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11 条记录 (耗时 0.022 秒)

    Method of producing a galactosyl-cyclodextrin
    1.
    发明授权
    Method of producing a galactosyl-cyclodextrin 失效
    生产半乳糖基 - 环糊精的方法

    公开(公告)号：US5523218A

    公开(公告)日：1996-06-04

    申请号：US368392

    申请日：1994-12-30

    申请人： Sumio Kitahata ,  Koji Hara ,  Koki Fujita ,  Nobuhiro Kuwahara ,  Kyoko Koizumi

    发明人： Sumio Kitahata ,  Koji Hara ,  Koki Fujita ,  Nobuhiro Kuwahara ,  Kyoko Koizumi

    IPC分类号： C08B37/16 ,  C12P19/18 ,  C12P19/04 ,  C12P19/08 ,  C12P19/44

    CPC分类号： A61Q19/00 ,  A61K8/738 ,  C08B37/0012 ,  C12P19/18

    摘要： Disclosed are (1) a novel galactosyl-cyclodextrin having a galactosyl group as bonded to the hydroxyl group of the glucosyl group of a cyclodextrin via an .alpha.-bond and a method of producing said galactosyl-cyclodextrin; (2) a novel galactosyl-cyclodextrin having a galactosyl group as bonded to the hydroxyl group of the glucosyl group of a cyclodextrin via a .beta.-bond and a method of producing said galactosyl-cyclodextrin; and (3) a novel mannosyl-cyclodextrin having a mannosyl group as bonded to the hydroxyl group of the glucosyl group of a cyclodextrin via an .alpha.-bond and a method of producing said mannosyl-cyclodextrin. The new branched cyclodextrins are expected to be widely useful in various fields of drug industry, food industry and cosmetic industry.

    摘要翻译： 公开了（1）具有通过α键与环糊精的葡糖基的羟基键合的半乳糖基的新型半乳糖基 - 环糊精和所述半乳糖基 - 环糊精的制备方法; （2）具有通过β键与环糊精的葡糖基的羟基键合的半乳糖基的新型半乳糖基 - 环糊精和所述半乳糖基 - 环糊精的制造方法; 和（3）具有通过α键与环糊精的葡糖基的羟基键合的甘露糖基的新型甘露糖基 - 环糊精和所述甘露糖基 - 环糊精的制造方法。 新型支链环糊精预期在药物工业，食品工业和化妆品行业的各个领域中广泛应用。

    Reagent for Determining .alpha.-amylase activity and method for determining .alpha.-amylase activity
    6.
    发明授权
    Reagent for Determining .alpha.-amylase activity and method for determining .alpha.-amylase activity 失效
    用于测定α-淀粉酶活性的试剂和测定α-淀粉酶活性的方法

    公开(公告)号：US5393660A

    公开(公告)日：1995-02-28

    申请号：US147717

    申请日：1993-11-04

    申请人： Sumio Kitahata ,  Nobuhiro Kuwahara ,  Koki Fujita ,  Koji Hara ,  Keiichi Majima ,  Shin-ichi Teshima ,  Yuzo Hayashi

    发明人： Sumio Kitahata ,  Nobuhiro Kuwahara ,  Koki Fujita ,  Koji Hara ,  Keiichi Majima ,  Shin-ichi Teshima ,  Yuzo Hayashi

    IPC分类号： C07H15/203 ,  C12Q1/40 ,  C12N9/26

    CPC分类号： C07H15/203 ,  C12Q1/40 ,  C12Q2334/00 ,  C12Q2334/10

    摘要： A reagent for determining a-amylase activity, comprising a maltooligosaccharide derivative of the following formula ##STR1## (wherein either one of R.sub.1 and R.sub.2 is .beta.-galactopyranosil and the other is hydrogen, R.sub.3 is a group bonded to the reducing terminal glucose via a bond cleavable by .alpha.-amylase, which becomes a measurable substance upon cleavage of the bond, and n is an integer of 0-2), which does not comprise adjuvant enzymes; and a method for determining .alpha.-amylase activity which comprises use of the reagent. The reagent of the present invention does not require use of any adjuvant enzyme and is stable since the substrate is not exposed to the decomposition by an adjuvant enzyme. The substrate used in the present invention has high affinity for .alpha.-amylase. Thus, the reagent and the determination method of the present invention make it possible to determine .alpha.-amylase activity with high sensitivity.

    摘要翻译： 一种用于测定α-淀粉酶活性的试剂，包括下式的麦芽低聚糖衍生物（Ⅰ）（其中R 1和R 2中的任一个是β-半乳糖吡喃糖苷，另一个是氢，R 3是键合到还原末端的基团 葡萄糖通过可以被α-淀粉酶切割的键，其在切割键时成为可测量物质，n是0-2的整数），其不包含辅酶; 以及一种测定α-淀粉酶活性的方法，其包括使用该试剂。 本发明的试剂不需要使用任何辅助酶，并且是稳定的，因为底物不被辅助酶暴露于分解。 用于本发明的底物对α-淀粉酶具有高亲和力。 因此，本发明的试剂和测定方法能够以高灵敏度确定α-淀粉酶活性。

    Quercetin-containing coloring
    9.
    发明授权
    Quercetin-containing coloring 失效
    含槲皮素的着色

    公开(公告)号：US5445842A

    公开(公告)日：1995-08-29

    申请号：US156805

    申请日：1993-11-22

    申请人： Takemi Tanaka ,  Hisashi Okemoto ,  Nobuhiro Kuwahara

    发明人： Takemi Tanaka ,  Hisashi Okemoto ,  Nobuhiro Kuwahara

    IPC分类号： A23L1/27 ,  A23L1/275 ,  C08B37/16 ,  C09B61/00

    CPC分类号： C09B61/00 ,  A23L5/43

    摘要： A quercetin-containing colorant which has as an effective component a quercetin included by cyclodextrin. Effective use thereof as a colorant is possible by imparting thereto resistance against light, heat and chemicals to quercetin which is a flavonoid yellow substance. The colorant may be added to various food products for use of quercetin as a stable coloring matter.

    摘要翻译： 含有槲皮素的着色剂，其具有由环糊精包括的槲皮素作为有效成分。 通过赋予其作为黄酮类黄色物质的槲皮素对光，热和化学品的抵抗能力，可以有效地使用它们作为着色剂。 着色剂可以添加到各种食品中以用作槲皮素作为稳定的着色剂。

    Cyclodextrin inclusion complex of taxol, and method for its production and its use
    10.
    发明授权
    Cyclodextrin inclusion complex of taxol, and method for its production and its use 失效
    紫杉醇的环糊精包合物及其生产方法及其应用

    公开(公告)号：US5684169A

    公开(公告)日：1997-11-04

    申请号：US470018

    申请日：1995-06-06

    申请人： Hiroki Hamada ,  Kyoko Saito ,  Katsuhiko Mikuni ,  Nobuhiro Kuwahara ,  Hideki Takahashi

    发明人： Hiroki Hamada ,  Kyoko Saito ,  Katsuhiko Mikuni ,  Nobuhiro Kuwahara ,  Hideki Takahashi

    IPC分类号： A61K31/335 ,  A61K47/48 ,  C07D305/14

    CPC分类号： B82Y5/00 ,  A61K31/335 ,  A61K47/48969

    摘要： There is provided an unbranched cyclodextrin or a branched cyclodextrin inclusion complex of taxol. The complex is produced by adding an unbranched cyclodextrin of a branched cyclodextrin to taxol at a molar ratio of 1-20 times with respect to taxol. A method is provided for the improvement of the solubility of taxol in water by adding an unbranched cyclodextrin or a branched cyclodextrin thereto at a molar ratio of 1-20 times with respect to taxol. The solubility of taxol in water is improved by the present invention. A cyclodextrin inclusion complex of taxol according to the present invention serves to make taxol more easily absorbed when administered to a cancer patient, which is beneficial to cancer patients and the physiological effects of taxol may therefore be more effectively induced.

    摘要翻译： 提供紫杉醇的无支链环糊精或支链环糊精包合物。 通过将支链环糊精的无支链环糊精与紫杉醇以相对于紫杉醇为1-20倍的摩尔比添加到紫杉醇中而制备。 提供了一种通过以相对于紫杉醇为1-20倍的摩尔比添加无支链环糊精或支链环糊精来提高紫杉醇在水中的溶解度的方法。 本发明提高了紫杉醇在水中的溶解度。 根据本发明的紫杉醇的环糊精包合物用于在给予癌症患者时更容易地吸收紫杉醇，这有利于癌症患者，因此可以更有效地诱导紫杉醇的生理作用。