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1.发明授权Methods and compositions for improving bioavailability of epigallocatechin gallate (EGCG) 有权提高表没食子儿茶素没食子酸酯（EGCG）的生物利用度的方法和组合物公开(公告)号：US08906414B1
公开(公告)日：2014-12-09
申请号：US12768380
申请日：2010-04-27
CPC分类号： A61K9/127 , A61K31/353
摘要： Compositions and methods of increasing the bioavailability of catechins are presented. Compositions for increasing the bioavailability of catechins include compositions where the catechin is added to a solution of ethanol and water; compositions where the catechin is encapsulated within a nanoparticle; and compositions in which a nanoparticle complex is formed between the catechin and the nanoparticle. Each of these compositions was shown to increase bioavailability of EGCG and is useful in treating diseases such as Alzheimer's and HIV-associated dementia.
摘要翻译： 提出了增加儿茶素生物利用度的组合物和方法。 用于增加儿茶素的生物利用度的组合物包括将儿茶素加入到乙醇和水的溶液中的组合物; 儿茶素包封在纳米颗粒内的组合物; 以及其中在儿茶素和纳米颗粒之间形成纳米颗粒复合物的组合物。 这些组合物中的每一种显示出提高EGCG的生物利用度，并且可用于治疗诸如阿尔茨海默病和HIV相关性痴呆的疾病。
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2.发明申请COMPOUNDS FOR STIMULATING STEM CELL PROLIFERATION INCLUDING AFA-OMEGA (EtOH) 审中-公开用于刺激包括AFA-OMEGA（EtOH）的干细胞增殖的化合物公开(公告)号：US20080089905A1
公开(公告)日：2008-04-17
申请号：US11757251
申请日：2007-06-01
申请人： Cyndy Davis Sanberg , Paula Bickford , Paul Sanberg , Jun Tan , R. Shytle , Jerry Anderson
发明人： Cyndy Davis Sanberg , Paula Bickford , Paul Sanberg , Jun Tan , R. Shytle , Jerry Anderson
CPC分类号： A61K31/205 , A61K31/59 , A61K35/748 , A61K36/45 , A61K36/82 , A61K2300/00
摘要： A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of substances selected from blueberry, carnosine, catechin, green tea extract, VitaBlue, Vitamin D3, Spirulina, AFA or effective combinations and derivatives of these. For example, a supplement comprising wild blueberry, green tea extract, carnosine, vitamin D3, and AFA-Omega (EtOH) or Spirulina and AFA-Omega (EtOH) exhibits a synergistic and unexpected association with substantially increased proliferation of bone marrow stem cells and CD34+. A therapeutic amount of a substance that is associated with a substantial increase in stem cells may be used to prevent and repair damaged tissues of the brain, due to stroke, the heart, due to coronary artery disease or a heart attack.
摘要翻译： 用于刺激干细胞增殖和分化的方法和组合物用于自我修复哺乳动物的损伤。 施用补充物，其具有选自蓝莓，肌肽，儿茶素，绿茶提取物，维生素B，维生素D3，螺旋藻，AFA中的有效剂量的物质或这些的有效组合和衍生物。 例如，包含野生蓝莓，绿茶提取物，肌肽，维生素D3和AFA-Omega（EtOH）或螺旋藻和AFA-Omega（EtOH）的补充物显示出与骨髓干细胞的增殖显着增加的协同和意想不到的关联， CD34 +。 可以使用与干细胞显着增加相关的物质的治疗量来预防和修复由于冠状动脉疾病或心脏病发作引起的脑中风，心脏的受损组织。
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3.发明申请公开(公告)号：US20080085330A1
公开(公告)日：2008-04-10
申请号：US11757266
申请日：2007-06-01
申请人： Cyndy Davis Sanberg , Paula Bickford , Paul Sanberg , Jun Tan , R. Shytle
发明人： Cyndy Davis Sanberg , Paula Bickford , Paul Sanberg , Jun Tan , R. Shytle
CPC分类号： A61K31/205 , A61K31/59 , A61K35/748 , A61K36/45 , A61K36/82 , A61K2300/00
摘要： A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of substances selected from blueberry, carnosine, catechin, green tea extract, VitaBlue, Vitamin D3, Spirulina, AFA or effective combinations and derivatives of these. For example, a supplement comprising wild blueberry, green tea extract, carnosine, vitamin D3, and a Spirulina and/or an AFA-Omega (EtOH) exhibited a synergistic and unexpected association with substantially increased proliferation of bone marrow stem cells and CD34+. A therapeutic amount of a substance that is associated with a substantial increase in stem cells may be used to prevent and repair damages tissues of the brain, due to stroke, the heart, due to coronary artery disease or a heart attack.
摘要翻译： 用于刺激干细胞增殖和分化的方法和组合物用于自我修复哺乳动物的损伤。 施用补充剂，其具有选自蓝莓，肌肽，儿茶素，绿茶提取物，维生素B，维生素D 3，螺旋藻，AFA或其有效组合和衍生物的有效剂量的物质。 例如，包含野生蓝莓，绿茶提取物，肌肽，维生素D 3和螺旋藻和/或AFA-Omega（EtOH）的补充物显示与骨髓干细胞和CD34的增加的显着增加的协同和意想不到的关联 +。 可以使用治疗量的与干细胞显着增加相关的物质来预防和修复由于冠状动脉疾病或心脏病发作引起的脑中风，心脏损伤的组织。
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4.发明授权Treating amyotrophic lateral sclerosis (ALS)with isolated aldehyde dehydrogenase-positive umbilical cord blood cells 有权用分离的醛脱氢酶阳性脐带血细胞治疗肌萎缩性侧索硬化（ALS）公开(公告)号：US08765119B2
公开(公告)日：2014-07-01
申请号：US10908322
申请日：2005-05-06
申请人： Svitlana Garbuzova-Davis , Andrew Balber , Cyndy Davis-Sanberg , Tracy Gentry , Nicole Kuzmin-Nichols , Paul R Sanberg , Alison Willing
发明人： Svitlana Garbuzova-Davis , Andrew Balber , Cyndy Davis-Sanberg , Tracy Gentry , Nicole Kuzmin-Nichols , Paul R Sanberg , Alison Willing
IPC分类号： A01N63/00 , A61K35/28 , A61K35/48 , A61K35/12 , A61K35/50 , A61K35/30 , A61K9/00 , C12N5/0789 , C12N5/071 , C12N5/074 , C12N5/0775
CPC分类号： A61K35/28 , A61K9/0085 , A61K31/203 , A61K35/30 , A61K35/50 , A61K35/51 , A61K45/06 , A61K2035/124 , C12N5/0607 , C12N5/0647 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N2501/13 , C12N2501/385 , C12N2506/11 , A61K2300/00
摘要： A method of treating a patient with a neurodegenerative disease, such as ALS, using progenitor cells isolated from human umbilical cord blood. Non-invasive transplantation of aldehyde dehydrogenase (ALDH+) expressing progenitor cells provides cell replacement and protection of motor neurons.
摘要翻译： 使用从人脐带血分离的祖细胞来治疗患有神经变性疾病的患者（例如ALS）的方法。 表达祖细胞的醛脱氢酶（ALDH +）的非侵入性移植提供了运动神经元的细胞替代和保护。
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公开(公告)号：US08574640B2
公开(公告)日：2013-11-05
申请号：US12901329
申请日：2010-10-08
CPC分类号： A61K31/59 , A61K31/205 , A61K36/45 , A61K36/82 , A61K2300/00
摘要： A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of blueberry, carnosine, catechin, green tea extract, VitaBlue, Vitamin D3 or combinations of these. For example, a therapeutic amount of two or more of the supplements may be selected having a synergistic effect, allowing a lower dose to achieve the same or greater effective protection as a higher dose of any one of the supplements.
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公开(公告)号：US20110038963A1
公开(公告)日：2011-02-17
申请号：US12901329
申请日：2010-10-08
CPC分类号： A61K31/59 , A61K31/205 , A61K36/45 , A61K36/82 , A61K2300/00
摘要： A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of blueberry, carnosine, catechin, green tea extract, VitaBlue, Vitamin D3 or combinations of these. For example, a therapeutic amount of two or more of the supplements may be selected having a synergistic effect, allowing a lower dose to achieve the same or greater effective protection as a higher dose of any one of the supplements.
摘要翻译： 用于刺激干细胞增殖和分化的方法和组合物用于自我修复哺乳动物的损伤。 施用补充剂具有有效剂量的蓝莓，肌肽，儿茶素，绿茶提取物，维生素B，维生素D3或它们的组合。 例如，可以选择治疗量的两种或更多种补充剂，其具有协同作用，允许较低剂量实现与任何一种补充剂的较高剂量相同或更高的有效保护。
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公开(公告)号：US07442394B2
公开(公告)日：2008-10-28
申请号：US11415907
申请日：2006-05-02
CPC分类号： A61K31/59 , A61K31/205 , A61K36/45 , A61K36/82 , A61K2300/00
摘要： A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of blueberry, carnosine, catechin, green tea extract, VITABLUE® blueberry extract, Vitamin D3 or combinations of these. For example, a therapeutic amount of two or more of the supplements may be selected having a synergistic effect, allowing a lower dose to achieve the same or greater effective protection as a higher dose of any one of the supplements.
摘要翻译： 用于刺激干细胞增殖和分化的方法和组合物用于自我修复哺乳动物的损伤。 施用补充剂具有有效剂量的蓝莓，肌肽，儿茶素，绿茶提取物，蓝莓提取物，维生素D3或它们的组合。 例如，可以选择治疗量的两种或更多种补充剂，其具有协同作用，允许较低剂量实现与任何一种补充剂的较高剂量相同或更高的有效保护。
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公开(公告)号：US09827285B1
公开(公告)日：2017-11-28
申请号：US14291773
申请日：2014-05-30
IPC分类号： A61K36/28 , A61K36/45 , A61K36/82 , A61K36/87 , A61K31/4172 , A61K31/593 , A61K31/05
CPC分类号： A61K36/87 , A61K31/05 , A61K31/4172 , A61K31/593 , A61K36/45 , A61K36/82 , A61K2300/00
摘要： Provided herein are compositions, formulations, kits, and methods for improving or modifying cognitive performance in an individual having normal-age related cognitive decline. The composition can include an amount of a blueberry extract, L-carnosine, a green tea extract, vitamin D3, and a grape extract. The composition can be included in a pharmaceutical formulation and be administered to a subject having normal-age related cognitive decline according to a dosing regimen.
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公开(公告)号：US20090280198A1
公开(公告)日：2009-11-12
申请号：US12288848
申请日：2008-10-23
CPC分类号： A61K31/59 , A61K31/205 , A61K36/45 , A61K36/82 , A61K2300/00
摘要： A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of blueberry, carnosine, catechin, green tea extract, VitaBlue, Vitamin D3 or combinations of these. For example, a therapeutic amount of two or more of the supplements may be selected having a synergistic effect, allowing a lower dose to achieve the same or greater effective protection as a higher dose of any one of the supplements.
摘要翻译： 用于刺激干细胞增殖和分化的方法和组合物用于自我修复哺乳动物的损伤。 施用补充剂具有有效剂量的蓝莓，肌肽，儿茶素，绿茶提取物，维生素B，维生素D3或它们的组合。 例如，可以选择治疗量的两种或更多种补充剂，其具有协同作用，允许较低剂量实现与任何一种补充剂的较高剂量相同或更高的有效保护。
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公开(公告)号：US20060275512A1
公开(公告)日：2006-12-07
申请号：US11415907
申请日：2006-05-02
申请人： Cyndy Davis Sanberg , Paul Sanberg , Paula Bickford , R. Shytle , Jun Tan
发明人： Cyndy Davis Sanberg , Paul Sanberg , Paula Bickford , R. Shytle , Jun Tan
IPC分类号： A61K36/82 , A61K36/45 , A61K31/59 , A61K31/205
CPC分类号： A61K31/59 , A61K31/205 , A61K36/45 , A61K36/82 , A61K2300/00
摘要： A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of blueberry, carnosine, catechin, green tea extract, VitaBlue, Vitamin D3 or combinations of these. For example, a therapeutic amount of two or more of the supplements may be selected having a synergistic effect, allowing a lower dose to achieve the same or greater effective protection as a higher dose of any one of the supplements.
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