公开(公告)号：US20170362380A1

公开(公告)日：2017-12-21

申请号：US15534269

申请日：2015-12-09

Applicant: The Regents of the University of California

Inventor： Karen Christman ,  Gregory Grover ,  Michael Madani ,  Masaki Fujita

IPC: C08G65/48 ,  A61L24/00 ,  A61L31/14 ,  C08F16/06 ,  C08B37/08 ,  C08B37/02

CPC classification number: C08G65/48 ,  A61L24/0031 ,  A61L31/145 ,  C08B37/0021 ,  C08B37/0072 ,  C08F16/06 ,  C08G2650/50 ,  C08J3/075 ,  C08J3/246 ,  C08J2300/206 ,  C08J2371/02 ,  C08J2400/206 ,  C08J2471/02

Abstract: Methods and hydrogels for preventing or reducing cellular adhesion and protein adsorption to a tissue (e.g. cardiac tissue) are disclosed. The hydrogels generally include at least two component polymers, a first polymer including an aminooxy group and a second polymer including a reactive oxo group, that are cross-linked by oxime bonds. The hydrogels are suitable for binding to and coating a tissue or cell. The hydrogels operate to reduce cellular adhesions and protein adsorption to the tissue or cell.

公开(公告)号：US20210379245A1

公开(公告)日：2021-12-09

申请号：US17286534

申请日：2019-10-25

Applicant: The Regents of the University of California

Inventor： Karen Christman ,  Martin Spang ,  Gregory Grover

IPC: A61L27/36 ,  A61L27/54 ,  A61K38/01

Abstract: Compositions and methods for their manufacture and use are provided comprising a soluble extracellular matrix fraction for intravascular delivery which forms a gel or coating in situ for treatment of myocardial infarction and ischemia in a variety of tissues and endothelial injury/dysfunction.

公开(公告)号：US10201613B2

公开(公告)日：2019-02-12

申请号：US14426259

申请日：2013-08-20

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Heather D. Maynard ,  Tatiana Segura ,  Gregory Grover ,  Jonathan Lam

IPC: A61K47/42 ,  A61K9/00 ,  A61K9/06 ,  A61K35/545 ,  C08G65/48 ,  C08J3/075 ,  C08J3/24 ,  C08L101/02 ,  C08L101/06 ,  C08G65/333 ,  C08G65/337

Abstract: A method of creating a hydrogel, comprising the step of condensing first and second functional groups, wherein the first group comprises a molecule or macromolecule of interest containing two or more hydroxylamine or aminooxy groups and the second group comprises a molecule or macromolecule of interest containing two or more aldehyde/ketone/other reactive oxo groups, under conditions such that a hydrogel forms.

公开(公告)号：US20150202305A1

公开(公告)日：2015-07-23

申请号：US14426259

申请日：2013-08-20

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Heather D. Maynard ,  Tatiana Segura ,  Gregory Grover ,  Jonathan Lam

IPC: A61K47/42 ,  A61K35/545 ,  C08G65/48 ,  A61K9/06

CPC classification number: A61K47/42 ,  A61K9/0024 ,  A61K9/06 ,  A61K35/545 ,  C08G65/33303 ,  C08G65/33337 ,  C08G65/337 ,  C08G65/48 ,  C08G2650/30 ,  C08G2650/44 ,  C08J3/075 ,  C08J3/246 ,  C08J2300/104 ,  C08J2300/106 ,  C08L101/025 ,  C08L101/06 ,  C08L2203/02

Abstract: A method of creating a hydrogel, comprising the step of condensing first and second functional groups, wherein the first group comprises a molecule or macromolecule of interest containing two or more hydroxylamine or aminooxy groups and the second group comprises a molecule or macromolecule of interest containing two or more aldehyde/ketone/other reactive oxo groups, under conditions such that a hydrogel forms.

Abstract translation: 一种产生水凝胶的方法，包括冷凝第一和第二官能团的步骤，其中第一组包含目标分子或大分子含有两个或多个羟胺或氨基氧基，第二组包括目标分子或大分子，含有两个 或更多的醛/酮/其它反应性氧代基，在形成水凝胶的条件下。