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公开(公告)号：US6083931A
公开(公告)日：2000-07-04
申请号：US930680
申请日：1997-12-09
IPC分类号： A61K31/726 , A61P35/00 , C07H7/027 , A61K31/715
CPC分类号： A61K31/7012 , A61K31/726 , C07H7/027
摘要： The present invention is aimed at providing an anticancer agent which can inhibit the metastasis of cancer cells when used alone. In addition, the present invention is also aimed at providing an anticancer agent which can inhibit the metastasis of cancer cells while causing a small side effect and very small toxicity even for an extended time of administration. The cancer metastasis-inhibiting anticancer agent according to the present invention is characterized by containing sialic acid, its salt, a polymer of sialic acid or a salt of the polymer as an effective ingredient.
摘要翻译： PCT No.PCT / JP96 / 00268 Sec。 371日期1997年12月9日第 102（e）日期1997年12月9日PCT提交1996年2月8日PCT公布。 公开号WO97 / 28807 日期：1997年8月14日本发明旨在提供一种当单独使用时能抑制癌细胞转移的抗癌剂。 另外，本发明的目的还在于提供一种能够抑制癌细胞的转移，同时引起副作用小，毒性甚至延长施用时的毒性也非常小的抗癌剂。 根据本发明的癌转移抑制抗癌剂的特征在于含有唾液酸，其盐，唾液酸的聚合物或聚合物的盐作为有效成分。
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2.发明授权Therapeutic drug for endotoxin blood symptom and multi-organ failure induced thereby 失效由此引起内毒素血症和多器官功能衰竭的治疗药物公开(公告)号：US06395717B1
公开(公告)日：2002-05-28
申请号：US08776032
申请日：1997-01-23
申请人： Michio Ohta , Takaaki Hasegawa , Masayuki Nadai , Yasuko Yoshida , Mitsuo Kawase , Tadahiko Inukai
发明人： Michio Ohta , Takaaki Hasegawa , Masayuki Nadai , Yasuko Yoshida , Mitsuo Kawase , Tadahiko Inukai
IPC分类号： A61K31726
CPC分类号： A61K31/726 , A61K31/7012 , A61K31/715 , Y10S514/921
摘要： Therapeutic drugs for endotoxin blood symptom and multi-organ failure induced by it is provided, which therapeutic during are composed of sialic acid its salt, polymers of sialic acid or a salt of the polymer as effective components and have high therapeutic effects for shock death and organ failure induced by endotoxin as well as high safety, and are effective for treatment of endotoxin-shock, and organ failure.
摘要翻译： 提供了由其引起的内毒素血症和多器官功能衰竭的治疗药物，其由唾液酸盐，唾液酸聚合物或聚合物的盐作为有效成分组成，对休克死亡具有很高的治疗效果， 内毒素引起的器官功能衰竭以及安全性高，对内毒素休克和器官功能衰竭有效。
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公开(公告)号：US5143847A
公开(公告)日：1992-09-01
申请号：US441475
申请日：1989-11-27
申请人： Mitsuo Kawase , Yasuko Yoshida , Hitoshi Yonekawa
发明人： Mitsuo Kawase , Yasuko Yoshida , Hitoshi Yonekawa
摘要： An enzyme-fixed bioreactor, including a reaction column, enzyme-fixed catalyst particles uniformly and densely filled in the reaction column, the catalyst particles being composed of carrier sepiolite particles consisting essentially of sepiolite and an enzyme carried on the surface of the carrier sepiolite particles. The bioreactor has stable heat resistant and chemical properties, high productivity, and is economically superior to prior art, without fear of destruction of the catalyst, short path, and clogging in the reaction column.
摘要翻译： 一种酶固定生物反应器，包括反应柱，酶固定的催化剂颗粒，均匀且密集地填充在反应塔中，催化剂颗粒由主要由海泡石组成的载体海泡石颗粒和承载在载体海泡石颗粒表面上的酶组成 。 该生物反应器具有稳定的耐热性和化学性质，高生产率，并且在经济上优于现有技术，而不用担心催化剂破坏，短路径和反应柱堵塞。
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公开(公告)号：US20070238870A1
公开(公告)日：2007-10-11
申请号：US11572506
申请日：2005-07-29
IPC分类号： C12M1/00
CPC分类号： B01L3/502746 , B01L3/502707 , B01L2300/0636 , B01L2300/0822 , B01L2300/0877 , B01L2300/0887 , B01L2300/165
摘要： The hybridization device of the invention aims to attain a hybridization reaction of high reproducibility. A hybridization device 2 for a hybridization reaction of nucleic acid has a cover member 10 that defines a cavity 12, which includes a nucleic acid fixation area 6 of a substrate 4 for fixation of a nucleic acid probe and has capacity for storage of a liquid for the hybridization reaction therein. At least part of an area exposed to inside of the cavity 12 forms a hydrophobic region 18. Adequate control of the surface characteristic of the area exposed to the cavity for implementing the hybridization reaction desirably enhances the signal intensity and reduces a variation in signal intensity, thus attaining the hybridization reaction of high reproducibility.
摘要翻译： 本发明的杂交装置旨在实现高再现性的杂交反应。 用于核酸杂交反应的杂交装置2具有限定空腔12的覆盖构件10，其包括用于固定核酸探针的基底4的核酸固定区域6，并且具有用于储存用于 其中的杂交反应。 暴露于空腔12内部的区域的至少一部分形成疏水区域18。 为了实现杂交反应，暴露于空腔的区域的表面特性的适当控制期望增强信号强度并降低信号强度的变化，从而实现高再现性的杂交反应。
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5.发明授权Cancer metastasis inhibitor containing a streptococcus agalactiae Ia type or Ib type surface polysaccharide as a main ingredient 失效含有无乳链球菌Ia型或Ib型表面多糖作为主要成分的癌症转移抑制剂
公开(公告)号：US5939404A
公开(公告)日：1999-08-17
申请号：US894461
申请日：1997-08-19
IPC分类号： A61K31/715 , A61K35/74 , C12P19/04 , A61K39/09 , C08B37/00
CPC分类号： C12P19/04 , A61K31/715
摘要： The present invention relates to the technology for inhibiting the cancer metastasis, and is aimed at the provision of a pharmaceutical composition for effectively inhibiting the metastasis of the cancer. A cancer metastasis inhibitor according to the present invention is characterized by containing a sugar chain separated from a surface of a Streptococcus agalactiae Ia type or Ib type as a main ingredient. Since the surface sugar chains of the Streptococcus agalactiae Ia type or Ib type have structures similar to surface sugar chains of the cancer cells, the former surface sugar chains adhere to E-selectin appearing in an intravascular endothelial cell, competitively inhibit the adhesion between intravascular endothelial cells and the cancer cells, and effectively prevent of the metastasis of the cancer, when the sugar chains exist in blood of a patient.
摘要翻译： PCT No.PCT / JP95 / 02735 Sec。 371日期1997年8月19日 102（e）日期1997年8月19日PCT 1995年12月27日PCT PCT。 公开号WO97 / 24130 日期：1997年7月10日本发明涉及抑制癌症转移的技术，其目的在于提供有效抑制癌症转移的药物组合物。 根据本发明的癌症转移抑制剂的特征在于含有从无乳链球菌Ia型或Ib型表面分离的糖链作为主要成分。 由于无乳链球菌Ia型或Ib型的表面糖链具有类似于癌细胞的表面糖链的结构，所以前表面糖链粘附在出现在血管内内皮细胞中的E-选择素，竞争性地抑制血管内皮细胞 细胞和癌细胞，并且当糖链存在于患者的血液中时，有效地预防癌症的转移。
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公开(公告)号：US20110046015A1
公开(公告)日：2011-02-24
申请号：US12864619
申请日：2009-01-29
申请人： Hiroyuki Honda , Tsutomu Kawabe , Mina Okochi , Miyoko Matsushima , Naoki Matsumoto , Mitsuo Kawase , Yasuko Yoshida , Tomokazu Takase
发明人： Hiroyuki Honda , Tsutomu Kawabe , Mina Okochi , Miyoko Matsushima , Naoki Matsumoto , Mitsuo Kawase , Yasuko Yoshida , Tomokazu Takase
CPC分类号： G01N33/54393
摘要： Disclosed is a peptide immobilization technique which can achieve the immobilization of a satisfactory quantity of a peptide on a solid support. In the immobilization of a peptide on a solid support, a surfactant is allowed to coexist on the solid support together with the peptide. In this manner, the quantity of the peptide immobilized on the solid support can be increased.
摘要翻译： 公开了一种肽固定技术，其可以实现将令人满意的量的肽固定在固体支持物上。 在将肽固定在固体支持物上时，允许表面活性剂与肽一起共存在固体支持物上。 以这种方式，可以增加固定在固体支持物上的肽的量。
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公开(公告)号：US20070292853A1
公开(公告)日：2007-12-20
申请号：US10593349
申请日：2005-03-18
CPC分类号： C12Q1/6827 , C12Q2565/501 , C12Q2537/143 , C12Q2525/204
摘要： A DNA array for detecting a single nucleotide polymorphism of a gene, which comprises, on a solid support, a first probe spots group consisting of one or more probe spots each containing one or more probes hybridizable with a polynucleotide of the gene, in which the probes are exactly complementary to the first polymorphism pattern of the gene, and a second probe spots group consisting of one or more probe spots each containing one or more probes hybridizable with the polynucleotide of the gene, in which the probes are exactly complementary to the second polymorphism pattern of the gene, wherein probe lengths in the probe spots is different from each other. This DNA array enables more exact SNP detection.
摘要翻译： 一种用于检测基因的单核苷酸多态性的DNA阵列，其在固体支持物上包含由一个或多个探针点组成的第一探针斑点，每个探针点含有一个或多个与该基因的多核苷酸杂交的探针，其中 探针与基因的第一多态性模式完全互补，第二探针点组由一个或多个探针点组成，每个探针点含有一个或多个可与基因的多核苷酸杂交的探针，其中探针与第二个 基因的多态性模式，其中探针点中的探针长度彼此不同。 该DNA阵列能够进行更准确的SNP检测。
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公开(公告)号：US4723791A
公开(公告)日：1988-02-09
申请号：US921125
申请日：1986-10-21
申请人： Kiyokatsu Miura , Nobuo Hiraiwa , Hajime Naruse , Shogo Tanaka , Hisaomi Kumai , Mitsuo Kawase , Naoto Kitagawa
发明人： Kiyokatsu Miura , Nobuo Hiraiwa , Hajime Naruse , Shogo Tanaka , Hisaomi Kumai , Mitsuo Kawase , Naoto Kitagawa
CPC分类号： B60G99/00 , B60G3/205 , B60G7/02 , F16F1/387 , B60G2200/144 , B60G2204/15 , B60G2204/41 , B60G2204/41042 , B60G2204/42 , B60G2204/45
摘要： A suspension of a vehicle includes a set of suspension arms each supporting a wheel, a subframe pivotably connected on its left and right sides with the respective suspension arms, the subframe having on its each side portions forward and rearward of a rotary axis of the wheel and six elastic mounts. The subframe is coupled on each side thereof with a car body through two of the elastic mounts disposed at lateral interval in one of the portion and one elastic mount disposed in the other of the portions.
摘要翻译： 车辆的悬架包括一组支撑车轮的悬架臂，一个在其左侧和右侧与相应悬架臂可枢转地连接的车架，该副车架在车轮的旋转轴线的前后两侧 和六个弹性支架。 子框架在其每一侧上与轿厢主体连接，其中两个弹性支架以横向间隔设置在设置在另一个部分中的一个部分和一个弹性支架中。
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公开(公告)号：US5100553A
公开(公告)日：1992-03-31
申请号：US570042
申请日：1990-08-20
申请人： Tadashi Nomura , Mitsuo Kawase , Naoki Murata
发明人： Tadashi Nomura , Mitsuo Kawase , Naoki Murata
CPC分类号： C12M21/04 , C02F3/2806 , C02F3/34 , C12M25/18 , Y02E50/343
摘要： Proliferation activity of methane bacteria in organic waste water can be improved by maintaining the ratio of the amounts of nickel, iron and cobalt contained in the waste water to the BOD thereof to not lower than certain values, and various organic waste waters, such as waste liquor formed during the production of beer and the like, can be treated in a high BOD removal ratio of not lower than 90% while maintaining a high BOD load of not lower than 10 kg/m.sup.3 .multidot.day.
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公开(公告)号：US4872439A
公开(公告)日：1989-10-10
申请号：US151182
申请日：1988-02-01
申请人： Hidefumi Sonoda , Eiji Mori , Mitsuo Kawase , Kazuhiro Yoneshige , Akira Takahashi , Hirokazu Komiya , Akira Tanaka
发明人： Hidefumi Sonoda , Eiji Mori , Mitsuo Kawase , Kazuhiro Yoneshige , Akira Takahashi , Hirokazu Komiya , Akira Tanaka
IPC分类号： B60K15/035 , F02M25/08
CPC分类号： F02M25/089 , B60K15/03504 , B60K15/03519 , F02M25/0836 , F02M2025/0845 , Y10T137/86332
摘要： A device for preventing an outflow of a fuel vapor from a fuel tank comprising a breather pipe which connects the upper interior of the fuel tank to a charcoal canister. A float-valve assembly is mounted on the upper wall of the fuel tank. This assembly comprises a breather passage connected to the charcoal canister via the breather pipe, a normally closed solenoid valve arranged in the breather passage, and a float normally allowing the breather passage to be open to the interior of the fuel tank. When the replenishment of the fuel tank is carried out, the solenoid valve is opened to feed fuel vapor in the fuel tank into the charcoal canister.
摘要翻译： 一种用于防止来自燃料箱的燃料蒸气流出的装置，包括将燃料箱的上部内部连接到活性炭罐的通气管。 浮子阀组件安装在燃油箱的上壁上。 该组件包括通过通气管连接到木炭罐的通气通道，布置在通气通道中的常闭电磁阀和通常允许通气通道打开到燃料箱内部的浮子。 当进行燃料箱的补充时，电磁阀打开，将燃料箱内的燃料蒸气送入活性炭罐。
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