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447 条记录 (耗时 0.055 秒)

    Substituted 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof
    2.
    发明授权
    Substituted 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof 失效
    取代的4H-色烯和类似物作为胱天蛋白酶的激活剂和凋亡诱导剂及其用途

    公开(公告)号：US07507762B2

    公开(公告)日：2009-03-24

    申请号：US11072499

    申请日：2005-03-07

    申请人： John A. Drewe ,  Sui Xiong Cai ,  Yan Wang

    发明人： John A. Drewe ,  Sui Xiong Cai ,  Yan Wang

    IPC分类号： A61K31/352 ,  A61K31/36

    CPC分类号： C07D311/58 ,  C07D311/92 ,  C07D405/04 ,  C07D407/04 ,  C07D409/04 ,  C07D491/04

    摘要： The present invention is directed to substituted 4H-chromene and analogs thereof, represented by the general Formula I: wherein A, B, X, Y, Z and R5 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

    摘要翻译： 本发明涉及由通式I表示的取代的4H-色烯及其类似物：其中A，B，X，Y，Z和R5如本文所定义。 本发明还涉及发现具有式I的化合物是胱天蛋白酶的活化剂和凋亡诱导剂。 因此，本发明的胱天蛋白酶和细胞凋亡诱导剂的激活剂可用于诱导异常细胞发生不受控制的生长和扩散的各种临床病症中的细胞死亡。

    Substituted 2-aminoacetamides and the use thereof
    4.
    发明授权
    Substituted 2-aminoacetamides and the use thereof 有权
    取代的2-氨基乙酰胺及其用途

    公开(公告)号：US08426431B2

    公开(公告)日：2013-04-23

    申请号：US12986587

    申请日：2011-01-07

    申请人： Nancy C. Lan ,  Yan Wang ,  Sui Xiong Cai

    发明人： Nancy C. Lan ,  Yan Wang ,  Sui Xiong Cai

    IPC分类号： A61K31/505 ,  A61K31/47 ,  A61K31/165

    CPC分类号： C07C233/05 ,  A61K31/165 ,  C07C237/06 ,  C07C237/08 ,  C07C2601/14 ,  C07D211/46 ,  C07D213/65 ,  C07D213/68 ,  C07D215/20 ,  C07D239/34 ,  C07D241/08 ,  C07D309/12 ,  C07D317/64

    摘要： The invention is directed to substituted 2-aminoacetamides represented by formula (II): and to pharmaceutically acceptable salts and prodrugs thereof, wherein the substituents are defined herein. The invention is also directed to the use of substituted 2-aminoacetamides in methods for the treatment of neuronal damage following global and focal ischemia, and for the treatment, prevention or amelioration of pain, anxiety, or manic depression, as anticonvulsants, as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

    摘要翻译： 本发明涉及由式（II）表示的取代的2-氨基乙酰胺及其药学上可接受的盐和前药，其中取代基在本文中定义。 本发明还涉及取代的2-氨基乙酰胺在治疗全球和局灶性缺血后的神经元损伤的方法中的用途，以及用作治疗，预防或改善作为抗惊厥药物的抗痉挛剂的疼痛，焦虑或躁狂抑郁症 ，作为局部麻醉剂，作为抗心律失常药物和治疗或预防糖尿病性神经病变。

    Substituted 2-aminoacetamides and the use thereof
    5.
    发明授权
    Substituted 2-aminoacetamides and the use thereof 失效
    取代的2-氨基乙酰胺及其用途

    公开(公告)号：US07541465B2

    公开(公告)日：2009-06-02

    申请号：US11443174

    申请日：2006-05-31

    申请人： Nancy Lan ,  Yan Wang ,  Sui Xiong Cai

    发明人： Nancy Lan ,  Yan Wang ,  Sui Xiong Cai

    IPC分类号： C07D211/94 ,  C07D211/96 ,  C07D211/98 ,  A61K31/513

    CPC分类号： C07C233/05 ,  A61K31/165 ,  C07C237/06 ,  C07C237/08 ,  C07C2601/14 ,  C07D211/46 ,  C07D213/65 ,  C07D213/68 ,  C07D215/20 ,  C07D239/34 ,  C07D241/08 ,  C07D309/12 ,  C07D317/64

    摘要： The invention is directed to substituted 2-aminoacetamides represented by formula (II): and to pharmaceutically acceptable salts and prodrugs thereof, wherein the substituents are defined herein. The invention is also directed to the use of substituted 2-aminoacetamides in methods for the treatment of neuronal damage following global and focal ischemia, and for the treatment, prevention or amelioration of pain, as anticonvulsants, as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

    摘要翻译： 本发明涉及由式（II）表示的取代的2-氨基乙酰胺及其药学上可接受的盐和前药，其中取代基在本文中定义。 本发明还涉及取代的2-氨基乙酰胺在治疗全球和局灶性缺血后的神经元损伤的方法中的用途，以及用作治疗，预防或改善疼痛的抗惊厥药作为抗痉挛剂，作为局部麻醉剂，如 抗心律失常药物和治疗或预防糖尿病性神经病变。