公开(公告)号：US07540286B2

公开(公告)日：2009-06-02

申请号：US10861554

申请日：2004-06-03

申请人： Steven D. Cross ,  Mathieu Herbette ,  Andrew J. G. Kelly ,  Daniel J. Myers ,  William W. Shen ,  Ryan D. Timmons ,  Curtis Tom ,  Justin M. Virgili ,  Martin J. Wensley

发明人： Steven D. Cross ,  Mathieu Herbette ,  Andrew J. G. Kelly ,  Daniel J. Myers ,  William W. Shen ,  Ryan D. Timmons ,  Curtis Tom ,  Justin M. Virgili ,  Martin J. Wensley

IPC分类号： A61M11/00

CPC分类号： H05B1/0244 ,  A61M11/002 ,  A61M11/041 ,  A61M11/042 ,  A61M15/0021 ,  A61M15/0045 ,  A61M15/0048 ,  A61M15/0065 ,  A61M15/008 ,  A61M15/0081 ,  A61M16/1075 ,  A61M16/14 ,  H05B2203/021

摘要： Devices and methods of entraining a substance within an airflow are disclosed. Condensation aerosol delivery devices and methods of consistently producing multiple doses of a substance, such as a drug, having high purity, high yield, characterized by a particle size distribution appropriate for pulmonary delivery, and which can be administered to a user in a single dose are also disclosed.

摘要翻译： 公开了在气流中夹带物质的装置和方法。 冷凝气溶胶输送装置和一贯生产多剂量物质（例如药物）的方法，其具有高纯度，高产率，其特征在于适于肺部输送的粒度分布，并且其可以以单剂量施用于使用者 也被披露。

公开(公告)号：US08333197B2

公开(公告)日：2012-12-18

申请号：US12474680

申请日：2009-05-29

申请人： Stephen D. Cross ,  Mathieu Herbette ,  Andrew J. G. Kelly ,  Daniel J. Myers ,  William W. Shen ,  Ryan D. Timmons ,  Curtis Tom ,  Justin M. Virgili ,  Martin J. Wensley

发明人： Stephen D. Cross ,  Mathieu Herbette ,  Andrew J. G. Kelly ,  Daniel J. Myers ,  William W. Shen ,  Ryan D. Timmons ,  Curtis Tom ,  Justin M. Virgili ,  Martin J. Wensley

IPC分类号： A61M11/00

CPC分类号： H05B1/0244 ,  A61M11/002 ,  A61M11/041 ,  A61M11/042 ,  A61M15/0021 ,  A61M15/0045 ,  A61M15/0048 ,  A61M15/0065 ,  A61M15/008 ,  A61M15/0081 ,  A61M16/1075 ,  A61M16/14 ,  H05B2203/021

摘要： Devices and methods of entraining a substance within an airflow are disclosed. Condensation aerosol delivery devices and methods of consistently producing multiple doses of a substance, such as a drug, having high purity, high yield, characterized by a particle size distribution appropriate for pulmonary delivery, and which can be administered to a user in a single dose are also disclosed.

摘要翻译： 公开了在气流中夹带物质的装置和方法。 冷凝气溶胶输送装置和一贯生产多剂量物质（例如药物）的方法，其具有高纯度，高产率，其特征在于适于肺部输送的粒度分布，并且其可以以单剂量施用于使用者 也被披露。

公开(公告)号：US20090235926A1

公开(公告)日：2009-09-24

申请号：US12474680

申请日：2009-05-29

申请人： Steven D. Cross ,  Matthieu Herbette ,  Andrew J.G. Kelly ,  Daniel J. Myers ,  William W. Shen ,  Ryan D. Timmons ,  Curtis Tom ,  Justin M. Virgili ,  Martin J. Wensley

发明人： Steven D. Cross ,  Matthieu Herbette ,  Andrew J.G. Kelly ,  Daniel J. Myers ,  William W. Shen ,  Ryan D. Timmons ,  Curtis Tom ,  Justin M. Virgili ,  Martin J. Wensley

IPC分类号： A61M11/00

CPC分类号： H05B1/0244 ,  A61M11/002 ,  A61M11/041 ,  A61M11/042 ,  A61M15/0021 ,  A61M15/0045 ,  A61M15/0048 ,  A61M15/0065 ,  A61M15/008 ,  A61M15/0081 ,  A61M16/1075 ,  A61M16/14 ,  H05B2203/021

摘要： Devices and methods of entraining a substance within an airflow are disclosed. Condensation aerosol delivery devices and methods of consistently producing multiple doses of a substance, such as a drug, having high purity, high yield, characterized by a particle size distribution appropriate for pulmonary delivery, and which can be administered to a user in a single dose are also disclosed.

摘要翻译： 公开了在气流中夹带物质的装置和方法。 冷凝气溶胶输送装置和一贯生产多剂量物质（例如药物）的方法，其具有高纯度，高产率，其特征在于适于肺部输送的粒度分布，并且其可以以单剂量施用于使用者 也被披露。

公开(公告)号：US20110233043A1

公开(公告)日：2011-09-29

申请号：US13078654

申请日：2011-04-01

申请人： Steven D. Cross ,  Matthieu Herbette ,  Andrew J.G. Kelly ,  Daniel J. Myers ,  William W. Shen ,  Ryan D. Timmons ,  Curtis Tom ,  Justin M. Virgili ,  Martin J. Wensley

发明人： Steven D. Cross ,  Matthieu Herbette ,  Andrew J.G. Kelly ,  Daniel J. Myers ,  William W. Shen ,  Ryan D. Timmons ,  Curtis Tom ,  Justin M. Virgili ,  Martin J. Wensley

IPC分类号： B01D5/00 ,  B01D3/00

CPC分类号： H05B1/0244 ,  A61M11/002 ,  A61M11/041 ,  A61M11/042 ,  A61M15/0021 ,  A61M15/0045 ,  A61M15/0048 ,  A61M15/0065 ,  A61M15/008 ,  A61M15/0081 ,  A61M16/1075 ,  A61M16/14 ,  H05B2203/021

摘要： Devices and methods of entraining a substance within an airflow are disclosed. Condensation aerosol delivery devices and methods of consistently producing multiple doses of a substance, such as a drug, having high purity, high yield, characterized by a particle size distribution appropriate for pulmonary delivery, and which can be administered to a user in a single dose are also disclosed.

摘要翻译： 公开了在气流中夹带物质的装置和方法。 冷凝气溶胶输送装置和一贯生产多剂量物质（例如药物）的方法，其具有高纯度，高产率，其特征在于适于肺部输送的粒度分布，并且其可以以单剂量施用于使用者 也被披露。

公开(公告)号：US07913688B2

公开(公告)日：2011-03-29

申请号：US10442385

申请日：2003-05-20

申请人： Stephen Cross ,  Craig C. Hodges ,  Ron L. Hale ,  Peter M. Lloyd ,  Daniel J. Myers ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz ,  Curtis Tom ,  Martin J. Wensley

发明人： Stephen Cross ,  Craig C. Hodges ,  Ron L. Hale ,  Peter M. Lloyd ,  Daniel J. Myers ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz ,  Curtis Tom ,  Martin J. Wensley

IPC分类号： A61M15/08 ,  F23D11/00 ,  F23D14/00

CPC分类号： A61M15/00 ,  A61M11/002 ,  A61M11/041 ,  A61M11/042 ,  A61M11/047

摘要： A device for delivering a drug by inhalation is disclosed. The device includes a body defining an interior flow-through chamber having upstream and downstream chamber openings, and a drug supply unit contained within the chamber for producing, upon actuation, a heated drug vapor in a condensation region of the chamber. Gas drawn through the chamber region at a selected gas-flow rate is effective to form drug condensation particles from the drug vapor having a selected MMAD between 0.02 and 0.1 MMAD or between 1 and 3.5 μm. A gas-flow control valve disposed upstream of the unit functions to limit gas-flow rate through the condensation region to the selected gas-flow rate. An actuation switch in the device activates the drug-supply unit, such that the drug-supply unit can be controlled to produce vapor when the gas-flow rate through the chamber is at the selected flow rate.

摘要翻译： 公开了一种通过吸入传送药物的装置。 该装置包括限定具有上游和下游室开口的内部流通室的主体，以及容纳在该室内的药物供应单元，用于在致动时产生在该室的冷凝区域中的加热的药物蒸气。 以选定的气体流速通过室区域抽吸的气体有效地从具有0.02至0.1MMAD的选定MMAD或1至3.5μm之间的药物蒸气形成药物凝结颗粒。 设置在单元上游的气体流量控制阀用于将通过冷凝区域的气体流量限制到所选择的气体流量。 装置中的致动开关激活药物供应单元，使得当通过腔室的气体流量处于所选择的流速时，可以控制药物供应单元产生蒸汽。

公开(公告)号：US07645442B2

公开(公告)日：2010-01-12

申请号：US10633876

申请日：2003-08-04

申请人： Ron L. Hale ,  Peter M. Lloyd ,  Amy Lu ,  Daniel J. Myers ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz ,  Dennis W. Solas ,  Soonho Song ,  Curtis Tom ,  Martin J. Wensley

发明人： Ron L. Hale ,  Peter M. Lloyd ,  Amy Lu ,  Daniel J. Myers ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz ,  Dennis W. Solas ,  Soonho Song ,  Curtis Tom ,  Martin J. Wensley

IPC分类号： A61K9/12 ,  A61K9/14 ,  A61M15/00

CPC分类号： A61M11/041 ,  A61K9/007 ,  A61K9/0073 ,  A61M11/042 ,  A61M11/047 ,  A61M15/002 ,  A61M15/0028 ,  A61M2016/0039 ,  A61M2205/3606 ,  A61M2205/3653 ,  A61M2205/368 ,  A61M2205/50 ,  B05B7/1686 ,  B05B17/04 ,  Y10S514/958

摘要： A device, method, and system for producing a condensation aerosol are disclosed. The device includes a chamber having an upstream opening and a downstream opening which allow gas to flow through the chamber, and a heat-conductive substrate located at a position between the upstream and downstream openings. Formed on the substrate is a drug composition film containing a therapeutically effective dose of a drug when the drug is administered in aerosol form. A heat source in the device is operable to supply heat to the substrate to produce a substrate temperature greater than 300° C., and to substantially volatilize the drug composition film from the substrate in a period of 2 seconds or less. The device produces an aerosol containing less than about 10% by weight drug composition degradation products and at least 50% of the drug composition of said film.

摘要翻译： 公开了一种用于生产冷凝气雾剂的装置，方法和系统。 该装置包括具有允许气体流过腔室的上游开口和下游开口的腔室，以及位于上游和下游开口之间位置的导热基底。 在基质上形成药物组合物膜，当药物以气溶胶形式施用时，其含有治疗有效剂量的药物。 装置中的热源可操作以向衬底供应热量以产生大于300℃的衬底温度，并且在2秒或更短的时间内使药物组合物膜从衬底基本挥发。 该装置产生含有小于约10重量％的药物组合物降解产物和所述膜的药物组合物的至少50％的气溶胶。

公开(公告)号：US07513781B2

公开(公告)日：2009-04-07

申请号：US11645859

申请日：2006-12-27

申请人： Charles Galauner ,  Gregory Menn ,  Richard A. Nelson ,  Hazelton P. Avery ,  Timothy E. Purkis ,  Richard A. Faje ,  Ryan D. Timmons ,  Andrew J.G. Kelly ,  Martin J. Wensley

发明人： Charles Galauner ,  Gregory Menn ,  Richard A. Nelson ,  Hazelton P. Avery ,  Timothy E. Purkis ,  Richard A. Faje ,  Ryan D. Timmons ,  Andrew J.G. Kelly ,  Martin J. Wensley

IPC分类号： H01R12/00

CPC分类号： A61M11/041 ,  A61M11/042 ,  H01R12/716 ,  H01R13/04 ,  H05B3/06

摘要： An improved heating element connector assembly includes an insulative, rectangular frame with a central opening, and a plurality of conductive terminals which are press fit into openings in the frame. The terminals are spaced apart from each other lengthwise of two opposing sidewalls of the frame, and pairs of terminals are aligned with each other between the two sidewalls. A plurality of conductive strips are held together in an assembly and the ends of the strips are interconnected along two spaced apart lines by carrier members that may be molded over the ends of the conductive strips. The carrier members extend down into cavities on the frame and terminals are pushed into the cavities to bear against the ends of the strips and effect an electrical connection between the terminals and the strips.

摘要翻译： 改进的加热元件连接器组件包括具有中心开口的绝缘矩形框架和压配合到框架中的开口中的多个导电端子。 端子在框架的两个相对的侧壁的纵向彼此间隔开，并且端子对在两个侧壁之间彼此对准。 多个导电条被保持在组件中，并且条的端部沿着两个间隔开的线通过可以在导电条的端部上模制的载体构件互连。 载体构件向下延伸到框架上的空腔中，并且端子被推入空腔中以抵靠条的端部并且实现端子和条带之间的电连接。

公开(公告)号：US20090229600A1

公开(公告)日：2009-09-17

申请号：US12471070

申请日：2009-05-22

申请人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Daniel Mufson ,  Daniel D. Rogers ,  Soonho Song ,  Martin J. Wensley ,  Daniel J. Myers ,  Jeffrey A. McKinney ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz

发明人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Daniel Mufson ,  Daniel D. Rogers ,  Soonho Song ,  Martin J. Wensley ,  Daniel J. Myers ,  Jeffrey A. McKinney ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz

IPC分类号： A61M11/00

CPC分类号： A61M11/044 ,  A61K9/007 ,  A61K9/0073 ,  A61K31/235 ,  A61K31/4468 ,  A61K31/485 ,  A61K31/519 ,  A61M11/001 ,  A61M11/02 ,  A61M15/00 ,  A61M15/0028 ,  A61M16/109 ,  A61M2016/0039 ,  A61M2205/3606 ,  A61M2205/3653 ,  A61M2205/368 ,  A61M2205/50 ,  B05B7/1686 ,  B05B17/04

摘要： The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy

摘要翻译： 本发明涉及含有小颗粒的气溶胶的吸入输送。 具体地说，本发明涉及形成用于吸入治疗的气雾剂的方法。 在本发明的方法方面，提供了一种形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）以大于1000℃/ s的速率加热涂覆有包含药物的组合物的基底，从而形成蒸气; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以形成蒸气，其中涂覆的组合物为小于10μm厚的膜的形式; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以在小于100毫秒内形成蒸气，其中蒸气的质量大于0.1mg; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶

公开(公告)号：US20080216828A1

公开(公告)日：2008-09-11

申请号：US12045674

申请日：2008-03-10

申请人： Martin J. Wensley ,  Marc Glazer ,  James Bresson ,  Ryan Timmons ,  Daniel J. Myers

发明人： Martin J. Wensley ,  Marc Glazer ,  James Bresson ,  Ryan Timmons ,  Daniel J. Myers

IPC分类号： A61M16/10

CPC分类号： A61M11/042 ,  A61K9/0009 ,  A61K9/007 ,  A61K9/12 ,  A61K31/135 ,  A61K31/138 ,  A61K31/196 ,  A61K31/197 ,  A61K31/433 ,  A61K31/4468 ,  A61K31/451 ,  A61K31/4525 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/53 ,  A61K31/5415 ,  A61K31/56 ,  A61K31/573 ,  A61K31/58 ,  A61K31/7076 ,  A61M11/001 ,  A61M11/041 ,  A61M11/047 ,  A61M15/00 ,  A61M15/0015 ,  A61M15/06 ,  A61M2205/3653 ,  A61M2205/8268

摘要： Drug supply units are disclosed which comprise substrates having a plurality of holes formed therein.

摘要翻译： 公开了包括其中形成有多个孔的基板的药物供应单元。

公开(公告)号：US20130032139A1

公开(公告)日：2013-02-07

申请号：US13569006

申请日：2012-08-07

申请人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Amy T. Lu ,  Daniel J. Myers ,  Joshua D. Rabinowitz ,  Martin J. Wensley ,  Jeffrey A. McKinney ,  Alejandro C. Zaffaroni

发明人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Amy T. Lu ,  Daniel J. Myers ,  Joshua D. Rabinowitz ,  Martin J. Wensley ,  Jeffrey A. McKinney ,  Alejandro C. Zaffaroni

IPC分类号： A61M11/04

CPC分类号： A61K9/0004 ,  A61K9/007 ,  A61K9/0078 ,  A61K9/12 ,  A61K31/4468 ,  A61K31/519 ,  A61K31/5415 ,  A61K31/5517 ,  A61K31/553 ,  A61M11/002 ,  A61M11/005 ,  A61M11/04 ,  A61M11/041 ,  A61M11/042 ,  A61M11/047 ,  A61M15/00 ,  A61M2207/00

摘要： The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided, wherein the device, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Methods for use are also disclosed.

摘要翻译： 本发明提供用于治疗疾病和/或间歇或急性病症的新型凝结气溶胶。 这些凝结气溶胶几乎没有或没有热解降解产物，其特征在于MMAD为1-3微米。 这些气溶胶是通过在使薄膜上的气体通过膜的同时快速加热涂覆有厚度为0.05至20μm的药物薄膜的基材，形成用于吸入的理想颗粒尺寸的颗粒。 还提供了包含药物和用于产生冷凝气雾剂的装置的试剂盒，其中所述装置具有用于加热药物的元件，所述元件作为膜涂覆在基底上并且当施用药物时含有治疗有效剂量的药物 气溶胶形式，以及允许蒸汽冷却以形成气溶胶的元素。 还公开了使用方法。