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    Transdermally absorbable Donepezil Preparation
    1.
    发明申请
    Transdermally absorbable Donepezil Preparation 审中-公开
    透皮吸收多奈哌齐制剂

    公开(公告)号：US20090175929A1

    公开(公告)日：2009-07-09

    申请号：US12227201

    申请日：2007-05-08

    申请人： Takaaki Terahara ,  Yasunari Michinaka ,  Kazunosuke Aida ,  Masaru Nakanishi ,  Wataru Hattori ,  Takao Kuroda

    发明人： Takaaki Terahara ,  Yasunari Michinaka ,  Kazunosuke Aida ,  Masaru Nakanishi ,  Wataru Hattori ,  Takao Kuroda

    IPC分类号： A61K9/70 ,  A61K31/4353

    CPC分类号： A61K9/7053 ,  A61K9/7061 ,  A61K31/445 ,  A61K47/02 ,  A61K47/12 ,  A61K47/20 ,  C07D211/32

    摘要： Disclosed is a donepezil-containing transdermally absorbable preparation which develops reduced adverse side effects and shows a satisfactory level of therapeutic effect. The preparation comprises an adhesive and a donepezil component (containing crystalline donepezil having type-B crystal polymorphism) and/or a salt thereof, wherein the donepezil component or the salt thereof is contained in an amount of 9 to 50% by mass relative to the total weight of the adhesive. The preparation (particularly, one having a non-aqueous adhesive layer) shows an excellent penetration of donepezil and/or a salt thereof into the skin, retains good stability of the active ingredient therein, and is remarkably reduced in local stimulation and adverse side effects.

    摘要翻译： 公开了一种含多奈哌齐的透皮吸收制剂，其具有减少的副作用，并显示令人满意的治疗效果。 该制剂包含粘合剂和多奈哌齐组分（含有具有B型晶体多晶型的结晶多奈哌齐）和/或其盐，其中所述多奈哌齐组分或其盐的含量相对于所述组合物为9〜50质量％ 粘合剂的总重量。 该制剂（特别是具有非水性粘合剂层的制剂）显示出多奈哌齐和/或其盐对皮肤的渗透性优异，保持其中活性成分的良好稳定性，并且局部刺激和不良副作用显着降低 。

    Transdermal Absorption Patch
    2.
    发明申请
    Transdermal Absorption Patch 审中-公开
    经皮吸收贴片

    公开(公告)号：US20080138388A1

    公开(公告)日：2008-06-12

    申请号：US11883672

    申请日：2006-01-24

    申请人： Kazunosuke Aida ,  Yasunari Michinaka ,  Takaaki Terahara

    发明人： Kazunosuke Aida ,  Yasunari Michinaka ,  Takaaki Terahara

    IPC分类号： A61K9/70 ,  A61K31/445 ,  A61P43/00

    CPC分类号： A61K9/7061 ,  A61K31/445 ,  A61K31/454

    摘要： It is intended to provide a transdermal absorption patch which is highly excellent in transdermal absorption properties and long-lasting drug effect even in the case where a drug-effect component contained in the transdermal absorption patch is a basic drug hardly soluble in a pressure-sensitive adhesive base, has a high stability of the drug contained therein with the passage of time and can achieve improvement in the compliance and simplification of the administration method. These problems can be solved by providing a transdermal absorption patch which contains a basic drug having an octanol/water partition coefficient (logarithm) in the free state of 3 or above, a pressure-sensitive adhesive base and a (meth)acrylic copolymer having carboxyl group.

    摘要翻译： 旨在提供一种透皮吸收贴片，即使在经皮吸收贴剂中含有的药物作用成分是几乎不溶于压敏药物的碱性药物的情况下，其经皮吸收性能和持久的药物作用也非常优异 粘合剂基，随着时间的流逝，其中所含药物的稳定性高，并且可以提高施用方法的顺应性和简化性。 这些问题可以通过提供一种透皮吸收贴片来解决，该贴剂含有游离状态3以上的辛醇/水分配系数（对数），粘合剂基和具有羧基的（甲基）丙烯酸共聚物）的碱性药物 组。

    Transdermal preparations and method for relieving side effects in pergolide therapy
    3.
    发明申请
    Transdermal preparations and method for relieving side effects in pergolide therapy 审中-公开
    透皮制剂和缓释百草苷治疗副作用的方法

    公开(公告)号：US20070082037A1

    公开(公告)日：2007-04-12

    申请号：US10577746

    申请日：2004-10-29

    申请人： Arata Toshimitsu ,  Kazunosuke Aida ,  Takaaki Terahara ,  Naruhito Higo

    发明人： Arata Toshimitsu ,  Kazunosuke Aida ,  Takaaki Terahara ,  Naruhito Higo

    IPC分类号： A61K31/48 ,  A61K9/70

    CPC分类号： A61K9/7061 ,  A61K9/7076 ,  A61K31/48

    摘要： It is intended to provide pergolide-containing transdermal preparations having reducreduced side effects and exerting sufficient therapeutic effects. Namely, a pergolide-containing transdermal preparation which is capable of achieving a plasma AUC ratio of pergolide or the like to at least one pergolide metabolite of 1:0.5 to 1:5; and/or transdermal preparation containing pergolide and/or a pharmaceutically acceptable salt thereof which is capable of achieving a ratio (A/B) of the maximum plasma level (A) of pergolide and/or a pharmaceutically acceptable salt thereof to the plasma level (B) thereof in the next administration of less than 2.

    摘要翻译： 旨在提供具有降低的副作用并施加足够治疗效果的含有pergolide的透皮制剂。 即，含有速溶胶的透皮制剂，能够实现速溶胶等的血浆AUC比例为1:0.5至1:5的至少一种pergolide代谢物; 和/或透皮制剂，其含有速溶胶和/或其药学上可接受的盐，其能够实现血浆白蛋白的最大血浆水平（A）和/或其药学上可接受的盐与血浆水平的比（A / B） B）在下一次给药时不到2次。

    Adhesive patch
    4.
    发明授权
    Adhesive patch 有权
    胶贴

    公开(公告)号：US08691267B2

    公开(公告)日：2014-04-08

    申请号：US10525646

    申请日：2003-08-07

    申请人： Takaaki Terahara ,  Kazunosuke Aida ,  Arata Toshimitsu ,  Naruhito Higo

    发明人： Takaaki Terahara ,  Kazunosuke Aida ,  Arata Toshimitsu ,  Naruhito Higo

    IPC分类号： A61K9/70 ,  A61F13/02

    CPC分类号： A61K9/7053 ,  A61K9/7061 ,  A61K9/7076 ,  A61K31/405 ,  A61K31/4422 ,  A61K31/48

    摘要： A patch comprising a backing layer and an adhesive layer disposed on the backing layer and compounded with a drug and an adhesive base agent, wherein the adhesive base agent comprises styrene-isoprene-styrene block copolymer, 2-ethylhexyl acrylate-vinyl acetate copolymer and a basic nitrogen-including polymer including a basic nitrogen and having no adhesion property at normal temperature.

    摘要翻译： 一种贴剂，包括背衬层和设置在背衬层上并与药物和粘合剂基剂复配的粘合剂层，其中所述粘合剂基剂包括苯乙烯 - 异戊二烯 - 苯乙烯嵌段共聚物，丙烯酸2-乙基己酯 - 乙酸乙烯酯共聚物和 碱性含氮聚合物，包括碱性氮，并且在常温下不具有附着性。

    Cover material and plaster with cover material
    6.
    发明申请
    Cover material and plaster with cover material 审中-公开
    覆盖材料和石膏与封面材料

    公开(公告)号：US20070190123A1

    公开(公告)日：2007-08-16

    申请号：US10587832

    申请日：2005-01-31

    申请人： Kazunosuke Aida ,  Arata Toshimitsu ,  Takaaki Terahara ,  Naruhito Higo

    发明人： Kazunosuke Aida ,  Arata Toshimitsu ,  Takaaki Terahara ,  Naruhito Higo

    IPC分类号： A61F13/02

    CPC分类号： A61K9/7084 ,  A61F2013/00646 ,  A61L15/44 ,  A61L2300/40 ,  A61L2300/608

    摘要： The present invention provides a cover material 10, adapted to be attached to skin in a manner covering over the entirety of a patch 20, comprising a pressure-sensitive adhesive layer 12 on one side of a support 11, wherein said patch 20 comprises a drug-containing layer 22 for contacting with the skin, said layer being provided on a support film 21 with a thickness of 12-30 μm, and wherein the cover material 10 is adapted to be attached to said support film 21 and a region of the skin around said patch 20 in such a manner that the pressure-sensitive adhesive layer 12 contacts with the edges of the drug-containing layer 22, and the pressure-sensitive adhesive layer 12 comprises a pressure-sensitive adhesive obtained by polymerizing vinyl acetate or N-vinyl-2-pyrrolidone and a (meth)acrylic acid alkyl ester with a C8 alkyl group as essential monomer components. According to the invention, it is possible to provide a cover material capable of reducing irritation to an affected area such as skin when a patch employing a drug such as pergolide mesylate is covered and affixed to the affected area.

    摘要翻译： 本发明提供了一种覆盖材料10，其适于以覆盖整个贴片20的方式附着到皮肤上，其包括在支撑体11的一侧上的压敏粘合剂层12，其中所述贴片20包括药物 容纳层22，用于与皮肤接触，所述层设置在厚度为12-30μm的支撑膜21上，并且其中覆盖材料10适于附着到所述支撑膜21和皮肤区域 围绕所述贴片20，使得压敏粘合剂层12与药物含有层22的边缘接触，并且压敏粘合剂层12包含通过聚合乙酸乙烯酯或N-乙烯基缩水甘油酯获得的压敏粘合剂， 乙烯基-2-吡咯烷酮和具有C8烷基作为必需单体成分的（甲基）丙烯酸烷基酯。 根据本发明，可以提供一种覆盖材料，其能够在使用药物例如甲磺酸格列德里特的贴剂覆盖并固定在受影响的区域时能够减少对患部的皮肤的刺激。

    Adhesive patch
    7.
    发明申请
    Adhesive patch 审中-公开
    胶贴

    公开(公告)号：US20060110433A1

    公开(公告)日：2006-05-25

    申请号：US10526065

    申请日：2003-08-07

    申请人： Takaaki Terahara ,  Kazunosuke Aida ,  Arata Toshimitsu ,  Naruhito Higo

    发明人： Takaaki Terahara ,  Kazunosuke Aida ,  Arata Toshimitsu ,  Naruhito Higo

    IPC分类号： A61K31/48 ,  A61F13/02 ,  A61L15/16

    CPC分类号： A61K9/7053 ,  A61K9/7061 ,  A61K9/7076 ,  A61K31/48

    摘要： A patch comprising a backing layer and an adhesive layer disposed on the backing layer and compounded with an adhesive base agent and pergolide and/or a pharmaceutically acceptable salt thereof, wherein the adhesive base agent comprises an acrylic polymer including no substantial carboxyl group and hydroxyl group and having self-adhesion properties and a rubber polymer, and the weight ratio of the content of the acrylic polymer to the content of the rubber polymer is from 1:1 to 1:9.

    摘要翻译： 一种贴剂，其包括背衬层和设置在背衬层上并与粘合剂基剂和高氯代内酯和/或其药学上可接受的盐复合的粘合剂层，其中所述粘合剂基剂包含不含实质性羧基和羟基的丙烯酸聚合物 并且具有自粘性和橡胶聚合物，并且丙烯酸类聚合物的含量与橡胶聚合物的含量的重量比为1:1至1:9。

    MICRONEEDLE DEVICE
    8.
    发明申请
    MICRONEEDLE DEVICE 有权
    MICRONEEDLE设备

    公开(公告)号：US20120130306A1

    公开(公告)日：2012-05-24

    申请号：US13376656

    申请日：2010-06-10

    申请人： Takaaki Terahara ,  Seiji Tokumoto

    发明人： Takaaki Terahara ,  Seiji Tokumoto

    IPC分类号： A61M5/00

    CPC分类号： A61K9/0021 ,  A61K47/34 ,  A61M37/0015 ,  A61M2037/0023 ,  Y02A50/471

    摘要： Provided is a microneedle device where a coating agent has been applied to microneedles having a biodegradable resin. It has been found that the application of the coating agent to microneedles of a biodegradable resin having a predetermined strength allows the microneedles to have excellent performance. Further, with regard to the coating agent, a predetermined type and amount thereof are also useful to demonstrate performance. Accordingly, when a microneedle device 1 is arranged so that at least a part of a microneedle array 2 provided with microneedles 3 made from polylactic acid having a weight average molecular weight of 40,000 or more is coated with a carrier containing physiologically active ingredients, it is possible to attain excellent migration characteristics of the physiologically active ingredients to a living body.

    摘要翻译： 提供了一种微针装置，其中将涂布剂施加到具有可生物降解树脂的微针上。 已经发现，将具有预定强度的可生物降解树脂的涂覆剂涂覆在微针上，使得微针具有优异的性能。 此外，关于涂布剂，其预定类型和量也可用于显示性能。 因此，在配置微针装置1的情况下，由具有重均分子量为40,000以上的聚乳酸制成的具有微针3的微针阵列2的至少一部分被包含生理活性成分的载体包覆， 可能获得生物活性成分对生物体的优异迁移特性。