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公开(公告)号：US5641518A
公开(公告)日：1997-06-24
申请号：US386432
申请日：1995-02-10
申请人： Stephen F. Badylak , Sherry Voytik
发明人： Stephen F. Badylak , Sherry Voytik
CPC分类号： A61L27/3683 , A61F2/28 , A61K35/38 , A61L27/3629 , A61L27/365 , A61F2002/2835 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61L2430/02
摘要： A method for repairing damaged or diseased bone is described. The method comprises the step of implanting into the damaged or diseased region a bone graft composition in powder form, the composition comprising the tunica submucosa delaminated from the tunica muscularis and at least the luminal portion of the tunica mucosa of a segment of vertebrate intestine.
摘要翻译： 描述了修复受损或患病骨的方法。 该方法包括以下步骤：向粉碎或患病区域注入粉末形式的骨移植组合物，所述组合物包括从肌层剥离的粘膜下粘膜和至少脊椎动物肠段的中膜粘膜的腔内部分。
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2.发明授权
公开(公告)号：US5516533A
公开(公告)日：1996-05-14
申请号：US343204
申请日：1994-11-22
IPC分类号： A61F2/02 , A61F2/28 , A61F2/30 , A61F2/38 , A61F2/44 , A61K35/38 , A61L27/00 , A61L27/36 , A61P3/00 , A61P43/00
CPC分类号： A61L27/3695 , A61F2/28 , A61K35/38 , A61L27/3629 , A61L27/3645 , A61L27/365 , A61L27/367 , A61L27/3683 , A61L27/3691 , A61F2002/2835 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61L2400/06
摘要： A fluidized, injectable tissue graft composition is described. The composition comprises comminuted intestinal submucosa or protease-digested intestinal submucosa. Methods for the preparation and use of injectable tissue graft compositions are described. In preferred embodiments the tissue graft material is prepared from the intestinal submucosa comprising the tunica submucosa, the muscularis mucosa and the stratum compactum of a segment of intestinal tissue of a warm-blooded vertebrate. Effective amounts of the fluidized graft compositions can be injected to promote repair tissue defects by inducing formation of endogenous tissues.
摘要翻译： 描述流化的，可注射的组织移植组合物。 组合物包括粉碎的肠粘膜下层或蛋白酶消化的肠粘膜下层。 描述了可注射组织移植组合物的制备和使用方法。 在优选的实施方案中，组织移植材料由包括粘膜下层的粘膜下层，温带脊椎动物的肠组织段的肌层粘膜和层压的肠粘膜下层制备。 可以注射有效量的流化接枝组合物以通过诱导内源性组织的形成来促进修复组织缺陷。
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公开(公告)号：US06653291B1
公开(公告)日：2003-11-25
申请号：US08390700
申请日：1995-02-17
IPC分类号： A01N4304
CPC分类号： A61K48/0025 , A61F2/28 , A61F2002/2835 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61K35/38 , A61K48/00 , A61L27/3629
摘要： A composition useful for the production of transformed eukaryotic cells is described. The composition comprises submucosal tissue and a nucleic acid sequence. The nucleic acid sequence is typically recombinant DNA including gene(s) encoding for one or more biofunctional proteins. Injection or implantation of the composition into a host induces the formation of transformed cells capable of expressing gene(s) encoded by the nucleic acid sequence.
摘要翻译： 描述了可用于生产转化真核细胞的组合物。 组合物包含粘膜下组织和核酸序列。 核酸序列通常是包含编码一种或多种生物功能蛋白质的基因的重组DNA。 将组合物注入或植入宿主中诱导能够表达由核酸序列编码的基因的转化细胞的形成。
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公开(公告)号：US06485723B1
公开(公告)日：2002-11-26
申请号：US09566497
申请日：2000-05-08
IPC分类号： A61K500
CPC分类号： A61L27/3808 , A61K35/38 , A61K35/44 , A61L27/3604 , A61L27/3629 , A61L27/3641 , A61L27/3683 , A61L27/3839 , C12N5/0068 , C12N5/0655 , C12N5/0676 , C12N5/0679 , C12N2500/32 , C12N2500/38 , C12N2533/92 , A61K2300/00
摘要： An improved tissue graft construct comprising submucosa of a warm-blooded vertebrate and a preselected group of eukaryotic cells are described. The improved tissue graft constructs can be used in accordance with the present invention to enhance the repair of damaged or diseased tissues in vivo.
摘要翻译： 描述了包括温血脊椎动物的粘膜下层和预选的真核细胞组的改进的组织移植物构建体。 可以根据本发明使用改进的组织移植物构建体，以增强体内受损或患病组织的修复。
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公开(公告)号：US5695998A
公开(公告)日：1997-12-09
申请号：US386452
申请日：1995-02-10
申请人： Stephen F. Badylak , George Boder , Sherry Voytik , Robert J. Demeter , John Critser , Chi Liu
发明人： Stephen F. Badylak , George Boder , Sherry Voytik , Robert J. Demeter , John Critser , Chi Liu
CPC分类号： C12N5/0655 , C12M23/34 , C12M25/02 , C12N5/0068 , C12N5/0676 , C12N5/0679 , C12N2500/32 , C12N2500/38 , C12N2533/92 , Y10S623/915
摘要： A cell culture growth substrate comprising submucosal tissue of a warm-blooded vertebrate and a method for culturing eukaryotic cells are described. Submucosal tissue used in accordance with the present invention supports the proliferation and differentiation of eukaryotic cells when said cells are contacted with submucosal tissue under conditions conducive to cell proliferation.
摘要翻译： 描述了包含温血脊椎动物的粘膜下组织的细胞培养生长底物和培养真核细胞的方法。 根据本发明使用的粘膜下组织当所述细胞在有利于细胞增殖的条件下与粘膜下组织接触时，支持真核细胞的增殖和分化。
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公开(公告)号：US07820634B2
公开(公告)日：2010-10-26
申请号：US11799724
申请日：2007-05-02
CPC分类号： A61K48/0025 , A61F2/28 , A61F2002/2835 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61K35/38 , A61K48/00 , A61L27/3629
摘要： A composition useful for the production of transformed eukaryotic cells is described. The composition comprises submucosal tissue and a nucleic acid sequence. The nucleic acid sequence is typically recombinant DNA including gene(s) encoding for one or more biofunctional proteins. The submucosal tissue component of the present composition comprises the tunica submucosa of vertebrate intestine delaminated from the tunica muscularis and at least the luminal portion of the tunica mucosa. Injection or implantation of the composition into a host induces the formation of transformed cells capable of expressing gene(s) encoded by the nucleic acid sequence.
摘要翻译： 描述了可用于生产转化真核细胞的组合物。 组合物包含粘膜下组织和核酸序列。 核酸序列通常是包含编码一种或多种生物功能蛋白质的基因的重组DNA。 本发明组合物的粘膜下组织组分包括从肌层剥离的脊椎动物肠的粘膜下膜和至少中膜粘膜的腔内部分。 将组合物注入或植入宿主中诱导能够表达由核酸序列编码的基因的转化细胞的形成。
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公开(公告)号：US07771717B2
公开(公告)日：2010-08-10
申请号：US11705847
申请日：2007-02-13
IPC分类号： A61L27/00
CPC分类号： A61L27/3808 , A61K35/38 , A61K35/44 , A61L27/3604 , A61L27/3629 , A61L27/3641 , A61L27/3683 , A61L27/3839 , C12N5/0068 , C12N5/0655 , C12N5/0676 , C12N5/0679 , C12N2500/32 , C12N2500/38 , C12N2533/92 , A61K2300/00
摘要： An improved tissue graft construct comprising submucosa of a warm-blooded vertebrate and a preselected group of eukaryotic cells are described. The improved tissue graft constructs can be used in accordance with the present invention to enhance the repair of damaged or diseased tissues in vivo.
摘要翻译： 描述了包括温血脊椎动物的粘膜下层和预选的真核细胞组的改进的组织移植物构建体。 可以根据本发明使用改进的组织移植物构建体，以增强体内受损或患病组织的修复。
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公开(公告)号：US5866414A
公开(公告)日：1999-02-02
申请号：US530002
申请日：1995-09-19
申请人： Stephen F. Badylak , Sherry Voytik , George Boder
发明人： Stephen F. Badylak , Sherry Voytik , George Boder
CPC分类号： C12N5/0655 , C12M23/34 , C12M25/02 , C12N5/0068 , C12N5/0676 , C12N5/0679 , C12N2500/32 , C12N2500/38 , C12N2533/92 , Y10S623/915
摘要： A cell culture growth substrate comprising submucosal tissue of a warm-blooded vertebrate and a method for culturing eukaryotic cells are described. Submucosal tissue used in accordance with the present invention supports the proliferation and differentiation of eukaryotic cells when said cells are contacted with submucosal tissue under conditions conducive to cell proliferation.
摘要翻译： 描述了包含温血脊椎动物的粘膜下组织的细胞培养生长底物和培养真核细胞的方法。 根据本发明使用的粘膜下组织当所述细胞在有利于细胞增殖的条件下与粘膜下组织接触时，支持真核细胞的增殖和分化。
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9.发明授权Method for enhancing functional properties of submucosal tissue graft constructs 失效增强粘膜下组织移植物结构功能特性的方法
公开(公告)号：US5753267A
公开(公告)日：1998-05-19
申请号：US530001
申请日：1995-09-19
申请人： Stephen F. Badylak , Sherry Voytik
发明人： Stephen F. Badylak , Sherry Voytik
CPC分类号： C12N5/0655 , C12M23/34 , C12M25/02 , C12N5/0068 , C12N5/0676 , C12N5/0679 , C12N2500/32 , C12N2500/38 , C12N2533/92 , Y10S623/915
摘要： A tissue graft construct comprising submucosal tissue of a warm-blooded vertebrate and a proliferating population of cells is described. The submucosal graft constructs used in accordance with the present invention induce host tissue proliferation, remodeling and regeneration of appropriate tissue structures upon implantation in a host.
摘要翻译： 描述了包含温血脊椎动物的粘膜下组织和增殖细胞群的组织移植物构建体。 根据本发明使用的粘膜下移植物构建体在植入宿主体内诱导宿主组织增殖，重塑和适当组织结构的再生。
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公开(公告)号：US20110165126A1
公开(公告)日：2011-07-07
申请号：US12852897
申请日：2010-08-09
CPC分类号： A61L27/3808 , A61K35/38 , A61K35/44 , A61L27/3604 , A61L27/3629 , A61L27/3641 , A61L27/3683 , A61L27/3839 , C12N5/0068 , C12N5/0655 , C12N5/0676 , C12N5/0679 , C12N2500/32 , C12N2500/38 , C12N2533/92 , A61K2300/00
摘要： An improved tissue graft construct comprising submucosa of a warm-blooded vertebrate and a preselected group of eukaryotic cells are described. The improved tissue graft constructs can be used in accordance with the present invention to enhance the repair of damaged or diseased tissues in vivo.
摘要翻译： 描述了包括温血脊椎动物的粘膜下层和预选的真核细胞组的改进的组织移植物构建体。 可以根据本发明使用改进的组织移植物构建体，以增强体内受损或患病组织的修复。
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