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公开(公告)号：US20050266411A1
公开(公告)日：2005-12-01
申请号：US10853660
申请日：2004-05-25
申请人： Steven Hofstadler , Thomas Hall , David Ecker , Lawrence Blyn , Mark Eshoo , Vivek Samant , Neill White
发明人： Steven Hofstadler , Thomas Hall , David Ecker , Lawrence Blyn , Mark Eshoo , Vivek Samant , Neill White
IPC分类号： C12Q1/68 , G01N27/447 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： G01N27/62 , C12Q1/683 , C12Q1/6846 , G01N27/447 , G16B50/00 , C12Q2565/627 , C12Q2521/301
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA by amplification of a segment of mitochondrial DNA containing restriction sites, digesting the mitochondrial DNA segments with restriction enzymes, determining the molecular masses of the restriction fragments and comparing the molecular masses with the molecular masses of theoretical restriction digests of known mitochondrial DNA sequences stored in a database.
摘要翻译： 本发明提供了通过扩增含有限制性位点的线粒体DNA片段，用限制酶消化线粒体DNA片段，确定限制性片段的分子量并将分子量与分子量进行比较的线粒体DNA的快速法医分析方法 已知线粒体DNA序列的理论限制性消化存储在数据库中。
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公开(公告)号：US20050266397A1
公开(公告)日：2005-12-01
申请号：US10829826
申请日：2004-04-22
申请人： David Ecker , Steven Hofstadler , Rangarajan Sampath , Lawrence Blyn , Thomas Hall , Christian Massire
发明人： David Ecker , Steven Hofstadler , Rangarajan Sampath , Lawrence Blyn , Thomas Hall , Christian Massire
IPC分类号： C12N20060101 , C12N15/00 , C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/701 , C12N2770/20011 , Y10T436/24
摘要： The present invention provides a method for rapid identification and quantitation of bacteria by amplification of a segment of bacterial nucleic acid followed by analysis by mass spectrometry. The compositions provide for characterization of the molecular masses and base compositions of bacterial nucleic acids which are used to rapidly identify bacteria.
摘要翻译： 本发明提供了通过扩增细菌核酸片段，然后通过质谱法分析来快速鉴定和定量细菌的方法。 该组合物提供用于快速鉴定细菌的细菌核酸的分子量和碱性组成的表征。
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公开(公告)号：US20070224614A1
公开(公告)日：2007-09-27
申请号：US11683280
申请日：2007-03-07
申请人： Rangarajan Sampath , Thomas Hall , David Ecker , Lawrence Blyn
发明人： Rangarajan Sampath , Thomas Hall , David Ecker , Lawrence Blyn
CPC分类号： C12Q1/689 , C12Q1/6816 , C12Q1/6858 , C12Q2600/156 , C12Q2565/627 , C12Q2537/143
摘要： The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.
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公开(公告)号：US20070218489A1
公开(公告)日：2007-09-20
申请号：US11685603
申请日：2007-03-13
申请人： Rangarajan Sampath , Thomas Hall , David Ecker , Lawrence Blyn
发明人： Rangarajan Sampath , Thomas Hall , David Ecker , Lawrence Blyn
CPC分类号： C12Q1/689 , C12Q1/6816 , C12Q1/6858 , C12Q2600/156 , C12Q2565/627 , C12Q2537/143
摘要： The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.
摘要翻译： 本发明提供通过分子量和碱组成分析快速鉴定和定量细菌的组合物，试剂盒和方法。
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公开(公告)号：US20070248969A1
公开(公告)日：2007-10-25
申请号：US11685598
申请日：2007-03-13
申请人： Rangarajan Sampath , Thomas Hall , David Ecker , Lawrence Blyn
发明人： Rangarajan Sampath , Thomas Hall , David Ecker , Lawrence Blyn
CPC分类号： C12Q1/689 , C12Q1/6816 , C12Q1/6858 , C12Q2600/156 , C12Q2565/627 , C12Q2537/143
摘要： The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.
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公开(公告)号：US20070243544A1
公开(公告)日：2007-10-18
申请号：US11685610
申请日：2007-03-13
申请人： Rangarajan Sampath , Thomas Hall , David Ecker , Lawrence Blyn
发明人： Rangarajan Sampath , Thomas Hall , David Ecker , Lawrence Blyn
CPC分类号： C12Q1/689 , C12Q1/6816 , C12Q1/6858 , C12Q2600/156 , C12Q2565/627 , C12Q2537/143
摘要： The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.
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公开(公告)号：US20070238116A1
公开(公告)日：2007-10-11
申请号：US11685579
申请日：2007-03-13
申请人： Rangarajan Sampath , Thomas Hall , David Ecker , Lawrence Blyn
发明人： Rangarajan Sampath , Thomas Hall , David Ecker , Lawrence Blyn
CPC分类号： C12Q1/689 , C12Q1/6816 , C12Q1/6858 , C12Q2600/156 , C12Q2565/627 , C12Q2537/143
摘要： The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.
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8.发明申请公开(公告)号：US20070218467A1
公开(公告)日：2007-09-20
申请号：US11491376
申请日：2006-07-21
申请人： David Ecker , Steven Hofstadler , Thomas Hall , Kristin Lowery
发明人： David Ecker , Steven Hofstadler , Thomas Hall , Kristin Lowery
CPC分类号： C12Q1/6872 , C12Q1/6827 , C12Q1/6844 , C12Q1/6858 , C12Q1/6881 , C12Q2600/156 , C12Q2600/16 , C12Q2565/627 , C12Q2537/143 , C12Q2531/113 , C12Q2545/10
摘要： There is a need for nucleic acid analysis which is both specific and rapid, and in which no nucleic acid sequencing is required. The present invention addresses this need, among others by providing a method of nucleic acid amplification of overlapping sub-segments of a nucleic acid followed by molecular mass measurement of resulting amplification products by mass spectrometry, and determination of the base compositions of the amplification products.
摘要翻译： 需要具有特异性和快速性的核酸分析，并且其中不需要核酸测序。 本发明除了提供核酸扩增核酸扩增方法之外，还通过质谱法对所得扩增产物进行分子量测定，以及确定扩增产物的碱基组成来解决这一需要。
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公开(公告)号：US20060275749A1
公开(公告)日：2006-12-07
申请号：US11210516
申请日：2005-08-24
CPC分类号： C12Q1/701 , C12Q1/6888
摘要： Oligonucleotide primers and compositions and kits containing the same for rapid identification of orthopoxviruses by amplification of a segment of viral nucleic acid followed by molecular mass analysis are provided.
摘要翻译： 提供了通过扩增一段病毒核酸，随后进行分子质量分析的寡核苷酸引物和包含其的组合物和试剂盒，用于快速鉴定正痘病毒。
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公开(公告)号：US20060259249A1
公开(公告)日：2006-11-16
申请号：US11073362
申请日：2005-03-03
申请人： Rangarajan Sampath , Vivek Samant , Christian Massire , Harold Levene , David Ecker , John McNeil
发明人： Rangarajan Sampath , Vivek Samant , Christian Massire , Harold Levene , David Ecker , John McNeil
IPC分类号： G06F19/00
摘要： The method described herein relate generally the identification of bioagents on the basis of base composition signatures for bioagent-identifying amplicons. Specifically, methods of the present invention are directed to the application of pattern recognition models, particularly probability pattern classifiers, to the identification of both known and previously unrecognized bioagents. In certain embodiments, the pattern classifiers relate to probability cloud patterns, such as mutational probability patterns. In other embodiments the pattern classifiers relate to polytope pattern models.
摘要翻译： 本文所述的方法一般涉及基于用于生物鉴别扩增子的碱基组成特征的生物标记的鉴定。 具体地，本发明的方法涉及模式识别模型，特别是概率模式分类器在识别已知和以前未被认识的生物标签的应用。 在某些实施例中，模式分类器涉及概率云模式，例如突变概率模式。 在其他实施例中，模式分类器涉及多面体图案模型。
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