公开(公告)号：US20130244238A1

公开(公告)日：2013-09-19

申请号：US13852613

申请日：2013-03-28

Applicant: T2 BIOSYSTEMS, INC.

Inventor： Lori Anne NEELY ,  Mark John Audeh ,  Matthew Blanco ,  James Franklin Chepin ,  Vasiliki Demas ,  Rahul K. Dhanda ,  Thomas Jay Lowery, JR.

IPC: G01N27/74

CPC classification number: G01N33/54326 ,  B82Y25/00 ,  C12Q1/6825 ,  C12Q1/6827 ,  C12Q1/689 ,  C12Q1/6895 ,  C12Q1/70 ,  C12Q1/701 ,  G01N24/08 ,  G01N27/745 ,  G01N33/5434 ,  G01N33/9493 ,  G01R33/093 ,  G01R33/1269 ,  G01R33/281 ,  G01R33/302 ,  G01R33/448 ,  C12Q2563/143 ,  C12Q2565/633 ,  C12Q2563/149 ,  C12Q2565/113

Abstract: This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.

公开(公告)号：US20190085381A1

公开(公告)日：2019-03-21

申请号：US15990400

申请日：2018-05-25

Applicant: T2 Biosystems, Inc.

Inventor： Lori Anne NEELY ,  Mark John AUDEH ,  Rahul DHANDA ,  Marilyn Lee FRITZEMEIER ,  Daniella Lynn PLOURDE ,  Charles William RITTERSHAUS

IPC: C12Q1/6825 ,  G01R33/44 ,  G01N33/70 ,  C12Q1/686 ,  C12Q1/6895 ,  C12Q1/689 ,  C12Q1/70 ,  C12Q1/6827 ,  G01N33/94 ,  G01N33/543

Abstract: This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.

公开(公告)号：US20130280708A1

公开(公告)日：2013-10-24

申请号：US13828637

申请日：2013-03-14

Applicant: T2 BIOSYSTEMS, INC.

Inventor： Lori Anne NEELY

IPC: C12Q1/68

CPC classification number: C12Q1/6895 ,  C12Q1/6818 ,  C12Q2600/158 ,  C12Q2600/16

Abstract: The invention features compositions and methods for the detection of Candida species in biological samples, such as human tissue samples. The invention features species specific nucleic acid probes that can hybridize to target nucleic acid molecules in Candida species and can be used in a variety of detection assays, such as fluorescence based assays or NMR based assays. The compositions and methods of the invention can be used to rapidly and accurately detect one or more Candida species in patients and can be used to assist in point-of care-decisions for treating Candida infections.

Abstract translation: 本发明的特征在于用于检测生物样品例如人组织样品中假丝酵母属物种的组合物和方法。 本发明的特征是能够与假丝酵母属物种中的靶核酸分子杂交的物种特异性核酸探针，并可用于各种检测测定，例如基于荧光的测定或基于NMR的测定。 本发明的组合物和方法可用于快速和准确地检测患者中的一种或多种念珠菌物种，并且可用于协助治疗念珠菌感染的护理点。

公开(公告)号：US20130095494A1

公开(公告)日：2013-04-18

申请号：US13649839

申请日：2012-10-11

Applicant: T2 Biosystems, Inc.

Inventor： Lori Anne NEELY

IPC: C12Q1/68

CPC classification number: G01N27/745 ,  C12Q1/6816 ,  C12Q1/6895 ,  C12Q2537/125 ,  C12Q2563/143 ,  C12Q2563/155 ,  C12Q2565/113 ,  C12Q2565/633 ,  C12Q2600/156 ,  G01N24/08 ,  G01R33/302 ,  G01R33/448 ,  G01R33/465 ,  Y10T436/24

Abstract: This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.

公开(公告)号：US20220228199A1

公开(公告)日：2022-07-21

申请号：US17713456

申请日：2022-04-05

Applicant: T2 Biosystems, Inc.

Inventor： Ulrich Hans THOMANN ,  Lori Anne NEELY ,  Rahul Krishan DHANDA ,  Frédéric SWEENEY ,  Thomas Jay LOWERY, JR. ,  Jessica Ann TOWNSEND ,  Jessica Lee SNYDER ,  Heidi Susanne GIESE ,  Cheryl Ann BANDOSKI-GRALINSKI ,  Daniella Lynn LOGAN

IPC: C12Q1/689 ,  C12N15/10 ,  G01N24/08

Abstract: The invention features methods, systems, and panels for rapid detection of tick-borne pathogens in a sample (including Borrelia spp. such as B. burgdorferi, B. afzelii, and B. garinii) and for diagnosis and monitoring of tick-transmitted diseases, including Lyme disease, Rocky Mountain spotted fever, Q-fever, babesiosis, ehrlichiosis, tularemia, and anaplasmosis.

公开(公告)号：US20200261873A1

公开(公告)日：2020-08-20

申请号：US16659215

申请日：2019-10-21

Applicant: T2 Biosystems, Inc.

Inventor： Adam SUCHOCKI ,  Mark John AUDEH ,  Matthew BLANCO ,  James Franklin CHEPIN ,  Vasiliki DEMAS ,  Marilyn Lee FRITZEMEIER ,  Thomas Jay LOWERY, JR. ,  Michael MIN ,  Lori Anne NEELY ,  Charles William RITTERSHAUS ,  Hwa-Tang WANG ,  Parris WELLMAN

IPC: B01F9/00 ,  C12Q1/686 ,  C12Q1/6816 ,  B01F15/00 ,  B01F13/00 ,  B65D1/46 ,  C12M1/00 ,  C12N1/06 ,  G01N33/49 ,  G01N27/74

Abstract: The present invention relates to containers for holding liquid samples. The containers may be useful for mixing a liquid sample or lysing cells in a liquid sample. The invention also relates to methods of using the containers of the invention.

公开(公告)号：US20180171388A1

公开(公告)日：2018-06-21

申请号：US15545663

申请日：2016-01-21

Applicant: T2 Biosystems, Inc.

Inventor： Ulrich Hans THOMANN ,  Lori Anne NEELY ,  Rahul Krishan DHANDA ,  Frédéric SWEENEY ,  Thomas Jay LOWERY, JR. ,  Jessica Ann TOWNSEND ,  Jessica Lee SNYDER ,  Heidi Susanne GIESE ,  Cheryl Ann BANDOSKI-GRALINSKI ,  Daniella Lynn LOGAN

IPC: C12Q1/689 ,  G01N24/08 ,  C12N15/10

CPC classification number: C12Q1/689 ,  C12N15/1013 ,  C12Q2600/112 ,  C12Q2600/124 ,  C12Q2600/156 ,  G01N24/08 ,  G01N2333/20 ,  G01N2800/26 ,  Y02A50/57

Abstract: The invention features methods, systems, and panels for rapid detection of tick-borne pathogens in a sample (including Borrelia spp. such as B. burgdorferi, B. afzelii, and B. garinii) and for diagnosis and monitoring of tick-transmitted diseases, including Lyme disease, Rocky Mountain spotted fever, Q-fever, babesiosis, ehrlichiosis, tularemia, and anaplasmosis.

公开(公告)号：US20170204475A1

公开(公告)日：2017-07-20

申请号：US15404756

申请日：2017-01-12

Applicant: T2 Biosystems, Inc.

Inventor： Lori Anne NEELY

IPC: C12Q1/68

CPC classification number: C12Q1/6895 ,  C12Q1/6818 ,  C12Q2600/158 ,  C12Q2600/16

Abstract: The invention features compositions and methods for the detection of Candida species in biological samples, such as human tissue samples. The invention features species specific nucleic acid probes that can hybridize to target nucleic acid molecules in Candida species and can be used in a variety of detection assays, such as fluorescence based assays or NMR based assays. The compositions and methods of the invention can be used to rapidly and accurately detect one or more Candida species in patients and can be used to assist in point-of care-decisions for treating Candida infections.

公开(公告)号：US20220154297A1

公开(公告)日：2022-05-19

申请号：US17410841

申请日：2021-08-24

Applicant: T2 Biosystems, Inc.

Inventor： Lori Anne NEELY

IPC: C12Q1/6895 ,  C12Q1/6818

Abstract: The invention features compositions and methods for the detection of Candida species in biological samples, such as human tissue samples. The invention features species specific nucleic acid probes that can hybridize to target nucleic acid molecules in Candida species and can be used in a variety of detection assays, such as fluorescence based assays or NMR based assays. The compositions and methods of the invention can be used to rapidly and accurately detect one or more Candida species in patients and can be used to assist in point-of care-decisions for treating Candida infections.

公开(公告)号：US20190032104A1

公开(公告)日：2019-01-31

申请号：US16071023

申请日：2017-01-20

Applicant: T2 Biosystems, Inc.

Inventor： Thomas Jay LOWERY, JR. ,  Michael Andy PFALLER ,  Rahul Krishan DHANDA ,  John J. MCDONOUGH ,  Glenn MAGNUSON ,  Lori Anne NEELY ,  Ulrich Hans THOMANN ,  William Coulter HARRIS ,  Justin Layne BLACK

IPC: C12Q1/06 ,  C12Q1/689 ,  C12Q1/14 ,  C12Q1/6806 ,  C12Q1/6893 ,  C12M1/34

Abstract: The invention features methods, panels, cartridges, kits, and systems for rapid and sensitive detection and identification of pathogens and determination of the pathogen's susceptibility to antimicrobial agents for diagnosis and treatment of disease, including bloodstream infection (e.g., bacteremia and fungemia), and sepsis.