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1.发明申请公开(公告)号：US20070032433A1
公开(公告)日：2007-02-08
申请号：US10052386
申请日：2002-01-18
申请人： Anil Saksena , Viyyoor Girijavallabhan , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping Mc Cormick , Haiyan Wang , Russell Pike , Stephane Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. Njoroge , Ashok Arasappan , Tejal Parekh , Ashit Ganguly , Kevin Chen , Srikanth Venkatraman , Henry Vaccaro , Patrick Pinto , Bama Santhanam , Scott Kemp , Odile Levy , Marguerita Lim-wilby , Susan Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang , Jesse Wong , Latha Nair
发明人： Anil Saksena , Viyyoor Girijavallabhan , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping Mc Cormick , Haiyan Wang , Russell Pike , Stephane Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. Njoroge , Ashok Arasappan , Tejal Parekh , Ashit Ganguly , Kevin Chen , Srikanth Venkatraman , Henry Vaccaro , Patrick Pinto , Bama Santhanam , Scott Kemp , Odile Levy , Marguerita Lim-wilby , Susan Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang , Jesse Wong , Latha Nair
CPC分类号： C07K5/0804 , A61K38/00 , C07K5/0202 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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公开(公告)号：US20060205672A1
公开(公告)日：2006-09-14
申请号：US11241656
申请日：2005-09-30
申请人： Anil Saksena , Viyyoor Girijavallabhan , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping McCormick , Haiyan Wang , Russell Pike , Stephane Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. Njoroge , Ashok Arasappan , Tejal Parekh , Ashit Ganguly , Kevin Chen , Srikanth Venkatraman , Henry Vaccaro , Patrick Pinto , Bama Santhanam , Scott Kemp , Odile Levy , Marguerita Lim-Wilby , Susan Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
发明人： Anil Saksena , Viyyoor Girijavallabhan , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping McCormick , Haiyan Wang , Russell Pike , Stephane Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. Njoroge , Ashok Arasappan , Tejal Parekh , Ashit Ganguly , Kevin Chen , Srikanth Venkatraman , Henry Vaccaro , Patrick Pinto , Bama Santhanam , Scott Kemp , Odile Levy , Marguerita Lim-Wilby , Susan Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
CPC分类号： C07K5/0202 , A61K38/00 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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3.发明申请公开(公告)号：US20050176648A1
公开(公告)日：2005-08-11
申请号：US11089192
申请日：2005-03-24
申请人： Anil Saksena , Viyyoor Girijavallabhan , Stephane Bogen , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping McCormick , Haiyan Wang , Russell Pike , Yi-Tsung Liu , Tin-Yau Chan , Zhaoning Zhu , Ashok Arasappan , Kevin Chen , Srikanth Venkatraman , Tejal Parekh , Patrick Pinto , Bama Santhanam , F. Njoroge , Ashit Ganguly , Henry Vaccaro , Scott Kemp , Odile Levy , Marguerita Lim-Wilby , Susan Tamura
发明人： Anil Saksena , Viyyoor Girijavallabhan , Stephane Bogen , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping McCormick , Haiyan Wang , Russell Pike , Yi-Tsung Liu , Tin-Yau Chan , Zhaoning Zhu , Ashok Arasappan , Kevin Chen , Srikanth Venkatraman , Tejal Parekh , Patrick Pinto , Bama Santhanam , F. Njoroge , Ashit Ganguly , Henry Vaccaro , Scott Kemp , Odile Levy , Marguerita Lim-Wilby , Susan Tamura
IPC分类号： C12N9/99 , A61K31/16 , A61K31/195 , A61K31/27 , A61K31/357 , A61K31/385 , A61K31/403 , A61K31/4164 , A61K31/445 , A61K31/7052 , A61K38/00 , A61K38/05 , A61K38/21 , A61K38/55 , A61K45/00 , A61P1/16 , A61P31/12 , A61P31/14 , A61P43/00 , C07C205/51 , C07C229/00 , C07D209/02 , C07K5/02 , C07K5/103 , C07K7/02 , C07K7/04 , C07K7/06 , A61K38/06 , A61K31/165 , A61K38/08
CPC分类号： C07K7/06 , A61K31/16 , A61K31/195 , A61K31/27 , A61K31/357 , A61K31/385 , A61K31/403 , A61K31/4164 , A61K31/445 , A61K38/05 , C07C205/51 , C07K5/101 , C07K7/02 , A61K2300/00
摘要： The present invention discloses novel peptide compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型肽化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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公开(公告)号：US20060252778A1
公开(公告)日：2006-11-09
申请号：US11142601
申请日：2005-06-01
申请人： Zhuyan Guo , Peter Orth , Zhaoning Zhu , Robert Mazzola , Tin-Yau Chan , Henry Vaccaro , Brian McKittrick , Joseph Kozlowski , Brian Lavey , Guowei Zhou , Sunil Paliwal , Shing-Chun Wong , Neng-Yang Shih , Pauline Ting , Kristin Rosner , Gerald Shipps , M. Siddiqui , David Belanger , Chaoyang Dai , Dansu Li , Vinay Girijavallabhan , Janeta Popovici-Muller , Wensheng Yu , Lianyun Zhao
发明人： Zhuyan Guo , Peter Orth , Zhaoning Zhu , Robert Mazzola , Tin-Yau Chan , Henry Vaccaro , Brian McKittrick , Joseph Kozlowski , Brian Lavey , Guowei Zhou , Sunil Paliwal , Shing-Chun Wong , Neng-Yang Shih , Pauline Ting , Kristin Rosner , Gerald Shipps , M. Siddiqui , David Belanger , Chaoyang Dai , Dansu Li , Vinay Girijavallabhan , Janeta Popovici-Muller , Wensheng Yu , Lianyun Zhao
IPC分类号： C07D471/02 , C07D498/02 , A61K31/519 , A61K31/506 , A61K31/4709 , A61K31/43 , A61K31/4245
CPC分类号： C07D409/14 , C07C235/06 , C07C235/08 , C07C235/10 , C07C2601/08 , C07D207/20 , C07D207/26 , C07D209/44 , C07D215/14 , C07D217/06 , C07D263/32 , C07D295/185 , C07D307/52 , C07D333/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF-α or combinations thereof.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂化物或异构体，其可用于治疗由MMP，ADAM，TACE，TNF-α或其组合介导的疾病或病症。
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公开(公告)号：US20110065682A1
公开(公告)日：2011-03-17
申请号：US12993607
申请日：2009-05-18
申请人： Martin C. Clasby , William J. Greenlee , Yan Xia , Tin-Yau Chan , Mariappan V. Chelliah , Samuel Chackalamannil , Haiyan Pu, , Keith A. Eagen , Henry Vaccaro , Brian A. McKittrick, , Liyuan Wang , Xiaobang Gao
发明人： Martin C. Clasby , William J. Greenlee , Yan Xia , Tin-Yau Chan , Mariappan V. Chelliah , Samuel Chackalamannil , Haiyan Pu, , Keith A. Eagen , Henry Vaccaro , Brian A. McKittrick, , Liyuan Wang , Xiaobang Gao
IPC分类号： A61K31/55 , C07D403/14 , A61K31/4184 , C07D413/14 , A61K31/5377 , C07D403/04 , A61K31/4192 , C07D401/14 , A61K31/454 , A61K31/4439 , A61K31/422 , A61K31/506 , A61K31/496 , A61P7/02
CPC分类号： C07D487/04 , C07D231/18 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14
摘要： The present invention relates to novel heterocyclic compounds of Formulae I-III; as disclosed herein or a pharmaceutically acceptable salt, solvate, ester, prodrug or stereoisomer thereof. Also disclosed are pharmaceutical compositions comprising said compounds, and methods for using said compounds for treating or preventing a thromboembolic disorder.
摘要翻译： 本发明涉及式I-III的新型杂环化合物; 如本文所公开的或其药学上可接受的盐，溶剂化物，酯，前药或立体异构体。 还公开了包含所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓栓塞性疾病的方法。
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公开(公告)号：US20080076750A1
公开(公告)日：2008-03-27
申请号：US11854738
申请日：2007-09-13
申请人： Robert Aslanian , Tin-Yau Chan , Joel Harris , Brian McKittrick , Bernard Neustadt , Anandan Palani , Tony Priestley , Elizabeth Smith , Andrew Stamford , Henry Vaccaro , Dong Xiao
发明人： Robert Aslanian , Tin-Yau Chan , Joel Harris , Brian McKittrick , Bernard Neustadt , Anandan Palani , Tony Priestley , Elizabeth Smith , Andrew Stamford , Henry Vaccaro , Dong Xiao
IPC分类号： A61K31/397 , A61P25/04 , A61P3/00
CPC分类号： A61K31/4427 , C07D471/10 , C07D519/00
摘要： The present invention relates to methods for treating or preventing a disorder of lipid metabolism, pain, diabetes, a vascular condition, demyelination or nonalcoholic fatty liver disease, comprising administering a compound having the formula or a pharmaceutically acceptable salt, solvate, ester, prodrug or stereoisomer thereof, wherein: R1 and R2 are defined in Tables 1-6 herein, and R3 is -phenyl, -4-chlorophenyl, -2-pyridyl, or -3-pyridyl.
摘要翻译： 本发明涉及治疗或预防脂质代谢紊乱，疼痛，糖尿病，血管病症，脱髓鞘或非酒精性脂肪性肝病的方法，包括给予具有下式的化合物或其药学上可接受的盐，溶剂合物，酯，前药或 其中：R 1和R 2在本文的表1-6中定义，R 3是 - 苯基， 氯苯基，-2-吡啶基或-3-吡啶基。
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公开(公告)号：US08148363B2
公开(公告)日：2012-04-03
申请号：US12993607
申请日：2009-05-18
申请人： Martin C. Clasby , William J. Greenlee , Yan Xia , Tin-Yau Chan , Mariappan V. Chelliah , Samuel Chackalamannil , Haiyan Pu , Keith A. Eagen , Henry Vaccaro , Brian A. McKittrick , Liyuan Wang , Xiaobang Gao
发明人： Martin C. Clasby , William J. Greenlee , Yan Xia , Tin-Yau Chan , Mariappan V. Chelliah , Samuel Chackalamannil , Haiyan Pu , Keith A. Eagen , Henry Vaccaro , Brian A. McKittrick , Liyuan Wang , Xiaobang Gao
IPC分类号： A61K31/55 , A61K31/4184 , A61K31/5377 , A61K31/4192 , A61K31/454 , A61K31/4439 , A61K31/422 , A61K31/506 , A61K31/496 , A61P7/02 , C07D403/14 , C07D413/14 , C07D403/04 , C07D401/14
CPC分类号： C07D487/04 , C07D231/18 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14
摘要： The present invention relates to novel heterocyclic compounds of Formulae I-III; as disclosed herein or a pharmaceutically acceptable salt, solvate, ester, prodrug or stereoisomer thereof. Also disclosed are pharmaceutical compositions comprising said compounds, and methods for using said compounds for treating or preventing a thromboembolic disorder.
摘要翻译： 本发明涉及式I-III的新型杂环化合物; 如本文所公开的或其药学上可接受的盐，溶剂化物，酯，前药或立体异构体。 还公开了包含所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓栓塞性疾病的方法。
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公开(公告)号：US20080076751A1
公开(公告)日：2008-03-27
申请号：US11854754
申请日：2007-09-13
申请人： Robert Aslanian , Chad Bennett , Duane Burnett , Tin-Yau Chan , Eugenia Kiselgof , Chad Knutson , Joel Harris , Brian McKittrick , Anandan Palani , Elizabeth Smith , Henry Vaccaro , Dong Xiao , Hyunjin Kim
发明人： Robert Aslanian , Chad Bennett , Duane Burnett , Tin-Yau Chan , Eugenia Kiselgof , Chad Knutson , Joel Harris , Brian McKittrick , Anandan Palani , Elizabeth Smith , Henry Vaccaro , Dong Xiao , Hyunjin Kim
IPC分类号： A61K31/397 , A61P25/04 , A61P3/00 , C07D471/10
CPC分类号： C07D471/10
摘要： The present invention relates to Azetidinone Derivatives, compositions comprising an Azetidinone Derivative and methods for treating or preventing a disorder of lipid metabolism, pain, diabetes, a vascular condition, demyelination or nonalcoholic fatty liver disease, comprising administering to a patient an effective amount of an Azetidinone Derivative.
摘要翻译： 本发明涉及氮杂环丁酮衍生物，包含氮杂环丁酮衍生物的组合物和用于治疗或预防脂质代谢紊乱，疼痛，糖尿病，血管病症，脱髓鞘或非酒精性脂肪性肝病的方法，包括向患者施用有效量的 氮杂环丁酮衍生物。
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公开(公告)号：US20130296300A1
公开(公告)日：2013-11-07
申请号：US13996371
申请日：2011-12-19
申请人： Christopher W. Boyce , Salem Fevrier , Kevin D. McCormick , Anandan Palani , Robert G. Aslanian , Phieng Siliphaivanh , Joey L. Methot , William Colby Brown , Henry Vaccaro
发明人： Christopher W. Boyce , Salem Fevrier , Kevin D. McCormick , Anandan Palani , Robert G. Aslanian , Phieng Siliphaivanh , Joey L. Methot , William Colby Brown , Henry Vaccaro
IPC分类号： C07D215/48 , A61K31/4709 , C07D401/06 , C07D401/12 , A61K45/06 , C07D405/12 , C07D401/14 , C07D491/107 , C07D471/04 , A61K31/4375 , A61K31/47 , A61K31/496
CPC分类号： C07D215/48 , A61K31/4375 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K45/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D471/04 , C07D491/107
摘要： The invention provides certain quinolines and aza-quinolines of the Formula (I), and their pharmaceutically acceptable salts, wherein E, J1, Ja, Jb, R2, R3, R22, Ra, Rb, Rc, Rd, X, Y, b, n, and q are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with uncontrolled or inappropriate stimulation of CRTH2 function.
摘要翻译： 本发明提供了式（I）的某些喹啉和氮杂喹啉及其药学上可接受的盐，其中E，J1，Ja，Jb，R2，R3，R22，Ra，Rb，Rc，Rd，X，Y，b ，n和q如本文所定义。 本发明还提供包含这些化合物的药物组合物，以及使用该化合物治疗与不受控制或不适当刺激CRTH2功能相关的疾病或病症的方法。
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公开(公告)号：US20070015774A1
公开(公告)日：2007-01-18
申请号：US11486300
申请日：2006-07-13
IPC分类号： A61K31/517 , C07D409/02 , C07D403/02 , C07D405/02
CPC分类号： C07D239/90 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12
摘要： The present invention provides compounds of Formula I (wherein R1, R2, R3, L, and X are as defined herein). or a pharmaceutically acceptable salt, solvate or ester thereof. The present invention also provides compositions comprising these compounds that are useful for treating cellular proliferative diseases, disorders associated with activity of mutants of p53, or in causing apoptosis of cancer cells.
摘要翻译： 本发明提供式I化合物（其中R 1，R 2，R 3，L和X如本文所定义）。 或其药学上可接受的盐，溶剂合物或酯。 本发明还提供了包含这些化合物的组合物，其可用于治疗细胞增殖性疾病，与p53的突变体的活性相关的病症或引起癌细胞凋亡。
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