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公开(公告)号：US07199305B2
公开(公告)日：2007-04-03
申请号：US10444061
申请日：2003-05-23
IPC分类号： H05K1/16
CPC分类号： H01L22/32 , H01L2924/0002 , H01L2924/3011 , Y10S977/721 , Y10S977/722 , Y10S977/723 , Y10S977/724 , H01L2924/00
摘要： The invention provides a nanolithographic protosubstrate adapted for nanolithographic formation of nanostructures on the protosubstrate comprising: a substrate having a top surface exposed for nanolithographic formation of nanostructures, wherein the top surface comprises: electrically insulating surface regions; and at least one discreet electrode topology surrounded by the electrically insulating surface regions, wherein the electrode topology is adapted with electrical interconnections for electrically coupling the electrode topology to an external device.
摘要翻译： 本发明提供一种适于纳米结构在原始衬底上纳米光刻形成的纳米光刻底物，其包括：具有暴露于纳米结构的纳米光刻形成的顶表面的基底，其中所述顶表面包括：电绝缘表面区域; 以及由电绝缘表面区域围绕的至少一个离散电极拓扑，其中电极拓扑结构适用于将电极拓扑电耦合到外部设备的电互连。
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2.发明申请公开(公告)号：US20050035983A1
公开(公告)日：2005-02-17
申请号：US10705776
申请日：2003-11-12
申请人： Sylvain Cruchon-Dupeyrat , Michael Nelson , Robert Elghanian , Joseph Fragala , Igor Touzov , Debjyoti Banerjee
发明人： Sylvain Cruchon-Dupeyrat , Michael Nelson , Robert Elghanian , Joseph Fragala , Igor Touzov , Debjyoti Banerjee
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y30/00 , B82Y40/00
摘要： Inkwells adapted for use in direct-write nanolithography and other applications including use of wells, channels, and posts. The wells can possess a geometry which matches the geometry of tips which are dipped into the inkwells. The channels can be open or closed. Hydrophilicity and hydrophobicity can be used to control ink flow. SEM can be used to characterize the inkwells. Ink flow can be monitored with video. Hydrophobic material layers can be used to prevent cross contamination. Microsyringes can be used to fill reservoirs. Satellite reservoirs can be used to prevent bubble formation.
摘要翻译： Inkwells适用于直写纳米光刻技术和其他应用，包括使用井，通道和柱。 孔可以具有与浸入墨水孔中的尖端的几何形状相匹配的几何形状。 通道可以打开或关闭。 亲水性和疏水性可用于控制油墨流动。 SEM可用于表征墨水。 墨水流量可以用视频监控。 疏水材料层可用于防止交叉污染。 微量注射器可用于填充储存器。 可以使用卫星储层来防止气泡形成。
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3.发明申请公开(公告)号：US20070008390A1
公开(公告)日：2007-01-11
申请号：US11399621
申请日：2006-04-07
申请人： Sylvain Cruchon-Dupeyrat , Michael Nelson , Robert Elghanian , Joseph Fragala , Igor Touzov , Debjyoti Banerjee
发明人： Sylvain Cruchon-Dupeyrat , Michael Nelson , Robert Elghanian , Joseph Fragala , Igor Touzov , Debjyoti Banerjee
IPC分类号： B41J2/175
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y30/00 , B82Y40/00
摘要： Inkwells adapted for use in direct-write nanolithography and other applications including use of wells, channels, and posts. The wells can possess a geometry which matches the geometry of tips which are dipped into the inkwells. The channels can be open or closed. Hydrophilicity and hydrophobicity can be used to control ink flow. SEM can be used to characterize the inkwells. Ink flow can be monitored with video. Hydrophobic material layers can be used to prevent cross contamination. Microsyringes can be used to fill reservoirs. Satellite reservoirs can be used to prevent bubble formation.
摘要翻译： Inkwells适用于直写纳米光刻技术和其他应用，包括使用井，通道和柱。 孔可以具有与浸入墨水孔中的尖端的几何形状相匹配的几何形状。 通道可以打开或关闭。 亲水性和疏水性可用于控制油墨流动。 SEM可用于表征墨水。 墨水流量可以用视频监控。 疏水材料层可用于防止交叉污染。 微量注射器可用于填充储存器。 可以使用卫星储层来防止气泡形成。
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公开(公告)号：US20100294844A1
公开(公告)日：2010-11-25
申请号：US11109877
申请日：2005-04-20
申请人： Cedric Loiret-Bernal , Linette Demers , Bjoern Rosner , Michael Nelson , Ray Eby , Joseph S. Fragala , Raymond Roger Shile , Hua Zhang , John Edward Bussan , Sylvain Cruchon-Dupeyrat
发明人： Cedric Loiret-Bernal , Linette Demers , Bjoern Rosner , Michael Nelson , Ray Eby , Joseph S. Fragala , Raymond Roger Shile , Hua Zhang , John Edward Bussan , Sylvain Cruchon-Dupeyrat
CPC分类号： B30B15/065 , B30B15/34 , G06K19/06028
摘要： Methods for providing pharmaceutical compositions and objects with identification regions and identification features which are difficult to detect. Microlithography, nanolithography, and stamping methods are used. The identification features can be positive protrusions or negative indentations with respect to the surface. The identification regions can comprise bar codes and holograms. DPN printing or other lithographies such as electron beam lithography, optical lithography, or nanoimprint lithography can be used to prepare stamps, which are then used to prepare the identification features. Redundant patterns can be formed. The invention is useful for counterfeit prevention. An apparatus for stamping the identification features is also described.
摘要翻译： 用于提供药物组合物和物体具有难以检测的识别区域和识别特征的方法。 使用微光刻，纳米光刻和冲压方法。 识别特征可以是相对于表面的正突起或负凹痕。 识别区域可以包括条形码和全息图。 可以使用DPN印刷或诸如电子束光刻，光刻或纳米压印光刻的其它平版印刷术来制备标记，然后将其用于制备识别特征。 可以形成冗余图案。 本发明可用于防伪。 还描述了用于冲压识别特征的装置。
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5.发明申请Apparatus and methods for preparing identification features including pharmaceutical applications 审中-公开用于制备识别特征的装置和方法，包括药物应用公开(公告)号：US20100294147A1
公开(公告)日：2010-11-25
申请号：US11305327
申请日：2005-12-19
申请人： Cedric Loiret-Bernal , Bjoern Rosner , Sylvain Cruchon-Dupeyrat , John E. Bussan , Michael Nelson
发明人： Cedric Loiret-Bernal , Bjoern Rosner , Sylvain Cruchon-Dupeyrat , John E. Bussan , Michael Nelson
IPC分类号： B41F17/36
CPC分类号： B41F19/068 , B41F17/36
摘要： Semi-automated or automated manufacturing of micro- or nanostructured identification features on objects and compositions, and especially pharmaceutical compositions. In particular, a motorized stamping apparatus capable of precise hot embossing with or without closed-loop control of the loading; a modular stamp head for a high-throughput parallel stamping apparatus that comprise an array of compact, error-tolerant, individually temperature-controllable stamping elements; inexpensive stamp holders for said elements, as well as associated methods. The inventive features do not reside in the method of making the stamps.
摘要翻译： 在物体和组合物上，特别是药物组合物的半自动或自动化制造微结构或纳米结构的识别特征。 特别是一种电动冲压装置，能够精确地加热或不加负荷闭环控制的热压花; 用于高通量并行冲压装置的模块化压头，其包括紧凑的，容错的，单独的温度可控的冲压元件阵列; 用于所述元件的廉价邮票持有者以及相关方法。 本发明的特征不在于制作邮票的方法。
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6.发明申请APPARATUS AND METHODS FOR PREPARING IDENTIFICATION FEATURES INCLUDING PHARMACEUTICAL APPLICATIONS 审中-公开用于准备鉴定特征的装置和方法，包括药物应用公开(公告)号：US20120272845A1
公开(公告)日：2012-11-01
申请号：US13539259
申请日：2012-06-29
申请人： Cedric Loiret-Bernal , Bjoern Rosner , Sylvain Cruchon-Dupeyrat , John E. Bussan , Michael Nelson
发明人： Cedric Loiret-Bernal , Bjoern Rosner , Sylvain Cruchon-Dupeyrat , John E. Bussan , Michael Nelson
IPC分类号： B44B5/00
CPC分类号： B41F19/068 , B41F17/36
摘要： Semi-automated or automated manufacturing of micro- or nanostructured identification features on objects and compositions, and especially pharmaceutical compositions. In particular, a motorized stamping apparatus capable of precise hot embossing with or without closed-loop control of the loading; a modular stamp head for a high-throughput parallel stamping apparatus that comprise an array of compact, error-tolerant, individually temperature-controllable stamping elements; inexpensive stamp holders for said elements, as well as associated methods. The inventive features do not reside in the method of making the stamps.
摘要翻译： 在物体和组合物上，特别是药物组合物的半自动或自动化制造微结构或纳米结构的识别特征。 特别是一种电动冲压装置，能够精确地加热或不加负荷闭环控制的热压花; 用于高通量并行冲压装置的模块化压头，其包括紧凑的，容错的，单独的温度可控的冲压元件阵列; 用于所述元件的廉价邮票持有者以及相关方法。 本发明的特征不在于制作邮票的方法。
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公开(公告)号：US20100297190A1
公开(公告)日：2010-11-25
申请号：US12536465
申请日：2009-08-05
申请人： Cedric Loiret-Bernal , Linette Demers , Bjoern Rosner , Michael Nelson , Ray Eby , Joseph S. Fragala , Raymond Roger Shile , Hua Zhang , John Edward Bussan , Sylvain Cruchon-Dupeyrat
发明人： Cedric Loiret-Bernal , Linette Demers , Bjoern Rosner , Michael Nelson , Ray Eby , Joseph S. Fragala , Raymond Roger Shile , Hua Zhang , John Edward Bussan , Sylvain Cruchon-Dupeyrat
CPC分类号： B30B15/065 , B30B15/34 , G06K19/06028
摘要： Methods for providing pharmaceutical compositions and objects with identification regions and identification features which are difficult to detect. Microlithography, nanolithography, and stamping methods are used. The identification features can be positive protrusions or negative indentations with respect to the surface. The identification regions can comprise bar codes and holograms. DPN printing or other lithographies such as electron beam lithography, optical lithography, or nanoimprint lithography can be used to prepare stamps, which are then used to prepare the identification features. Redundant patterns can be formed. The invention is useful for counterfeit prevention. An apparatus for stamping the identification features is also described.
摘要翻译： 用于提供药物组合物和物体具有难以检测的识别区域和识别特征的方法。 使用微光刻，纳米光刻和冲压方法。 识别特征可以是相对于表面的正突起或负凹痕。 识别区域可以包括条形码和全息图。 可以使用DPN印刷或诸如电子束光刻，光刻或纳米压印光刻的其它平版印刷术来制备标记，然后将其用于制备识别特征。 可以形成冗余图案。 本发明可用于防伪。 还描述了用于冲压识别特征的装置。
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公开(公告)号：US20100294927A1
公开(公告)日：2010-11-25
申请号：US11519199
申请日：2006-09-12
CPC分类号： A61K9/2072 , G06Q10/08 , G06Q50/22
摘要： The various embodiments provide methods and apparatus high-throughput reading and decoding of information-encoding features (especially identification features) on pharmaceutical compositions for the purpose of e.g. counterfeiting detection and inventory tracking/tracing. A preferred embodiment provides high-throughput imaging of regular arrays of pharmaceutical tablets with a scanning electron microscope. Another preferred embodiment provides video-rate scanning probe imaging of pharmaceutical compositions and especially atomic force microscopy imaging thereof.
摘要翻译： 各种实施例提供了用于例如药物组合物的信息编码特征（特别是识别特征）的高通量读取和解码方法和装置。 伪造检测和库存跟踪/跟踪。 优选的实施方案提供了用扫描电子显微镜对药物片剂的规则阵列的高通量成像。 另一个优选实施例提供药物组合物的视频速率扫描探针成像，特别是其原子力显微镜成像。
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9.发明授权公开(公告)号：US07034854B2
公开(公告)日：2006-04-25
申请号：US10705776
申请日：2003-11-12
申请人： Sylvain Cruchon-Dupeyrat , Michael Nelson , Robert Elghanian , Joseph S. Fragala , Igor Touzov , Debjyoti Banerjee
发明人： Sylvain Cruchon-Dupeyrat , Michael Nelson , Robert Elghanian , Joseph S. Fragala , Igor Touzov , Debjyoti Banerjee
IPC分类号： B41J2/005
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y30/00 , B82Y40/00
摘要： Inkwells adapted for use in direct-write nanolithography and other applications including use of wells, channels, and posts. The wells can possess a geometry which matches the geometry of tips which are dipped into the inkwells. The channels can be open or closed. Hydrophilicity and hydrophobicity can be used to control ink flow. SEM can be used to characterize the inkwells. Ink flow can be monitored with video. Hydrophobic material layers can be used to prevent cross contamination. Microsyringes can be used to fill reservoirs. Satellite reservoirs can be used to prevent bubble formation.
摘要翻译： Inkwells适用于直写纳米光刻技术和其他应用，包括使用井，通道和柱。 孔可以具有与浸入墨水孔中的尖端的几何形状相匹配的几何形状。 通道可以打开或关闭。 亲水性和疏水性可用于控制油墨流动。 SEM可用于表征墨水。 墨水流量可以用视频监控。 疏水材料层可用于防止交叉污染。 微量注射器可用于填充储存器。 可以使用卫星储层来防止气泡形成。
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公开(公告)号：US08235302B2
公开(公告)日：2012-08-07
申请号：US11109877
申请日：2005-04-20
申请人： Cedric Loiret-Bernal , Linette Demers , Bjoern Rosner , Michael Nelson , Ray Eby , Joseph S. Fragala , Raymond Roger Shile , Hua Zhang , John Edward Bussan , Sylvain Cruchon-Dupeyrat
发明人： Cedric Loiret-Bernal , Linette Demers , Bjoern Rosner , Michael Nelson , Ray Eby , Joseph S. Fragala , Raymond Roger Shile , Hua Zhang , John Edward Bussan , Sylvain Cruchon-Dupeyrat
CPC分类号： B30B15/065 , B30B15/34 , G06K19/06028
摘要： Methods for providing pharmaceutical compositions and objects with identification regions and identification features which are difficult to detect. Microlithography, nanolithography, and stamping methods are used. The identification features can be positive protrusions or negative indentations with respect to the surface. The identification regions can comprise bar codes and holograms. DPN printing or other lithographies such as electron beam lithography, optical lithography, or nanoimprint lithography can be used to prepare stamps, which are then used to prepare the identification features. Redundant patterns can be formed. The invention is useful for counterfeit prevention. An apparatus for stamping the identification features is also described.
摘要翻译： 用于提供药物组合物和物体具有难以检测的识别区域和识别特征的方法。 使用微光刻，纳米光刻和冲压方法。 识别特征可以是相对于表面的正突起或负凹痕。 识别区域可以包括条形码和全息图。 可以使用DPN印刷或诸如电子束光刻，光刻或纳米压印光刻的其它平版印刷术来制备标记，然后将其用于制备识别特征。 可以形成冗余图案。 本发明可用于防伪。 还描述了用于冲压识别特征的装置。
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