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公开(公告)号：US20050069966A1
公开(公告)日：2005-03-31
申请号：US10813336
申请日：2004-03-29
申请人： Stephen Grimes , John Little , Lorraine McLoughlin
发明人： Stephen Grimes , John Little , Lorraine McLoughlin
IPC分类号： C07K16/26 , G01N33/53 , G01N33/537 , G01N33/543 , G01N33/68 , G01N33/74
CPC分类号： G01N33/6893 , G01N33/74 , G01N2333/595
摘要： The invention provides assay methods for the detection and quantitation of gastrin hormones, including total and free gastrin hormone in a sample. ELISA-type heterogeneous phase assays suitable for use with biological fluid samples such as blood, plasma or other bodily fluids of a mammal, particularly a human subject are provided. The method provides a precise assay for the amounts of free and total G17 and G34 in biological fluid samples, as well as the amounts of free and total Gly-extended G17, and Gly-extended G34. Also provided are methods of determining suitable treatment for patient suffering from a gastrin hormone-mediated disease or condition employing gastrin hormone immunoassays.
摘要翻译： 本发明提供了用于检测和定量胃泌素激素的测定方法，包括样品中的总的和游离的胃泌素激素。 提供了适用于哺乳动物，特别是人类受试者的生物流体样品如血液，血浆或其它体液的ELISA型异相测定。 该方法提供了生物流体样品中游离和总G17和G34的量的精确测定，以及游离和总Gly扩展的G17和Gly延伸的G34的量。 还提供了确定患有胃泌素激素介导的疾病或使用胃泌素激素免疫测定的病症的患者的适合治疗的方法。
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公开(公告)号：US07964371B2
公开(公告)日：2011-06-21
申请号：US11800889
申请日：2007-05-07
申请人： Stephen Grimes , John Little , Lorraine McLoughlin
发明人： Stephen Grimes , John Little , Lorraine McLoughlin
IPC分类号： G01N33/53 , G01N33/537 , G01N33/543
CPC分类号： G01N33/6893 , G01N33/74 , G01N2333/595
摘要： The invention provides assay methods for the detection and quantitation of gastrin hormones, including total and free gastrin hormone in a sample. ELISA-type heterogeneous phase assays suitable for use with biological fluid samples such as blood, plasma or other bodily fluids of a mammal, particularly a human subject are provided. The method provides a precise assay for the amounts of free and total G17 and G34 in biological fluid samples, as well as the amounts of free and total Gly-extended G17, and Gly-extended G34. Also provided are methods of determining suitable treatment for patient suffering from a gastrin hormone-mediated disease or condition employing gastrin hormone immunoassays.
摘要翻译： 本发明提供了用于检测和定量胃泌素激素的测定方法，包括样品中的总的和游离的胃泌素激素。 提供了适用于哺乳动物，特别是人类受试者的生物流体样品如血液，血浆或其它体液的ELISA型异相测定。 该方法提供了生物流体样品中游离和总G17和G34的量的精确测定，以及游离和总Gly扩展的G17和Gly延伸的G34的量。 还提供了确定患有胃泌素激素介导的疾病或使用胃泌素激素免疫测定的病症的患者的适合治疗的方法。
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公开(公告)号：US20070249005A1
公开(公告)日：2007-10-25
申请号：US11800889
申请日：2007-05-07
申请人： Stephen Grimes , John Little , Lorraine McLoughlin
发明人： Stephen Grimes , John Little , Lorraine McLoughlin
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N33/74 , G01N2333/595
摘要： The invention provides assay methods for the detection and quantitation of gastrin hormones, including total and free gastrin hormone in a sample. ELISA-type heterogeneous phase assays suitable for use with biological fluid samples such as blood, plasma or other bodily fluids of a mammal, particularly a human subject are provided. The method provides a precise assay for the amounts of free and total G17 and G34 in biological fluid samples, as well as the amounts of free and total Gly-extended G17, and Gly-extended G34. Also provided are methods of determining suitable treatment for patient suffering from a gastrin hormone-mediated disease or condition employing gastrin hormone immunoassays.
摘要翻译： 本发明提供了用于检测和定量胃泌素激素的测定方法，包括样品中的总的和游离的胃泌素激素。 提供了适用于哺乳动物，特别是人类受试者的生物流体样品如血液，血浆或其它体液的ELISA型异相测定。 该方法提供了生物流体样品中游离和总G17和G34的量的精确测定，以及游离和总Gly扩展的G17和Gly延伸的G34的量。 还提供了确定患有胃泌素激素介导的疾病或使用胃泌素激素免疫测定的病症的患者的适合治疗的方法。
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公开(公告)号：US07235376B2
公开(公告)日：2007-06-26
申请号：US10813336
申请日：2004-03-29
申请人： Stephen Grimes , John Little , Lorraine McLoughlin
发明人： Stephen Grimes , John Little , Lorraine McLoughlin
IPC分类号： G01N33/53 , G01N33/537 , G01N33/543 , C07K16/00
CPC分类号： G01N33/6893 , G01N33/74 , G01N2333/595
摘要： The invention provides assay methods for the detection and quantitation of gastrin hormones, including total and free gastrin hormone in a sample. ELISA-type heterogeneous phase assays suitable for use with biological fluid samples such as blood, plasma or other bodily fluids of a mammal, particularly a human subject are provided. The method provides a precise assay for the amounts of free and total G17 and G34 in biological fluid samples, as well as the amounts of free and total Gly-extended G17, and Gly-extended G34. Also provided are methods of determining suitable treatment for patient suffering from a gastrin hormone-mediated disease or condition employing gastrin hormone immunoassays.
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公开(公告)号：US20120219605A1
公开(公告)日：2012-08-30
申请号：US13505971
申请日：2010-11-05
申请人： Peter Blackburn , Stephen Grimes
发明人： Peter Blackburn , Stephen Grimes
IPC分类号： A61K9/107 , A61J1/00 , A61P31/16 , A61K39/145 , A61P37/04
CPC分类号： A61K39/145 , A61K39/12 , A61K39/39 , A61K2039/55555 , A61K2039/55566 , A61K2039/58 , A61K2039/70 , C12N2760/16134 , C12N2760/16234
摘要： Vaccine compositions comprising influenza antigens formulated as nanoparticulate water in oil miniemulsions. The vaccines may be formulated at the point of use and are useful in emergency response conditions.
摘要翻译： 包含流感抗原的疫苗组合物，其被配制为纳米颗粒水中的微型乳状液。 疫苗可以在使用时配制，并且在紧急反应条件下有用。
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公开(公告)号：US20070066809A1
公开(公告)日：2007-03-22
申请号：US11499261
申请日：2006-08-03
申请人： Stephen Grimes , Ronald Makishima
发明人： Stephen Grimes , Ronald Makishima
IPC分类号： C07K16/00
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/34 , C07K2317/73 , G01N33/577 , G01N33/74 , G01N2333/595
摘要： The present invention provides monoclonal antibodies (MAbs) selective for the N-termini and C-termini of the gastrin hormone forms, gastrin-17 (G17), glycine-extended gastrin-17 (G17-Gly), gastrin-34 (G34) and glycine-extended gastrin-34 (G34-Gly); and the hybridomas that produce these MAbs. Also provided are panels of MAbs useful for the detection and quantitation of gastrin-17 (G17), glycine-extended gastrin-17 (G17-Gly), gastrin-34 (G34) and glycine-extended gastrin-34 (G34-Gly). These assays are useful for monitoring a gastrin-mediated disease or condition, or for monitoring the progress of a course of therapy. The invention further provides solid phase assays including immunohistochemical (IHC) and immunofluorescence (IF) assays suitable for detection and visualization of gastrin species in solid samples, such as biopsy samples or tissue slices. Pharmaceutical compositions of the MAbs of the invention are also provided, along with methods of diagnosis, prevention and treatment of gastrin-mediated diseases or conditions. Methods of evaluating a gastrin hormone-blocking treatment are described. The course of a gastrin-mediated disease or condition may be monitored in a patient by means of assay methods provided.
摘要翻译： 本发明提供对胃泌素激素形式的N-末端和C-末端选择性的单克隆抗体（MAb），胃泌素-17（G17），甘氨酸延长胃泌素-17（G17-Gly），胃泌素-34（G34） 和甘氨酸延长胃泌素-34（G34-Gly）; 和产生这些MAb的杂交瘤。 还提供了可用于检测和定量胃泌素-17（G17），甘氨酸延长胃泌素-17（G17-Gly），胃泌素-34（G34）和甘氨酸延长胃泌素-34（G34-Gly） 。 这些测定法可用于监测胃泌素介导的疾病或病症，或用于监测治疗过程的进展。 本发明进一步提供固相测定法，包括免疫组织化学（IHC）和免疫荧光（IF）测定法，其适于检测和可视化固体样品例如活检样本或组织切片中的胃泌素种类。 还提供本发明的MAb的药物组合物以及胃泌素介导的疾病或病症的诊断，预防和治疗的方法。 描述了评估胃泌素激素阻断治疗的方法。 胃泌素介导的疾病或病症的过程可以通过提供的测定方法在患者体内监测。
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公开(公告)号：US20070065454A1
公开(公告)日：2007-03-22
申请号：US11489775
申请日：2006-07-20
CPC分类号： A61K38/24 , A61K9/127 , A61K38/09 , A61K38/2207 , A61K38/27 , A61K39/0005 , A61K2039/55555 , A61K2039/6031
摘要： The invention provides liposomal vehicles for encapsulating relatively high levels of water-soluble substances including immunogens directed against gastrin and gonadotropin releasing hormone. The liposome encapsulating large amounts of immunogens can be injected parentally to induce effective immune responses without exhibiting significant adverse tissue reactogenicity.
摘要翻译： 本发明提供用于包封相对高水平的水溶性物质的脂质体载体，包括针对胃泌素和促性腺激素释放激素的免疫原。 包封大量免疫原的脂质体可以亲本注射以诱导有效的免疫应答，而不显示显着的不利组织反应原性。
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公开(公告)号：US06359114B1
公开(公告)日：2002-03-19
申请号：US08484740
申请日：1995-06-07
IPC分类号： C07K114
CPC分类号： B01D61/145 , B01J19/0046 , B01J2219/00283 , B01J2219/00355 , B01J2219/00479 , B01J2219/00725 , C07K1/02 , C07K1/34 , C40B40/10 , C40B60/14
摘要： A system is described for conjugating, isolating, and purifying proteins. The system contains an ultrafiltration apparatus which is connected with a reaction vessel reservoir.
摘要翻译： 描述了用于共轭，分离和纯化蛋白质的系统。 该系统包含与反应容器储存器连接的超滤装置。
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9.发明授权Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease 失效用于治疗和预防胃和十二指肠溃疡疾病的免疫原性组合物和方法
公开(公告)号：US5622702A
公开(公告)日：1997-04-22
申请号：US219773
申请日：1994-03-30
CPC分类号： A61K39/0005 , C07K14/595 , C07K16/26 , A61K2039/6037 , A61K2039/627 , C07K2317/34
摘要： Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric hormones and inhibit the binding of the hormones to physiological receptors thus limiting the secretion of stomach acid. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are also disclosed.
摘要翻译： 公开了可用于治疗或预防胃或十二指肠溃疡疾病的免疫原性组合物。 免疫原性组合物通过在受试者中诱导抗体有效地起作用，所述抗体选择性中和特异性肽胃激素并抑制激素与生理受体的结合，从而限制胃酸的分泌。 还公开了包含有效量的免疫原性组合物和使用组合物的治疗方法的药物组合物。
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10.发明授权公开(公告)号：US09498522B2
公开(公告)日：2016-11-22
申请号：US13057952
申请日：2009-08-06
申请人： Peter Blackburn , Stephen Grimes
发明人： Peter Blackburn , Stephen Grimes
IPC分类号： A61K39/385 , A61K39/39 , A61K39/00
CPC分类号： A61K39/0007 , A61K2039/55566 , A61K2039/6037 , A61K2039/6081 , Y02A50/466
摘要： A safe and effective vaccine to prevent, slow, halt or reverse progression of Alzheimer's disease in human patients is disclosed. The vaccine includes Aβ1-42 or an beta amyloid self epitope (e.g. Aβ1-15, or other 7-mer or 15-mer peptide epitopes derived from Aβ1-42) conjugated to an immunogenic carrier (e.g. DT) formulated in a water-in-oil Th2-biased adjuvant/delivery system.
摘要翻译： 公开了一种安全有效的预防，缓慢，停止或逆转老年痴呆症进展的疫苗。 疫苗包括与在水中配制的免疫原性载体（例如DT）缀合的Aβ1-42或β淀粉样蛋白自身表位（例如Aβ1-15或衍生自Aβ1-42的其他7-聚体或15聚体肽表位） - Th2偏向的辅助/输送系统。
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