物及其用于治疗与HCV蛋白酶相关的病症的方法。 新化合物通常包括15-20个成员大环，并且具有结构式1的一般结构：其中Z'，L'，M'，R 1，X和D在本文中定义。
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5.发明申请Sulfur compounds as inhibitors of Hepatitis C virus NS3 serine protease 有权硫化合物作为丙型肝炎病毒NS3丝氨酸蛋白酶的抑制剂公开(公告)号：US20070042968A1
公开(公告)日：2007-02-22
申请号：US11064673
申请日：2005-02-24
申请人： Frank Bennett , Raymond Lovey , Yuhua Huang , Siska Hendrata , Anil Saksena , Stephane Bogen , Yi-Tsung Liu , F. Njoroge , Srikanth Venkatraman , Kevin Chen , Mousumi Sannigrahi , Ashok Arasappan , Viyyoor Girijavallabhan , Francisco Velazquez
发明人： Frank Bennett , Raymond Lovey , Yuhua Huang , Siska Hendrata , Anil Saksena , Stephane Bogen , Yi-Tsung Liu , F. Njoroge , Srikanth Venkatraman , Kevin Chen , Mousumi Sannigrahi , Ashok Arasappan , Viyyoor Girijavallabhan , Francisco Velazquez
IPC分类号： A61K38/04 , C07K7/04 , C07D417/02 , C07D49/02
CPC分类号： C07D209/52 , A61K38/00 , C07D207/16 , C07D209/56 , C07D405/12 , C07D409/12 , C07D411/12 , C07D491/04 , C07K5/0202
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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6.发明申请Novel compounds as inhibitors of hepatitis C virus NS3 serine protease 失效新型化合物作为丙型肝炎病毒NS3丝氨酸蛋白酶的抑制剂公开(公告)号：US20050288233A1
公开(公告)日：2005-12-29
申请号：US11065509
申请日：2005-02-24
申请人： Srikanth Venkatraman , F. Njoroge , Melissa Blackman , Wanli Wu , Latha Nair , Ashok Arasappan , Stephane Bogen , Kevin Chen , Mousumi Sannigrahi , Frank Bennett , Viyyoor Girijavallabhan
发明人： Srikanth Venkatraman , F. Njoroge , Melissa Blackman , Wanli Wu , Latha Nair , Ashok Arasappan , Stephane Bogen , Kevin Chen , Mousumi Sannigrahi , Frank Bennett , Viyyoor Girijavallabhan
IPC分类号： A61K38/00 , A61K38/04 , C07D209/52 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12 , C07K5/04 , C07K5/06 , C07K5/065 , C07K5/08
CPC分类号： C07D209/52 , A61K38/00 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12 , C07K5/06034 , C07K5/06078
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的疾病的方法。
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7.发明申请3,4-(cyclopentyl)-fused proline compounds as inhibitors of hepatitis C virus NS3 serine protease 失效3,4-（环戊基） - 脯氨酸化合物作为丙型肝炎病毒NS3丝氨酸蛋白酶的抑制剂公开(公告)号：US20050197301A1
公开(公告)日：2005-09-08
申请号：US11064757
申请日：2005-02-24
申请人： F. Njoroge , Srikanth Venkatraman , Ashok Arasappan , Francisco Velazquez , Viyyoor Girijavallabhan
发明人： F. Njoroge , Srikanth Venkatraman , Ashok Arasappan , Francisco Velazquez , Viyyoor Girijavallabhan
IPC分类号： A61K38/04 , C07D209/52 , C07K5/02 , C07K5/04 , C07K5/08
CPC分类号： C07K5/0202
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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8.发明申请Novel peptidomimetic NS3-serine protease inhibitors of hepatitis C virus 失效丙型肝炎病毒的新型拟肽NS3-丝氨酸蛋白酶抑制剂公开(公告)号：US20050085425A1
公开(公告)日：2005-04-21
申请号：US10925329
申请日：2004-08-24
申请人： Kevin Chen , F. Njoroge , Weiying Yang , Bancha Vibulbhan , Viyyoor Girijavallabhan , Srikanth Venkatraman , Francisco Velazquez
发明人： Kevin Chen , F. Njoroge , Weiying Yang , Bancha Vibulbhan , Viyyoor Girijavallabhan , Srikanth Venkatraman , Francisco Velazquez
IPC分类号： A61K31/40 , A61K31/519 , A61K38/00 , A61K38/04 , A61K38/06 , C07K5/02 , C07K5/04 , C07K5/08 , C07K7/06
CPC分类号： C07K5/0202 , A61K31/40 , A61K38/00 , C07K5/021 , C07K5/0827 , C07K7/06
摘要： The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts or solvates of said compound, or of said prodrug, said compound having the general structure shown in Formula 1: useful in the treatment or prevention or amelioration of one or more symptoms of hepatitis C.
摘要翻译： 本申请公开了所述化合物或所述前药的药学上可接受的盐或溶剂化物的化合物或其对映异构体，立体异构体，旋转异构体，互变异构体，前体药物，所述化合物具有式1所示的一般结构：有用的 治疗或预防或改善一种或多种丙型肝炎症状。
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9.发明申请Novel compounds as inhibitors of hepatitis C virus NS3 serine protease 失效新型化合物作为丙型肝炎病毒NS3丝氨酸蛋白酶的抑制剂公开(公告)号：US20070049536A1
公开(公告)日：2007-03-01
申请号：US11542228
申请日：2006-10-03
申请人： Srikanth Venkatraman , F. Njoroge , Melissa Blackman , Wanli Wu , Latha Nair , Ashok Arasappan , Stephane Bogen , Kevin Chen , Mousumi Sannigrahi , Frank Bennett , Viyyoor Girijavallabhan
发明人： Srikanth Venkatraman , F. Njoroge , Melissa Blackman , Wanli Wu , Latha Nair , Ashok Arasappan , Stephane Bogen , Kevin Chen , Mousumi Sannigrahi , Frank Bennett , Viyyoor Girijavallabhan
CPC分类号： C07D209/52 , A61K38/00 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12 , C07K5/06034 , C07K5/06078
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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公开(公告)号：US20070032434A1
公开(公告)日：2007-02-08
申请号：US11542156
申请日：2006-10-03
申请人： Srikanth Venkatraman , F. Njoroge , Melissa Blackman , Wanli Wu , Latha Nair , Ashok Arasappan , Stephane Bogen , Kevin Chen , Mousumi Sannigrahi , Frank Bennett , Viyyoor Girijavallabhan
发明人： Srikanth Venkatraman , F. Njoroge , Melissa Blackman , Wanli Wu , Latha Nair , Ashok Arasappan , Stephane Bogen , Kevin Chen , Mousumi Sannigrahi , Frank Bennett , Viyyoor Girijavallabhan
CPC分类号： C07D209/52 , A61K38/00 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12 , C07K5/06034 , C07K5/06078
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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