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公开(公告)号：US20130193065A1
公开(公告)日：2013-08-01
申请号：US13831537
申请日：2013-03-14
CPC分类号： B01D69/04 , B81C1/00071 , B82Y30/00 , G03F7/2051 , Y10S977/78 , Y10S977/84 , Y10T137/0324 , Y10T137/3006
摘要： In accordance with the invention, there is a method of forming a nanochannel including depositing a photosensitive film stack over a substrate and forming a pattern on the film stack using interferometric lithography. The method can further include depositing a plurality of silica nanoparticles to form a structure over the pattern and removing the pattern while retaining the structure formed by the plurality of silica nanoparticles, wherein the structure comprises an enclosed nanochannel.
摘要翻译： 根据本发明，存在一种形成纳米通道的方法，其包括在衬底上沉积感光膜堆叠并且使用干涉光刻在膜堆上形成图案。 该方法可以进一步包括沉积多个二氧化硅纳米颗粒以在图案上形成结构并除去图案，同时保留由多个二氧化硅纳米颗粒形成的结构，其中该结构包括封闭的纳米通道。
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2.发明授权Structural illumination and evanescent coupling for the extension of imaging interferometric microscopy 有权用于成像干涉显微镜扩展的结构照明和ev逝耦合公开(公告)号：US09541374B2
公开(公告)日：2017-01-10
申请号：US14230582
申请日：2014-03-31
CPC分类号： G01B9/02015 , G01B9/04 , G01N21/65 , G01N2021/653 , G02B21/0056 , G02B21/06 , G02B21/18 , G02B21/365 , G06T3/4061
摘要： In accordance with the aspects of the present disclosure, a method and apparatus is disclosed for three-dimensional imaging interferometric microscopy (IIM), which can use at least two wavelengths to image a three-dimensional object. The apparatus can include a first, a second, and a third optical system. The first optical system is disposed to provide a substantially coherent illumination to the 3D object, wherein the illumination is characterized by a plurality of wavelengths. The second optical system includes an optical image recording device and one or more additional optical components characterized by a numerical aperture NA. The third optical system provides interferometric reintroduction of a portion of the coherent illumination as a reference beam into the second optical system. An image recording device records each sub-image formed as a result of interference between the illumination that is scattered by the 3D object and the reference beam.
摘要翻译： 根据本公开的方面，公开了用于三维成像干涉显微镜（IIM）的方法和装置，其可以使用至少两个波长来成像三维物体。 该装置可以包括第一，第二和第三光学系统。 第一光学系统设置成向3D对象提供基本相干的照明，其中照明由多个波长表征。 第二光学系统包括光学图像记录装置和由数值孔径NA表征的一个或多个附加光学部件。 第三光学系统将相干照明的一部分的干涉重新引入作为参考光束进入第二光学系统。 图像记录装置记录由作为3D对象散射的照明与参照光束之间的干涉而形成的各子图像。
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3.发明申请公开(公告)号：US20130094077A1
公开(公告)日：2013-04-18
申请号：US13629598
申请日：2012-09-27
IPC分类号： G02B21/06
CPC分类号： G02B21/06 , G01N2021/653 , G02B21/0056 , G02B21/365 , G06T3/4061
摘要： In accordance with the aspects of the present disclosure, a method and apparatus is disclosed for imaging interferometric microscopy (IIM), which can use an immersion medium to enhance resolution up to a resolution of linear systems resolution limit of λ/4n, where λ is the wavelength in free space and n is the index of refraction of a transmission medium.
摘要翻译： 根据本公开的方面，公开了用于成像干涉显微镜（IIM）的方法和装置，其可以使用浸没介质来增强分辨率，直到λ/ 4n的线性系统分辨率极限的分辨率，其中λ是 自由空间中的波长和n是传输介质的折射率。
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公开(公告)号：US09156004B2
公开(公告)日：2015-10-13
申请号：US13831537
申请日：2013-03-14
CPC分类号： B01D69/04 , B81C1/00071 , B82Y30/00 , G03F7/2051 , Y10S977/78 , Y10S977/84 , Y10T137/0324 , Y10T137/3006
摘要： In accordance with the invention, there is a method of forming a nanochannel including depositing a photosensitive film stack over a substrate and forming a pattern on the film stack using interferometric lithography. The method can further include depositing a plurality of silica nanoparticles to form a structure over the pattern and removing the pattern while retaining the structure formed by the plurality of silica nanoparticles, wherein the structure comprises an enclosed nanochannel.
摘要翻译： 根据本发明，存在一种形成纳米通道的方法，其包括在衬底上沉积感光膜堆叠并且使用干涉光刻在膜堆上形成图案。 该方法可以进一步包括沉积多个二氧化硅纳米颗粒以在图案上形成结构并除去图案，同时保留由多个二氧化硅纳米颗粒形成的结构，其中该结构包括封闭的纳米通道。
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5.发明申请公开(公告)号：US20090310214A1
公开(公告)日：2009-12-17
申请号：US12347619
申请日：2008-12-31
CPC分类号： G02B21/0032 , G02B21/00 , G02B21/365 , G06T3/4061 , G06T2207/10056 , G06T2207/20056 , G06T2207/20221 , G06T2207/30148
摘要： In accordance with the invention, there are imaging interferometric microscopes and methods for imaging interferometric microscopy using structural illumination and evanescent coupling for the extension of imaging interferometric microscopy. Furthermore, there are coherent anti-Stokes Raman (CARS) microscopes and methods for coherent anti-Stokes Raman (CARS) microscopy, wherein imaging interferometric microscopy techniques are applied to get material dependent spectroscopic information.
摘要翻译： 根据本发明，存在成像干涉显微镜和用于使用结构照明和ev逝耦合来成像干涉显微镜的成像干涉显微镜成像的方法。 此外，还有相干的反斯托克斯拉曼（CARS）显微镜和相干反斯托克斯拉曼（CARS）显微镜的方法，其中应用成像干涉显微技术获得材料依赖的光谱信息。
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公开(公告)号：US10060904B1
公开(公告)日：2018-08-28
申请号：US14868128
申请日：2015-09-28
IPC分类号： G01N33/48 , G01N33/487 , B81C1/00 , G01N27/447 , C12Q1/68 , G03F7/20
CPC分类号： G01N33/48721 , B81C1/00071 , C12Q1/6869 , C12Q2565/631
摘要： In accordance with the disclosure, a method of forming a nanochannel is provided. The method includes depositing a photosensitive film stack over a substrate; forming a pattern on the film stack using interferometric lithography; depositing a plurality of silica nanoparticles to form a structure over the pattern; removing the pattern while retaining the structure formed by the plurality of silica nanoparticles, wherein the structure comprises one or more enclosed nanochannels, wherein each of the one or more nanochannels comprise one or more sidewalls and a roof; and partially sealing the roof of one or more nanochannels, wherein the roof comprises no more than one unsealed nanochannel per squared micron.
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公开(公告)号：US09927397B1
公开(公告)日：2018-03-27
申请号：US14555453
申请日：2014-11-26
申请人： Steven R. J. Brueck , Jeremy Scott Edwards , Alexander Neumann , Yuliya Kuznetsova , Edgar A. Mendoza , C. Jeffrey Brinker
发明人： Steven R. J. Brueck , Jeremy Scott Edwards , Alexander Neumann , Yuliya Kuznetsova , Edgar A. Mendoza , C. Jeffrey Brinker
IPC分类号： G01N27/447 , C12Q1/68 , B01L3/00
CPC分类号： G01N27/44791 , B01L3/502707 , B01L3/50273 , B01L3/502746 , B01L2200/0663 , B01L2300/0645 , B01L2300/0896 , B01L2400/0421 , B81C1/00 , C12Q1/6869 , G01N33/48721 , C12Q2563/157 , C12Q2563/159 , C12Q2565/631
摘要： Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (>wavelength), ˜1-nm aperture “tortuous” nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.
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8.发明授权公开(公告)号：US08526105B2
公开(公告)日：2013-09-03
申请号：US13345267
申请日：2012-01-06
CPC分类号： G02B21/0032 , G02B21/00 , G02B21/365 , G06T3/4061 , G06T2207/10056 , G06T2207/20056 , G06T2207/20221 , G06T2207/30148
摘要： In accordance with the invention, there are imaging interferometric microscopes and methods for imaging interferometric microscopy using structural illumination and evanescent coupling for the extension of imaging interferometric microscopy. Furthermore, there are coherent anti-Stokes Raman (CARS) microscopes and methods for coherent anti-Stokes Raman (CARS) microscopy, wherein imaging interferometric microscopy techniques are applied to get material dependent spectroscopic information.
摘要翻译： 根据本发明，存在成像干涉显微镜和用于使用结构照明和ev逝耦合来成像干涉显微镜的成像干涉显微镜成像的方法。 此外，还有相干的反斯托克斯拉曼（CARS）显微镜和相干反斯托克斯拉曼（CARS）显微镜的方法，其中应用成像干涉显微技术获得材料依赖的光谱信息。
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9.发明授权Structural illumination and evanescent coupling for the extension of imaging interferometric microscopy 有权用于成像干涉显微镜扩展的结构照明和ev逝耦合公开(公告)号：US09239455B2
公开(公告)日：2016-01-19
申请号：US13629598
申请日：2012-09-27
CPC分类号： G02B21/06 , G01N2021/653 , G02B21/0056 , G02B21/365 , G06T3/4061
摘要： In accordance with the aspects of the present disclosure, a method and apparatus is disclosed for imaging interferometric microscopy (IIM), which can use an immersion medium to enhance resolution up to a resolution of linear systems resolution limit of λ/4n, where λ is the wavelength in free space and n is the index of refraction of a transmission medium.
摘要翻译： 根据本公开的方面，公开了一种用于成像干涉显微镜（IIM）的方法和装置，其可以使用浸没介质来增强分辨率，直到λ/ 4n的线性系统分辨率极限的分辨率，其中λ是 自由空间中的波长和n是传输介质的折射率。
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公开(公告)号：US10969364B1
公开(公告)日：2021-04-06
申请号：US15896843
申请日：2018-02-14
申请人： Steven R. J. Brueck , Jeremy Scott Edwards , Alexander Neumann , Yuliya Kuznetsova , Edgar A. Mendoza , C. Jeffrey Brinker
发明人： Steven R. J. Brueck , Jeremy Scott Edwards , Alexander Neumann , Yuliya Kuznetsova , Edgar A. Mendoza , C. Jeffrey Brinker
IPC分类号： G01N27/447 , B01L3/00 , C12Q1/6869
摘要： Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (>wavelength), ˜1-nm aperture “tortuous” nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.
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