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公开(公告)号：US20110020396A1
公开(公告)日：2011-01-27
申请号：US12859356
申请日：2010-08-19
申请人： Susan Barnett , Indresh Srivastava
发明人： Susan Barnett , Indresh Srivastava
IPC分类号： A61K39/21 , C07K14/155 , A61P31/18
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/545 , A61K2039/55566 , A61K2039/6031 , C07K14/70514 , C07K16/1063 , C07K16/2812 , C07K2317/32 , C07K2317/76 , C07K2319/32 , C12N2740/10043 , C12N2740/16122 , C12N2740/16134 , C12N2770/36143 , C12N2800/107
摘要： Env-CD4 polypeptide complexes and hybrids that expose cryptic epitopes important in virus neutralization are disclosed. Method of diagnosis, treatment and prevention using the polypeptides are also provided.
摘要翻译： 公开了暴露在病毒中和中重要的隐蔽表位的Env-CD4多肽复合物和杂交体。 还提供了使用多肽进行诊断，治疗和预防的方法。
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公开(公告)号：US20120276128A1
公开(公告)日：2012-11-01
申请号：US13544063
申请日：2012-07-09
申请人： Susan Barnett , Indresh Srivastava
发明人： Susan Barnett , Indresh Srivastava
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/545 , A61K2039/55566 , A61K2039/6031 , C07K14/70514 , C07K16/1063 , C07K16/2812 , C07K2317/32 , C07K2317/76 , C07K2319/32 , C12N2740/10043 , C12N2740/16122 , C12N2740/16134 , C12N2770/36143 , C12N2800/107
摘要： Env-CD4 polypeptide complexes and hybrids that expose cryptic epitopes important in virus neutralization are disclosed. Methods of diagnosis, treatment and prevention using the polypeptides are also provided.
摘要翻译： 公开了暴露在病毒中和中重要的隐蔽表位的Env-CD4多肽复合物和杂交体。 还提供了使用多肽进行诊断，治疗和预防的方法。
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公开(公告)号：US20050175631A1
公开(公告)日：2005-08-11
申请号：US10501606
申请日：2003-01-14
IPC分类号： A61K9/00 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/21 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K14/16 , C07K16/00 , C07K17/00 , C12P21/06
CPC分类号： C07K14/005 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/543 , A61K2039/55544 , A61K2039/55594 , A61K2039/575 , A61K2039/6037 , C12N2740/16034 , C12N2740/16222
摘要： This invention is directed to pharmaceutical compositions comprising an HIV antigen and a mucosal adjuvant and methods for raising an immune response in a subject by administering these compositions. Preferably, the pharmaceutical compositions of the invention can be used to treat or prevent HIV infection.
摘要翻译： 本发明涉及包含HIV抗原和粘膜佐剂的药物组合物以及通过施用这些组合物在受试者中提高免疫应答的方法。 优选地，本发明的药物组合物可用于治疗或预防HIV感染。
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4.发明授权Chimeric HIV Env proteins comprising CD4 mini-proteins or CD4 mimetics that are capable of inducing neutralizing antibody responses against cryptic Env epitopes 有权包含能够诱导针对隐性Env表位的中和抗体应答的CD4微型蛋白或CD4模拟物的嵌合HIV Env蛋白公开(公告)号：US07811580B2
公开(公告)日：2010-10-12
申请号：US10514055
申请日：2003-05-07
申请人： Susan Barnett , Indresh Srivastava
发明人： Susan Barnett , Indresh Srivastava
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/545 , A61K2039/55566 , A61K2039/6031 , C07K14/70514 , C07K16/1063 , C07K16/2812 , C07K2317/32 , C07K2317/76 , C07K2319/32 , C12N2740/10043 , C12N2740/16122 , C12N2740/16134 , C12N2770/36143 , C12N2800/107
摘要： Env-CD4 complexes and hybrids are disclosed that expose cryptic epitopes that are important in virus neutralization. Methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided.
摘要翻译： 公开了Env-CD4复合物和杂交体，其暴露在病毒中和中重要的神经表位。 还提供了使用多核苷酸和多肽进行诊断，治疗和预防的方法。
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公开(公告)号：US20070166784A1
公开(公告)日：2007-07-19
申请号：US10571882
申请日：2004-09-15
申请人： Susan Barnett , Victor Gomez-Roman , Ying Lian , Bo Peng , Marjorie Robert-Guroff , Indresh Srivastava
发明人： Susan Barnett , Victor Gomez-Roman , Ying Lian , Bo Peng , Marjorie Robert-Guroff , Indresh Srivastava
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55566 , A61K2039/57 , C07K16/1063 , C07K2317/21 , C07K2317/732 , C07K2317/76 , C12N2740/16134
摘要： The present invention relates to methods, polynucleotides, and polypeptides encoding immunogenic HIV polypeptides derived from different strains within an HIV subtype and/or immunogenic HIV polypeptides from different subtypes. Uses of the polynucleotides and polypeptides in combination approaches for generating immune responses are described. The combination approaches described herein have been shown to induce broad and potent neutralizing activity against diverse HIV strains from multiple strains within a given subtype and against diverse subtypes. Formulations of compositions for generating immune responses and methods of use for such compositions are also disclosed.
摘要翻译： 本发明涉及编码来自不同亚型的HIV亚型中的不同菌株和/或来自不同亚型的免疫原性HIV多肽的免疫原性HIV多肽的方法，多核苷酸和多肽。 描述了用于产生免疫应答的组合方法中多核苷酸和多肽的用途。 已经显示本文描述的组合方法可以诱导针对给定亚型中的多种菌株和针对不同亚型的多种HIV株的广泛和有效的中和活性。 还公开了用于产生免疫应答的组合物的制剂和用于这种组合物的方法。
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公开(公告)号：US20060073576A1
公开(公告)日：2006-04-06
申请号：US10514055
申请日：2003-05-07
申请人： Susan Barnett , Indresh Srivastava
发明人： Susan Barnett , Indresh Srivastava
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/545 , A61K2039/55566 , A61K2039/6031 , C07K14/70514 , C07K16/1063 , C07K16/2812 , C07K2317/32 , C07K2317/76 , C07K2319/32 , C12N2740/10043 , C12N2740/16122 , C12N2740/16134 , C12N2770/36143 , C12N2800/107
摘要： Env-CD4 complexes and hybrids are disclosed that expose cryptic epitopes that are important in virus neutralization. Methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided.
摘要翻译： 公开了Env-CD4复合物和杂交体，其暴露在病毒中和中重要的神经表位。 还提供了使用多核苷酸和多肽进行诊断，治疗和预防的方法。
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公开(公告)号：US07718401B2
公开(公告)日：2010-05-18
申请号：US12026619
申请日：2008-02-06
申请人： Susan W. Barnett , Jan zur Megede , Indresh Srivastava , Ying Lian , Karin Hartog , Hong Liu , Catherine Greer , Mark Selby , Christopher Walker
发明人： Susan W. Barnett , Jan zur Megede , Indresh Srivastava , Ying Lian , Karin Hartog , Hong Liu , Catherine Greer , Mark Selby , Christopher Walker
CPC分类号： C12N7/00 , A61K39/00 , A61K48/00 , A61K2039/5156 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , C07K14/005 , C12N15/86 , C12N2740/16023 , C12N2740/16043 , C12N2740/16052 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , C12N2800/108 , C12N2840/20 , C12N2840/203
摘要： The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.
摘要翻译： 本发明涉及HIV多肽在各种细胞类型中的有效表达，包括但不限于哺乳动物，昆虫和植物细胞。 还描述了编码含有HIV Gag的多肽的合成表达盒，以及包括DNA免疫，产生包装细胞系以及产生含有Env-，tat-或Gag的蛋白质的应用中的表达盒的用途。 本发明提供了生产病毒样颗粒（VLP）的方法，以及VLP的使用，包括但不限于用于呈递抗体的媒介物和在施用VLP的受试者中刺激免疫应答。
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公开(公告)号：US08168418B2
公开(公告)日：2012-05-01
申请号：US12770905
申请日：2010-04-30
申请人： Susan W Barnett , Jan Zur Megede , Indresh Srivastava , Ying Lian , Karin Hartog , Hong Liu , Catherine Greer , Mark Selby , Christopher Walker
发明人： Susan W Barnett , Jan Zur Megede , Indresh Srivastava , Ying Lian , Karin Hartog , Hong Liu , Catherine Greer , Mark Selby , Christopher Walker
CPC分类号： C12N7/00 , A61K39/00 , A61K48/00 , A61K2039/5156 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , C07K14/005 , C12N15/86 , C12N2740/16023 , C12N2740/16043 , C12N2740/16052 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , C12N2800/108 , C12N2840/20 , C12N2840/203
摘要： The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.
摘要翻译： 本发明涉及HIV多肽在各种细胞类型中的有效表达，包括但不限于哺乳动物，昆虫和植物细胞。 描述了编码含有HIV Gag的多肽的合成表达盒，以及包括DNA免疫，产生包装细胞系以及产生含有Env，tat或Gag的蛋白质的应用中的表达盒的用途。 本发明提供了生产病毒样颗粒（VLP）的方法，以及VLP的使用，包括但不限于用于呈递抗体的媒介物和在施用VLP的受试者中刺激免疫应答。
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公开(公告)号：US20110065146A1
公开(公告)日：2011-03-17
申请号：US12770905
申请日：2010-04-30
申请人： Susan W. Barnett , Jan zur Megede , Indresh Srivastava , Ying Lian , Karin Hartog , Hong Liu , Catherine Greer , Mark Selby , Christopher Walker
发明人： Susan W. Barnett , Jan zur Megede , Indresh Srivastava , Ying Lian , Karin Hartog , Hong Liu , Catherine Greer , Mark Selby , Christopher Walker
IPC分类号： C12P21/00
CPC分类号： C12N7/00 , A61K39/00 , A61K48/00 , A61K2039/5156 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , C07K14/005 , C12N15/86 , C12N2740/16023 , C12N2740/16043 , C12N2740/16052 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , C12N2800/108 , C12N2840/20 , C12N2840/203
摘要： The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.
摘要翻译： 本发明涉及HIV多肽在各种细胞类型中的有效表达，包括但不限于哺乳动物，昆虫和植物细胞。 描述了编码含有HIV Gag的多肽的合成表达盒，以及包括DNA免疫，产生包装细胞系以及产生含有Env，tat或Gag的蛋白质的应用中的表达盒的用途。 本发明提供了生产病毒样颗粒（VLP）的方法，以及VLP的使用，包括但不限于用于呈递抗体的媒介物和在施用VLP的受试者中刺激免疫应答。
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公开(公告)号：US20080261271A1
公开(公告)日：2008-10-23
申请号：US12026619
申请日：2008-02-06
申请人： Susan W. Barnett , Jan zur Megede , Indresh Srivastava , Ying Lian , Karin Hartog , Hong Liu , Catherine Greer , Mark Selby , Christopher Walker
发明人： Susan W. Barnett , Jan zur Megede , Indresh Srivastava , Ying Lian , Karin Hartog , Hong Liu , Catherine Greer , Mark Selby , Christopher Walker
IPC分类号： C12N15/49
CPC分类号： C12N7/00 , A61K39/00 , A61K48/00 , A61K2039/5156 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , C07K14/005 , C12N15/86 , C12N2740/16023 , C12N2740/16043 , C12N2740/16052 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , C12N2800/108 , C12N2840/20 , C12N2840/203
摘要： The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.
摘要翻译： 本发明涉及HIV多肽在各种细胞类型中的有效表达，包括但不限于哺乳动物，昆虫和植物细胞。 还描述了编码含有HIV Gag的多肽的合成表达盒，以及包括DNA免疫，产生包装细胞系以及产生含有Env-，tat-或Gag的蛋白质的应用中的表达盒的用途。 本发明提供了生产病毒样颗粒（VLP）的方法，以及VLP的使用，包括但不限于用于呈递抗体的媒介物和在施用VLP的受试者中刺激免疫应答。
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