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公开(公告)号：US06927056B2
公开(公告)日：2005-08-09
申请号：US10363937
申请日：2001-09-06
申请人： Stephen Todd , Angelo M. Delegeane , Ameena R. Gandhi , Danniel B. Nguyen , April J. A. Hafalia , Liam Kearney , Yan Lu , Ernestine A. Lee , Narinder K. Chawla , Debopriya Das , Chandra S. Arvizu , Monique G. Yao , Deborah A. Kallick , Vicki S. Elliott , Li Ding , Henry Yue , Roopa M. Reddy , Dyung Aina M. Lu , Jayalaxmi Ramkumar , Junming Yang , Catherine M. Tribouley , Neil Burford , Mariah R. Baughn , Preeti G. Lal , Mark L. Borowsky , Farrah A. Khan , Rajagopal Gururajan , Y. Tom Tang , Janice K. Au-Young , Bridget A. Warren , Roberto Hernandez , Brendan M. Duggan
发明人： Stephen Todd , Angelo M. Delegeane , Ameena R. Gandhi , Danniel B. Nguyen , April J. A. Hafalia , Liam Kearney , Yan Lu , Ernestine A. Lee , Narinder K. Chawla , Debopriya Das , Chandra S. Arvizu , Monique G. Yao , Deborah A. Kallick , Vicki S. Elliott , Li Ding , Henry Yue , Roopa M. Reddy , Dyung Aina M. Lu , Jayalaxmi Ramkumar , Junming Yang , Catherine M. Tribouley , Neil Burford , Mariah R. Baughn , Preeti G. Lal , Mark L. Borowsky , Farrah A. Khan , Rajagopal Gururajan , Y. Tom Tang , Janice K. Au-Young , Bridget A. Warren , Roberto Hernandez , Brendan M. Duggan
IPC分类号： A01K67/00 , C07H21/04 , C12N9/64 , C12N15/09 , C12P21/06 , C12Q1/68 , C12N1/20 , C12N15/00 , C12N15/63
CPC分类号： C12N9/6421 , A01K2217/05 , A01K2217/075 , C07H21/04 , C12N9/6472 , C12Q1/6837 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , Y02A50/52
摘要： The invention provides a human cysteine proteases and polynucleotides which encode those proteases. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists, as well as methods for diagnosing, treating, or preventing disorders associated with aberrant expression of cysteine proteases.
摘要翻译： 本发明提供编码这些蛋白酶的人半胱氨酸蛋白酶和多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂，以及用于诊断，治疗或预防与半胱氨酸蛋白酶异常表达相关的紊乱的方法。
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公开(公告)号：US06303297B1
公开(公告)日：2001-10-16
申请号：US08969987
申请日：1997-11-13
申请人： Steve E. Lincoln , Tod M. Klingler , Janice Au-Young , Y. Tom Tang , Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Phillip R. Hawkins , Lynn E. Murry , Angelo M. Delegeane , Wendy B. Levine , Jennifer L. Hillman , Surya K. Goli , Christina M. Altus , Olga Bandman , Samuel T. LaBrie , Purvi Shah
发明人： Steve E. Lincoln , Tod M. Klingler , Janice Au-Young , Y. Tom Tang , Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Phillip R. Hawkins , Lynn E. Murry , Angelo M. Delegeane , Wendy B. Levine , Jennifer L. Hillman , Surya K. Goli , Christina M. Altus , Olga Bandman , Samuel T. LaBrie , Purvi Shah
IPC分类号： C12Q168
CPC分类号： C12N9/6445 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K14/82 , C07K16/303 , C12Q1/68 , C12Q1/6809 , G01N33/574 , G06F19/18 , G06F19/22 , G06F19/28
摘要： The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.
摘要翻译： 本发明是用于遗传信息和相关注释信息的计算机化存储和检索系统。 系统的数据存储在与公共数据库接口的关系数据库中，以便在本发明的数据库内以及该数据库内的信息和外部公共数据库之间进行分析。 序列数据在进入系统之前进行编辑，并存储在策略化的功能集群组织中。 与数据相关联的信息存储在链接到序列数据的存储的表达式数据库中。
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公开(公告)号：US5808001A
公开(公告)日：1998-09-15
申请号：US900491
申请日：1997-07-25
IPC分类号： C12N15/09 , C07K16/40 , C12N1/21 , C12N9/64 , C12N15/00 , C12N15/57 , C12P21/08 , C12Q1/68 , C12R1/91 , C07K16/00
CPC分类号： C12N9/6475
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a new human interleukin-1 converting enzyme homolog (ICEY). The present invention also provides for antisense molecules to the nucleotide sequences which encode ICEY, expression vectors for the production of purified ICEY, antibodies capable of binding specifically to ICEY, hybridization probes or oligonucleotides for the detection of ICEY-encoding nucleotide sequences, genetically engineered host cells for the expression of ICEY, diagnostic tests for activation of monocyte/macrophages based on ICEY-encoding nucleic acid molecules, and use of the protein to produce antibodies capable of binding specifically to the protein and use of the protein to screen for inhibitors.
摘要翻译： 本发明提供鉴定和编码新的人白细胞介素-1转换酶同源物（ICEY）的核苷酸和氨基酸序列。 本发明还提供编码ICEY的核苷酸序列的反义分子，用于产生纯化的ICEY的表达载体，能够特异性结合ICEY的抗体，用于检测ICEY编码核苷酸序列的杂交探针或寡核苷酸，遗传工程化宿主 用于表达ICEY的细胞，用于基于编码ICEY编码核酸分子的单核细胞/巨噬细胞活化的诊断试验，以及使用该蛋白质产生能够特异性结合该蛋白质的抗体并使用蛋白质筛选抑制剂。
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公开(公告)号：US5738991A
公开(公告)日：1998-04-14
申请号：US568031
申请日：1995-12-06
CPC分类号： C12N9/6424 , A61K38/00
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a human homolog of rat elastase IV (HEIV) expressed in pancreas tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode HEIV, hybridization probes or oligonucleotides for the detection of HEIV-encoding nucleotide sequences, and a diagnostic test based on HEIV-encoding nucleic acid molecules. The present invention further provides for genetically engineered host cells for the expression of HEIV, biologically active HEIV, antibodies capable for binding specifically to HEIV, and treatment methods comprising administration of compounds, such antibodies or inhibitors, capable of binding HEIV to alter its activity.
摘要翻译： 本发明提供了鉴定和编码在胰腺组织中表达的大鼠弹性蛋白酶IV（HEIV）的人同源物的核苷酸和氨基酸序列。 本发明还提供编码用于检测编码HEIV的核苷酸序列的HEIV，杂交探针或寡核苷酸的核苷酸序列的反义分子，以及基于编码HEIV的核酸分子的诊断测试。 本发明还提供用于表达HEIV，生物活性HEIV，能够特异性结合HEIV的抗体的基因工程宿主细胞，以及包含能够结合HEIV以改变其活性的化合物，例如抗体或抑制剂的治疗方法。
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公开(公告)号：US5840562A
公开(公告)日：1998-11-24
申请号：US928613
申请日：1997-09-12
CPC分类号： C12N9/6472
摘要： The present invention provides a polynucleotide (ncp) which identifies and encodes a novel cysteine protease (NCP) expressed in cells of both the adrenal gland and human umbilical vein endothelium. The present invention also provides for antisense molecules and oligomers designed from the nucleotide sequence or its antisense. The invention further provides genetically engineered expression vectors and host cells for the production of purified NCP peptide, antibodies capable of binding to NCP, inhibitors which bind to NCP and pharmaceutical compositions based on NCP specific antibodies or inhibitors. The invention specifically provides for diagnostic assays based on altered ncp expression and which allow identification of such a condition. These assays utilize probes designed from ncp encoding or controlling nucleic acid sequences or antibodies specific for the NCP.
摘要翻译： 本发明提供了鉴定和编码在肾上腺和人脐静脉内皮的细胞中表达的新型半胱氨酸蛋白酶（NCP）的多核苷酸（ncp）。 本发明还提供由核苷酸序列或其反义设计的反义分子和寡聚体。 本发明进一步提供用于产生纯化的NCP肽，能够结合NCP的抗体，结合NCP的抑制剂和基于NCP特异性抗体或抑制剂的药物组合物的遗传工程表达载体和宿主细胞。 本发明特别提供了基于改变的ncp表达并允许鉴定这种病症的诊断测定法。 这些测定使用从ncp编码或控制核酸序列或针对NCP特异的抗体设计的探针。
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公开(公告)号：US5654146A
公开(公告)日：1997-08-05
申请号：US443865
申请日：1995-05-31
IPC分类号： C12N15/09 , C07K16/40 , C12N1/21 , C12N9/64 , C12N15/00 , C12N15/57 , C12P21/08 , C12Q1/68 , C12R1/91 , C12N9/00 , C12N15/12 , G01N33/573
CPC分类号： C12N9/6475
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a new human interleukin-1 converting enzyme homolog (ICEY). The present invention also provides for expression vectors for the production of purified ICEY, hybridization probes for the detection of ICEY-encoding nucleotide sequences, genetically engineered host cells for the expression of ICEY, diagnostic tests for ICEY or for polynucleotides encoding ICEY, and use of the protein to produce antibodies capable of binding specifically to the protein and use of the protein to screen for inhibitors.
摘要翻译： 本发明提供鉴定和编码新的人白细胞介素-1转换酶同源物（ICEY）的核苷酸和氨基酸序列。 本发明还提供用于产生纯化的ICEY的表达载体，用于检测编码ICEY的核苷酸序列的杂交探针，用于表达ICEY的遗传工程化宿主细胞，用于ICEY的ICEY诊断试验或用于编码ICEY的多核苷酸的用途 该蛋白质产生能够特异性结合蛋白质的抗体并使用蛋白质筛选抑制剂。
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7.发明授权
公开(公告)号：US6030791A
公开(公告)日：2000-02-29
申请号：US153304
申请日：1998-09-15
申请人： Scott M. Braxton , Dinh Diep , Angelo M. Delegeane
发明人： Scott M. Braxton , Dinh Diep , Angelo M. Delegeane
IPC分类号： A61K38/00 , C12N9/64 , G01N33/53 , A61K39/395 , C07K14/52
CPC分类号： C12N9/6424 , A61K38/00
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a human homolog of rat elastase IV (HEIV) expressed in pancreas tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode HEIV, hybridization probes or oligonucleotides for the detection of HEIV-encoding nucleotide sequences, and a diagnostic test based on HEIV-encoding nucleic acid molecules. The present invention further provides for genetically engineered host cells for the expression of HEIV, biologically active HEIV, antibodies capable for binding specifically to HEIV, and treatment methods comprising administration of compounds, such antibodies or inhibitors, capable of binding HEIV to alter its activity.
摘要翻译： 本发明提供了鉴定和编码在胰腺组织中表达的大鼠弹性蛋白酶IV（HEIV）的人同源物的核苷酸和氨基酸序列。 本发明还提供编码用于检测编码HEIV的核苷酸序列的HEIV，杂交探针或寡核苷酸的核苷酸序列的反义分子，以及基于编码HEIV的核酸分子的诊断测试。 本发明还提供用于表达HEIV，生物活性HEIV，能够特异性结合HEIV的抗体的基因工程宿主细胞，以及包含能够结合HEIV以改变其活性的化合物，例如抗体或抑制剂的治疗方法。
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公开(公告)号：US6007997A
公开(公告)日：1999-12-28
申请号：US193524
申请日：1998-11-17
CPC分类号： C12N9/6472
摘要： The present invention provides a polynucleotide (ncp) which identifies and encodes a novel cysteine protease (NCP) expressed in cells of both the adrenal gland and human umbilical vein endothelium. The present invention also provides for antisense molecules and oligomers designed from the nucleotide sequence or its antisense. The invention further provides genetically engineered expression vectors and host cells for the production of purified NCP peptide, antibodies capable of binding to NCP, inhibitors which bind to NCP and pharmaceutical compositions based on NCP specific antibodies or inhibitors. The invention specifically provides for diagnostic assays based on altered ncp expression and which allow identification of such a condition. These assays utilize probes designed from ncp encoding or controlling nucleic acid sequences or antibodies specific for the NCP.
摘要翻译： 本发明提供了鉴定和编码在肾上腺和人脐静脉内皮的细胞中表达的新型半胱氨酸蛋白酶（NCP）的多核苷酸（ncp）。 本发明还提供由核苷酸序列或其反义设计的反义分子和寡聚体。 本发明进一步提供用于产生纯化的NCP肽，能够结合NCP的抗体，结合NCP的抑制剂和基于NCP特异性抗体或抑制剂的药物组合物的遗传工程表达载体和宿主细胞。 本发明特别提供了基于改变的ncp表达并允许鉴定这种病症的诊断测定法。 这些测定使用从ncp编码或控制核酸序列或针对NCP特异的抗体设计的探针。
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公开(公告)号：US5856109A
公开(公告)日：1999-01-05
申请号：US966319
申请日：1997-11-07
申请人： Scott M. Braxton , Dinh Diep , Angelo M. Delegeane
发明人： Scott M. Braxton , Dinh Diep , Angelo M. Delegeane
CPC分类号： C12N9/6424 , A61K38/00
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a human homolog of rat elastase IV (HEIV) expressed in pancreas tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode HEIV, hybridization probes or oligonucleotides for the detection of HEIV-encoding nucleotide sequences, and a diagnostic test based on HEIV-encoding nucleic acid molecules. The present invention further provides for genetically engineered host cells for the expression of HEIV, biologically active HEIV, antibodies capable for binding specifically to HEIV, and treatment methods comprising administration of compounds, such antibodies or inhibitors, capable of binding HEIV to alter its activity.
摘要翻译： 本发明提供了鉴定和编码在胰腺组织中表达的大鼠弹性蛋白酶IV（HEIV）的人同源物的核苷酸和氨基酸序列。 本发明还提供编码用于检测编码HEIV的核苷酸序列的HEIV，杂交探针或寡核苷酸的核苷酸序列的反义分子，以及基于编码HEIV的核酸分子的诊断测试。 本发明还提供用于表达HEIV，生物活性HEIV，能够特异性结合HEIV的抗体的基因工程宿主细胞，以及包含能够结合HEIV以改变其活性的化合物，例如抗体或抑制剂的治疗方法。
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