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9 条记录 (耗时 0.034 秒)

    Interaction of NMDA receptor with protein tyrosine phosphatase
    4.
    发明申请
    Interaction of NMDA receptor with protein tyrosine phosphatase 审中-公开
    NMDA受体与蛋白酪氨酸磷酸酶的相互作用

    公开(公告)号：US20050266509A1

    公开(公告)日：2005-12-01

    申请号：US10913631

    申请日：2004-08-06

    申请人： Jasna Jerecic ,  Roman Urfer

    发明人： Jasna Jerecic ,  Roman Urfer

    IPC分类号： C12Q1/48 ,  G01N33/53

    CPC分类号： A61K31/00 ,  C12Q1/42 ,  G01N33/9406 ,  G01N2333/70571

    摘要： The present invention relates to the identification of a binding between NMDA receptor (NMDA-R) subunits and the protein tyrosine phosphatase PTPMEG. The present invention provides methods for screening a PTP agonist or antagonist that modulates NMDA-R signaling. The present invention also provides methods and compositions for treatment of disorders mediated by abnormal NMDA-R signaling.

    摘要翻译： 本发明涉及鉴定NMDA受体（NMDA-R）亚基与蛋白酪氨酸磷酸酶PTPMEG之间的结合。 本发明提供了筛选调节NMDA-R信号传导的PTP激动剂或拮抗剂的方法。 本发明还提供了用于治疗由NMDA-R异常信号传导介导的病症的方法和组合物。

    ADDL receptor polypeptides, polynucleotides and host cells for recombinant production
    7.
    发明授权
    ADDL receptor polypeptides, polynucleotides and host cells for recombinant production 有权
    ADDL受体多肽，多核苷酸和用于重组生产的宿主细胞

    公开(公告)号：US09217024B2

    公开(公告)日：2015-12-22

    申请号：US12745887

    申请日：2008-12-17

    申请人： Jasna Jerecic ,  Grant A. Krafft

    发明人： Jasna Jerecic ,  Grant A. Krafft

    IPC分类号： A61P25/28 ,  A61P25/00 ,  A61K39/395 ,  C07K14/705

    CPC分类号： C07K14/705

    摘要： This invention provides a novel receptor expressed on neuronal cells in a developmentally-specific manner. Accordingly, this invention provides the amino acid sequences of selected portions of the receptor and polynucleotides encoding these portions as well as antibodies that bind to the polypeptide portions of the receptor. Compositions and methods for using the compositions are also provided.

    摘要翻译： 本发明提供了以发育特异性方式在神经细胞上表达的新型受体。 因此，本发明提供受体的选定部分的氨基酸序列和编码这些部分的多核苷酸以及结合受体多肽部分的抗体。 还提供了组合物和使用该组合物的方法。

    ADDL Binding to Hippocampal Neurons
    8.
    发明申请
    ADDL Binding to Hippocampal Neurons 审中-公开
    ADDL与海马神经元的结合

    公开(公告)号：US20080014596A1

    公开(公告)日：2008-01-17

    申请号：US11560834

    申请日：2006-11-16

    申请人： Jasna Jerecic ,  Grant A. Krafft

    发明人： Jasna Jerecic ,  Grant A. Krafft

    IPC分类号： G01N33/567 ,  G01N33/53

    CPC分类号： G01N33/5058 ,  G01N2333/4709 ,  G01N2800/2821

    摘要： Disclosed herein are methods for the quantification of ADDL binding to neuronal cells, including, but not limited to, primary cultures of hippocampal neurons. The method identifies and selects neurons based on any means capable of distinguishing neuronal cells, including, but not limited to, MAP2 immunoreactivity, which ensures that glial cells are excluded from an ADDL binding analysis; antibodies selective for neuronal cell surface receptors and/or other surface markers; reagents specific for neuronal signalling markers present intracellularly; and the like. Furthermore, ADDL binding occurs in a sub-population of 16 DIV neurons and is heterogeneous in intensity among individual cells. Also, ADDL binding can be further specified and quantified by using additional markers. Additionally, the presence or absence of ADDL binding is used to identify, characterize, analyze, assess, and/or evaluate agents (e.g., including, but not limited to, small molecules, antibodies, chemical compounds, dietary components, environmental conditions, etc.) that modulate ADDL binding. Such modulation can be positive or negative, including, but not limited to, ADDL binding inhibition, either total inhibition or partial inhibition, and the like.

    摘要翻译： 本文公开了用于定量ADDL与神经元细胞结合的方法，包括但不限于海马神经元的原代培养物。 该方法基于能够区分神经元细胞的任何手段识别和选择神经元，包括但不限于MAP2免疫反应性，其确保从ADDL结合分析中排除胶质细胞; 对神经元细胞表面受体和/或其他表面标记物有选择性的抗体; 特异于神经元信号标记的试剂存在于细胞内; 等等。 此外，ADDL结合发生在16个DIV神经元的亚群中，并且在各个细胞之间的强度异质性。 此外，可以通过使用额外的标记进一步指定和量化ADDL结合。 此外，ADDL结合的存在或不存在用于鉴定，表征，分析，评估和/或评价试剂（例如，包括但不限于小分子，抗体，化合物，饮食组分，环境条件等） 。）调制ADDL绑定。 这种调节可以是阳性或阴性，包括但不限于ADDL结合抑制，总抑制或部分抑制等。

    Interaction of NMDA receptor with protein serine threonine phosphatases
    9.
    发明申请
    Interaction of NMDA receptor with protein serine threonine phosphatases 审中-公开
    NMDA受体与蛋白丝氨酸苏氨酸磷酸酶的相互作用

    公开(公告)号：US20050074831A1

    公开(公告)日：2005-04-07

    申请号：US10386971

    申请日：2003-03-11

    申请人： Jasna Jerecic ,  Janice Williams ,  Jean Bucaria ,  Thorsten Melcher

    发明人： Jasna Jerecic ,  Janice Williams ,  Jean Bucaria ,  Thorsten Melcher

    IPC分类号： G01N33/94 ,  C12Q1/44

    CPC分类号： G01N33/9406 ,  G01N2500/00

    摘要： The present invention relates to the identification of a binding between NMDA receptor (NMDA-R) subunits and a serine/threonine protein phosphatase (PSTP), e.g., PP2A. The present invention provides methods for screening a PSTP agonist or antagonist that modulates NMDA-R signaling. The present invention also provide methods and compositions for treatment of disorders mediated by abnormal NMDA-R signaling.

    摘要翻译： 本发明涉及鉴定NMDA受体（NMDA-R）亚基与丝氨酸/苏氨酸蛋白磷酸酶（PSTP）如PP2A之间的结合。 本发明提供了筛选调节NMDA-R信号传导的PSTP激动剂或拮抗剂的方法。 本发明还提供了用于治疗由NMDA-R异常信号传导介导的病症的方法和组合物。