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    Stem cell populations and methods of use
    4.
    发明授权
    Stem cell populations and methods of use 有权
    干细胞群体和使用方法

    公开(公告)号：US07863043B2

    公开(公告)日：2011-01-04

    申请号：US10589173

    申请日：2004-05-04

    申请人： Tracy Gentry ,  Sandra J. Foster ,  Andrew E. Balber

    发明人： Tracy Gentry ,  Sandra J. Foster ,  Andrew E. Balber

    IPC分类号： C12N5/08

    CPC分类号： C12N5/0647 ,  A61K2035/124 ,  C12N5/0663

    摘要： Populations of stem cells and methods for their isolation and use are provided. These stem cell populations comprise aldehyde dehydrogenase positive (ALDHbr) cells isolated from bone marrow, and ALDHbr CD105+ cells derived from any stem cell source. These populations may also comprise cells expressing such surface markers as CD34, CD38, CD41, CD45, CD105, CD133, CD135, CD117, and HLA-DR, and/or are substantially free from such cell surface markers as CD3, CD7, CD 10, CD 13, CD 14, C1319, CD33, CD35, CD56, CD 127, CD 138, and glycophorin A. The population may also comprise cells expressing CD90. The stem cell populations of the invention are isolated from a stem cell source such as bone marrow, peripheral blood, umbilical cord blood, and fetal liver. Methods of the invention comprise isolating and purifying stem cell populations from stem cell sources, and methods of using these cells to reconstitute, repair, and regenerate tissues.

    摘要翻译： 提供干细胞群体及其分离和使用的方法。 这些干细胞群体包含从骨髓分离的醛脱氢酶阳性（ALDHbr）细胞和来自任何干细胞来源的ALDHbr CD105 +细胞。 这些群体还可以包含表达CD34，CD38，CD41，CD45，CD105，CD133，CD135，CD117和HLA-DR等表面标志物的细胞，和/或基本上不含CD3，CD7，CD10等细胞表面标志物 ，CD13，CD14，C1319，CD33，CD35，CD56，CD127，CD138和血型糖蛋白A.所述群体还可以包含表达CD90的细胞。 本发明的干细胞群体从干细胞源如骨髓，外周血，脐带血和胎肝分离。 本发明的方法包括从干细胞来源分离和纯化干细胞群体，以及使用这些细胞重组，修复和再生组织的方法。

    Stem Cell Populations and Methods of Use
    6.
    发明申请
    Stem Cell Populations and Methods of Use 有权
    干细胞群体和使用方法

    公开(公告)号：US20080241171A1

    公开(公告)日：2008-10-02

    申请号：US10589173

    申请日：2004-05-04

    申请人： Tracy Gentry ,  Sandra J. Foster ,  Andrew E. Balber

    发明人： Tracy Gentry ,  Sandra J. Foster ,  Andrew E. Balber

    IPC分类号： A61K35/28 ,  C12N5/08 ,  G01N33/53 ,  C12Q1/02 ,  A61P35/00 ,  A61P37/00 ,  A61P25/00

    CPC分类号： C12N5/0647 ,  A61K2035/124 ,  C12N5/0663

    摘要： Populations of stem cells and methods for their isolation and use are provided. These stem cell populations comprise aldehyde dehydrogenase positive (ALDHbr) cells isolated from bone marrow, and ALDHbr CD105+ cells derived from any stem cell source. These populations may also comprise cells expressing such surface markers as CD34, CD38, CD41, CD45, CD105, CD133, CD135, CD117, and HLA-DR, and/or are substantially free from such cell surface markers as CD3, CD7, CD 10, CD 13, CD 14, C1319, CD33, CD35, CD56, CD 127, CD 138, and glycophorin A. The population may also comprise cells expressing CD90. The stem cell populations of the invention are isolated from a stem cell source such as bone marrow, peripheral blood, umbilical cord blood, and fetal liver. Methods of the invention comprise isolating and purifying stem cell populations from stem cell sources, and methods of using these cells to reconstitute, repair, and regenerate tissues.

    摘要翻译： 提供干细胞群体及其分离和使用的方法。 这些干细胞群体包含从骨髓分离的醛脱氢酶阳性（ALDH）和/或来自任何干细胞的ALDH细胞CD105 + 资源。 这些群体还可以包含表达CD34，CD38，CD41，CD45，CD105，CD133，CD135，CD117和HLA-DR等表面标志物的细胞，和/或基本上不含CD3，CD7，CD10等细胞表面标志物 ，CD13，CD14，C1319，CD33，CD35，CD56，CD127，CD138和血型糖蛋白A.所述群体还可以包含表达CD90的细胞。 本发明的干细胞群体从干细胞源如骨髓，外周血，脐带血和胎肝分离。 本发明的方法包括从干细胞来源分离和纯化干细胞群体，以及使用这些细胞重组，修复和再生组织的方法。