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公开(公告)号：US20220361764A1
公开(公告)日：2022-11-17
申请号：US17844958
申请日：2022-06-21
摘要： A system and method for non-invasively estimating an absolute blood flow of a vascular region in a subject using optical data are provided. In some aspects, the method includes acquiring optical data from the vascular region using one or more optical sensors placed about the subject, and determining, using the optical data, an index of blood flow and a blood volume associated with the vascular region. The method also includes computing a blood inflow and a blood outflow using the index of blood flow and the blood volume, and estimating an absolute blood flow using the blood inflow and blood outflow. The method further includes generating a report indicative of the absolute blood flow of the vascular region.
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公开(公告)号：US09265460B2
公开(公告)日：2016-02-23
申请号：US14517398
申请日：2014-10-17
发明人： David Boas , Stefan Carp , Mark Martino , Qianqian Fang
CPC分类号： A61B5/4312 , A61B5/0035 , A61B5/0073 , A61B5/0091 , A61B6/502 , A61B2562/17
摘要： An exemplary apparatus can be provided to determine information regarding a sample(s), which can include, for example an arrangement(s) composed of, at least partially, a particular material in a predetermined area thereof, and including a light facilitating device that can be configured to provide or receive a light radiation(s) to or from the sample(s). The particular material can have a characteristic which can facilitate a sufficient amount of X-ray radiation to pass therethrough so as to generate an X-ray image(s). An X-ray absorption of the material can be at most about 10 times that of a ¼″ acrylic plate. The light facilitating device can include a light transmitting configuration which can provide the light radiation(s) to the sample.
摘要翻译： 可以提供示例性装置以确定关于样品的信息，其可以包括例如由至少部分地由其至少部分地在其预定区域中的特定材料构成的装置，并且包括轻便装置， 可以被配置为向或从样品提供或接收光辐射。 特定材料可以具有能够促进足够量的X射线辐射通过其中以产生X射线图像的特性。 该材料的X射线吸收量可以是¼“丙烯酸板的至多约10倍。 光促进装置可以包括能够向样品提供光辐射的透光构造。
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公开(公告)号：US11723547B2
公开(公告)日：2023-08-15
申请号：US17844958
申请日：2022-06-21
IPC分类号： A61B5/0205 , A61B5/026 , A61B5/00 , A61B5/03 , A61B5/318 , A61B5/369 , A61B5/029 , A61B5/021 , A61B5/08 , A61B5/145 , A61B5/1455
CPC分类号： A61B5/031 , A61B5/0075 , A61B5/0205 , A61B5/029 , A61B5/0261 , A61B5/318 , A61B5/369 , A61B5/6814 , A61B5/7246 , A61B5/7278 , A61B5/021 , A61B5/08 , A61B5/14546 , A61B5/14552 , A61B2562/0238
摘要： A system and method for non-invasively estimating an absolute blood flow of a vascular region in a subject using optical data are provided. In some aspects, the method includes acquiring optical data from the vascular region using one or more optical sensors placed about the subject, and determining, using the optical data, an index of blood flow and a blood volume associated with the vascular region. The method also includes computing a blood inflow and a blood outflow using the index of blood flow and the blood volume, and estimating an absolute blood flow using the blood inflow and blood outflow. The method further includes generating a report indicative of the absolute blood flow of the vascular region.
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公开(公告)号：US11660010B2
公开(公告)日：2023-05-30
申请号：US17508718
申请日：2021-10-22
IPC分类号： A61B5/026 , A61B5/00 , A61B5/1455
CPC分类号： A61B5/0261 , A61B5/0075 , A61B5/14552 , A61B5/4064 , A61B5/14551 , A61B5/14553 , A61B5/6814 , A61B2562/0238 , A61B2562/0242
摘要： Systems and methods for path length selected diffuse correlation spectroscopy (PLS-DCS) are disclosed. The systems and methods are suitable for measuring dynamics of a target medium. The systems and methods can utilize light sources having a coherence length that is shorter than a path length distribution of the target medium and can utilize a reference optical path to interferometrically detect PLS-DCS signals. The coherence length and reference path length can be selected to provide sensitivity to portions of the target medium that correspond to a desired path length distribution.
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公开(公告)号：US20190053721A1
公开(公告)日：2019-02-21
申请号：US16079881
申请日：2017-02-24
摘要： Systems and methods for path length selected diffuse correlation spectroscopy (PLS-DCS) are disclosed. The systems and methods are suitable for measuring dynamics of a target medium. The systems and methods can utilize light sources having a coherence length that is shorter than a path length distribution of the target medium and can utilize a reference optical path to interferometrically detect PLS-DCS signals. The coherence length and reference path length can be selected to provide sensitivity to portions of the target medium that correspond to a desired path length distribution.
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公开(公告)号：US11872022B2
公开(公告)日：2024-01-16
申请号：US16970670
申请日：2019-02-18
发明人： Maria Angela Franceschini , Stefan Carp , Davide Tamborini , David Boas , Bruce Rosen , Megan Blackwell , Oleg Shatrovoy
IPC分类号： A61B5/026 , G01J1/44 , H01L31/107 , H01L31/109
CPC分类号： A61B5/0261 , G01J1/44 , A61B2562/0233 , G01J2001/448 , G01J2001/4453 , G01J2001/4466 , H01L31/107 , H01L31/109
摘要： An apparatus, including: a probe to interface with a surface of a tissue; a light source optically coupled to the probe, the light source directing light of at least 1000 nm into the tissue; a detector optically coupled to the probe, the detector to detect light based on scattering of light from the light source in the tissue, and the detector having a light sensitivity in a range of at least 1000 nm; a processor coupled to the detector, the processor to: receive a signal from the detector corresponding to the detected light from the light source, and determine a blood flow measurement from the region of interest using diffuse correlation spectroscopy based on the signal.
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公开(公告)号：US20220248971A1
公开(公告)日：2022-08-11
申请号：US17508718
申请日：2021-10-22
IPC分类号： A61B5/026 , A61B5/00 , A61B5/1455
摘要： Systems and methods for path length selected diffuse correlation spectroscopy (PLS-DCS) are disclosed. The systems and methods are suitable for measuring dynamics of a target medium. The systems and methods can utilize light sources having a coherence length that is shorter than a path length distribution of the target medium and can utilize a reference optical path to interferometrically detect PLS-DCS signals. The coherence length and reference path length can be selected to provide sensitivity to portions of the target medium that correspond to a desired path length distribution.
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8.发明申请公开(公告)号：US20190261869A1
公开(公告)日：2019-08-29
申请号：US16349405
申请日：2017-11-14
IPC分类号： A61B5/026 , A61B5/00 , A61B5/1455
摘要： The present disclosure provides systems and methods for multi-distance, multi-wavelength diffuse correlation spectroscopy (MD-MW DCS). The systems and methods can include two, three, or more different wavelengths and two, three, or more different source-detector distances. The dynamics of a target medium can be determined using detected signals at the different wavelengths and different source-detector distances.
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公开(公告)号：US20180070830A1
公开(公告)日：2018-03-15
申请号：US15564489
申请日：2016-04-11
IPC分类号： A61B5/00 , A61B5/026 , A61B5/1455 , A61B5/021
CPC分类号： A61B5/0075 , A61B5/021 , A61B5/0261 , A61B5/0402 , A61B5/14553 , A61B5/4064 , A61B5/72 , A61B5/7203 , A61B6/00 , G01J3/40
摘要： The present disclosure generally relates to improvements to systems and methods for measuring the dynamic properties of scattering particles within a medium, including fluid flow. Specifically, the present disclosure relates to systems and methods for time-resolved diffuse correlation spectroscopy. This disclosure provides systems and methods for determining dynamics in a target medium. The systems and methods can utilize time-resolved diffuse correlation spectroscopy.
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公开(公告)号：US11089972B2
公开(公告)日：2021-08-17
申请号：US15565044
申请日：2016-04-11
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/026 , A61B5/029 , A61B5/03 , A61B5/0402 , A61B5/0476 , A61B5/318 , A61B5/369 , A61B5/021 , A61B5/08 , A61B5/145 , A61B5/1455
摘要： A system and method for non-invasively monitoring intracranial pressure are provided. In some aspects, the method comprises acquiring diffuse correlation spectroscopy data at a temporal resolution greater than a pulsatile frequency of cerebral blood flow of a subject using one or more optical sensors placed about a subject, and determining a pulsatile cerebral blood flow using the acquired data, The method also includes correlating the determined pulsatile cerebral blood flow with physiological data acquired from the subject, and estimating an intracranial pressure based on the correlation. The method further includes generating a report indicative of the estimated intracranial pressure.
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