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1.发明申请Cerebral Intraventricular Transplantation as Method of Treating Amyotrophic Lateral Sclerosis (ALS) 有权脑室内移植作为治疗肌萎缩性侧索硬化症（ALS）的方法公开(公告)号：US20050249708A1
公开(公告)日：2005-11-10
申请号：US10908322
申请日：2005-05-06
申请人： Svitlana Garbuzova-Davis , Andrew Balber , Cyndy Davis-Sanberg , Tracy Gentry , Nicole Kuzmin-Nichols , Paul Sanberg , Alison Willing
发明人： Svitlana Garbuzova-Davis , Andrew Balber , Cyndy Davis-Sanberg , Tracy Gentry , Nicole Kuzmin-Nichols , Paul Sanberg , Alison Willing
IPC分类号： A61K31/203 , A61K35/12 , A61K35/14 , A61K35/28 , A61K35/51 , A61K45/00 , A61K45/06 , C12N5/074 , C12N5/0789 , C12N5/08
CPC分类号： A61K35/28 , A61K9/0085 , A61K31/203 , A61K35/30 , A61K35/50 , A61K35/51 , A61K45/06 , A61K2035/124 , C12N5/0607 , C12N5/0647 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N2501/13 , C12N2501/385 , C12N2506/11 , A61K2300/00
摘要： A method of treating a patient with a neurodegenerative disease, such as ALS, using progenitor cells isolated from human umbilical cord blood. Non-invasive transplantation of aldehyde dehydrogenase (ALDH+) expressing progenitor cells provides cell replacement and protection of motor neurons.
摘要翻译： 使用从人脐带血分离的祖细胞来治疗患有神经变性疾病的患者（例如ALS）的方法。 表达祖细胞的醛脱氢酶（ALDH + +）表达的非侵入性移植提供了运动神经元的细胞替代和保护。
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2.发明申请COMPOUNDS FOR STIMULATING STEM CELL PROLIFERATION INCLUDING AFA-OMEGA (EtOH) 审中-公开用于刺激包括AFA-OMEGA（EtOH）的干细胞增殖的化合物公开(公告)号：US20080089905A1
公开(公告)日：2008-04-17
申请号：US11757251
申请日：2007-06-01
申请人： Cyndy Davis Sanberg , Paula Bickford , Paul Sanberg , Jun Tan , R. Shytle , Jerry Anderson
发明人： Cyndy Davis Sanberg , Paula Bickford , Paul Sanberg , Jun Tan , R. Shytle , Jerry Anderson
CPC分类号： A61K31/205 , A61K31/59 , A61K35/748 , A61K36/45 , A61K36/82 , A61K2300/00
摘要： A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of substances selected from blueberry, carnosine, catechin, green tea extract, VitaBlue, Vitamin D3, Spirulina, AFA or effective combinations and derivatives of these. For example, a supplement comprising wild blueberry, green tea extract, carnosine, vitamin D3, and AFA-Omega (EtOH) or Spirulina and AFA-Omega (EtOH) exhibits a synergistic and unexpected association with substantially increased proliferation of bone marrow stem cells and CD34+. A therapeutic amount of a substance that is associated with a substantial increase in stem cells may be used to prevent and repair damaged tissues of the brain, due to stroke, the heart, due to coronary artery disease or a heart attack.
摘要翻译： 用于刺激干细胞增殖和分化的方法和组合物用于自我修复哺乳动物的损伤。 施用补充物，其具有选自蓝莓，肌肽，儿茶素，绿茶提取物，维生素B，维生素D3，螺旋藻，AFA中的有效剂量的物质或这些的有效组合和衍生物。 例如，包含野生蓝莓，绿茶提取物，肌肽，维生素D3和AFA-Omega（EtOH）或螺旋藻和AFA-Omega（EtOH）的补充物显示出与骨髓干细胞的增殖显着增加的协同和意想不到的关联， CD34 +。 可以使用与干细胞显着增加相关的物质的治疗量来预防和修复由于冠状动脉疾病或心脏病发作引起的脑中风，心脏的受损组织。
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3.发明申请公开(公告)号：US20080085330A1
公开(公告)日：2008-04-10
申请号：US11757266
申请日：2007-06-01
申请人： Cyndy Davis Sanberg , Paula Bickford , Paul Sanberg , Jun Tan , R. Shytle
发明人： Cyndy Davis Sanberg , Paula Bickford , Paul Sanberg , Jun Tan , R. Shytle
CPC分类号： A61K31/205 , A61K31/59 , A61K35/748 , A61K36/45 , A61K36/82 , A61K2300/00
摘要： A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of substances selected from blueberry, carnosine, catechin, green tea extract, VitaBlue, Vitamin D3, Spirulina, AFA or effective combinations and derivatives of these. For example, a supplement comprising wild blueberry, green tea extract, carnosine, vitamin D3, and a Spirulina and/or an AFA-Omega (EtOH) exhibited a synergistic and unexpected association with substantially increased proliferation of bone marrow stem cells and CD34+. A therapeutic amount of a substance that is associated with a substantial increase in stem cells may be used to prevent and repair damages tissues of the brain, due to stroke, the heart, due to coronary artery disease or a heart attack.
摘要翻译： 用于刺激干细胞增殖和分化的方法和组合物用于自我修复哺乳动物的损伤。 施用补充剂，其具有选自蓝莓，肌肽，儿茶素，绿茶提取物，维生素B，维生素D 3，螺旋藻，AFA或其有效组合和衍生物的有效剂量的物质。 例如，包含野生蓝莓，绿茶提取物，肌肽，维生素D 3和螺旋藻和/或AFA-Omega（EtOH）的补充物显示与骨髓干细胞和CD34的增加的显着增加的协同和意想不到的关联 +。 可以使用治疗量的与干细胞显着增加相关的物质来预防和修复由于冠状动脉疾病或心脏病发作引起的脑中风，心脏损伤的组织。
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公开(公告)号：US08574640B2
公开(公告)日：2013-11-05
申请号：US12901329
申请日：2010-10-08
CPC分类号： A61K31/59 , A61K31/205 , A61K36/45 , A61K36/82 , A61K2300/00
摘要： A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of blueberry, carnosine, catechin, green tea extract, VitaBlue, Vitamin D3 or combinations of these. For example, a therapeutic amount of two or more of the supplements may be selected having a synergistic effect, allowing a lower dose to achieve the same or greater effective protection as a higher dose of any one of the supplements.
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公开(公告)号：US20110038963A1
公开(公告)日：2011-02-17
申请号：US12901329
申请日：2010-10-08
CPC分类号： A61K31/59 , A61K31/205 , A61K36/45 , A61K36/82 , A61K2300/00
摘要： A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of blueberry, carnosine, catechin, green tea extract, VitaBlue, Vitamin D3 or combinations of these. For example, a therapeutic amount of two or more of the supplements may be selected having a synergistic effect, allowing a lower dose to achieve the same or greater effective protection as a higher dose of any one of the supplements.
摘要翻译： 用于刺激干细胞增殖和分化的方法和组合物用于自我修复哺乳动物的损伤。 施用补充剂具有有效剂量的蓝莓，肌肽，儿茶素，绿茶提取物，维生素B，维生素D3或它们的组合。 例如，可以选择治疗量的两种或更多种补充剂，其具有协同作用，允许较低剂量实现与任何一种补充剂的较高剂量相同或更高的有效保护。
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公开(公告)号：US07442394B2
公开(公告)日：2008-10-28
申请号：US11415907
申请日：2006-05-02
CPC分类号： A61K31/59 , A61K31/205 , A61K36/45 , A61K36/82 , A61K2300/00
摘要： A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of blueberry, carnosine, catechin, green tea extract, VITABLUE® blueberry extract, Vitamin D3 or combinations of these. For example, a therapeutic amount of two or more of the supplements may be selected having a synergistic effect, allowing a lower dose to achieve the same or greater effective protection as a higher dose of any one of the supplements.
摘要翻译： 用于刺激干细胞增殖和分化的方法和组合物用于自我修复哺乳动物的损伤。 施用补充剂具有有效剂量的蓝莓，肌肽，儿茶素，绿茶提取物，蓝莓提取物，维生素D3或它们的组合。 例如，可以选择治疗量的两种或更多种补充剂，其具有协同作用，允许较低剂量实现与任何一种补充剂的较高剂量相同或更高的有效保护。
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公开(公告)号：US20090280198A1
公开(公告)日：2009-11-12
申请号：US12288848
申请日：2008-10-23
CPC分类号： A61K31/59 , A61K31/205 , A61K36/45 , A61K36/82 , A61K2300/00
摘要： A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of blueberry, carnosine, catechin, green tea extract, VitaBlue, Vitamin D3 or combinations of these. For example, a therapeutic amount of two or more of the supplements may be selected having a synergistic effect, allowing a lower dose to achieve the same or greater effective protection as a higher dose of any one of the supplements.
摘要翻译： 用于刺激干细胞增殖和分化的方法和组合物用于自我修复哺乳动物的损伤。 施用补充剂具有有效剂量的蓝莓，肌肽，儿茶素，绿茶提取物，维生素B，维生素D3或它们的组合。 例如，可以选择治疗量的两种或更多种补充剂，其具有协同作用，允许较低剂量实现与任何一种补充剂的较高剂量相同或更高的有效保护。
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公开(公告)号：US20060275512A1
公开(公告)日：2006-12-07
申请号：US11415907
申请日：2006-05-02
申请人： Cyndy Davis Sanberg , Paul Sanberg , Paula Bickford , R. Shytle , Jun Tan
发明人： Cyndy Davis Sanberg , Paul Sanberg , Paula Bickford , R. Shytle , Jun Tan
IPC分类号： A61K36/82 , A61K36/45 , A61K31/59 , A61K31/205
CPC分类号： A61K31/59 , A61K31/205 , A61K36/45 , A61K36/82 , A61K2300/00
摘要： A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of blueberry, carnosine, catechin, green tea extract, VitaBlue, Vitamin D3 or combinations of these. For example, a therapeutic amount of two or more of the supplements may be selected having a synergistic effect, allowing a lower dose to achieve the same or greater effective protection as a higher dose of any one of the supplements.
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9.发明授权Human cord blood as a source of neural tissue repair of the brain and spinal cord 有权人脐带血作为脑和脊髓神经组织修复的来源公开(公告)号：US08309352B2
公开(公告)日：2012-11-13
申请号：US11558411
申请日：2006-11-09
CPC分类号： A61K35/30 , A61K35/12 , A61K35/51 , A61K2035/124 , C12N5/0618 , C12N2501/13 , C12N2501/385 , C12N2506/1369
摘要： The present invention relates to the use of umbilical cord blood cells from a donor or patient to provide neural cells which may be used in transplantation. The isolated cells according to the present invention may be used to effect autologous and allogeneic transplantation and repair of neural tissue, in particular, tissue of the brain and spinal cord and to treat neurodegenerative diseases of the brain and spinal cord.
摘要翻译： 本发明涉及来自供体或患者的脐带血细胞用于提供可用于移植的神经细胞。 根据本发明的分离的细胞可以用于实现神经组织，特别是脑和脊髓的组织的自体和同种异体移植和修复，并且治疗脑和脊髓的神经变性疾病。
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10.发明申请Human Cord Blood as a Source of Neural Tissue Repair of the Brain and Spinal Cord 有权人类脐带血作为脑和脊髓神经组织修复的来源公开(公告)号：US20070237751A1
公开(公告)日：2007-10-11
申请号：US11558411
申请日：2006-11-09
CPC分类号： A61K35/30 , A61K35/12 , A61K35/51 , A61K2035/124 , C12N5/0618 , C12N2501/13 , C12N2501/385 , C12N2506/1369
摘要： The present invention relates to the use of umbilical cord blood cells from a donor or patient to provide neural cells which may be used in transplantation. The isolated cells according to the present invention may be used to effect autologous and allogeneic transplantation and repair of neural tissue, in particular, tissue of the brain and spinal cord and to treat neurodegenerative diseases of the brain and spinal cord.
摘要翻译： 本发明涉及来自供体或患者的脐带血细胞用于提供可用于移植的神经细胞。 根据本发明的分离的细胞可以用于实现神经组织，特别是脑和脊髓的组织的自体和同种异体移植和修复，并且治疗脑和脊髓的神经变性疾病。
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