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公开(公告)号：US20050255098A1
公开(公告)日：2005-11-17
申请号：US10844035
申请日：2004-05-11
申请人： Steven Rosen , Linda Noble
发明人： Steven Rosen , Linda Noble
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2854
摘要： The present invention provides methods of treating traumatic spinal cord injury, methods of reducing cell-mediated demyelination of long descending fiber tracts or local circuits in the spinal cord following traumatic spinal cord injury, and methods for improving or restoring locomotor recovery and/or fine motor movement in an individual following spinal cord injury. The present invention further provides compositions for use in the methods. The methods generally involve administering to an individual in need thereof an effective amount of an L-selectin antagonist.
摘要翻译： 本发明提供治疗创伤性脊髓损伤的方法，在创伤性脊髓损伤后脊髓中长期下降的纤维束或局部回路减少细胞介导的脱髓鞘的方法，以及用于改善或恢复运动恢复和/或精细运动的方法 脊髓损伤后个体运动。 本发明还提供了用于该方法的组合物。 所述方法通常涉及向有需要的个体施用有效量的L-选择素拮抗剂。
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公开(公告)号：US11121419B2
公开(公告)日：2021-09-14
申请号：US16151424
申请日：2018-10-04
IPC分类号： H01M10/613 , H02J7/00 , H01M10/659 , H02J7/35 , H01M10/615 , H01M10/63 , H01M16/00 , H01M10/6567 , H01M10/66
摘要： Systems and methods for managing and utilizing heat associated with battery charge and/or discharge cycles are described herein. A system as described herein includes a battery array comprising one or more batteries, a heat collector physically coupled to respective batteries of the battery array that captures heat associated with at least one of charge cycles or discharge cycles of the respective batteries of the battery array, and a routing controller communicatively coupled to the heat collector that initiates transference of the heat captured by the heat collector as an energy source to one or more subsystems that are distinct from the heat collector.
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公开(公告)号：US20090298052A1
公开(公告)日：2009-12-03
申请号：US11569992
申请日：2005-06-06
申请人： David Atkins , John Backus , Robert Belly , Steven Rosen , Robert White
发明人： David Atkins , John Backus , Robert Belly , Steven Rosen , Robert White
IPC分类号： C12Q1/68
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/16
摘要： A method of diagnosing the presence or predicting the course of breast cancer by measuring the expression of a combination of Marker genes comprising a tissue-specific gene and a non-tissue specific gene in a cell or tissue sample derived from a patient. In one aspect of the invention, the genes are mammaglobin and CK19. Kits, nucleic acid primers and probes and controls are provided.
摘要翻译： 通过测量源自患者的细胞或组织样品中包含组织特异性基因和非组织特异性基因的标记基因的组合的表达来诊断存在或预测乳腺癌病程的方法。 在本发明的一个方面，基因是乳腺球蛋白和CK19。 提供试剂盒，核酸引物和探针和对照。
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公开(公告)号：US07070971B2
公开(公告)日：2006-07-04
申请号：US10697828
申请日：2003-10-29
申请人： Steven Rosen , Jin Kyu Lee , Stefan Hemmerich
发明人： Steven Rosen , Jin Kyu Lee , Stefan Hemmerich
CPC分类号： C12N9/1051 , A61K38/00 , C12Q1/6883 , C12Q2600/158
摘要： Novel glycosylsulfotransferases (GST-4α, GST-4β, and GST-6) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including various diagnostic and therapeutic agent screening applications. Also provided are methods of inhibiting selectin mediated binding events and methods of treating disease conditions associated therewith, particularly by administering an inhibitor of at least one of GST-4α, GST-4β, and GST-6.
摘要翻译： 提供了新的糖基转移酶（GST-4α，GST-4beta和GST-6）及其相关的多肽，以及编码其的核酸组合物。 本发明的多肽和核酸组合物可用于各种应用，包括各种诊断和治疗剂筛选应用。 还提供了抑制选择蛋白介导的结合事件的方法和治疗与之相关的疾病状况的方法，特别是通过施用GST-4α，GST-4beta和GST-6中的至少一种的抑制剂。
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公开(公告)号：US20060063230A1
公开(公告)日：2006-03-23
申请号：US11219360
申请日：2005-09-02
申请人： Roman Naworth , Steven Rosen
发明人： Roman Naworth , Steven Rosen
CPC分类号： A61K38/1816 , A61K38/34 , A61K39/00 , C07K16/40 , C07K2319/00 , C12N9/16 , C12Q1/44 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Y301/06014 , G01N33/57484 , G01N2333/916 , G01N2500/04 , A61K2300/00
摘要： Novel sulfatases and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including various diagnostic and therapeutic agent screening applications. Also provided are methods of inhibiting tumor-induced angiogenesis and methods of treating disease conditions associated therewith, particularly by administering an inhibitor of a subject sulfatase.
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公开(公告)号：US10795332B2
公开(公告)日：2020-10-06
申请号：US16247082
申请日：2019-01-14
IPC分类号： G06N20/00 , G06K9/00 , G06K9/62 , G10L17/00 , G10L17/06 , H04L12/28 , G05B19/042 , H04L29/06 , G10L17/22 , G06N3/08 , G05B15/02 , G05B17/02
摘要： Systems, computer-implemented methods and/or computer program products that facilitate automating home control are provided. In one embodiment a computer-implemented method comprises: using a voice recognition component to identify user identification by analyzing voice signatures; using a face recognition component to determine user identification by analyzing facial features; using an authentication component to verify user identification and authorize control access to functionality of one or more automated home control systems; using a communication component to facilitate communication between the one or more automated home control systems and one or more devices; using a service component to execute a set of functions based on authorized user commands and information communicated from the one or more devices; and using a machine learning component to learn user preferences by correlating a set of functions with the authorized users commands.
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公开(公告)号：US20190219976A1
公开(公告)日：2019-07-18
申请号：US16247082
申请日：2019-01-14
IPC分类号： G05B19/042 , G06N20/00 , H04L29/06 , G06K9/00 , G10L17/00 , G10L17/06 , G10L17/22 , H04L12/28
摘要： Systems, computer-implemented methods and/or computer program products that facilitate automating home control are provided. In one embodiment a computer-implemented method comprises: using a voice recognition component to identify user identification by analyzing voice signatures; using a face recognition component to determine user identification by analyzing facial features; using an authentication component to verify user identification and authorize control access to functionality of one or more automated home control systems; using a communication component to facilitate communication between the one or more automated home control systems and one or more devices; using a service component to execute a set of functions based on authorized user commands and information communicated from the one or more devices; and using a machine learning component to learn user preferences by correlating a set of functions with the authorized users commands.
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公开(公告)号：US20190102812A1
公开(公告)日：2019-04-04
申请号：US16151396
申请日：2018-10-04
摘要： Techniques for autonomously managing an intelligent space are provided. In one example, a method is provided that can comprise detecting, by a system operatively coupled to a processor, a number of occupants located in a space for a period of time. The number of occupants can be an integer greater than zero. The method can also comprise associating, by the system, the number of occupants with an entity. Further, the method can comprise billing, by the system, the entity a cost based on the number of occupants.
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公开(公告)号：US20130008052A1
公开(公告)日：2013-01-10
申请号：US13546166
申请日：2012-07-11
申请人： Steven Rosen
发明人： Steven Rosen
CPC分类号： A43B5/18 , A43B1/0009 , A43B13/122 , A43B13/187
摘要： A cushioning attachment for shoes including athletic shoes and, in particular, running shoes includes two component features: a cushioning feature, and a resilient/traction feature. In addition, the cushioning attachment can include a securing feature for securing the device to the outsole of the shoe of a wearer. In the cushioning attachments, the cushioning feature is typically a first layer of the attachment while the resilient/traction feature is typically a second layer of the attachment. The attachment can also include a heel addition layer attached to the top of the first layer.
摘要翻译： 鞋的缓冲附件包括运动鞋，特别是跑步鞋包括两个组件特征：缓冲特征和弹性/牵引特征。 此外，缓冲附件可以包括用于将装置固定到穿着者的鞋的外底的固定特征。 在缓冲附件中，缓冲特征通常是附件的第一层，而弹性/牵引特征通常是附件的第二层。 附件还可以包括附接到第一层的顶部的跟部添加层。
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公开(公告)号：US5318890A
公开(公告)日：1994-06-07
申请号：US695805
申请日：1991-05-06
申请人： Steven Rosen , Mark Singer , Yasuyuki Imai , Ted Yednock
发明人： Steven Rosen , Mark Singer , Yasuyuki Imai , Ted Yednock
IPC分类号： A61K38/00 , A61P29/00 , C07K14/47 , C07K14/705 , C07K16/28 , C12N15/12 , C12Q1/02 , G01N33/53 , G01N33/566 , C12Q1/00
CPC分类号： C07K14/4727 , C07K14/70564 , C07K14/70596 , C07K16/28 , C07K16/2854 , A61K38/00 , C07K2317/34 , C07K2319/00 , C07K2319/33
摘要： The present invention provides novel assays for determining the ability of a test compound to inhibit intercellular adhesion mediated by a selectin receptor, such as the LHR. The assays involve contacting the test compound with the receptor and an isolated receptor-binding agent. The receptor-binding agent is a sulfated polysaccharide, a sulfated glycolipid, or a compound comprising the extracellular region of an endothelial cell surface glycoprotein. Also provided are compositions comprising a compound comprising the extracellular region of an endothelial cell surface protein, which is specifically recognized by lymphocyte homing receptors.
摘要翻译： 本发明提供了用于测定测试化合物抑制由选择素受体（例如LHR）介导的细胞间粘附的能力的新型测定法。 测定包括使测试化合物与受体和分离的受体结合剂接触。 受体结合剂是硫酸化多糖，硫酸化糖脂或包含内皮细胞表面糖蛋白的胞外区的化合物。 还提供了包含由淋巴细胞归巢受体特异性识别的内皮细胞表面蛋白的细胞外区的化合物的组合物。
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