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公开(公告)号：US20220361764A1
公开(公告)日：2022-11-17
申请号：US17844958
申请日：2022-06-21
摘要： A system and method for non-invasively estimating an absolute blood flow of a vascular region in a subject using optical data are provided. In some aspects, the method includes acquiring optical data from the vascular region using one or more optical sensors placed about the subject, and determining, using the optical data, an index of blood flow and a blood volume associated with the vascular region. The method also includes computing a blood inflow and a blood outflow using the index of blood flow and the blood volume, and estimating an absolute blood flow using the blood inflow and blood outflow. The method further includes generating a report indicative of the absolute blood flow of the vascular region.
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公开(公告)号：US11723547B2
公开(公告)日：2023-08-15
申请号：US17844958
申请日：2022-06-21
IPC分类号： A61B5/0205 , A61B5/026 , A61B5/00 , A61B5/03 , A61B5/318 , A61B5/369 , A61B5/029 , A61B5/021 , A61B5/08 , A61B5/145 , A61B5/1455
CPC分类号： A61B5/031 , A61B5/0075 , A61B5/0205 , A61B5/029 , A61B5/0261 , A61B5/318 , A61B5/369 , A61B5/6814 , A61B5/7246 , A61B5/7278 , A61B5/021 , A61B5/08 , A61B5/14546 , A61B5/14552 , A61B2562/0238
摘要： A system and method for non-invasively estimating an absolute blood flow of a vascular region in a subject using optical data are provided. In some aspects, the method includes acquiring optical data from the vascular region using one or more optical sensors placed about the subject, and determining, using the optical data, an index of blood flow and a blood volume associated with the vascular region. The method also includes computing a blood inflow and a blood outflow using the index of blood flow and the blood volume, and estimating an absolute blood flow using the blood inflow and blood outflow. The method further includes generating a report indicative of the absolute blood flow of the vascular region.
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公开(公告)号：US11660010B2
公开(公告)日：2023-05-30
申请号：US17508718
申请日：2021-10-22
IPC分类号： A61B5/026 , A61B5/00 , A61B5/1455
CPC分类号： A61B5/0261 , A61B5/0075 , A61B5/14552 , A61B5/4064 , A61B5/14551 , A61B5/14553 , A61B5/6814 , A61B2562/0238 , A61B2562/0242
摘要： Systems and methods for path length selected diffuse correlation spectroscopy (PLS-DCS) are disclosed. The systems and methods are suitable for measuring dynamics of a target medium. The systems and methods can utilize light sources having a coherence length that is shorter than a path length distribution of the target medium and can utilize a reference optical path to interferometrically detect PLS-DCS signals. The coherence length and reference path length can be selected to provide sensitivity to portions of the target medium that correspond to a desired path length distribution.
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公开(公告)号：US20190053721A1
公开(公告)日：2019-02-21
申请号：US16079881
申请日：2017-02-24
摘要： Systems and methods for path length selected diffuse correlation spectroscopy (PLS-DCS) are disclosed. The systems and methods are suitable for measuring dynamics of a target medium. The systems and methods can utilize light sources having a coherence length that is shorter than a path length distribution of the target medium and can utilize a reference optical path to interferometrically detect PLS-DCS signals. The coherence length and reference path length can be selected to provide sensitivity to portions of the target medium that correspond to a desired path length distribution.
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公开(公告)号：US11089972B2
公开(公告)日：2021-08-17
申请号：US15565044
申请日：2016-04-11
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/026 , A61B5/029 , A61B5/03 , A61B5/0402 , A61B5/0476 , A61B5/318 , A61B5/369 , A61B5/021 , A61B5/08 , A61B5/145 , A61B5/1455
摘要： A system and method for non-invasively monitoring intracranial pressure are provided. In some aspects, the method comprises acquiring diffuse correlation spectroscopy data at a temporal resolution greater than a pulsatile frequency of cerebral blood flow of a subject using one or more optical sensors placed about a subject, and determining a pulsatile cerebral blood flow using the acquired data, The method also includes correlating the determined pulsatile cerebral blood flow with physiological data acquired from the subject, and estimating an intracranial pressure based on the correlation. The method further includes generating a report indicative of the estimated intracranial pressure.
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公开(公告)号：US20180103861A1
公开(公告)日：2018-04-19
申请号：US15565044
申请日：2016-04-11
IPC分类号： A61B5/03 , A61B5/0205 , A61B5/026 , A61B5/0402 , A61B5/0476 , A61B5/029 , A61B5/00
CPC分类号： A61B5/031 , A61B5/0075 , A61B5/0205 , A61B5/021 , A61B5/0261 , A61B5/029 , A61B5/0402 , A61B5/0476 , A61B5/08 , A61B5/14546 , A61B5/14552 , A61B5/6814 , A61B5/7246 , A61B5/7278 , A61B2562/0238
摘要： A system and method for non-invasively monitoring intracranial pressure are provided. In some aspects, the method comprises acquiring diffuse correlation spectroscopy data at a temporal resolution greater than a pulsatile frequency of cerebral blood flow of a subject using one or more optical sensors placed about a subject, and determining a pulsatile cerebral blood flow using the acquired data, The method also includes correlating the determined pulsatile cerebral blood flow with physiological data acquired from the subject, and estimating an intracranial pressure based on the correlation. The method further includes generating a report indicative of the estimated intracranial pressure.
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公开(公告)号：US11872022B2
公开(公告)日：2024-01-16
申请号：US16970670
申请日：2019-02-18
发明人： Maria Angela Franceschini , Stefan Carp , Davide Tamborini , David Boas , Bruce Rosen , Megan Blackwell , Oleg Shatrovoy
IPC分类号： A61B5/026 , G01J1/44 , H01L31/107 , H01L31/109
CPC分类号： A61B5/0261 , G01J1/44 , A61B2562/0233 , G01J2001/448 , G01J2001/4453 , G01J2001/4466 , H01L31/107 , H01L31/109
摘要： An apparatus, including: a probe to interface with a surface of a tissue; a light source optically coupled to the probe, the light source directing light of at least 1000 nm into the tissue; a detector optically coupled to the probe, the detector to detect light based on scattering of light from the light source in the tissue, and the detector having a light sensitivity in a range of at least 1000 nm; a processor coupled to the detector, the processor to: receive a signal from the detector corresponding to the detected light from the light source, and determine a blood flow measurement from the region of interest using diffuse correlation spectroscopy based on the signal.
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公开(公告)号：US20220248971A1
公开(公告)日：2022-08-11
申请号：US17508718
申请日：2021-10-22
IPC分类号： A61B5/026 , A61B5/00 , A61B5/1455
摘要： Systems and methods for path length selected diffuse correlation spectroscopy (PLS-DCS) are disclosed. The systems and methods are suitable for measuring dynamics of a target medium. The systems and methods can utilize light sources having a coherence length that is shorter than a path length distribution of the target medium and can utilize a reference optical path to interferometrically detect PLS-DCS signals. The coherence length and reference path length can be selected to provide sensitivity to portions of the target medium that correspond to a desired path length distribution.
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公开(公告)号：US20180070830A1
公开(公告)日：2018-03-15
申请号：US15564489
申请日：2016-04-11
IPC分类号： A61B5/00 , A61B5/026 , A61B5/1455 , A61B5/021
CPC分类号： A61B5/0075 , A61B5/021 , A61B5/0261 , A61B5/0402 , A61B5/14553 , A61B5/4064 , A61B5/72 , A61B5/7203 , A61B6/00 , G01J3/40
摘要： The present disclosure generally relates to improvements to systems and methods for measuring the dynamic properties of scattering particles within a medium, including fluid flow. Specifically, the present disclosure relates to systems and methods for time-resolved diffuse correlation spectroscopy. This disclosure provides systems and methods for determining dynamics in a target medium. The systems and methods can utilize time-resolved diffuse correlation spectroscopy.
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公开(公告)号：US10912504B2
公开(公告)日：2021-02-09
申请号：US15111721
申请日：2015-01-14
申请人： Canon U.S.A. Inc. , The General Hospital Corporation , Haruo Nakaji , Maria Angela Franceschini , David Boas , Erin Buckley , Pei-Yi Lin , Stefan Carp
发明人： Haruo Nakaji , Maria Angela Franceschini , David Boas , Erin Buckley , Pei-Yi Lin , Stefan Carp
IPC分类号： A61B5/1455 , A61B5/026 , A61B5/00 , A61B5/145
摘要： There is provided herewith an apparatus, probe, and method for the combination of near-infrared spectroscopy (NIRS) and diffuse correlation spectroscopy (DCS). The apparatus, probe and method allow for the simultaneous detection of NIRS and DCS.
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