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公开(公告)号：US20090042241A1
公开(公告)日：2009-02-12
申请号：US12062808
申请日：2008-04-04
CPC分类号： B01L3/502761 , B01L3/502753 , B01L2200/0636 , B01L2200/0647 , B01L2300/0636 , B01L2300/0654 , B01L2300/0681 , B01L2300/0816 , B01L2300/0822 , B01L2300/0864 , B01L2300/0877 , B01L2400/086 , G01N15/1056 , G01N15/1484 , G01N33/5005 , G01N33/5094 , G01N33/582 , G01N2015/1006 , G01N2015/1486 , G01N2015/149 , Y10T436/11 , Y10T436/13 , Y10T436/25 , Y10T436/2575
摘要： Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.
摘要翻译： 这里描述的是涉及可用于细胞感测，计数和/或分选的微流体装置的具体实施方案。 特定方面涉及能够将单细胞类型与致密细胞群分化的微加工装置。 一个具体实施方案涉及一种装置及其使用方法，用于从整个未稀释的血液样品中检测，计数和/或分选白细胞。
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公开(公告)号：US08354075B1
公开(公告)日：2013-01-15
申请号：US11408514
申请日：2006-04-20
申请人： Yu-Chong Tai , Siyang Zheng , Harvey Kasdan
发明人： Yu-Chong Tai , Siyang Zheng , Harvey Kasdan
CPC分类号： B01L3/502761 , B01L3/502746 , B01L2200/0636 , B01L2200/0652 , B01L2400/0487 , B01L2400/0688 , Y10T436/2575
摘要： The present invention provides a streamline-based device and a method for using the device for continuous separation of particles including cells in biological fluids. The device includes a main microchannel and an array of side microchannels disposed on a substrate. The main microchannel has a plurality of stagnation points with a predetermined geometric design, for example, each of the stagnation points has a predetermined distance from the upstream edge of each of the side microchannels. The particles are separated and collected in the side microchannels.
摘要翻译： 本发明提供了一种基于流线的装置和使用该装置用于连续分离包括生物流体中的细胞的颗粒的方法。 该器件包括主微通道和设置在衬底上的侧面微通道阵列。 主微通道具有多个具有预定几何设计的停滞点，例如，每个停滞点距离每个侧面微通道的上游边缘具有预定距离。 将颗粒分离并收集在侧面微通道中。
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公开(公告)号：US20050033455A1
公开(公告)日：2005-02-10
申请号：US10716842
申请日：2003-11-18
申请人： Harvey Kasdan , Kenneth Gold , Jon Tindel , Ken Atterholt , David Fridge
发明人： Harvey Kasdan , Kenneth Gold , Jon Tindel , Ken Atterholt , David Fridge
IPC分类号： G01N15/14 , G01N35/10 , G05B19/042 , G05B19/045 , G05B11/01
CPC分类号： G01N15/1463 , G01N15/1456 , G01N15/1459 , G01N35/00871 , G01N35/1009 , G05B19/0421 , G05B19/045 , G05B2219/2207 , G05B2219/2231 , G05B2219/2233 , G05B2219/23256 , G05B2219/23289 , G05B2219/23428 , G05B2219/25484 , G05B2219/2657
摘要： The invention is a state machine having a host controller that controls a level-1 controller controller, wherein the level-1 controller controls the level-2 controller. The level-2 controller controls system component controllers, which in turn control system components to execute a process segment. For example, the machine includes a host controller that selects a set of states to be executed, a level-1 controller that activates the set of states in a predetermined order, wherein each state includes commands, and a level-2 controller that controls system components according to the commands. The invention also includes a method of executing a process by identifying a set of states to be executed, issuing state commands that need to be issued to execute the current state in the set of states, and activating a next state only after all expected status reports have been received for the current state.
摘要翻译： 本发明是具有控制1级控制器控制器的主机控制器的状态机，其中1级控制器控制2级控制器。 2级控制器控制系统组件控制器，这些控制器又控制系统组件来执行进程段。 例如，该机器包括主机控制器，该主机控制器选择要执行的一组状态，以预定顺序激活状态集合的级别1的控制器，其中每个状态包括命令，以及控制系统的二级控制器 组件根据命令。 本发明还包括通过识别要执行的一组状态来执行处理的方法，发出需要发出的状态命令以执行该状态集合中的当前状态，并且仅在所有预期状态报告之后激活下一状态 已经收到了目前的状态。
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公开(公告)号：US20050008228A1
公开(公告)日：2005-01-13
申请号：US10850786
申请日：2004-05-21
申请人： Eric Chapoulaud , Harvey Kasdan
发明人： Eric Chapoulaud , Harvey Kasdan
IPC分类号： G01N20060101 , G01N15/14 , G06K9/03 , G06K9/62
CPC分类号： G06K9/00127 , G01N15/1429 , G01N15/1463 , G01N2015/1465 , G01N2015/1486 , G01N2015/1488
摘要： Most automatic particle classification methods produce errors. The invention provides a method for improving the accuracy of particle classification while shortening the amount of manual review time required from the operator. The method uses class weights, which are statistically-derived correction factors that accounts for frequency of classification errors. A first class weight and a second class weight are assigned to the first class and the second class, respectively. The number of particles in each of the first and the second classes is multiplied by the first class weight and the second class weight, respectively, to generate a corrected number of particles in each of the classes. If particles are reclassified, the class weights are recalculated in response to the reclassification. The method is usable with a complete classification where all the particles in a sample are classified, or a selective classification of a subset of the particles in the sample.
摘要翻译： 大多数自动粒子分类方法产生错误。 本发明提供了一种提高粒子分级精度的方法，同时缩短了操作者所需的手动审查时间。 该方法使用类权重，这是统计学派生的校正因子，考虑到分类错误的频率。 第一类和第二类的权重分别分配给第一类和第二类。 第一类和第二类中的每一个中的粒子数分别乘以第一等级权重和第二类权重，以在每个类中生成校正的粒子数。 如果粒子重新分类，则根据重新分类重新计算类别权重。 该方法可用于将样品中所有颗粒分类的完整分类，或样品中颗粒子集的选择性分类。
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公开(公告)号：US06594586B1
公开(公告)日：2003-07-15
申请号：US09182601
申请日：1998-10-28
申请人： Xubo Song , Yaser Abu-Mostafa , Joseph Sill , Harvey Kasdan
发明人： Xubo Song , Yaser Abu-Mostafa , Joseph Sill , Harvey Kasdan
IPC分类号： G06K900
CPC分类号： G06K9/6278 , G01N33/56972 , G06K9/00147 , G06K9/72 , Y10S436/80
摘要： Analysis of white blood cells is carried out by first analyzing the sample using image processing to obtain a no-context estimate of each cell's content. Then, a post processing operation is carried out to refine the estimate to include information about neighboring white blood cells. The estimate is refined to take into account the identity of the neighboring cells.
摘要翻译： 通过使用图像处理首先分析样本来获得白细胞的分析，以获得每个细胞内容的无上下文估计。 然后，执行后处理操作以细化估计以包括关于相邻白细胞的信息。 该估计被细化以考虑相邻小区的身份。
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6.发明申请Method and apparatus for detection and tracking of objects within a defined area 有权用于检测和跟踪定义区域内物体的方法和装置公开(公告)号：US20050200453A1
公开(公告)日：2005-09-15
申请号：US11040137
申请日：2005-01-21
申请人： Richard Turner , Harvey Kasdan
发明人： Richard Turner , Harvey Kasdan
CPC分类号： G08B25/009 , G07C9/00087 , G07C9/00111 , G08B13/2462 , G08B21/02 , G08B21/22
摘要： A method and apparatus for detecting and tracking an object with a defined area, and determining its position, status movement and identity therein, includes interrogating the defined area to communicate with an information device on object and transmit received to a master controller unit, which determines the object's presence, position, movement and identity with the defined area. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or the meaning of the claims.
摘要翻译： 一种用于检测和跟踪具有限定区域的对象并确定其中的位置，状态移动和身份的方法和装置，包括询问所定义的区域以与对象的信息设备进行通信，并将接收到的信息发送到主控制器单元，该主控制器单元确定 对象的存在，位置，移动和身份与定义的区域。 要强调的是，该摘要被提供以符合要求摘要的规则，这将允许搜索者或其他读者快速确定技术公开的主题。 提交它的理解是，它不会用于解释或限制权利要求的范围或含义。
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公开(公告)号：US08447417B2
公开(公告)日：2013-05-21
申请号：US11950311
申请日：2007-12-04
IPC分类号： G05B15/02
CPC分类号： G01N15/1463 , G01N15/1456 , G01N15/1459 , G01N35/00871 , G01N35/1009 , G05B19/0421 , G05B19/045 , G05B2219/2207 , G05B2219/2231 , G05B2219/2233 , G05B2219/23256 , G05B2219/23289 , G05B2219/23428 , G05B2219/25484 , G05B2219/2657
摘要： The invention is a state machine having a host controller that controls a level-1 controller, wherein the level-1 controller controls the level-2 controller. The level-2 controller controls system component controllers, which in turn control system components to execute a process segment. For example, the machine includes a host controller that selects a set of states to be executed, a level-1 controller that activates the set of states in a predetermined order, wherein each state includes commands, and a level-2 controller that controls system components according to the commands. A method of executing a process includes identifying a set of states to be executed, issuing state commands that need to be issued to execute the current state in the set of states, and activating a next state only after all expected status reports have been received for the current state.
摘要翻译： 本发明是具有控制1级控制器的主机控制器的状态机，其中1级控制器控制2级控制器。 2级控制器控制系统组件控制器，这些控制器又控制系统组件来执行进程段。 例如，该机器包括主机控制器，该主机控制器选择要执行的一组状态，以预定顺序激活状态集合的级别1的控制器，其中每个状态包括命令，以及控制系统的二级控制器 组件根据命令。 执行处理的方法包括识别要执行的一组状态，发出需要发出的状态命令以执行该状态集合中的当前状态，并且仅在已经接收到所有预期状态报告之后激活下一状态 当前状态。
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公开(公告)号：US20080140224A1
公开(公告)日：2008-06-12
申请号：US11950311
申请日：2007-12-04
IPC分类号： G05B15/02
CPC分类号： G01N15/1463 , G01N15/1456 , G01N15/1459 , G01N35/00871 , G01N35/1009 , G05B19/0421 , G05B19/045 , G05B2219/2207 , G05B2219/2231 , G05B2219/2233 , G05B2219/23256 , G05B2219/23289 , G05B2219/23428 , G05B2219/25484 , G05B2219/2657
摘要： The invention is a state machine having a host controller that controls a level-1 controller, wherein the level-1 controller controls the level-2 controller. The level-2 controller controls system component controllers, which in turn control system components to execute a process segment. For example, the machine includes a host controller that selects a set of states to be executed, a level-1 controller that activates the set of states in a predetermined order, wherein each state includes commands, and a level-2 controller that controls system components according to the commands. A method of executing a process includes identifying a set of states to be executed, issuing state commands that need to be issued to execute the current state in the set of states, and activating a next state only after all expected status reports have been received for the current state.
摘要翻译： 本发明是具有控制1级控制器的主机控制器的状态机，其中1级控制器控制2级控制器。 2级控制器控制系统组件控制器，这些控制器又控制系统组件来执行进程段。 例如，该机器包括主机控制器，该主机控制器选择要执行的一组状态，以预定顺序激活状态集合的级别1的控制器，其中每个状态包括命令，以及控制系统的二级控制器 组件根据命令。 执行处理的方法包括识别要执行的一组状态，发出需要发出的状态命令以执行该状态集合中的当前状态，并且仅在已经接收到所有预期状态报告之后激活下一状态 当前状态。
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9.发明申请公开(公告)号：US20060220787A1
公开(公告)日：2006-10-05
申请号：US11366050
申请日：2006-03-01
申请人： Richard Turner , Harvey Kasdan
发明人： Richard Turner , Harvey Kasdan
IPC分类号： G05B19/00
CPC分类号： G08B25/009 , G07C9/00087 , G07C9/00111 , G08B13/2462 , G08B21/02 , G08B21/22
摘要： A method and apparatus for detecting and tracking an object within a defined area, and determining its position, status, movement and identity therein, includes interrogating the defined area to communicate with an information device associated with an object and transmit information received to a master controller unit, which determines the object's presence, position, status, movement and identity within the defined area. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or the meaning of the claims.
摘要翻译： 一种用于检测和跟踪定义区域内的对象并确定其中的位置，状态，移动和身份的方法和装置，包括询问所定义的区域以与与对象相关联的信息设备进行通信并将接收到的信息发送到主控制器 单元，其确定对象在定义区域内的存在，位置，状态，移动和身份。 要强调的是，该摘要被提供以符合要求摘要的规则，这将允许搜索者或其他读者快速确定技术公开的主题。 提交它的理解是，它不会用于解释或限制权利要求的范围或含义。
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10.发明授权Method and apparatus for verifying uniform flow of a fluid sample through a flow cell and distribution on a slide 有权用于验证流体样品通过流动池的均匀流动并在载玻片上分布的方法和装置公开(公告)号：US06424415B1
公开(公告)日：2002-07-23
申请号：US09632091
申请日：2000-08-02
申请人： Harvey Kasdan , Jaehyl Ko
发明人： Harvey Kasdan , Jaehyl Ko
IPC分类号： G01N3348
CPC分类号： G01N15/147
摘要： Particles in a fluid are counted as the fluid flows through an examination area of a particle analyzer. Parameters based upon the particle count are calculated. It is determined whether the at least one calculated parameter is within an allowable range for the parameter. Based on this determination, an indication is provided of uniformity of the fluid sample in the examination area.
摘要翻译： 当流体流过颗粒分析仪的检查区域时，流体中的颗粒被计数。 计算基于粒子数的参数。 确定该至少一个计算的参数是否在参数的允许范围内。 基于该确定，提供在检查区域中流体样品的均匀性的指示。
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