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    MICROSCOPE
    1.
    发明申请
    MICROSCOPE 审中-公开
    显微镜

    公开(公告)号：US20110102888A1

    公开(公告)日：2011-05-05

    申请号：US12907196

    申请日：2010-10-19

    申请人： Susumu Honda ,  Tatsuo Nakata

    发明人： Susumu Honda ,  Tatsuo Nakata

    IPC分类号： G02B21/08 ,  G02B21/06

    CPC分类号： G02B21/088 ,  G02B21/06 ,  G02B21/16 ,  G02B21/32

    摘要： Provided is a microscope that allows irradiation with uniform illumination light without decreasing the amount of light. Employed is a microscope 1 including an incoherent light source 31 that emits incoherent light I; an optical fiber 35 on which the incoherent light I is incident and which guides the incident incoherent light I by repeated total reflection; a DMD 37 having an array of movable micromirrors each reflecting or transmitting the guided incoherent light I; an objective lens 18 that irradiates a specimen 19 with the incoherent light I reflected or transmitted by the DMD 37 and that collects fluorescence F coming from the specimen 19; a dichroic mirror 17 that splits off the collected fluorescence F coming from the specimen 19 from the incoherent light I; and a CCD camera 13 that is disposed at a position conjugate to the position of the DMD 37 and that detects the fluorescence F coming from the specimen 19 and split off by the dichroic mirror 17.

    摘要翻译： 本发明提供一种能够在不减少光量的情况下照射均匀的照明光的显微镜。 使用的显微镜​​1包括发出非相干光I的非相干光源31; 其中非相干光I入射的光纤35并且通过重复的全反射来引导入射的非相干光I; 具有可移动微镜阵列的DMD37，每个反射或透射被引导的非相干光I; 对由样品19照射由DMD37反射或透射的非相干光I并收集来自样品19的荧光F的物镜18; 分离反射镜17，其分离来自样品19的不相干光I的所收集的荧光F; 以及CCD摄像机13，其设置在与DMD37的位置共轭的位置，并且检测来自检体19的荧光F，并由分色镜17分离。

    Low-charging fiber and method for producing the same
    2.
    发明授权
    Low-charging fiber and method for producing the same 有权
    低充电纤维及其制造方法

    公开(公告)号：US08802756B2

    公开(公告)日：2014-08-12

    申请号：US13816058

    申请日：2011-08-12

    申请人： Yukako Kageyama ,  Susumu Honda ,  Makoto Satake ,  Hiroaki Kaneko

    发明人： Yukako Kageyama ,  Susumu Honda ,  Makoto Satake ,  Hiroaki Kaneko

    IPC分类号： C08K5/52

    CPC分类号： D01F8/14 ,  C08K5/521 ,  D01D5/0007 ,  D01F1/09 ,  D01F6/625 ,  D01F6/92 ,  D04H1/4326 ,  D04H1/435 ,  D04H1/728

    摘要： An object to be achieved by the invention is to provide a biodegradable low-charging fiber. The prevent inventors have found that when a specific amount of a specific phospholipid that is not known to have antistatic properties is added to a biodegradable polymer, and the resulting mixture is formed into a fiber having a smooth surface, low-charging properties are developed. The invention has thus been accomplished. The invention is a fiber having an average surface porosity of less than 3% and made of a biodegradable polymer that contains a specific amount of a specific phospholipid.

    摘要翻译： 本发明要实现的目的是提供一种可生物降解的低充电纤维。 防止发明人已经发现，将特定量的不知道具有抗静电特性的特定磷脂加入可生物降解的聚合物中，并将所得混合物形成为具有光滑表面的纤维时，开发了低充电性能。 从而完成了本发明。 本发明是平均表面孔隙率小于3％并由含有特定量的特定磷脂的可生物降解的聚合物制成的纤维。

    MICROSCOPE
    3.
    发明申请
    MICROSCOPE 有权
    显微镜

    公开(公告)号：US20120243081A1

    公开(公告)日：2012-09-27

    申请号：US13423634

    申请日：2012-03-19

    申请人： Susumu Honda

    发明人： Susumu Honda

    IPC分类号： G02B21/06

    CPC分类号： G02B21/002 ,  G02B7/005 ,  G02B7/006 ,  G02B21/16 ,  G02B26/101

    摘要： A microscope includes: an objective lens radiating laser light and illumination light onto a specimen; a first detection optical system detecting first observation light produced from the specimen when the laser light is radiated; a second detection optical system detecting second observation light produced from the specimen when the illumination light is radiated; optical elements placed so as to be capable of being inserted into or removed from a light path of the first detection optical system or the second detection optical system; a rotating turret selectively switching the optical elements to be inserted into the light path; a storage section storing correction information about a relative misalignment between the first observation light and the second observation light caused when the optical elements are switched; and a control section correcting the relative misalignment between the first observation light and the second observation light based on the correction information.

    摘要翻译： 显微镜包括：物镜，将激光和照明光照射到样本上; 第一检测光学系统，当激光照射时，检测从样本产生的第一观察光; 第二检测光学系统，当照射光照射时，检测从样本产生的第二观察光; 光学元件放置成能够插入或从第一检测光学系统或第二检测光学系统的光路中移除; 旋转转台选择性地切换要插入到光路中的光学元件; 存储部分，其存储关于当所述光学元件被切换时引起的所述第一观察光和所述第二观察光之间的相对未对准的校正信息; 以及控制部，其基于所述校正信息来校正所述第一观察光与所述第二观察光之间的相对未对准。

    Examination Apparatus, Fluoroscopy Apparatus, Examination Method, And Experimental Method
    5.
    发明申请
    Examination Apparatus, Fluoroscopy Apparatus, Examination Method, And Experimental Method 有权
    检查装置，荧光检查装置，检查方法和实验方法

    公开(公告)号：US20070273877A1

    公开(公告)日：2007-11-29

    申请号：US10594311

    申请日：2005-03-29

    申请人： Yoshihiro Kawano ,  Keiji Shimizu ,  Minoru Sukekawa ,  Tsuyoshi Mochizuki ,  Susumu Honda ,  Kazuhiro Hayashi

    发明人： Yoshihiro Kawano ,  Keiji Shimizu ,  Minoru Sukekawa ,  Tsuyoshi Mochizuki ,  Susumu Honda ,  Kazuhiro Hayashi

    IPC分类号： G01J3/30 ,  G02B21/36

    CPC分类号： G01N21/6458 ,  G02B21/248

    摘要： Even when the magnifying power is reduced, an image can be obtained at high resolution without significantly reducing the numerical aperture, and examination accuracy is improved. There is provided a microscope examination apparatus including a light source for emitting excitation light or illumination light to a specimen placed on a stage; an objective lens opposing the stage and capable of focusing fluorescence or reflected light from the specimen; an image-forming lens for forming an image of the specimen obtained by the objective lens; and an image-capturing unit for capturing the image of the specimen forming by the image-forming lens, wherein a plurality of the objective lenses having different magnifying powers is provided, and an objective-lens switching mechanism for switching among the objective lenses is provided, and wherein a plurality of the image-forming lenses having different magnifying powers is provided, and an image-forming-lens switching mechanism for switching among the image-forming lenses 5a and 5b is provided.

    摘要翻译： 即使放大倍数减小，也能够以高分辨率获得图像，而不会显着降低数值孔径，提高了检查精度。 提供了一种显微镜检查装置，其包括用于向放置在台架上的样本发射激发光或照明光的光源; 与舞台相对并且能够聚焦来自样本的荧光或反射光的物镜; 用于形成由所述物镜获得的所述样本的图像的图像形成透镜; 以及图像捕获单元，用于捕获由图像形成透镜形成的样本的图像，其中提供具有不同放大倍率的多个物镜，并且提供用于在物镜之间切换的物镜切换机构 并且其中提供了具有不同放大倍率的多个图像形成透镜，并且提供了用于在成像透镜5a和5b之间切换的图像形成透镜切换机构。

    Polyoxyalkylene monoalkyl ether, process for producing the same, polymerizable polyoxyalkylene monoalkyl ether derivative, polymer of said derivative and dispersant comprising said polymer
    8.
    发明授权
    Polyoxyalkylene monoalkyl ether, process for producing the same, polymerizable polyoxyalkylene monoalkyl ether derivative, polymer of said derivative and dispersant comprising said polymer 有权
    聚氧化烯单烷基醚，其制备方法，可聚合的聚氧化烯单烷基醚衍生物，所述衍生物的聚合物和包含所述聚合物

    公开(公告)号：US06956018B2

    公开(公告)日：2005-10-18

    申请号：US10888992

    申请日：2004-07-13

    申请人： Akinori Itoh ,  Susumu Honda ,  Tatsuya Matsui ,  Yoshihiro Hayashi

    发明人： Akinori Itoh ,  Susumu Honda ,  Tatsuya Matsui ,  Yoshihiro Hayashi

    IPC分类号： C08F283/06 ,  C08G65/26 ,  C08L71/02 ,  C11D1/72 ,  C07C43/15 ,  C08J3/02 ,  C11D3/37

    CPC分类号： C08G65/2609 ,  C08F283/06 ,  C08F283/065 ,  C08L71/02 ,  C08L2666/04

    摘要： A polymerizable polyoxyalkylene monoalkyl ether derivative prepared by using a polyoxyalklene monoalkyl ether which gives, in gel permeation chromatography, a chromatogram which satisfies a relation expressed by an equation: S1/S0≦0.15, wherein S1 represents the area under a portion of the chromatogram from the start of elution to the earliest elution time when the intensity of the refractive index has a value of L/3, L representing the shortest distance between the greatest maximum point of the intensity of the refractive index and the base line and S0 represents the area under a portion of the chromatogram from the start of elution to an elution time when the intensity of the refractive index has the greatest maximum value; a process for producing the above ether comprising adjusting the content of water in a reactor, which is used in addition polymerization of alkylene oxides with addition to a monohydric alcohol, so as to satisfy an equation: Wi×(Cf−Ci)/V≦10, wherein the content of water in the reactor is obtained by placing a solvent having a content of water Ci (ppm) in an amount Wi (g) in the reactor having an inner volume V (ml), stirring the solvent to clean the reactor, removing the solvent from the reactor and obtaining a content of water Cf (ppm) in the removed solvent.

    摘要翻译： 通过使用聚氧化烯单烷基醚制备的可聚合的聚氧化烯单烷基醚衍生物，所述聚氧化烯单烷基醚在凝胶渗透色谱法中得到满足由下列公式表示的关系的色谱图：S＆lt; 1＆lt; > <= 0.15，其中S 1表示当折射率的强度为L / 3时的从洗脱开始到最早洗脱时间的色谱图的一部分的面积，L 代表折射率强度的最大最大点与基线之间的最短距离，S O表示从洗脱开始到洗脱时间的部分色谱图下的面积 折射率的强度具有最大的最大值; 一种制备上述醚的方法，包括调节反应器中的水含量，该反应器用于加成环氧烷与一元醇的加成聚合，以满足下式：Wix（Cf-Ci）/ V <= 10，其中反应器中的水含量是通过将具有内容积V（ml）的反应器中具有含量为Wi（g）的水分量（ppm）的溶剂置于内部体积V（ml）中，搅拌溶剂来清洗 反应器中，从反应器中除去溶剂，并在去除的溶剂中获得水含量Cf（ppm）。

    Polypeptides and production thereof
    9.
    发明授权
    Polypeptides and production thereof 失效
    多肽及其生产

    公开(公告)号：US5157004A

    公开(公告)日：1992-10-20

    申请号：US575552

    申请日：1990-08-29

    申请人： Masao Sakaguchi ,  Susumu Honda ,  Osamu Nishimura

    发明人： Masao Sakaguchi ,  Susumu Honda ,  Osamu Nishimura

    IPC分类号： A61K38/00 ,  C07K14/57

    CPC分类号： C07K14/57 ,  A61K38/00

    摘要： The present invention provides a novel polypeptide which shows higher IFN-.gamma. activity than intact IFN-.gamma. and a method of producing the same.The polypeptides not only possesses a remarkable antiviral activity, antitumor activity, immunopotentiating activity etc. but also is highly stable, therefore, it can be used advantageously as pharmaceuticals etc.

    摘要翻译： 本发明提供了一种与完整IFN-γ相比显示更高的IFN-γ活性的新型多肽及其制备方法。 该多肽不仅具有显着的抗病毒活性，抗肿瘤活性，免疫增强活性等，而且高度稳定，因此可有利地用作药物等。

    Biological-specimen observation apparatus
    10.
    发明授权
    Biological-specimen observation apparatus 有权
    生物标本观察装置

    公开(公告)号：US08791427B2

    公开(公告)日：2014-07-29

    申请号：US12336124

    申请日：2008-12-16

    申请人： Susumu Honda ,  Chika Nakajima

    发明人： Susumu Honda ,  Chika Nakajima

    IPC分类号： G21K5/10

    CPC分类号： G01N21/645 ,  G01N2021/6421 ,  G01N2021/6493

    摘要： The distribution of a fluorescent material in a specimen can be observed and the fluorescent material can be obtained as clear, highly quantitative image data. A biological-specimen observation apparatus is provided which comprises a stage on which a specimen is mounted; a position detector, provided on the stage, that detects the position of the specimen; a light source that emits excitation light or illumination light onto the specimen mounted on the stage; an objective lens, disposed opposing the stage, that collects fluorescence or reflected light from the specimen; an image-forming lens that forms an image on the specimen, collected by the objective lens; an image acquisition unit that acquires the image on the specimen, formed by the image-forming lens; an image storage unit that stores the image obtained by the image acquisition unit and positional information of the specimen detected by the position detector in association with each other; and an image processing unit that performs combining processing of a plurality of the images stored by the image storage unit on the basis of the positional information stored in association with the images.

    摘要翻译： 可以观察到荧光材料在样品中的分布，并且可以获得作为清晰，高度定量的图像数据的荧光材料。 提供一种生物样本观察装置，其包括安装有试样的台阶; 设置在台架上的检测样本位置的位置检测器; 将激发光或照明光发射到安装在舞台上的样本上的光源; 与舞台相对设置的物镜，其从样本收集荧光或反射光; 在物体上形成图像的图像形成透镜; 图像获取单元，其获取由所述图像形成透镜形成的所述样本上的图像; 图像存储单元，其存储由图像获取单元获得的图像和由位置检测器检测到的样本的位置信息彼此相关联; 以及图像处理单元，其基于与图像相关联地存储的位置信息来执行由图像存储单元存储的多个图像的组合处理。