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公开(公告)号：US07002146B2
公开(公告)日：2006-02-21
申请号：US10863967
申请日：2004-06-08
IPC分类号： H01J49/26
CPC分类号： G01N30/7253 , H01J27/24 , H01J49/0431 , H01J49/145 , H01J49/162
摘要： An atmospheric pressure ion source, e.g. for a mass spectrometer, that produces ions by atmospheric pressure photoionization (APPI). It includes a vaporizer, a photon source for photoionizing vapor molecules upon exit from the vaporizer, a passageway for transporting ions to, for example, a mass spectrometer system, and a means for directing the ions into the passageway. The center axis of the vaporizer and the center axis of the passageway form an angle that may be about 90 degrees. Included in the invention is a method for creating ions by atmospheric pressure photoionization along an axis and directing them into a passageway oriented at an angle to that axis.
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公开(公告)号：US07488953B2
公开(公告)日：2009-02-10
申请号：US11444095
申请日：2006-05-31
IPC分类号： H01J27/02
CPC分类号： H01J49/107 , H01J49/0445 , H01J49/162 , H01J49/165 , H01J49/168
摘要： The present invention provides an apparatus and method for use with a mass spectrometer. The multimode ionization source of the present invention provides one or more atmospheric pressure ionization sources (e.g., electrospray, atmospheric pressure chemical ionization and/or atmospheric pressure photoionization) for ionizing molecules. A method of producing ions using the multimode ionization source is also disclosed. The apparatus and method provide the advantages of the combined ion sources without the inherent disadvantages of the individual sources. In an embodiment, the multimode ionization source includes an infrared emitter enclosed in an inner chamber for drying a charged aerosol. ESI/APCI multimode sources may include a corona needle shield and/or an auxiliary electrode.
摘要翻译： 本发明提供了一种与质谱仪一起使用的装置和方法。 本发明的多模电离源提供用于电离分子的一个或多个大气压电离源（例如电喷雾，大气压化学电离和/或大气压光电离）。 还公开了使用多模电离源产生离子的方法。 该装置和方法提供了组合离子源的优点，而没有各个源的固有缺点。 在一个实施例中，多模式电离源包括封闭在内室中用于干燥带电气溶胶的红外发射器。 ESI / APCI多模式源可以包括电晕针护罩和/或辅助电极。
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公开(公告)号：US06653626B2
公开(公告)日：2003-11-25
申请号：US10155364
申请日：2002-05-23
IPC分类号： H01J4926
CPC分类号： G01N30/7253 , H01J27/24 , H01J49/0431 , H01J49/145 , H01J49/162
摘要： An atmospheric pressure ion source, e.g. for a mass spectrometer, that produces ions by atmospheric pressure photoionization (APPI). It includes a vaporizer, a photon source for photoionizing vapor molecules upon exit from the vaporizer, a passageway for transporting ions to, for example, a mass spectrometer system, and a means for directing the ions into the passageway. The center axis of the vaporizer and the center axis of the passageway form an angle that may be about 90 degrees. Included in the invention is a method for creating ions by atmospheric pressure photoionization along an axis and directing them into a passageway oriented at an angle to that axis.
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公开(公告)号：US07309859B2
公开(公告)日：2007-12-18
申请号：US11290187
申请日：2005-11-30
IPC分类号： H01J49/26
CPC分类号： G01N30/7253 , H01J27/24 , H01J49/0431 , H01J49/145 , H01J49/162
摘要： An atmospheric pressure ion source, e.g. for a mass spectrometer, that produces ions by atmospheric pressure photoionization (APPI). It includes a vaporizer, a photon source for photoionizing vapor molecules upon exit from the vaporizer, a passageway for transporting ions to, for example, a mass spectrometer system, and a means for directing the ions into the passageway. The center axis of the vaporizer and the center axis of the passageway form an angle that may be about 90 degrees. Included in the invention is a method for creating ions by atmospheric pressure photoionization along an axis and directing them into a passageway oriented at an angle to that axis.
摘要翻译： 大气压离子源，例如 用于通过大气压光电离（APPI）产生离子的质谱仪。 它包括蒸发器，用于在蒸发器出口时使蒸汽分子光离子化的光子源，用于将离子输送到例如质谱仪系统的通道和用于将离子引导到通道中的装置。 蒸发器的中心轴线和通道的中心轴线形成大约90度的角度。 本发明中包括一种通过沿着轴的大气压力光离子化产生离子的方法，并将它们引导到与该轴成一定角度的通道中。
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公开(公告)号：US06812459B2
公开(公告)日：2004-11-02
申请号：US10640151
申请日：2003-08-13
IPC分类号： H01J4926
CPC分类号： G01N30/7253 , H01J27/24 , H01J49/0431 , H01J49/145 , H01J49/162
摘要： An atmospheric pressure ion source, e.g. for a mass spectrometer, that produces ions by atmospheric pressure photoionization (APPI). It includes a vaporizer, a photon source for photoionizing vapor molecules upon exit from the vaporizer, a passageway for transporting ions to, for example, a mass spectrometer system, and a means for directing the ions into the passageway. The center axis of the vaporizer and the center axis of the passageway form an angle that may be about 90 degrees. Included in the invention is a method for creating ions by atmospheric pressure photoionization along an axis and directing them into a passageway oriented at an angle to that axis.
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公开(公告)号：US06646257B1
公开(公告)日：2003-11-11
申请号：US10245987
申请日：2002-09-18
IPC分类号： B01D5944
CPC分类号： H01J49/107 , H01J49/162 , H01J49/165 , H01J49/168
摘要： The present invention provides an apparatus and method for use with a mass spectrometer. The multimode ionization source of the present invention provides one or more atmospheric pressure ionization sources (i.e. electrospray, atmospheric pressure chemical ionization and/or atmospheric pressure photoionization) for ionizing molecules. A method of producing ions using the multimode ionization source is also disclosed. The apparatus and method provide the advantages of the combined ion sources without the inherent disadvantages of the individual sources.
摘要翻译： 本发明提供了一种与质谱仪一起使用的装置和方法。 本发明的多模电离源提供用于电离分子的一个或多个大气压电离源（即电喷雾，大气压化学电离和/或大气压光电离）。 还公开了使用多模电离源产生离子的方法。 该装置和方法提供了组合离子源的优点，而没有各个源的固有缺点。
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7.发明授权Apparatus for forming liquid droplets having a mechanically fixed inner microtube 有权用于形成具有机械固定内微管的液滴的装置
公开(公告)号：US6032876A
公开(公告)日：2000-03-07
申请号：US203907
申请日：1998-12-01
申请人： James L. Bertsch , Steven M. Fischer , Darrell L. Gourley , Harvey D. Loucks, Jr. , Hans-Peter Zimmerman
发明人： James L. Bertsch , Steven M. Fischer , Darrell L. Gourley , Harvey D. Loucks, Jr. , Hans-Peter Zimmerman
CPC分类号： H01J49/0431 , B05B15/06 , B05B5/0255 , B05B7/066 , B05B7/068 , G01N30/7246 , H01J49/167 , B05B13/0278 , B05B7/0876 , G01N2030/847
摘要： The invention relates to an apparatus for forming liquid droplets, such as a micro nebulizer, useful for preparing samples for subsequent analysis via MS, AA, ICP, CE/MS, and similar analytical systems. The apparatus has a mechanically stabilized inner microtube or needle, thereby ensuring controllably uniform droplet size. The mechanical stabilization is provided by securing the inner microtube or needle, such as by narrowing the inner diameter of the outer microtube or otherwise narrowing the annular intermediate space between the inner and outer microtubes for a predetermined length. Thus, the inner microtube is secured in a centered or otherwise predetermined fixed radial position, with minimum perturbation of the fluid flow. Further, a tip, when coupled with the exit end of the outer microtube, provides a region in which the sheath fluid flow in the outer microtube stabilizes prior to both exiting the tip and colliding with the liquid analyte exiting the inner microtube.
摘要翻译： 本发明涉及用于形成液滴的装置，例如微型喷雾器，可用于制备样品用于随后通过MS，AA，ICP，CE / MS和类似分析系统的分析。 该装置具有机械稳定的内微管或针，从而确保可控制地均匀的液滴尺寸。 通过固定内部微管或针来提供机械稳定性，例如通过使外部微管的内径变窄或以其它方式使内部和外部微管之间的环形中间空间变窄预定长度。 因此，内部微管被固定在中心或另外预定的固定的径向位置，同时具有最小的流体流扰动。 此外，当与外部微管的出口端耦合时，尖端提供了一个区域，其中外部微管中的鞘液流动在两个离开尖端之前稳定，并且与离开内微管的液体分析物碰撞。
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公开(公告)号：US07078681B2
公开(公告)日：2006-07-18
申请号：US10640176
申请日：2003-08-13
IPC分类号： H01J49/10
CPC分类号： H01J49/107 , H01J49/0445 , H01J49/162 , H01J49/165 , H01J49/168
摘要： The present invention provides an apparatus and method for use with a mass spectrometer. The multimode ionization source of the present invention provides one or more atmospheric pressure ionization sources (e.g., electrospray, atmospheric pressure chemical ionization and/or atmospheric pressure photoionization) for ionizing molecules. A method of producing ions using the multimode ionization source is also disclosed. The apparatus and method provide the advantages of the combined ion sources without the inherent disadvantages of the individual sources. In an embodiment, the multimode ionization source includes an infrared emitter enclosed in an inner chamber for drying a charged aerosol. ESI/APCI multimode sources may include a corona needle shield and/or an auxiliary electrode.
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9.发明授权
公开(公告)号：US5753910A
公开(公告)日：1998-05-19
申请号：US679481
申请日：1996-07-12
CPC分类号： H01J49/24 , H01J49/145 , H01J49/165 , G01N30/7266
摘要： An atmospheric pressure ionization source is provided which includes an ionization chamber that is formed from the combination of an angled chamber body and a correspondingly angled chamber seal. The ionization chamber is used for electrospray or atmospheric pressure chemical ionization of a liquid sample to provide ionized molecules. The ionized molecules can be passed to an associated analytical device that is capable of detecting and measuring the mass-to-charge ratio and/or the mass and charge of the molecules. A mass spectrometer which includes the present atmospheric pressure ionization source is also provided, as well as a liquid chromatography/mass spectrometry (LC/MS) analysis system which includes an LC/MS interface comprising the present atmospheric pressure ionization source.
摘要翻译： 提供了一种大气压电离源，其包括由倾斜室体和相应成角度的室密封的组合形成的电离室。 电离室用于液体样品的电喷雾或大气压化学电离以提供电离分子。 电离分子可以传递到能够检测和测量分子的质荷比和/或质量和电荷的相关分析装置。 还提供了包括本气氛电离离子源的质谱仪，以及包括包含本气氛电离电离源的LC / MS界面的液相色谱/质谱（LC / MS）分析系统。
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10.发明授权
公开(公告)号：US5726447A
公开(公告)日：1998-03-10
申请号：US679647
申请日：1996-07-12
申请人： Edward Aisawa , James L. Bertsch , J. Michael Flanagan , Darrell L. Gourley , Val C. Robinson , Joseph Vandenburg
发明人： Edward Aisawa , James L. Bertsch , J. Michael Flanagan , Darrell L. Gourley , Val C. Robinson , Joseph Vandenburg
CPC分类号： H01J49/145
摘要： The invention relates to an ionization chamber. More particularly, the invention relates to a mass spectrometer system having an ionization chamber incorporating a corona needle removable from outside the closed ionization chamber. In preferred embodiments, the corona needle is self-positioning and engages and disengages operational or safety electrical connections.
摘要翻译： 本发明涉及电离室。 更具体地说，本发明涉及一种质谱仪系统，其具有电离室，该离子化室包含从封闭电离室外部可去除的电晕针。 在优选实施例中，电晕针是自定位的，并接合和分离操作或安全的电连接。
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