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公开(公告)号：US11110148B2
公开(公告)日：2021-09-07
申请号：US15981981
申请日：2018-05-17
IPC分类号： D01F4/02 , A61K38/18 , A61L27/22 , A61L27/26 , A61L27/36 , A61L27/38 , A61L27/56 , D01D5/00 , A61K47/42
摘要： The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
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2.发明申请COVALENTLY IMMOBILIZED PROTEIN GRADIENTS IN THREE-DIMENSIONAL POROUS SCAFFOLDS 审中-公开三维多孔蛋白质中共同固定的蛋白质降解公开(公告)号：US20130230491A1
公开(公告)日：2013-09-05
申请号：US13775328
申请日：2013-02-25
摘要： The invention provides a method for forming an immobilized agent gradient within a 3-dimensional porous scaffold. A 3-dimensional scaffold formed from a biocompatible material is provided. The surface of the scaffold and/or the agent is activated so as to allow binding of the agent to the scaffold. The activated scaffold is contacted with a solution containing the agent. Contact with the solution is maintained for a sufficient period of time to allow diffusion of the solution through a portion of the scaffold, thereby forming a desired gradient of the agent through the 3-dimensional scaffold.
摘要翻译： 本发明提供了在三维多孔支架内形成固定化剂梯度的方法。 提供由生物相容性材料形成的3维支架。 支架和/或试剂的表面被活化，以允许试剂与支架结合。 活化的支架与含有该试剂的溶液接触。 保持与溶液接触足够的时间以允许溶液扩散通过支架的一部分，从而通过3维支架形成所需试剂的梯度。
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公开(公告)号：US20190008923A1
公开(公告)日：2019-01-10
申请号：US15981981
申请日：2018-05-17
IPC分类号： A61K38/18 , A61K47/42 , A61L27/22 , D01F4/02 , D01D5/00 , A61L27/56 , A61L27/38 , A61L27/36 , A61L27/26 , C08L89/00
摘要： The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
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公开(公告)号：US09132197B2
公开(公告)日：2015-09-15
申请号：US13767190
申请日：2013-02-14
IPC分类号： A61K38/17 , A61K47/42 , A61L27/22 , A61L27/26 , A61L27/36 , A61L27/38 , A61L27/56 , D01D5/00 , D01F4/02 , A61K38/18
CPC分类号： A61K38/1825 , A61K38/1841 , A61K47/42 , A61L27/227 , A61L27/26 , A61L27/3604 , A61L27/3847 , A61L27/3852 , A61L27/3895 , A61L27/56 , D01D5/00 , D01F4/02 , Y10T428/29 , C08L89/00
摘要： The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
摘要翻译： 本发明提供生产多孔丝素蛋白支架材料的方法。 多孔丝素蛋白支架可用于组织工程。 可以调节本文所述的丝素蛋白支架的孔隙率以模拟在天然组织中发现的密度梯度。 因此，用于三维组织工程的方法，例如， 还提供使用丝素蛋白骨架材料的骨和软骨。
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公开(公告)号：US09993527B2
公开(公告)日：2018-06-12
申请号：US13680570
申请日：2012-11-19
IPC分类号： A61K38/18 , A61K47/42 , A61L27/38 , A61L27/56 , A61L27/22 , A61L27/26 , A61L27/36 , D01D5/00 , D01F4/02 , C12N5/00 , C12N5/079
CPC分类号： A61K38/1825 , A61K38/1841 , A61K47/42 , A61L27/227 , A61L27/26 , A61L27/3604 , A61L27/3847 , A61L27/3852 , A61L27/3895 , A61L27/56 , D01D5/00 , D01F4/02 , Y10T428/29 , C08L89/00
摘要： The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
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公开(公告)号：US20130158131A1
公开(公告)日：2013-06-20
申请号：US13767190
申请日：2013-02-14
IPC分类号： A61L27/56
CPC分类号： A61K38/1825 , A61K38/1841 , A61K47/42 , A61L27/227 , A61L27/26 , A61L27/3604 , A61L27/3847 , A61L27/3852 , A61L27/3895 , A61L27/56 , D01D5/00 , D01F4/02 , Y10T428/29 , C08L89/00
摘要： The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
摘要翻译： 本发明提供生产多孔丝素蛋白支架材料的方法。 多孔丝素蛋白支架可用于组织工程。 可以调节本文所述的丝素蛋白支架的孔隙率以模拟在天然组织中发现的密度梯度。 因此，用于三维组织工程的方法，例如， 还提供使用丝素蛋白骨架材料的骨和软骨。
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