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    CHARGED ENTITIES AS LOCOMOTIVE TO CONTROL MOTION OF POLYMERS THROUGH A NANOCHANNEL
    1.
    发明申请
    CHARGED ENTITIES AS LOCOMOTIVE TO CONTROL MOTION OF POLYMERS THROUGH A NANOCHANNEL 有权
    充电实体通过纳米通道控制聚合物的运动

    公开(公告)号：US20130068618A1

    公开(公告)日：2013-03-21

    申请号：US13611662

    申请日：2012-09-12

    申请人： Stefan Harrer ,  Binquan Luan ,  Glenn J. Martyna ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen M. Rossnagel ,  Ajay K. Royyuru ,  Gustavo A. Stolovitzky ,  George F. Walker

    发明人： Stefan Harrer ,  Binquan Luan ,  Glenn J. Martyna ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen M. Rossnagel ,  Ajay K. Royyuru ,  Gustavo A. Stolovitzky ,  George F. Walker

    IPC分类号： C25B15/00 ,  B82Y30/00

    CPC分类号： B82Y15/00 ,  C12Q1/6869 ,  C12Q2565/631

    摘要： A technique for controlling the motion of one or more charged entities linked to a polymer through a nanochannel is provided. A first reservoir and a second reservoir are connected by the nanochannel. An array of electrodes is positioned along the nanochannel, where fluid fills the first reservoir, the second reservoir, and the nanochannel. A first electrode is in the first reservoir and a second electrode is in the second reservoir. The first and second electrodes are configured to direct the one or more charged entities linked to the polymer into the nanochannel. An array of electrodes is configured to trap the one or more charged entities in the nanochannel responsive to being controlled for trapping. The array of electrodes is configured to move the one or more charged entities along the nanochannel responsive to being controlled for moving.

    摘要翻译： 提供了一种用于控制通过纳米通道连接到聚合物的一个或多个带电实体的运动的技术。 第一储存器和第二储存器通过纳米通道连接。 电极阵列沿纳米通道定位，其中流体填充第一储存器，第二储存器和纳米通道。 第一电极在第一储存器中，第二电极位于第二储存器中。 第一和第二电极被配置为将连接到聚合物的一个或多个带电实体引导到纳米通道中。 电极阵列被配置为捕捉纳米通道中的一个或多个带电实体，以响应于被捕获而被控制。 电极阵列被配置为响应于被控制移动而沿着纳米通道移动一个或多个带电实体。

    Charged entities as locomotive to control motion of polymers through a nanochannel
    4.
    发明授权
    Charged entities as locomotive to control motion of polymers through a nanochannel 有权
    充电实体作为机车，以控制聚合物通过纳米通道的运动

    公开(公告)号：US08691067B2

    公开(公告)日：2014-04-08

    申请号：US13234276

    申请日：2011-09-16

    申请人： Stefan Harrer ,  Binquan Luan ,  Glenn J. Martyna ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen M. Rossnagel ,  Ajay k. Royyuru ,  Gustavo A. Stolovitzky ,  George F. Walker

    发明人： Stefan Harrer ,  Binquan Luan ,  Glenn J. Martyna ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen M. Rossnagel ,  Ajay k. Royyuru ,  Gustavo A. Stolovitzky ,  George F. Walker

    IPC分类号： G01N27/26

    CPC分类号： B82Y15/00 ,  C12Q1/6869 ,  C12Q2565/631

    摘要： A technique for controlling the motion of one or more charged entities linked to a polymer through a nanochannel is provided. A first reservoir and a second reservoir are connected by the nanochannel. An array of electrodes is positioned along the nanochannel, where fluid fills the first reservoir, the second reservoir, and the nanochannel. A first electrode is in the first reservoir and a second electrode is in the second reservoir. The first and second electrodes are configured to direct the one or more charged entities linked to the polymer into the nanochannel. An array of electrodes is configured to trap the one or more charged entities in the nanochannel responsive to being controlled for trapping. The array of electrodes is configured to move the one or more charged entities along the nanochannel responsive to being controlled for moving.

    摘要翻译： 提供了一种用于控制通过纳米通道连接到聚合物的一个或多个带电实体的运动的技术。 第一储存器和第二储存器通过纳米通道连接。 电极阵列沿纳米通道定位，其中流体填充第一储存器，第二储存器和纳米通道。 第一电极在第一储存器中，第二电极位于第二储存器中。 第一和第二电极被配置为将连接到聚合物的一个或多个带电实体引导到纳米通道中。 电极阵列被配置为捕捉纳米通道中的一个或多个带电实体，以响应于被捕获而被控制。 电极阵列被配置为响应于被控制移动而沿着纳米通道移动一个或多个带电实体。

    Piezoelectric-based nanopore device for the active control of the motion of polymers through the same
    9.
    发明授权
    Piezoelectric-based nanopore device for the active control of the motion of polymers through the same 有权
    用于主动控制聚合物运动的压电基纳米孔装置

    公开(公告)号：US08039250B2

    公开(公告)日：2011-10-18

    申请号：US12723724

    申请日：2010-03-15

    申请人： Hongbo Peng ,  Gustavo A. Stolovitzky ,  Stephen M. Rossnagel ,  Stanislav Polonsky ,  Binquan Luan ,  Glenn J. Martyna

    发明人： Hongbo Peng ,  Gustavo A. Stolovitzky ,  Stephen M. Rossnagel ,  Stanislav Polonsky ,  Binquan Luan ,  Glenn J. Martyna

    IPC分类号： C12M1/34 ,  C12M3/00

    CPC分类号： C12Q1/6869 ,  Y10T29/42 ,  C12Q2565/631

    摘要： Apparatus, system, and methods are provided for utilizing piezoelectric material for controlling a polymer through a nanopore. A reservoir is formed filled with conductive fluid. A membrane is formed that separates the reservoir. A nanopore is formed through the membrane. The membrane comprises electrical conductive layers, piezoelectric layers, and insulating layers. The piezoelectric layers are operative to control a size of the nanopore for clamping/releasing a polymer as well as to control the thickness of part of the membrane when a voltage is applied to the piezoelectric layers. Combinations of clamping/releasing the polymer and changing the thickness of part of the membrane can move a polymer through the nanopore at any electrically controlled speed and also stretch or break a polymer in the nanopore.

    摘要翻译： 提供了利用压电材料通过纳米孔控制聚合物的装置，系统和方法。 形成填充有导电流体的储存器。 形成隔离储存器的膜。 通过膜形成纳米孔。 膜包括导电层，压电层和绝缘层。 压电层可操作以控制用于夹紧/释放聚合物的纳米孔的尺寸，以及当向压电层施加电压时控制膜的一部分的厚度。 夹持/释放聚合物和改变膜的一部分厚度的组合可以以任何电控速度移动聚合物通过纳米孔，并且还拉伸或破坏纳米孔中的聚合物。