公开(公告)号：US09863912B2

公开(公告)日：2018-01-09

申请号：US14556134

申请日：2014-11-29

申请人： The Regents of the University of California

发明人： William Dunbar ,  Jungsuk Kim

IPC分类号： G01N27/447 ,  G01N33/487 ,  B82Y30/00

CPC分类号： G01N27/44765 ,  B82Y30/00 ,  G01N27/447 ,  G01N27/44713 ,  G01N27/4473 ,  G01N27/44743 ,  G01N27/44791 ,  G01N33/48721

摘要： Provided is a device comprising an upper chamber, a middle chamber and a lower chamber, wherein the upper chamber is in communication with the middle chamber through a first pore, and the middle chamber is in communication with the lower chamber through a second pore, wherein the first pore and second pore are about 1 nm to about 100 nm in diameter, and are about 10 nm to about 1000 nm apart from each other, and wherein each of the chambers comprises an electrode for connecting to a power supply. Methods of using the device are also provided, in particular for sequencing a polynucleotide.

公开(公告)号：US09650670B2

公开(公告)日：2017-05-16

申请号：US14438868

申请日：2013-10-28

申请人： The Regents of the University of California

发明人： Jungsuk Kim ,  William Dunbar

IPC分类号： H03F3/52 ,  C12Q1/68 ,  H03F3/45 ,  G01N27/447 ,  H03F1/34

CPC分类号： C12Q1/6809 ,  C12Q1/6869 ,  G01N27/447 ,  G01N27/44791 ,  H03F1/34 ,  H03F3/45 ,  H03F3/45076 ,  H03F3/45475 ,  H03F2200/261 ,  H03F2200/411 ,  H03F2203/45336 ,  H03F2203/45411 ,  H03F2203/45512 ,  H03F2203/45528

摘要： A polynucleotide sequencer comprising an integrated and multiplexed network of patch clamp capacitive integrator-differentiator amplifiers with small feedback capacitors using pseudo-resistors.

公开(公告)号：US20150337367A1

公开(公告)日：2015-11-26

申请号：US14438868

申请日：2013-10-28

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Jungsuk Kim ,  William Dunbar

IPC分类号： C12Q1/68 ,  G01N27/447 ,  H03F3/45

CPC分类号： C12Q1/6809 ,  C12Q1/6869 ,  G01N27/447 ,  G01N27/44791 ,  H03F1/34 ,  H03F3/45 ,  H03F3/45076 ,  H03F3/45475 ,  H03F2200/261 ,  H03F2200/411 ,  H03F2203/45336 ,  H03F2203/45411 ,  H03F2203/45512 ,  H03F2203/45528

摘要： A polynucleotide sequencer comprising an integrated and multiplexed network of patch clamp capacitive integrator-differentiator amplifiers with small feedback capacitors using pseudo-resistors.

摘要翻译： 多核苷酸测序仪，其包括使用伪电阻器的具有小反馈电容器的片钳钳位电容积分器微分放大器的集成复用网络。